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All Journal Global Medical and Health Communication Jurnal Penelitian Pendidikan IPA (JPPIPA) Sumatera Medical Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Meike Rachmawati
Fakultas Kedokteran, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Histopathological Review of Granuloma in Diagnosis of Tuberculosis Lymphadenitis (TBL) Purbaningsih, Wida; Rachmawati, Meike; Triyani, Yani; Rahmi, Fadhilat Sabila
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12742

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Indonesia has the highest TB cases in West Java, East Java, and Central Java. Tuberculosis lymphadenitis (TBL) represents about 30–40% of cases of extrapulmonary tuberculosis. The study aimed to study the clinical and histopathological characteristics of TBL patients. The research design in this study used an exploratory, descriptive method. Data was taken from Al Islam Hospital Bandung as medical records from January 2019 to December 2020. The result showed that TBL primarily affects patients aged 6–11 years (28%), male gender (57%), patients not working (25%), and those residing in the East Bandung area (34%). Histopathological appearance showed granulomas of caseous necrosis, epithelioid cells, and Langhan's cells, indicated by types 1, 2, and 3. The most common type was type 1 (47%), which was more widely distributed in the right neck (46%) with size 1–3 cm. In conclusion, the frequency of TBL is higher in boys aged 6–11 years, residents of the East Bandung area, and patients who did not work. Well-formed granuloma of enlarged lymph nodes in the right neck with size 1–3 cm is most commonly found in TBL.
Karakteristik Kuantitas Konten Seluler Apus Mukosa Bukal Antara Perokok dan Non Perokok Azlia Salsabila Rahadian Putri; Kharisma, Yuktiana; Rachmawati, Meike
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10688

Abstract

Abstract. Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd place with the highest number of smokers in the world. The habit of consuming cigarettes can cause serious problems such as stroke, cancer and coronary heart disease. Long-term exposure to dangerous compounds in cigarettes such as tar, nicotine, bensopyrene can cause dysplasia that occurs in the mucosal epithelium of the oral cavity. This study aims to see differences in the quantity of cellular content of buccal mucosal smears between smokers and non-smokers. This research uses an analytical observational method through an approachcross sectional which was carried out on 20 people in the work environment of Bandung Islamic University. Data were obtained from the results of buccal mucosal swabs stained with dyepap smear(Pap) and observed under a light microscope. Data were analyzed using univariate and bivariate tests and tests were carried outT Independent andmann whitney. This research found that the characteristics of non-smokers were an average age of 46 years, a bachelor's degree, married with a middle income. Characteristics of smokers, the average age is 38 years, high school education, married with low income, Ujit independent get no difference in cell numbers between smokers and non-smokers, testmann whitney shows that there is a difference in the number of lymphocyte cells between the two populations with a P value of 0.009 (<0.05). Smoking does not cause changes in the quantity of cellular content of the buccal mucosa, but smoking can cause chronic inflammation and lead to mutations and malignancy in buccal mucosal cells. Abstrak. Rokok merupakan masalah kesehatan yang menjadi fokus utama di Indonesia, Indonesia masih menempati posisi ke 3 dengan angka perokok tertinggi di dunia. Kebiasaan mengkonsumsi rokok dapat menyebabkan masalah serius seperti stroke, kanker, dan penyakit jantung koroner. Paparan jangka panjang terhadap senyawa berbahaya dalam rokok seperti tar, nikotin, bensopiren dapat menimbulkan displasia yang terjadi pada epitel mukosa rongga mulut. Penelitian ini bertujuan untuk melihat perbedaan kuantitas konten selular apus mukosa bukal antara perokok dan non perokok. Penelitian ini menggunakan metode observasional analitik melalui pendekatan cross sectional yang dilakukan pada 20 orang di lingkungan kerja Universitas Islam Bandung. Data diperoleh dari hasil swab mukosa bukal yang diwarnai oleh pewarna papanicolaou (Pap) dan diamati dibawah mikroskop cahaya. Data dianalisis dengan uji univariat dan bivariat dan dilakukan uji T Independent dan mann whitney. Penelitian ini didapatkan karakteristik non perokok berusia rata rata 46 tahun, berpendidikan S1, sudah menikah dengan penghasilan menengah. Karakteristik perokok rata-rata berusia 38 tahun, berpendidikan SMA, sudah menikah dengan pendapatan rendah, Uji t independent mendapatkan tidak adanya perbedaan jumlah sel antara perokok dan non perokok, uji mann whitney menunjukan adanya perbedaan jumlah sel linfosit antara kedua populasi dengan nilai P sebesar 0.009 (<0.05). Merokok tidak menyebabkan perubahan kuantitas konten selular mukosa bukal, namun merokok dapat menyebabkan inflamasi kronis dan mengarah ke mutasi dan berujung keganasan pada sel mukosa bukal.
Perbandingan Efektivitas Antibakteri Ekstrak Air Kopi Arabika dengan Ekstrak Air Teh Hitam terhadap Kultur Bakteri Methicillin-Resistant Staphylococcus Aureus (MRSA) ATCC© 33591™ Secara Eksperimental in Vitro Rizky Alifian Ramadhan; Hendro Sudjono Yuwono; Meike Rachmawati
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10771

