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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biota Jurnal Florea Berkala Kedokteran BIOMA International Journal of Applied Biology Jurnal Ilmiah Kedokteran Wijaya Kusuma Briliant: Jurnal Riset dan Konseptual Jurnal Biologi Tropis The Indonesian Journal of Infectious Diseases Care : Jurnal Ilmiah Ilmu Kesehatan Majalah Kedokteran Andalas INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Abdidas Eureka Herba Indonesia Journal of Community Development Jurnal Pengabdian Masyarakat Kedokteran Sinnun Maxillofacial Journal Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa JAPI: Jurnal Akses Pengabdian Indonesia Journal of Community Services Jurnal Pengabdian Masyarakat Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran
Putu Oky Ari Tania
Bagian Biomedik Penelitian Biomolekuler Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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Expression Levels of Intestinal Toll-Like Receptors 2 and 4 in Acute Inflammation Caused by Intestinal Candidiasis: An Experimental Study in Wistar Rats Tania, Putu Oky Ari; Masfufatun, Masfufatun; Baktir, Afaf
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3345

Abstract

Background: Candida albicans grows in the gastrointestinal tract as a normal microflora that may cause intestinal candidiasis, characterized by formation of biofilm and inflammation. Candida is recognized by toll-like receptors (TLRs). This study aimed to explore the relationship between intestinal TLR 2 and TLR 4 expression levels in candidiasis at each phase of inflammation.Methods: An experimental study was performed using a simple randomized sampling on 30 male Wistar rats divided into a control and a treatment group. Each group was inoculated with Candida albicans. Dysbiosis conditions were designed in the treatment group using multiple antibiotics and on day 5 the rats were injected with subcutaneous cortisone acetate. The groups were terminated in five different times (days 7, 14, 21, 28 and 35). On the termination day, intestinal tissue was isolated and the TLR 2 and TLR 4 expression were analyzed by immunohistochemistry. The data were analyzed by parametric test with SPSS (p<0.05) and completed by post-hoc test Least Significance Difference (LSD) to compare pairs of groups.Results: The expression of TLR 2 and TLR 4 between control and treatment groups showed significant differences (p=0.005). In the treatment group, there was a gradual increase in the TLR2 and TLR 4 expressions.  Positive expression of TLR appeared more in the submucosal or basal area than apical surface. The treatment group showed the highest expression of both TLR2 (82.37%) and TLR4 (87.40%) on termination day 35.Conclusions: Inflammation caused by intestinal candidiasis can result in increased expression of intestinal TLR2 and 4 contributing to an increased risk of biofilm formation.
Effectiveness of the Combination of Facial Acupressure and Honey on Facial Skin Moisture Ayly Soekanto; Putu Oky Ari Tania; Andra Agnez Al Aska; Hardiyono Hardiyono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3783

Abstract

Background: Facial skin is the most sensitive part, so it is important to take care of it. Facial skin care is a treatment to keep facial skin elastic and maintain facial skin moisture. Facial acupressure is a method of treatment that begins with massaging the meridian points so that blood flow becomes smooth and facial muscles feel more relaxed. Using honey is a facial skin care method that is made into a mask. Objective: The research aims to determine the effectiveness of the combination of facial acupressure and honey on facial skin moisture. Methods: This research is an analytical experimental study, with a sample of 30 women aged 40 - 50 years. In the first treatment, a moisture test was carried out, followed by the second treatment, the moisture test was measured for the facial acupressure and after the third treatment, the combination of the facial acupressure with a honey mask was subjected to a moisture test.  The research was carried out twice a week for 4 weeks for a total of 8 times. The research was carried out in April – May 2024 at the Wijaya Surabaya clinic & in a doctor's practice and used a Skin Moisture Analyzer as a measuring tool to measure skin moisture. Using statistical analysis with the Mann-Whitney test (α= 0.05) with a p-value of 0.000. Result: The results of the third treatment showed an increase in facial skin moisture until it reached 93.4%, including moist skin and 6.6%, which was considered normal skin criteria. Conclusion: It has been proven that the combination of facial acupressure and honey is effective on facial skin moisture, experiencing very significant changes in humidity starting from the first, second and third treatments.
Efektivitas Paparan Sinar Inframerah dengan Variasi Waktu Paparan Terhadap Pertumbuhan Escherichia Coli Listyawati, Agusniar Furkani; Rianti, Emillia Devi Dwi; Tania, Putu Oky Ari
BRILIANT: Jurnal Riset dan Konseptual Vol 7 No 4 (2022): Volume 7 Nomor 4, November 2022
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.844 KB) | DOI: 10.28926/briliant.v7i4.1112

