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All Journal Global Medical and Health Communication Jurnal Penelitian Pendidikan IPA (JPPIPA) Sumatera Medical Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Meike Rachmawati
Fakultas Kedokteran, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Pancreas of Wistar Rats Wardani, Yunira; Dewi, Niluh Puspita; Alaydrus, Syafika; Rachmawati, Meike
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.8069

Abstract

Medicinal plants are considered a rich source of bioactive metabolites and have the potential for the discovery and development of new drugs, one of which is the purple leaf plant which is known to treat various diseases. The aim of this research was to determine the effect of administering purple leaf ethanol extract over a certain period of time at doses of 500 mg/kgBB, 2.000 mg/kgBB and 5.000 mg/kgBB on the histopathology of the Wistar rat pancreas. In this study, an experimental method was used with a randomized block design, using 20 male Wistar rats which were divided into 4 research groups, 1 control group which was given Na-CMC. and 3 treatment groups were given purple leaf ethanol extract at a dose of 500 mg/kgBB (P1), dose of 2.000 mg/kgBB (P2) and  dose of 5.000 mg/kgBB (P3). The test preparation was administered orally, for 28 days. The results of subchronic toxicity testing of purple leaf ethanol extract on Wistar rats carried out for 28 days, up to a dose of 5.000 mg/kg BB, showed that at a dose of 2.000 mg/kg BB – 5.000 mg/kg BB it was toxic to the histopathology of the Wistar rats pancreas, which was characterized by the presence of cell degeneration, increased organ index and the presence of symptoms of toxicity
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Lymph of Wistar Rats and Antioxidant Activity Darmayanti; Dewi, Niluh Puspita; Mariyani; Tandi, Joni; Rachmawati, Meike; Susanto, Yuliet
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8070

Abstract

This study aims to determine the toxic effects of purple leaf ethanol extract on lymph organs at doses of 500; 2.000; and 5.000 mg/kgBB administered for 28 days and and to determine the antioxidant activity of purple leaf Graptophyllum pictum (L.) This study is an experimental study with a random group design, using 20 test animals divided into 4 groups consisting of two treatment groups, namely in the normal control group given Na-CMC 0.5% and the experimental group given PLEE (k1: dose 500 mg/kgBB, k2: dose 2.000 mg/kgBB and k3: dose 5.000 mg/kgBB hematoxylin-eosin staining (HE) using a computer-connected Motic BA210 microscope with 40X magnification in 5 fields of view and antioxidant test using DPPH method with UV-Vis Spectrophotometer at 516 nm wavelength with concentration 20, 40, 60, 80, and 100 ppm. The results showed that leaf ethanol extract was toxic at a dose of 2.000 mg/kgBB – 5.000 mg/kgBB against the diameter of lymphatic organ pulp, organ index and organ weight, there were symptoms of toxicity and purple leaf ethanol extract had strong antioxidant activity with 66.26 μg/mL.
UJI TOKSISITAS SUB KRONIS EKSTRAK DAUN UNGU TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN Dipayana, I Made; Dewi, Niluh Puspita; Magfira; Tandi, Joni; Wirawan, Wayan; Rachmawati, Meike; Azizah, Nur
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8312

Abstract

Traditional herbal medicine has become increasingly popular as an alternative to conventional medical treatments. Although the plant offers numerous health benefits, caution should be exercised regarding its long-term use. Long-term use of traditional herbal remedies can have detrimental effects on the kidneys. This study was designed to assess the histological changes in the kidneys of male rats following 28 days of purple sage leaf extract administration and to identify potential harmful effects. The study utilized 20 male Wistar rats and utilized a randomized group design for the experimental methodology. Rats were categorized into four distinct groups, consisting of one control group and three treatment groups. The control group received solely sodium chloride, whereas the treatment group 1 (P1) received 500 mg/kg BB of purple sage ethanol extract. Treatment group 2 received up to 2000 mg/kg BB of purple sage ethanol extract, while treatment group 3 received up to 5000 mg/kg BB. The oral examination was conducted for a duration of 28 days. The treatment groups showed an increase in weight and organ index of the right kidney. The findings suggest a potential for toxicity resulting from the administration of purple sage leaf extract over a duration of 28 days.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Adhi Nugraha Akbari Ganie, Ratna Alaydrus, Syafika Amri Junus Andre Akbar Mubarok Andriane, Yuke Annisa Rahmah Furqaani Anugrah, Aninditya Putri Aryanti Aryanti Ayu Prasetia Azlia Salsabila Rahadian Putri Darmayanti Dewi, Mira Dyani Dipayana, I Made Dzikru Rahmah Robbika Az-Zahra Dzikru Rahmah Robbika Az-Zahra Ermina Widiyastuti Fajar Awalia Yulianto Faqiekha Jauziyah Al-Faghiyah Farah Faza Aulia Fasyah Rizki Putri Gunantara, Tito Harvi Puspa Wardani Hasrayati Agustina Hauradarry Aurella Permadi Hendro Sudjono Yuwono Herri S. Sastramihardja Ismawati Ismawati Ismawati Ismet Muchtar Nur Joni Tandi, Joni Julia Hartati Keumala Sari, Dina Khusnul Mulya Kautsar Laila, Nazmy Noor M. Nurhalim Shahib Magfira Mani, Suresh Mariyani Melati, Rina Meta Maulida Damayanti Meutia Sari, Liza Mia Kusmiati Mia Kusmiati Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Muhammad, Noorzaid Navira Salsabila Putri Niluh Puspita Dewi, Niluh Puspita Nur Azizah Nuzirwan Acang Raden Anita Indriyanti Raden Ganang Ibnusantosa Radina, Faqih Rahmi, Fadhilat Sabila Ratna Damailia Rizky Alifian Ramadhan Rizky Rizal Alfarysyi Robian, Rian Sabrina Ayu Fitria Santun Bhekti Rahimah Sari, Ajeng Kartika Shofa Nabila Bilqist Komarudin Siddiq, Tita Barriah Sri Suryanti Taufik Muhammad Fakih Titik Respati Uci Ari Lantika Wardani, Yunira Wida Purbaningsih Widiyastuti, Ermina Winni Maharani wirawan, Wayan Yani Triyani Yanti Daryanti Yuktiana Kharisma Yuliet Yuliet Yuniarti Yuniarti Zidan Zuhdi