Abstract

Abstract. S. aureus infections often occur in a community or hospital environment and management is still difficult due to the emergence of strains that are resistant to many antibiotics such as Methicillin-resistant Staphylococcus aureus (MRSA). Herbal medicine is an alternative treatment that is often used, including Arabica Coffee (Coffea Arabica) and black tea (Camelia Sinensis). Arabica coffee and black Tea contain polyphenols known as caffeine, chlorogenic acid and catechins. The catechins in black tea, namely epigallocatechin gallate (EGCG) and chlorogenic acid in coffee, have been proven to have antibacterial power against gram-positive bacteria. In gram-positive bacteria, EGCG and chlorogenic acid are able to inhibit the synthesis of the bacterial wall. This research used an experimental in vitro study with the method used by Kirby Bauer disc diffusion with 5 samples, Arabica coffee water extract and black tea water extract in two concentrations, 50% and 100% as treatment, and the antibiotic Vancomycin with a concentration of 100% as a positive control. The research results showed that Arabica coffee water extract had an average zone of inhibition, at a concentration of 100% (14.2 mm) and a concentration of 50% (9.7 mm) with a probability value (p-value) of 0.009 (p≤0, 01), while an inhibition zone was found in black tea water extract at a concentration of 100% (16.2 mm) and a concentration of 50% (11.5 mm) with a probability value (p-value) of 0.009 (p≤0.01) against Methicillin-resistant S. aureus. In conclusion, the inhibitory power of Black Tea water extract is stronger than that of Arabica coffee water extract against Methicillin-resistant Staphylococcus aureus bacteria. Abstrak. Infeksi S. aureus sering terjadi pada suatu komunitas atau lingkungan rumah sakit dan untuk pengelolaannya menjadi sulit karena munculnya strain yang resisten terhadap banyak obat antibiotik seperti Methicillin-resistant Staphylococcus aureus (MRSA). Obat herbal merupakan salah satu pengobatan alternatif yang sering dipergunakan, diantaranya terdapat kopi Arabika (Coffea Arabika) dan teh hitam (Camelia Sinensis). Kopi arabika dan teh hitam memiliki kandungan polifenol yang dikenal sebagai kafein, asam klorogenat dan katekin. Katekin pada teh hitam yaitu epigallocatechin gallat (EGCG) dan asam klorogenat pada kopi terbukti memiliki daya antibakteri terhadap bakteri gram positif. Pada bakteri gram positif EGCG dan asam klorogenat mampu menghambat sintesis dari dinding bakteri. Penelitian ini menggunakan studi eksperimental in vitro dengan metode yang digunakan disc diffusion Kirby Bauer dengan 5 sampel, yakni ekstrak air kopi Arabika dan ekstrak air teh hitam dalam dua konsentrasi yaitu 50% dan 100% sebagai perlakuan, dan antibiotik Vancomycin degan konsentrasi 100% sebagai kontrol positif. Hasil penelitian didapatkan ekstrak air kopi Arabika memiliki rata-rata zona inhibisi yaitu pada konsentrasi 100%, (14,2 mm) dan konsentrasi 50% (9,7 mm) dengan nilai probabilitas (p-value) sebesar 0,009 (p≤0,01), sedangkan ditemukan zona inhibisi pada ekstrak air teh hitam pada konsentrasi 100%, (16,2 mm) dan konsentrasi 50% (11,5 mm) dengan nilai probabilitas (p-value) sebesar 0,009 (p≤0,01) terhadap Methicillin-resistant S. aureus. Kesimpulannya, bahwa daya hambat ekstrak air Teh Hitam lebih kuat dibandingkan dengan ekstrak air kopi Arabika terhadap bakteri Methicillin-resistant Staphylococcus aureus.
Scoping Review: Efektifitas Ekstrak Air Kopi terhadap Pembentukan Zona Hambat pada Kultur Propionibacterium Acnes Andre Akbar Mubarok; Hendro Sudjono Yuwono; Meike Rachmawati
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12424

