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All Journal Dentika Dental Journal Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) JURNAL FARMASIMED (JFM) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Applied Research (IJAR) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal ABDIMAS MUTIARA
Denny Satria, Denny
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Putri Aisyia Fauzi, Ziza; Harahap, Urip; Yuandani, Yuandani; Berkat Waruwu, Syukur; Purnomo, Hari; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Immunostimulant Effect Test Of Curcuminoid Extract From Turmeric Rhizome (Curcuma Domestica Val.) In VCO On Rats Induced Cyclophosphamide Againts An Increasing Total Leukocytes And Leukocyte Differential Damayanti, Damayanti; Yuandani, Yuandani; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.852

Abstract

Turmeric (Curcuma domestica Val.) is a traditional Indonesian plant that has many benefits. Curcuminoids are turmeric compounds known to have effects as immunomodulators and have been proven in several in vivo tests. Immunosuppressive drugs such as cyclophosphamide are widely given to improve clinical symptoms in autoimmune patients and cancer treatment which can cause susceptibility to infection.Therefore,this study aimed to determine the immunostimulating effect of curcuminoid extract from turmeric rhizome on cyclophosphamide-induced white rats. Proof of the immunostimulating effect of curcuminoid extracts was by testing the total leukocytes and leukocytesdifferential. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant.
Cytotoxic Effects of Extract and Fractions of African Leaves (Vernonia amygdalina Delile.) Against WiDr Cells Simanjuntak, Ezra; Satria, Denny; Hasibuan, Poppy
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tf07jx42

Abstract

Background: Colon cancer remains a major unresolved health problem worldwide, ranking as the third leading cause of death. African leaf (Vernonia amygdalina) is one of the plants widely used in traditional medicine. Several studies have identified phytoconstituents, including flavonoids, sesquiterpene lactones, and bactericidal saponins, with diverse pharmacological properties, including anticancer effects. Objective: This study aimed to determine cytotoxic activity of the extract and fraction of African leaf against WiDr cells. Method: African leaf extract was produced by reflux extraction with methanol, then fractionated using n-hexane, chloroform, and ethyl acetate. The analysis of total flavonoid and phenolic contents was carried out using a colorimetric method with AlCl3 and Folin-Ciocalteu reagent. Antioxidant activity was assessed using the DPPH method. Cytotoxic activity was tested using the MTT method against WiDr cells. Then, the data were analysed using the IC50 value. Results: The cytotoxicity test shows that the chloroform fraction has the strongest activity, with an IC50 value of 78.45 ± 8.95 μg/mL, followed by the n-hexane fraction of (119.07 ± 3.98 μg/mL), ethyl acetate fraction of (126.39 ± 3.28 μg/mL), methanol extract of (430.70 ± 31.92 μg/mL), and water fraction of (1607.71 ± 89.85 μg/mL). Conclusion: The chloroform fraction of African leaves shows strong cytotoxic activity against WiDr cells.
Cytotoxic Potential of Extract Methanol and Fraction of African Leaf (Vernonia amygdalina Del.) on B16F10 Cell Line in Melanoma Cancer Risqina Lubis, Sahwani; Hasibuan, Poppy Anjelisa Zaitun; Satria, Denny
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dyf31640

Abstract

Melanoma is a highly aggressive malignancy derived from melanocytes and is considered the most severe form of skin cancer. Natural products have increasingly attracted attention as potential sources for the discovery of novel anticancer agents. The purpose of this study is to assess the cytotoxic activity of Vernonia amygdalina Delile leaf methanol extract and chloroform fraction against B16F10 melanoma cells. Vernonia amygalina Del. Leaves extracted using reflux method and liquid-liquid fractionation. Identification of the contained compounds were identified using thin layer chromatography. B16F10 cells were cultured under standard conditions and treated with various concentrations of the chloroform fraction and methanol extract of Vernonia amygdalina Delile leaves and the cytotoxicity assay was performed using the MTT method to determine cell viability and IC₅₀ values. The analysis revealed IC₅₀ values of chloroform fraction (81.80±4.18) and followed by n-hexane fraction (187.33±12.48), etil acetate fraction (204.35±8.39), methanol extract (344.37±25.12) and residual fraction (4032.38±921.22). All fraction and the methanol extract demonstrated dose-dependent cytotoxicity, with the chloroform fraction exhibiting a more pronounced inhibitory effect. These results suggest that Vernonia amygdalina leaves contain bioactive constituents with significant anticancer potential against melanoma. Future studies should focus to the isolation of active compounds and comprehensive in vivo validation to strengthen the therapeutic prospects.
Co-Authors Amalia, Martina Aminah Dalimunthe Aminah Dalimunthe Brahmana, Nettietalia Br Budi Budi Damayanti Damayanti Diana Sofia Hanafiah Dohude, Gostry Aldica Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony Estefania, Kaban Vera Hafid Syahputra Harahap, Nurul Izzatunna Jhirah HARI PURNOMO Hari Purnomo4 Haro, Ginda Hasibuan, Poppy Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Jansen Silalahi Lisda Rimayanti Nasution Lubis, Arga Lubis, Meiva Amelia lubis, muhammad fauzan Manuppak Irianto, Manuppak Irianto Manurung, Kesaktian Melasari, Wulan Panduwi Muhammad Wahyu, Muhammad Munthe, Alfian Rejekinta Nasri Nasri, Nasri Octora, Debi Dinha Olivia Avriyanti Hanafiah Pitu Wulandari Putri, Maharani Syahnia Rifda Amaliya Ma’ruf Risqina Lubis, Sahwani Rosidah Rosidah Rosidah Rosidah, R Ruth Christiani N Daely Said Aldi Palevi Simanjuntak, Ezra Simanjuntak, Rio Siregar, Nina Ashariani Siti Bahirrah Siti Morin Sinaga Sitorus, Binsar Sitorus, Panal Sumaiyah, Sumaiyah Syukur Berkat Waruwu Tarigan, Yenni Gustiani Taruli Rohana Sinaga Urip Harahap Vadhila, Mumtaz Widjaja, Sri Suryani Yanti Yemima Yuandani Yuandani, Y Yuwanda, Cindy Ziza Putri Aisyia Fauzi Zuhairiah Nasution, Zuhairiah