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All Journal Althea Medical Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Nusantara Medical Science Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Plastik Rekonstruksi JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Rekonstruksi dan Estetik

Diah Mira Indramaya

Department Of Dermatology And Venereology Faculty Of Medicine Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya

Author-ID : 563308

Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Articles

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Salivary Cortisol Levels Representing Serum Cortisol Levels in Atopic Dermatitis Patients Novia Indriyani Adisty; Marsudi Hutomo; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder, recurrent lesion with a distinctive and specific distribution of lesions according phases. Patients with allergic diseases have been known to have a variety of patterns of cortisol. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and the role of cortisol has been studied in patients with DA. Free cortisol adrenal cortex is considered biologically active, which passively diffuses into all body fluids including saliva. Another advantage is the saliva examination is non-invasive, stress free and easy to do anywhere. Purpose: To analyze the correlation between levels of serum cortisol and salivary cortisol in patients with AD. Methods: Analytical, observational, cross-sectional study of the 29 AD patients who underwent blood and saliva samples by the method of "passive drooling" conducted on the hour 8:00 to 9:00 to see the levels of serum cortisol and salivary cortisol. Results: Twenty-nine subjects revealed mean serum cortisol levels 6,703,82g/dL, mean salivary cortisol levels was 1,430,96g/dL. Equation of salivary cortisol = 0,471+0,142*serum cortisol 2 (R=28,5%). Conclusions: The increasing of serum cortisol level of AD patients will result in increased levels of cortisol in saliva. Saliva collection methods by “passive drooling” were able to describe the serum cortisol levels at 28,5%.Key words: atopic dermatitis, serum cortisol, salivary cortisol.

Retrospective Study: Atopic Dermatitis in Childhood Kristina Sihaloho; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis is a chronically and relapsing inflammatory skin disease affecting individuals with atopic history or their families. Atopic dermatitis affects all ageswith percentage 15-30% in children and 1-2% in adults. Chronic pruritus, skin infection, sleep disorder, and growth disorder are signs and symptomps commonly found in childhood atopic dermatitis. Evaluation of the profile and management of DA were needed to improve the management of atopic dermatitis. Purpose:To evaluate the profile of childhood atopic dermatitis. Methods: A retrospective study of all new cases of childhood atopic dermatitis who visited the Pediatric Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 2007 to Desember 2011. Results: Numbers of chilhood atopic dermatitis increased from 2007 to 2011. Itchy was the main complaint of DA, but redness patches (32,3%) and xerosis cutis (9,1%) were also found. Atopic history in patients and or their families were found in 842 patients (74,3%). Treatment was antihistamin in 879 patients (77,5%). Conclusions: Chilhood atopic dermatitis are still increasing by years. Determining and avoiding trigger factors are education for DA's patients and their families in preventing it recurrency.Key words: atopic dermatitis, childhood, retrospective study.

Retrospective Study: Characteristic of Herpes Zoster Patients Lia Kinasih Ayuningati; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Herpes zoster (HZ) is a disease caused by the Varicella-zoster virus (VZV) that localized, primarily affects adults with characteristics of radicular pain, unilateral, and group of vesicles distributed according to dermatomes, innervated by a sensory nerve ganglion. Several risk factors for HZ is older populationand cellular immune dysfunction. Purpose: To evaluate general overview of HZ patients, hence better management can be provided. Methods: Retrospective study of newly diagnosed HZ patientsin Kemuning ward Dr. Soetomo General Hospital Surabaya during 2010-2013. Results: This study showed most commonly affected women (55.9%), themost common age was45-64 years old (40.7%)and the most common location was HZ thoracalis (31.4%). Conclusion: HZ is a common disease, which most commonly occured illness in elderlywith predisposing factors, that can determine the course of the disease, so we need proper management and education.Key words: herpes zoster, retrospective.

Retrospective Study: Glycolic Acid Peel in Photoaging Patient Brama Rachmantyo; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Photoaging is premature skin aging that is caused by sun exposure in long periode. Glycolic acid peel is one of photoaging treatment that improve skin at epidermal layer. Improper patient selection and irregular follow-up may become factors of unsuccessful treatment. Purpose: To evaluate gycolic acid peel treatment for photoaging for improvement of medical service in the future. Methods: A retrospective study to photoaging patiens that were managed with glicolyc acid peel in Medical Cosmeutic Division Dermatology and Venereology Departement Dr. Soetomo General Hospital Surabaya on period from January 2011 to December 2013. The data were collected from medical record, Results: New patient of photoaging is 455 patients in Medical Cosmetic Division, 15.8% patients were treated with glycolic acid peel. Diagnosis classification were using Glogau classification. Thirty six point one percent of patient did not undergo follow up and 47.1% of patient’s interval of follow up were more than 4 weeks. Majority of patient (37.5%) have no improvement. Conclusion: Education to photoaging patient that undergo glycolic acid peel need to be improved. Clinical worsening and no improvement in some patients may be caused by irregular follow up. Key words: photoaging, retrospective study, glycolic acid peel.