Abstract

Abstract. Acne vulgaris is an inflammatory disease that affects various age groups, especially teenagers. Based on the course of the disease, acne vulgaris is a primary inflammatory disease that affects the pilosebaceous unit and one of the causes is Cutibacterium acnes or previously known as Propionibacterium acnes. The prevalence of acne vulgaris in the world ranks 8th in terms of the total prevalence of skin diseases. In Indonesia, the prevalence of this disease is 80-85%, which occurs in adolescence with a peak at the age of 15-18 years. It is felt that the use of antibiotics as main line therapy has side effects that are considered to be detrimental to long-term health, namely resistance. The aim of this research is to analyze and compare the benefits of coffee as an alternative therapy for acne vulgaris. This research uses a Scoping review study to analyze, analyze and publish scientific papers through data sources, Pubmed, SpringerLink, Science Direct, ProQuest, and Garuda that meet the inclusion, exclusion and eligibility criteria using the JBI Critical Appraisal Checklist summarized in the PRISMA diagram. 17,508 articles were generated from 5 data sources, 487 articles met the inclusion criteria and 3 articles met the exclusion and eligibility criteria. The results of 3 articles stated that there were research results showing that the active substances in coffee, especially in the Coffea Canephora (robusta) variety, were effective in inhibiting the growth of Propionibacterium acnes bacteria which is the main etiology of acne vulgaris. The antibacterial ability of coffee has been proven to be quite good, with the level of effectiveness increasing with higher concentrations of coffee extract. These results give a positive impression of the potential use of coffee, especially Robusta, as an antibacterial agent to treat the problem of acne vulgaris. Abstrak. Acne vulgaris merupakan penyakit inflamasi yang dimiliki berbagai kelompok usia terutama remaja. Berdasarkan perjalanan penyakitnya acne Vulgaris merupakan penyakit inflamasi primer yang mempengaruhi unit pilosebaceous dengan salah satu pencetusnya adalah Cutibacterium acnes atau yang sebelumnya disebut sebagai Propionibacterium acnes. Prevalensi acne vulgaris di dunia menempati urutan ke-8 dari total prevalensi penyakit kulit. Di Indonesis prevalensi penyakit ini memiliki jumlah sebesar 80-85%, yang terjadi pada usia remaja dengan puncaknya pada usia 15-18 tahun. Penggunaan antibiotik sebagai terapi lini utama dirasa memiliki efek samping yang dinilai dapat merugikan utuk kesehatan jangka panjang yaitu resistensi. Tujuan penelitian ini adalah untuk menganalisis serta membandingkan manfaat kopi sebagai terapi alternatif akne vulgaris. Penelitian ini menggunakan studi Scoping reaview untuk mengidentifikasi, menganalisis dan mengevaluasi tulisan ilmiah melalui sumber data, Pubmed, SpringerLink, Science Direct, ProQuest, dan Garuda yang memenuhi kriteria inklusi, eklusi dan kelayakan menggunakan JBI Critical Appraisal Checklist dirangkum dalam diagram PRISMA. Dihasilkan 16.037 dari 5 sumber data, 479 artikel memenuhi kriteria inklusi dan 3 artikel memenuhi kriteria eklusi dan kelayakan. Hasil 3 artikel menyatakan terdapat hasil Penelitian menunjukkan bahwa zat aktif dalam kopi, terutama pada varietas Coffea Canephora (robusta), efektif dalam menghambat pertumbuhan bakteri Propionibacterium acnes yang menjadi etiologi utama acne vulgaris. Kemampuan antibakteri kopi terbukti cukup baik, dengan tingkat efektivitas yang meningkat seiring dengan konsentrasi ekstrak kopi yang lebih tinggi. Hasil ini memberikan implikasi positif terhadap potensi penggunaan kopi, khususnya robusta, sebagai agen antibakteri untuk mengatasi masalah acne vulgaris.
Karakteristik Klinis pada Pasien Limfadenitis Granulomatus Non-Tuberkulosis di RS Muhammadiyah Bandung Fasyah Rizki Putri; Kharisma, Yuktiana; Rachmawati, Meike
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12531