Abstract

Paparan sinar inframerah Near Infra Red (NIR) mengandung efek panas dengan panjang gelombang 0.78 – 3 μm. Penelitian ini bertujuan melihat kemampuan NIR menghambat pertumbuhan Escherichia coli dengan menggunakan variasi waktu paparan terhadap hambatan pertumbuhan. Metode penelitian eksperimental acak lengkap digunakan dengan empat kelompok perlakuan dari biakan Escherichia coli, yaitu K0, K1, K2 dan K3. Kelompok dibedakan berdasarkan waktu paparan infra merah dalam menit. Pada perlakuan 1(K1) yaitu diberikan paparan selama 25 menit, K2 diberikan paparan 30 menit, dan K3 diberi paparan 35 menit, sedangkan kelompok kontrol (K0) tanpa diberikan paparan. Hasil penelitian menunjukkan bahwa pada perlakuan K3, jumlah bakteri Escherichia coli yang tumbuh lebih sedikit apabila dibandingkan dengan perlakuan lainnya, sebesar 131 koloni. Uji statistik dengan ANOVA didapatkan p value sebesar 0,000 yang berarti ada pemberian infra merah berbagai variasi waktu berpengaruh terhadap jumlah koloni Escherichia coli. Berdasarkan hasil yang diperoleh maka waktu paparan terbaik yang diberikan paparan NIR adalah selama 35 menit.
EFEKTIVITAS EKSTRAK DAUN SALAM (Eugenia polyantha) MENURUNKAN KADAR MALONDIALDEHYDE PADA KONDISI TIKUS HIPERLIPID Tania, Putu Oky Ari; Cahyadi, I Kadek Angga Dwi
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.1426

Abstract

A high-fat diet leads to increasing intake of fatty acid in liver, making it susceptible to lipid peroxidation and free radical release. Malondialdehyde is a common biomarker for lipid peroxidation. Increasing free radicals should be balanced with the antioxidants in order to prevent oxidative stress. This study aim was to measured the effectiveness of bay leaf extract (Eugenia polyantha) in lowering MDA levels in hyperlipidemia rats. This study was an experimental study using 20 male rats divided into 4 groups. All rats were induced hyperlipidemia with high-fat diet for 12 days. KP was sacrificed in the next day after the feeding of high fat. KN administered by aquades 2 ml / day (peroral / po), P1 administered by bay leaves extract 1.08 g / day (p.0) and P2 received simvastatin treatment dose 0,0018 g / 150 g BB / day (p. 0). The results showed MDA levels in KP, KN, P1 and P2 were respectively 7.79; 7.07; 6.49; and 7.21 nmol / ml. One way ANOVA test showed p value was 0,073 (
Studi Invitro dan Insilico Efektivitas Antibakteri Kunyit Putih Terhadap Hambatan Pertumbuhan Escherichia Coli Tania, Putu Oky Ari; Listyawati, Agusniar Furkani; Soekanto, Ayly; Simamora, Dorta; Purbowati, Rini
The Indonesian Journal of Infectious Diseases Vol. 10 No. 1 (2024): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v10i1.188

