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All Journal Global Medical and Health Communication Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Global Medical and Health Communication
Meike Rachmawati
Fakultas Kedokteran, Universitas Islam Bandung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Integrated Exhaust System in Grossing Table for Formaldehyde Exposure Control Meike Rachmawati; Wida Purbaningsih; Meta Maulida Damayanti; Iman Apriana Effendi; Faradilla Azzahra Dinariansyah; Fathin Azimati Nadila; Ismawati; Nugraha; Aninditya Putri Anugrah; Fattahrani; Reyiena Kusumaryani Rahmat
Global Medical & Health Communication (GMHC) Vol. 13 No. 2 (2025): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i2.7422

Abstract

Formaldehyde, a widely used tissue fixative in anatomical pathology laboratories, poses significant health risks due to its irritant and carcinogenic properties. Exposure control during grossing procedures is critical, yet commercial grossing tables with integrated ventilation systems are often cost-prohibitive. This study aimed to develop and evaluate a cost-effective grossing table equipped with a local exhaust ventilation system to reduce formaldehyde exposure in compliance with occupational health and safety (OHS) standards. A quasi-experimental study was conducted in collaboration with an anatomical pathology laboratory in Bandung, Indonesia, from 2023 to 2025, testing three exhaust configurations: (1) control (no exhaust), (2) room exhaust only (S1), and (3) room + table-mounted exhaust (S2). Session-level analysis using the Kruskal-Wallis test revealed significant differences among configurations (p=0.035). Post-hoc Mann-Whitney tests confirmed that exposure in S2 was significantly lower than in the control (p=0.024, 95% CI=0.25–0.70), indicating a large effect size. Mean session exposures decreased from control (0.86–1.50 ppm) to S1 (0.74–0.85 ppm) and S2 (0.58–0.62 ppm). The corresponding 8-hour time-weighted averages (TWA) were 0.403 ppm (control), 0.257 ppm (S1), and 0.086 ppm (S2), compared to the limits of 0.75 ppm (OSHA), 0.1 ppm (ACGIH), and 0.016 ppm (NIOSH). Short-term exposure limits (STELs) were 1.55 ppm, 1.11 ppm, and 0.29 ppm, benchmarked against two ppm (OSHA), 0.3 ppm (ACGIH), and 0.1 ppm (NIOSH), respectively. In conclusion, the S2 setup met OSHA and ACGIH limits, demonstrating that integrated local exhaust effectively reduces formaldehyde exposure and provides an effective engineering control to improve occupational safety in pathology laboratories. This low-cost intervention offers a practical solution for safer working conditions in pathology laboratories.
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Pancreas of Wistar Rats Yunira Wardani; Niluh Puspita Dewi; Syafika Alaydrus; Meike Rachmawati
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.8069

Abstract

Medicinal plants are considered a rich source of bioactive metabolites and have the potential for the discovery and development of new drugs, one of which is the purple leaf plant which is known to treat various diseases. The aim of this research was to determine the effect of administering purple leaf ethanol extract over a certain period of time at doses of 500 mg/kgBB, 2.000 mg/kgBB and 5.000 mg/kgBB on the histopathology of the Wistar rat pancreas. In this study, an experimental method was used with a randomized block design, using 20 male Wistar rats which were divided into 4 research groups, 1 control group which was given Na-CMC. and 3 treatment groups were given purple leaf ethanol extract at a dose of 500 mg/kgBB (P1), dose of 2.000 mg/kgBB (P2) and  dose of 5.000 mg/kgBB (P3). The test preparation was administered orally, for 28 days. The results of subchronic toxicity testing of purple leaf ethanol extract on Wistar rats carried out for 28 days, up to a dose of 5.000 mg/kg BB, showed that at a dose of 2.000 mg/kg BB – 5.000 mg/kg BB it was toxic to the histopathology of the Wistar rats pancreas, which was characterized by the presence of cell degeneration, increased organ index and the presence of symptoms of toxicity
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Lymph of Wistar Rats and Antioxidant Activity Darmayanti; Niluh Puspita Dewi; Mariyani; Joni Tandi; Meike Rachmawati; Yuliet Susanto
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8070