Abstract

Abstract. Tuberculosis disease caused by the bacterium Mycobacterium tuberculosis is a global health problem with more than 10 million cases reported by the World Health Organization (WHO) throughout the world. Indonesia also has a significant prevalence rate, especially pulmonary TB, which is ranked fourth highest globally. This study aims to gain a comprehensive understanding of the clinical characteristics of non-tuberculous granulomatous lymphadenitis patients at the Muhammadiyah Hospital in Bandung. This research uses a descriptive method, with research time from January-December 2022. The sample for this research is medical record data from patients with non-tuberculous granulomatous lymphadenitis at Muhammadiyah Hospital in Bandung who meet the inclusion criteria using total sampling. The results of this research were 46 people, but only 40 people met the inclusion criteria. This study discusses the clinical characteristics of patients with non-tuberculous granulomatous lymphadenitis. From this research, it can be concluded that the clinical characteristics based on age are 22-31 years, based on gender the majority are women, the most frequent location of the KGB is the right neck and the symptoms that often appear are pain in the lump, fever and shortness of breath. Abstrak. Penyakit tuberkulosis yang disebabkan oleh bakteri Mycobacterium tuberculosis merupakan masalah kesehatan global dengan lebih dari 10 juta kasus dilaporkan oleh World Health Organization (WHO) di seluruh dunia. Indonesia juga memiliki tingkat prevalensi yang signifikan, terutama TBC paru yang menduduki peringkat global tertinggi keempat. Penelitian ini bertujuan untuk mendapatkan pemahaman menyeluruh tentang karakteristik klinis pada pasien limfadenitis granulomatus non-tuberkulosis di Rumah Sakit Muhammadiyah Bandung. Penelitian ini menggunakan metode descriptive, dengan waktu penelitian dari Januari-Desember 2022. Sampel penelitian ini adalah data rekam medis pasien limfadenitis granulomatous non tuberkulosis di RS Muhammadiyah Bandung yang memenuhi kriteria inklusi dengan menggunakan total sampling. Hasil penelitian ini didapatkan 46 orang, namun hanya 40 orang yang sesuai dengan kriteria inklusi. Penelitian ini mendiskusikan tentang karakteristik klinis pada pasien limfadenitis granulomatus non-tuberkulosis. Dari penelitian ini, dapat disimpulkan bahwa karakteristik klinis berdasarkan usia adalah 22-31 tahun, berdasarkan jenis kelamin yang paling banyak yaitu perempuan, letak KGB yang paling sering adalah leher kanan dan gejala yang sering muncul yaitu nyeri pada benjolan, demam, dan sesak nafas.
Karakteristik Pasien Otitis Media Akut Berdasarkan Jenis Kelamin, Umur dan Riwayat Infeksi Saluran Pernapasan Atas (ISPA) di RS Al-Islam Bandung Tahun 2020-2022 Faqiekha Jauziyah Al-Faghiyah; Mia Kusmiati; Meike Rachmawati
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12555

