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Retno Sari
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Antiseptic activity evaluation of piper leave from Piper betle Linn extract in hand gel antiseptic preparation Sari, Retno; Isadiartuti, Dewi
Indonesian Journal of Pharmacy Vol 17 No 4, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.263 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

It is known that piper leaves (sirih) from Piper betle Linn has been used traditionally as medicine, for example for mouthwash and wound curing. The usage of hand gels antiseptic preparation was getting increased in the current time as the incidence of desease caused by virus and bacteria like SARS appears.This research was aimed to develop preparation of hand gels from piper leaves extract obtained from extraction with hot water. The formulation of gels were made using 5%, 10%, 15%, 20% and 25% of piper leaves extract in Carbopol gel base. The evaluation of antiseptics activity was carried out using the Replica method. A series of test was done by pouring the gels at hand palm and slightly tap the thumb fingerprint to nutrient agar media. The media was incubated at 37°C for 24 hours,and the number of colonies of microorganism was counted. The antiseptic activity of the gels also compared with two hand gels antiseptic preparation containing ethanol and triclosan as antiseptic agentThe result showed that the piper leaves extract gels had a transparent pale yellow performance. The gel preparation with concentration of 15% extract had activity to reduce the microorganism of skin normal flora up to 50%. Yet the 25% concentration of piper leave extract could eliminate all the microorganism. It was also known that the 15% piper leaves extract gel had no significance different with the ethanol preparation, since the 20% and 25% piper leaves extract gels had similar antiseptic activity to the triclosan preparation.Key words: piper leaves extract, gel, antiseptic activity, replica methods
Co-Authors Abd Hakim Laenggeng, Abd Hakim Abhimata Paramanandana Adhitiawarman, Adhitiawarman Adjat Sudradjat Agustin Agustin Alam, Gust Rizki Samudra Noor Andi Saifah Andi Saryoko Anggai, Rifka Anggraini Annisa Maulidia Rahayyu Ardiputra, Muh Akbar Arief Cahyo Wibowo Bambang Sardi Bastoni Semendawai Budi Santoso, Satrio Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Isadiartuti Dhurriah Zain Dicky Kurniawan, Muhammad Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Diyah, Nuzul Wahyuning dwi hartanto Dwi Setyawan Eka Saputra, Bagas Eryka A. Novarinandha Esti Hendradi Fadjar Mulya Fauzia, Alfi Nur Febrianti, Clara Firmansyah, Mochamad Lutfi Firmansyah, Mochammad Lutfi Fitrallisan Fitrallisan Guli, Musjaya Hardini, Erza Shafiah Zahraani Pravita Hasan, Wafiqah Latuapo Ida Ayu Putu Sri Widnyani Idha Kusumawati Ilma Amalina Imam Sujadi Intan Nurul Rizki Irma Purnamasari, Ade Junadhi, Junadhi Juni Ekowati Kresna Ramanda Laksono Trisnantoro Lemako, Gideon Sulivan Lumbantoruan, Daniel M. Agus Syamsur Rijal Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Marlina Marlina Miatmoko, Andang Mirza Ardella Saputra Mochammad Hatta Muchammad Farchan Chanif Muchammad Farchan Hanif Mufariha, Mufariha Muh Agus S Rijal Muhammad Aditya Bryan Rahadi Muhammad Agus Syamsur Rijal Muhammad Fahrizal Himawan Muhammad Ilyas Mulyana, Septian Dwi Muzakki Ramadhan, Naufal Nasution, Ramadhani Syafitri Nugroho, Dito Pradita Nur Rahmiati, Nur Patigu, Rosy Feraningsih Pawahid Pawahid Pohwain, Berkhat Agung Prastika Krisma Jiwanti Prawiro, Sumarno Reto Raden Joko Kuncoroningrat Susilo Rahayyu, Annisa Maulidia Rahma Rahma Rahmawati, Nurul Dina Rahmiati Rahmiati Ramadanil Pitopang Ramadhan, Wahyu Satria Ramadhani, Firmansyah Ardian Rani Naomi Panjaitan Ratih Yulia Hayuningtyas Ridwansyah Ridwansyah Rifka Anggraini Anggai Rijal, Agus Syamsur Rijal, M. Agus Syamsur Rinaldi Dikanda, Arif Rohana, Melissa Rosyda, Susy Sartini Sartini Seimahuira, Syarah Septian Nafiatul Khasanah Siammita, Dhea Anansya Siti Nurhasanah Nugraha Sugiyartono Sugiyartono Sugiyartono, Sugiyartono Suhailah Hayaza Sukardiman Sulistyowati, Melanny Ika sultan, firdaus SUZANA, SUZANA Tahta Amrillah Taopik Hidayat Theo, Deli Tri Atmojo Kusmayadi Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Widji Soeratri Yeremia Budi Cristian