Serum Level of Vitamin D (25[OH]D) in Patient with Atopic Dermatitis Meidyta Sinantryana Widyaswari; Iskandar Zulkarnain; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic Dermatitis (AD) is a chronic inflammatory relapsing skin disorder along with itchy sensation. Etiopathogenesis DA remains unclear, however in common are caused by impaired epidermal barrier function of the skin and immune system that tend to ensue infection. Vitamin D is an immunomodulator and plays an important role in the pathogenesis of DA through improving the integrity of skin barrier permeability, expression of antimicrobial peptide (AMP), which inhibit infection, and reduce inflammation. Deficiency of vitamin D may increase the development risk of DA lesion. Purpose: To evaluate the serum levels of vitamin D (25[OH]D) in patients with DA. Methods: A descriptive observational cross-sectional study, in 34 DA patients at Dermatology and Venereology Outpatient Clinic of Dr. Soetomo Hospital Surabaya. Subjects were enrolled through consecutive sampling, serum vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA) method. Results: Serum levels of vitamin D (25[OH]D) in DA patients was 22.72±14.55 ng/mL. Serum levels of vitamin D based on the severity DA: mild (30.86±22.66 ng/mL); moderate (20.42±10.13 ng/mL); and severe (18.84±8.22 ng/mL). Conclusion: Deficiency of vitamin D can occur in DA patient with low level of serum vitamin D (25[OH]D), but the relationship with the severity of DA remains to be done further research. Key words: atopic dermatitis, vitamin D (25[OH]D).

A Retrospective Study: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Yuli Wahyu Rahmawati; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is rare, but threaten the patient's life. Purpose: To evaluate management of SJS and TEN. Methods: A retrospective study to patient with SJS and TEN in 2011-2014, data regarding the prevalent of patients, history of patients, etiology, clinical manifestation, supporting of examination, therapy, complication, mortality, follow up, and duration of treatment patients recorded from medical report. Result: Total patient with SSJ and NET were 37 patients. Most patients were female (73%) with majority age range 25-44 years (48.6%), epilepsy is the most comorbidities (27%), the main etiology the use of drug (62.1%), the highest class of drugs is analgesic drugs (38.6%), 37 patients using corticosteroid for therapy (100%), skin is the most complication (50.9%), and death rate was zero (0%). Conclusion: Management of patients with SJS and TEN gives complete recovery. Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, management.

Relationship between Diet and Acne Kristina Sihaloho; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne is a disorder of pilosebasea unit, that mostly affect an adolesecent, caused by hormonal changing. Dietary is one factor that was thought to induce acne. But the association between diet and acne are still controversial. Purpose: Review the role of some diets for acne Review: Acne is multifactorial disease, whereas diet is one of many factors that excarcerbate acne. Some dietaries are thought have some roles in acne, including carbohidrate, milk, chocolate, fatty acid, zinc-iodine, vitamin A, and antioxidant. Some research has proved the relationship between diets and acne but there are still few limitations. Conclusion: Relationship between diets and acne still need more research with better methods. Key words: acne, diet, glicemic index.

Haemorrhagic Bullous Lesion in Henoch-Schonlein Purpura Renata Prameswari; Diah Mira Indramaya; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Henoch-Schonlein purpura (HSP) is a vasculitis of the small vessels and the most common type of vasculitis in children. Vesicles and haemorrhagic bullae were thought to be rare in HSP and maybe difficult to diagnose. Purpose: To describe the rare case of haemorrhagic bullous lesion in HSP. Case: A 15-year-old Javanese girl was admitted to Dr. Soetomo General Hospital Surabaya with one week history of multiple haemorrhagic blisters on her extremities, accompanied with joint pain, abdominal pain, and severe nausea. Firstly, it’s only a few redness patches then become numerous and changed to haemorrhagic blisters. A dermatological examination shown multiple bullae and vesicles on multiple palpable erythematous purpura. There were hypokalemia on laboratory examination and histopathological examination concluded a leukocytoclastic vasculitis. Discussion: Fluid balance, oral corticosteroid, oral antihistamine, antiemetic injection, and potassium correction were administered to the patient. Dexamethasone was discontinued because there was a presence of melena. Symptomatic treatment was given and significantly improvement was achieved in one month after treatment. Conclusion: Henoch-Schonlein purpura is diagnosed based on history, physical, clinical, and histopathological examination. Vesicles and haemorrhagic bullae are rare in HSP, and it does not seem to have any prognosis value in the outcome of HSP. Key words: Henoch-Schonlein purpura, haemorrhagic bullous lesion, small vessel vasculitis.