Abstract

Abstract. Acute otitis media (OMA) is an acute inflammation of the middle ear that lasts < 3 weeks. Acute otitis media can be caused by viruses or bacteria. In previous research, the most common clinical symptom in children suffering from AOM was fluid discharge from the ears. It has also been found that 29-50% of all ARI develop into OMA. The aim of this study was to determine the characteristics of acute otitis media sufferers based on gender, age, duration of complaints, symptoms and history of ARI (Upper Respiratory Tract Infection). The research method used in this study was descriptive using a cross sectional design. Research subjects were patients diagnosed with OMA at the ENT clinic at Al-Islam Hospital Bandung in 2020-2022. Most of the OMA patients were female as many as 93 people (64.6%), dominated by patients aged 18-40 years as many as 52 people (36.1%), and the majority had no history of ARI, 141 people (97.9%). The conclusion of this research is that OMA cases in the ENT clinic at Al-Islam Hospital Bandung are dominated by women in the age range, most in the adult age range 18-40 years, and have a complaint duration of < 1 week with the most common symptoms being fever and discharge, and the majority have no history of ARI. OMA cases are more common in the adult age range, this is related to increased exposure to cigarettes in adulthood as well as environmental factors. Abstrak. Otitis media akut (OMA) merupakan inflamasi akut pada telinga bagian tengah yang berlangsung < 3 minggu. Otitis media akut dapat disebabkan oleh virus atau bakteri. Penelitian sebelumnya gejala klinis terbanyak pada anakpenderita OMA adalah keluarnya cairan daritelinga. Telah ditemukan juga bahwa 29-50% dari keseluruhan ISPA berkembang menjadi OMA. Tujuan penelitian ini untuk mengetahui karakteristik penderita otitis media akut berdasarkan jenis kelamin, umur, lama keluhan, gejala, dan riwayat ISPA (Infeksi SaluranPernapasan Atas) Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan menggunakan rancangan cross sectional. Subjek penelitian adalah pasien yang terdiagnosis OMA di klinik THT RS Al-Islam Bandung pada tahun 2020-2022. Sebagian besar pasien OMA berjenis kelamin perempuan sebanyak 93 orang (64,6%), didominasi pasien berusia 18-40 tahun sebanyak 52 orang (36.1%), serta sebagian besar tidak memiliki riwayat ISPA sebanyak 141 orang (97.9%). Simpulan penelitian ini kasus OMA di klinik THT RS Al-Islam Bandung didominasi oleh jenis kelamin perempuan pada rentang umur, terbanyak pada rentang usia dewasa 18-40 tahun, dan memiliki lama keluhan < 1 minggu dangan gejala tersering demam dan keluar cairan, serta sebagian besar tidak memiliki riwayat ISPA. Kasus OMA lebih banyak ditemukan pada rentang usia dewasa, hal ini berkaitan dengan paparan rokok yang meningkat pada usia dewasa serta faktor lingkungan.
Association between Clinical Characteristics of Pregnant Women in the Third Trimester and Low Back Pain Dewi, Mira Dyani; Rachmawati, Meike
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.13889

Abstract

Pregnancy is a physiological condition characterized by growth in both the fetus and the mother. Various biomechanical, physiological, and structural changes in pregnant women cause body posture changes, impacting low back pain (LBP). In the third trimester, LBP pain felt by pregnant women is usually accompanied by activity limitations and a decreased quality of life. This study aimed to determine the association between the clinical characteristics of pregnant women in the third trimester and low back pain. This research was conducted at the Department of Obstetrics and Gynecology and Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung from June to December 2017. The method is observational analysis with a cross-sectional approach with a sample of pregnant women in their third trimester who complained of lower back pain and lived in Bandung. According to the findings, the majority of pregnant women with LBP in the third trimester were under the age of 35 (33 of 38), had multiparous parity (25 of 38), had normal pre-pregnancy weight (21 of 38), gained an average of 11.28 kg during pregnancy, and had a median pain intensity of 5. Age was the only factor significantly correlated with LBP pain intensity; parity and weight gain during pregnancy did not. The study concludes a significant association between age in the third trimester of pregnancy and the intensity of LBP pain. Still, no significant association was found between parity and weight gain during pregnancy with the intensity of LBP pain.
Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus) Mani, Suresh; Akbari Ganie, Ratna; Keumala Sari, Dina; Meutia Sari, Liza; Rachmawati, Meike; Muhammad, Noorzaid
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11931

Abstract

Background: The inflammatory process is influenced by chemical mediators such as Nitric Oxide (NO), cytokines, and arachidonic acid metabolites. The therapeutic effect of herbal plants comes from phytochemicals with strong antioxidant activity. Objective: To examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This was a two-stage study: in vitro and in vivo. Anti-inflammatory activity is related not only to antioxidant properties but also to suppression of nitric oxide and pro-inflammatory cytokines. This effect is being explored using various herbal plants. One such plant is Cananga odorata (ylang flower), a tropical plant with fragrant petals that grows easily. Results: The total phenol content was 1.06% w/w. Antioxidant activity measured using DPPH method showed an IC50 of 808.86 ppm, indicating weak antioxidant activity. In rats, the extract reduced blood glucose levels but had no effect on lipid profiles. Toxicity testing showed no toxic effects. Histological analysis showed no differences between cardiovascular disease model mice and standard-fed mice. Conclusion: The ethanol extract of Cananga odorata did not show toxicity in the heart histopathology of white rats.
Gambaran Lesi Kanker Paru-paru Tikus Akibat Paparan Subkronis Pewarna Golongan Azo Zidan Zuhdi; Nuzirwan Acang; Meike Rachmawati
Jurnal Riset Kedokteran Volume 5, No.1, Juli 2025, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v5i1.6487