Abstract

Latar Belakang: Escherichia coli telah diamati sebagai salah satu bakteri penyebab resistensi antibiotik. Pasien ISK di India Selatan dilaporkan menunjukkan peningkatan resistensi terhadap ciprofloxacin. Senyawa bioaktif diperlukan sebagai kandidat antibiotik untuk mengendalikan infeksi bakteri. Curcuma zedoaria atau kunyit putih sebagai antimikroba terutama terhadap E. coli. Aktivitas antibakteri pada dinding sel paling sering digunakan sebagai agen bakterisida. Enzim penting untuk biosintesis peptidoglikan pada dinding sel bakteri adalah protein muramyl ligase E (MurE) (entri PDB: 7B9E) dan Gyrase B (entri PDB: 4ZVI), berpotensi sebagai target pengikatan dengan metabolit sekunder curcumenol dan germacrone dengan in silico (molecular docking). Tujuan: Penelitian ini bertujuan untuk melihat efektivitas ekstrak etanol kunyit putih dibandingkan antibiotik dalam menghambat pertumbuhan E. coli secara in vitro dan in silico. Metode: 5 kelompok yang digunakan, yaitu ekstrak kunyit putih konsentrasi 15%, 20% dan 25%, kelompok kontrol positif dengan pemberian ciprofloxacin dan negatif yang diberikan aquades. Metode yang digunakan adalah mengukur diameter zona hambat dan daya bunuh (jumlah koloni) E. coli dan uji in silico yang dilakukan pada software PyRx. Hasil : penelitian menunjukkan ekstrak kunyit putih konsentrasi 25% mempunyai zona hambat yang sangat kuat dengan diameter hambatan 36,2 mm, sedangkan kunyit putih tidak mempunyai daya membunuh pada konsentrasi 10, 15 dan 25%. Afinitas pengikatan terendah untuk protein MurE adalah germacrone, sedangkan untuk pengikatan DNA girase B adalah curcumenol. Kesimpulan: Kunyit putih mempunyai potensi sebagai antibakteri dan diduga ligan curcumenol dan germacrone dapat menghambat aktivitas protein MurE dan DNA Gyrase B.
Pendampingan Kesehatan Kepada Peternak Dan Pengenalan Penyakit Infeksi Ternak Mastitis Dan Resistensi Antimikroba Di KPUD Tani Wilis Tulungagung Tania, Putu Oky Ari; Masfufatun, Masfufatun; Tjandra, Lusiani; Nadila, Sucia; Colin, Muhammad; Nugraha, Wima Handika; Sakri, Brian Manggala
JAPI (Jurnal Akses Pengabdian Indonesia) Vol 10, No 3 (2025)
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/japi.v10i3.7562

Abstract

Penyakit infeksi pada ternak khususnya sapi perah ada jenis yang beresiko menularkan kepada peternak (zoonosis) atau sebaliknya dapat menularkan ke peternak atau sebaliknya. Mastitis merupakan penyakit infeksi yang menyerang ambing susu sapi perah yang dapat berdampak ekonomi dan kesehatan. Masalah kesehatan lain adalah resistensi antimikroba yang menjadi issue global khususnya di negara berkembang. Daerah Tulungagung, Jawa Timur menjadi daerah empat besar pemasok susu di Jawa Timur. Bidang usaha masyarakat yaitu KPUD Tani Wilis yang menaungi lebih dari 1800 masyarakat produktif yaitu peternak. Pemahaman mengenai penyakit infeksi yang belum tersentuh secara menyeluruh perlu ditingkatkan, untuk itu kegiatan ini bertujuan meningkatkan pengetahuan dan pengalaman peternak terutama terkait penyakit infeksi pada ternak maupun manusia. Tujuan: memberikan pendampingan dan pengenalan penyakit infeksi mastitis dan resistensi antimikroba pada sapi perah dan orang-orang di sekitar daerah pertanian. Metode: edukasi dengan metode pemaparan materi kepada 57 peserta dan konsultasi peternak ke narasumber, serta pembagian leaflet. Evaluasi kegiatan berupa penilaian pre-test dan pemberian leaflet di awal kegiatan. Hasilnya nilai tertinggi yaitu 100 poin didapatkan pada 23% peserta, dengan nilai terendah 60 poin ditunjukkan dengan prosentase terkecil sebesar 15%. Pada sesi konsultasi tidak kurang dari 11 pertanyaan diajukan kepada narasumber.
Combination of Moringa Leaves Mask (Moringa Oleifera L.) and Butterfly Pea Flower Mask (Clitorea Ternatea L.) Plus Honey for Face Skin Moisture Soekanto, Ayly; Tania, Putu Oky Ari; Al Aska, Andra Agnez; Hardiyono, Hardiyono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i2.4520