The Effects of Platelet Rich Plasma Topical Gel on Chronic Plantar Ulcer Healing in Leprosy Patient Diana Kartika Sari; M. Yulianto Listiawan; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Plantar ulcer is a physical disability that most often occurs in approximately 10-20% of leprosy patient. Conventional therapies such as dressings, surgical debridement, and skin graft can not provide satisfactory improvement. Platelet rich plasma (PRP) has a variety of growth factors required in ulcer wound healing. Purpose: To prove the effect of PRP topical gel to the size of wound, macrophage activation, neovascularization, fibrosis, and formation of granulation tissue on chronic plantar ulcer healing in leprosy patients. Methods: The analytic cohort study of 20 leprosy patients with chronic plantar ulcer in Morbus Hansen Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Biopsies were performed before and after PRP topical gel treatment on leprosy patient with chronic plantar ulcers. Results: After two doses of PRP topical gel, wound size of 9 patients (45%) was reduced <0.5 cm. Statistycal analysis showed significant differences in size of lesions (p = <0.05), the number of macrophages (p = <0.001), number of capillaries (p = 0.003), and the amount of granulation (p = 0.032) before and after PRP topical gel treatment. While the results of the analysis of the number of fibroblasts showed no significant difference (p = <0.05). Conclusion: PRP topical gel treatment gives good results, in terms of improvement in wound size, an increase in macrophages, neovascularization and granulation tissue.

Studi Retrospektif: Profil Penyakit Rosasea Ade Fernandes; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Rosasea adalah penyakit inflamasi kulit kronis yang biasanya terdapat pada bagian tengah wajah, termasuk pipi, hidung, dagu, dan dahi. Area yang terlibat tidak hanya wajah, tetapi juga daerah sekitarnya seperti leher, dada, punggung, dan kulit kepala serta mata. Tujuan: Mengevaluasi gambaran umum dan evaluasi pasien baru rosasea di Divisi Kosmetik Medik Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode tahun 2013-2015. Metode: Penelitian retrospektif dengan meneliti catatan medik pasien rosasea di Divisi Kosmetik Medik URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya selama Januari 2013 sampai Desember 2015. Hasil: Jumlah kunjungan pasien baru rosasea selama periode 2013-2015 sebesar 24 pasien. Sebagian besar pasien adalah wanita. Usia terbanyak adalah 25-44 tahun. Keluhan utama terbanyak adalah jerawat atau bintil serta kemerahan di wajah. Subtipe rosasea yang paling banyak ditemukan adalah subtipe eritematotelangiektasis sebesar 37,5%. Terapi yang terbanyak untuk pengobatan topikal adalah metronidazol dan pengobatan sistemik adalah doksisiklin. Sebesar 75% pasien melakukan kunjungan ulang. Simpulan: Terdapat penurunan jumlah pasien rosasea. Subtipe rosasea yang banyak ditemukan adalah subtipe eritematotelangiektasis dan subtipe papulopustular, subtipe phymatous hanya sedikit, sedangkan subtipe okular tidak ditemukan.

Co-Authors AA Sudharmawan, AA Abdul Karim Ade Fernandes Afif Hidayati Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agus Santoso Budi Amanda Gracia Manuputty Anggaraeni, Sylvia Anggun Tera Rahmasari Ardhiah Iswanda Putri Arifa Mustika Arifin Saiboo, Alvian Arisia Fadila Aruja Dhar Astindari Astindari Astindari, Astindari Azzahra, Alya Mutiara Bagus Haryo Kusumaputra, Bagus Haryo Bintanjoyo, Lunardi Brama Rachmantyo Budi Utomo Budi Utomo BUDI UTOMO Budiono Budiono Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti David Sontani Perdanakusuma Devi, Aprilin Krista Dewi Nurasrifah Diana Kartika Sari Dwi Murtiastutik Eliza, Frizka Esravila Ariya Wibisono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Fania Ayu Wardani Farah Meriana Fajrin Hamiseno, Gifta Marshanda Qanitah Hari Sukanto, Hari Harningtyas, Citra Dwi Irmadita Citrashanty, Irmadita Irwadi, Irfiansyah Iskandar Zulkarnain Iswinarno Doso Saputro Izzatul Fithriyah Kristina Sihaloho Kristina Sihaloho Kristina Sihaloho, Kristina Lia Kinasih Ayuningati Lia Kinasih Ayuningati, Lia Kinasih Linda Astari, Linda M. Yulianto Listiawan Mah Zhook Yueng Marsudi Hutomo Marsudi Hutomo, Marsudi Maya Wardiana Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Meidyta Sinantryana Widyaswari, Meidyta Sinantryana Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Milan Muhammed Muslim, Ronaldo Mutiara Arikah Balqis Novia Indriyani Adisty Novia Indriyani Adisty, Novia Indriyani Nurfaiza, Diandra Yasmin Pepy Dwi Endraswari, Pepy Dwi Perdanakusuma, David Sontani Pramitha, Riezky Januar Priangga Adi Wiratama Prida Ayudianti Pudji Lestari Rahmadewi Rahmadewi Rahmadewi Rebekah Setiabudi, Rebekah Renata Prameswari Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Rochmanti, Maftuchah Rochmanti Rubianti, Marissa Astari Saleh Ashafi Salsabilla, Dhea Hasna Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Septiana Widyantari Subur Prajitno Sunarso Suyoso Sunarso Suyoso, Sunarso Tasya Wikassa Tengku Riza Zarzani N Triana Novitasari Trisniartami Setyaningrum Umi Miranti Wardiana, Maya Widyantari, Septiana Yuindartanto, Andre Yuli Wahyu Rahmawati Zahrah Hikmah, Zahrah Zahruddin Ahmad Zahruddin Ahmad Zarasade, Lobredia

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