Abstract

Abstract. Bandung Regency has many large-scale textile industries. One part of the production process is coloring. About 60% of the entire dyeing process uses azo group dyes with an estimated usage of around 300,000 tons and is expected to increase. Azo dyes can cause a variety of health problems in different organs, one of them being the lungs. The purpose of this study was to determine the histopathological picture of lung cancer lesion in rats due to azo dye subchronic toxicity. This experimental study used four-week-old male wistar strain rats as subjects. There was a total of 28 rats that were divided into four groups, namely control, group P1 (dose of 190 mg/kgBB), group P2 (dose of 375 mg/kgBB), and group 3 (dose of 750 mg/kgBB). Congo red azo dye was mixed with rat food and was given for 13 weeks. Analysis was performed using the Kruskal-Wallis test. The results of this study were that no cancerous lesion found on all group. These results indicate that subchronic exposure to azo dyes is not sufficient to cause cancerous lesion in rat lungs. Abstrak. Kabupaten Bandung merupakan salah satu daerah yang banyak memiliki industri tekstil berskala besar. Salah satu bagian dari proses produksi dalam industri tekstil adalah pewarnaan. Sekitar 60% dari seluruh proses pewarnaan menggunakan pewarna golongan azo dengan perkiraan penggunaan sekitar 300.000 ton dan diperkirakan semakin meningkat. Zat pewarna azo merupakan bahan kimia yang dapat menimbulkan berbagai macam masalah kesehatan di berbagai organ, salah satunya paru-paru. Tujuan penelitian ini adalah untuk mengetahui gambaran histopatologis lesi kanker pada paru-paru tikus akibat paparan subkronis zat pewarna azo. Penelitian eksperimental ini menggunakan subjek tikus galur wistar berjenis kelamin jantan yang berumur empat minggu. Jumlah sampel tikus yang diuji coba sebanyak 28 tikus yang dibagi menjadi empat kelompok perlakuan, yaitu kontrol, kelompok P1 (dosis 190 mg/kgBB), kelompok P2 (dosis 375 mg/kgBB), dan kelompok 3 (dosis 750 mg/kgBB). Zat pewarna azo congo red dicampurkan dengan makanan tikus dan makanan yang sudah tercampur diberikan selama 13 minggu. Analisis dilakukan menggunakan uji Kruskal-Wallis. Hasil dari penelitian ini adalah bahwa tidak adanya lesi kanker pada paru-paru tikus di semua kelompok perlakuan. Hasil ini menunjukkan bahwa paparan subkronis zat pewarna azo belum memunculkan lesi keganasan pada paru-paru tikus.
Gambaran Klinis dan Histopatologis Pasien Limfadenopati Granulomatosa yang Berobat di Rumah Sakit Muhammadiyah Bandung Widiyastuti, Ermina; Ismawati, Ismawati; Rachmawati, Meike
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 1 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i1.13370