Abstract

Background: Facial skin care is needed to maintain and preserve moisture and elasticity of the facial skin. The use of organic masks can be used to treat and provide nutrition to the facial skin to overcome facial skin problems. Objective: The purpose of this study was to measure effectiveness of the combination of moringa leaves mask (Moringa oleifera L.) and honey with butterfly pea flower mask (Clitorea ternatea L.) on facial skin moisture. Methods: The research is an analytical experimental study, 30 women aged 40-50 years old were given a combination of moringa leaves mask and honey on the right side of the face and butterfly pea flower mask and honey on the left side of the face, then before using the mask and after using the mask, the moisture value of the facial skin was measured with a skin moisture analyzer. The treatment in this study was given twice a week for three weeks, from April to May 2025 at the Wijaya Surabaya doctor's practice and clinic, using statistical analysis of the Pearson Correlation test with a p value of 0.000 (α <0.005). Result: The combination of moringa leaves and honey experienced an increase in moisture value of 70% moist skin and 30% normal skin, and the combination of butterfly pea flower mask and honey experienced an increase of 60% moist skin and 40% to normal skin. Conclusion: The combination of moringa leaves mask and honey with butterfly pea flower mask and honey only has a difference of 10%, meaning that the use of both combinations of these masks is equally useful in increasing moisture in facial skin.
Kursus Singkat Monitoring Perkembangan Balita Dalam Penanganan Stunting Sebagai Upaya Peningkatan Pengetahuan Kader Surabaya Hebat Inawati Inawati; Titiek Sunaryati; Harman Agusaputra; Putu Oky Ari Tania
Journal of Community Development Vol. 5 No. 2 (2024): December
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v5i2.275

Abstract

Undernutrition is responsible for nearly 50% child deaths, especially in poor countries. Approximately 25% of toddlers worldwide experience stunted which is associated with mortality, cognitive impairment and reduced productivity. The mission of the Kementrian Kesehatan is to improve the level of public health through community empowerment (Posyandu). especially in Surabaya with the empowerment of Kader Surabaya Hebat (KSH). Wonokromo District, with an area of ​​8.42 Km2 and occupying 2.55% of the area of ​​Surabaya city, has 3 access to primary health facilities, covering 6 sub-districts (Kelurahan). The ratio of community health centers per Wonokromo sub-district is 1.9, this shows that the coverage of primary health access in Wonokromo is quite good. KSH knowledge needs to be improved through education, short courses and monitoring. The aim of this Pengabdian  activity is to increase knowledge regarding monitoring the toddlers development, especially in handling stunting toddlers. This activity was able to increase the knowledge of KSH as shown by an increase in the highest score of 100, from 10% to 54.2%. Increasing KSH knowledge is a first step so that it can be applied to the community, namely toddlers in the Wonokromo health center area, so that monitoring of stunting toddlers can run and can prevent or even reduce the stunting rate in Wonokromo.
Supplementation of Pumpkin Seed Oil and SCFASs as a Prospective Biotherapeutic to Preserve Gut Natural Microbiota of Colitis Mice Putu Oky Ari Tania; Dorta Simamora; Jimmy Hadi Widjaja; Rini Purbowati
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.399