Abstract

This study aims to determine the toxic effects of purple leaf ethanol extract on lymph organs at doses of 500; 2.000; and 5.000 mg/kgBB administered for 28 days and and to determine the antioxidant activity of purple leaf Graptophyllum pictum (L.) This study is an experimental study with a random group design, using 20 test animals divided into 4 groups consisting of two treatment groups, namely in the normal control group given Na-CMC 0.5% and the experimental group given PLEE (k1: dose 500 mg/kgBB, k2: dose 2.000 mg/kgBB and k3: dose 5.000 mg/kgBB hematoxylin-eosin staining (HE) using a computer-connected Motic BA210 microscope with 40X magnification in 5 fields of view and antioxidant test using DPPH method with UV-Vis Spectrophotometer at 516 nm wavelength with concentration 20, 40, 60, 80, and 100 ppm. The results showed that leaf ethanol extract was toxic at a dose of 2.000 mg/kgBB – 5.000 mg/kgBB against the diameter of lymphatic organ pulp, organ index and organ weight, there were symptoms of toxicity and purple leaf ethanol extract had strong antioxidant activity with 66.26 μg/mL.
UJI TOKSISITAS SUB KRONIS EKSTRAK DAUN UNGU TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN I Made Dipayana; Niluh Puspita Dewi; Magfira; Joni Tandi; Wayan Wirawan; Meike Rachmawati; Nur Azizah
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8312

Abstract

Traditional herbal medicine has become increasingly popular as an alternative to conventional medical treatments. Although the plant offers numerous health benefits, caution should be exercised regarding its long-term use. Long-term use of traditional herbal remedies can have detrimental effects on the kidneys. This study was designed to assess the histological changes in the kidneys of male rats following 28 days of purple sage leaf extract administration and to identify potential harmful effects. The study utilized 20 male Wistar rats and utilized a randomized group design for the experimental methodology. Rats were categorized into four distinct groups, consisting of one control group and three treatment groups. The control group received solely sodium chloride, whereas the treatment group 1 (P1) received 500 mg/kg BB of purple sage ethanol extract. Treatment group 2 received up to 2000 mg/kg BB of purple sage ethanol extract, while treatment group 3 received up to 5000 mg/kg BB. The oral examination was conducted for a duration of 28 days. The treatment groups showed an increase in weight and organ index of the right kidney. The findings suggest a potential for toxicity resulting from the administration of purple sage leaf extract over a duration of 28 days.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Adhi Nugraha Afiati Afiati Amri Junus Andre Akbar Mubarok Andriane, Yuke Aninditya Putri Anugrah Annisa Rahmah Furqaani Anugrah, Aninditya Putri Aryanti Aryanti Aulia, Yatasya Ayu Prasetia Azlia Salsabila Rahadian Putri Darmawan, Nabilah Yahdiani Darmayanti Dewi, Mira Dyani Dinariansyah, Faradilla Azzahra Dzikru Rahmah Robbika Az-Zahra Dzikru Rahmah Robbika Az-Zahra Ermina Widiyastuti Fajar Awalia Yulianto Faqiekha Jauziyah Al-Faghiyah Faradilla Azzahra Dinariansyah Farah Faza Aulia Fasyah Rizki Putri Fathin Azimati Nadila Fattahrani Firmansyah, Mochammad Agus Gunantara, Tito Harvi Puspa Wardani Hasanah, Afni Nur Hasrayati Agustina Hauradarry Aurella Permadi Hendro Sudjono Yuwono Herri S. Sastramihardja I Made Dipayana Iman Apriana Effendi Ismawati Ismawati Ismawati Ismawati Ismet Muchtar Nur Joni Tandi, Joni Julia Hartati Khusnul Mulya Kautsar Laila, Nazmy Noor M. Nurhalim Shahib Magfira Mariyani Melati, Rina Meta Maulida Damayanti Meta Maulida Damayanti Mia Kusmiati Mia Kusmiati Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Navira Salsabila Putri Niluh Puspita Dewi Nugraha Nur Azizah Nuzirwan Acang Raden Anita Indriyanti Raden Ganang Ibnusantosa Radina, Faqih Rahmat, Reyiena Kusumaryani Rahmi, Fadhilat Sabila Ratna Damailia Reyiena Kusumaryani Rahmat Rizky Alifian Ramadhan Rizky Rizal Alfarysyi Rizky Suganda Prawiradilaga Robian, Rian Sabirin, Muhammad Syah Misuari Sabrina Ayu Fitria Santun Bhekti Rahimah Sari, Ajeng Kartika Shofa Nabila Bilqist Komarudin Siddiq, Tita Barriah Sri Suryanti Syafika Alaydrus Taufik Muhammad Fakih Titik Respati Uci Ari Lantika Wayan Wirawan Wida Purbaningsih Widiyastuti, Ermina Winni Maharani Yani Triyani Yanti Daryanti Yuktiana Kharisma Yuliet Yuliet Yuniarti Yuniarti Yunira Wardani Zidan Zuhdi