Abstract

Limfadenopati granulomatosa memiliki beragam etiologi yang mendasarinya. Secara garis besar dapat diklasifikasikan karena infeksi dan non infeksi. Gambaran histopatologi limfadenitis granulomatosa membentuk struktur khusus seperti sel epiteloid disertai dengan sebukan sel radang, namun tidak spesifik. Limfadenitis tuberkulosis merupakan penyebab tersering limfadenopati di daerah endemis tuberkulosis seperti di Indonesia. Karakteristik klinis dan penunjang seperti pemeriksaan rontgen dapat membantu mendiagnosis penyakit yang mendasari lesi ini. Tujuan penelitian ini mengetahui gambaran klinis dan histopatologis limfadenitis granulomatosa di Rumah Sakit Muhammadiyah Bandung yang diharapkan dapat membantu mengarahkan diagnosis. Penelitian ini merupakan studi deskriptif kuantitatif yang diambil dari data rekam medis 40 pasien limfadenopati granulomatosa di Rumah Sakit Muhammadiyah Bandung periode Januari–Desember 2022. Hasil penelitian menunjukkan sebanyak 52% adalah perempuan, terbanyak di rentang usia 22–31 tahun (30%). Lesi terbanyak ditemukan di daerah leher kanan (35%) dengan gejala penyerta terbanyak adalah nyeri (20%). Hasil rontgen normal (23%) ditemukan lebih banyak dibanding dengan yang disertai kelainan. Karakteristik gambaran distribusi histopatologis paling banyak adalah sel radang limfosit (100%), histiosit (95%), dan sel epiteloid (92%), sedangkan paling sedikit adalah datia benda asing (20%). Limfadenitis tuberkulosis merupakan penyakit tersering yang mengakibatkan benjolan di leher dan menimbulkan gambaran histopatologi berupa granuloma yang beragam mulai dari granuloma bernekrosis, granuloma non nekrosis, dan granuloma supuratif. Pada penelitian ini didapatkan ketiga gambaran granuloma tersebut. Meskipun tempat penelitian ini di Indonesia merupakan endemi tuberkulosis, namun tetap perlu dipikirkan diagnosis banding lain yang harus disingkirkan sebelum menegakkan diagnosis yang tepat.AbstractGranulomatous limphadenopaty has various underlying etiologies. In general granulomatous lymphadenopathy can be classified as infectious and non-infectious. The histopathologic features of granulomatous lymphadenopathy creates a special structure with epitheloid cells surrounded by inflammatory cells, however these are not spesific. Tuberculous lymphadenitis is the frequent cause for lymphadenopathy in endemic area for tuberculosis as Indonesia. The clinical features and chest X-ray examination can be helpful for establishing the underlying diagnosis for the lesion. The aim of this research is to determine the clinical and histopathological features of granulomatous limphadenopaty at the Muhammadiyah Bandung Hospital for the period January–December 2022 which is expected to help in directing the diagnosis later. This study is a quantitative descriptional study from medical records of 40 patients with granulomatous lymphadenopathy admitted to Muhammadiyah Hospital in periode of January–December 2022. The results showed 52% patients were female, mostly in age group of 22–31 years old (30%). Most lesions located at right neck (35%), with pain as most frequent accompanied symptom (20%). Normal chest X-rays were more frequent than those with abnormal findings. The histopathologic features of the lesion showed the most histopathological distribution is lymphocyte inflammatory cells (100%), histiocytes (95%), and epithelioid cells (92%), while the least is foreign body datia (20%). Tuberculous lymphadenitis is the commonest etiology for diseases presenting with cervical adenopathy with histopatologic features of granuloma ranging from necrotizing, non necrotizing and suppurative granuloma. The three types of granulomas were found in this study. Despite that Indonesia the endemic area for tuberculosis, other differential diagnosis still needed to be eliminated before appropriate diagnosis can be made.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Adhi Nugraha Akbari Ganie, Ratna Alaydrus, Syafika Amri Junus Andre Akbar Mubarok Andriane, Yuke Annisa Rahmah Furqaani Anugrah, Aninditya Putri Aryanti Aryanti Ayu Prasetia Azlia Salsabila Rahadian Putri Darmayanti Dewi, Mira Dyani Dipayana, I Made Dzikru Rahmah Robbika Az-Zahra Dzikru Rahmah Robbika Az-Zahra Ermina Widiyastuti Fajar Awalia Yulianto Faqiekha Jauziyah Al-Faghiyah Farah Faza Aulia Fasyah Rizki Putri Gunantara, Tito Harvi Puspa Wardani Hasrayati Agustina Hauradarry Aurella Permadi Hendro Sudjono Yuwono Herri S. Sastramihardja Ismawati Ismawati Ismawati Ismet Muchtar Nur Joni Tandi, Joni Julia Hartati Keumala Sari, Dina Khusnul Mulya Kautsar Laila, Nazmy Noor M. Nurhalim Shahib Magfira Mani, Suresh Mariyani Melati, Rina Meta Maulida Damayanti Meutia Sari, Liza Mia Kusmiati Mia Kusmiati Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Muhammad, Noorzaid Navira Salsabila Putri Niluh Puspita Dewi, Niluh Puspita Nur Azizah Nuzirwan Acang Raden Anita Indriyanti Raden Ganang Ibnusantosa Radina, Faqih Rahmi, Fadhilat Sabila Ratna Damailia Rizky Alifian Ramadhan Rizky Rizal Alfarysyi Robian, Rian Sabrina Ayu Fitria Santun Bhekti Rahimah Sari, Ajeng Kartika Shofa Nabila Bilqist Komarudin Siddiq, Tita Barriah Sri Suryanti Taufik Muhammad Fakih Titik Respati Uci Ari Lantika Wardani, Yunira Wida Purbaningsih Widiyastuti, Ermina Winni Maharani wirawan, Wayan Yani Triyani Yanti Daryanti Yuktiana Kharisma Yuliet Yuliet Yuniarti Yuniarti Zidan Zuhdi