Abstract

Background: Ulcerative Colitis (UC) is an inflammatory disease in the colon, due to the disruption of the interaction between the immune response and the intestinal microbiota in a genetically susceptible host. The imbalance between commensal and pathogenic intestinal microbiota promotes inflammation. This study aims to explore the efficacy of pumpkin seed oil and SCFAs in maintaining the intestinal microbiota in UC model mice. Methods: Four groups, K1, K2, K3, and K4, as health control given distilled water (K1); K2, K3, and K4 induced UC with 2% DSS, followed by administration of Short Chain Fatty Acids (SCFAs) (K3), supplementation of SCFAs and pumpkin seed oil (K4). The number of colonies measured microbiota diversity (log CFU/mL/g) in NA, EMB, MRSA, and McConkey media. Hemoglobin and hematocrit were also measured to assess anemia. Results: The average number of bacterial colonies that grew on NA, EMB, MRSA, and McConkey media in K4 was 7.65, 5.78, 7.85, and 6.20, respectively, and the average HB and hematocrit levels were 14.2 g/dL and 42%, respectively. There was greater microbiota diversity and lactobacillus bacteria in UC rats given pumpkin seed oil and SCFAs, with fewer Enterobacteriaceae and E. coli than in the UC model. The increase in HB and hematocrit levels also showed the same trend. Conclusion: Pumpkin seed oil at a dose of 100 mg/kg and SCFAs can be a prospective biotherapy for maintaining the balance of the natural microbiota and increasing HB levels.
Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose Putu Oky Ari Tania; Puja Ayu Misuari; Satya Yudhayana; Ketut Ayesha Edelwise Prayoga
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1927

Abstract

High doses of paracetamol create necrosis in the liver and produce free radicals. When liver function decreased in a long time, it will lead to severe liver damage and it will be irreversible. Rhizome of Curcuma zedoaria has the potential effect as an antioxidant, it is assumed that  its properties inhibit the formation of free radicals which formed from toxic doses of paracetamol. The aim of this study was to examine the histological structure of the liver and to determine MDA levels in the administration of C. zedoaria toxic dose and paracetamol on the Rattus norvegicus. The study was used twenty-four rats divided into four groups (positive control: CMC 0.5%; negative control: paracetamol 1.35g/kg body weight; treatment group 1 (T1): C. zedoaria 105 mg/200g and paracetamol 1.35g/kg Body weight 2 hours later, and treatment group 2 (T2): paracetamol 1.35g/ kg Body weight and C. zedoaria 105 mg/200g 2 hours later).  The Kruskall-Wallis test results showed MDA level did not significantly different between groups (p = 0.087). Hepatocellular changes were observed descriptively with Hematoxylin-eosin staining. Positive control showed greater hepatocellular changes rather than other groups, hepatocyte cells were enlarged with cytoplasm showing eosinophilic granules infiltrates, enlarged irregular nuclei, nucleolus prominent, there are many necrosis cells.
Co-Authors AFAF BAKTIR Agusniar Furkani Listyawati Ahista Saskirana Putri Ahnaf Farel Al Raihaan akhmad sudibya, akhmad Amirotul Khifana Andiani Andiani Andra Agnez Al Aska Athaya Azalia Yasirah Ayling Sanjaya Ayly Soekanto Azka, Andra Agnes Al Cahyadi, I Kadek Angga Dwi Candra Rini Hasanah Putri Candra Rini Hasanah Putri Colin, Muhammad Deddy Hartanto Dinara Safina Salsabillah Dorta Simamora Dorta Simamora Emanuel, Endrayana Putut Laksminto Emilia Devi D. Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Enny Willianti, Enny Erlix R Purnama Erny Erny Erny Erny Fadilla Lutvi Aryanti Febtarini Rahmawati Febtarini Rahmawati Fuad Ama Furkani, Agusniar Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono HARMAN AGUSAPUTRA Harsono Wiradinata Haru Setiawan I Kadek Putra Dwipayana I Made Subhawa Harsa Ibrahim Njoto, Ibrahim Inawati Inawati Indra Firismanda Dermawan Jimmy Hadi Widjaja Kadek Adi Sudarmika Ketut Ayesha Edelwise Prayoga Kuntaman Kuntaman Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Marcela Anindita Masfufatun Masfufatun Masfufatun Maverick Nathanael Adirangga Meivy Isnoviana Muhammad Collin Nadila, Sucia Ni Kadek Evita Vara Rosieana Ni Made Ayu Gea Niquita Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika Nur Sri Wahyuni Olivia Rahayu Ramadhani Pramita Laksitarahmi Isrianto Puja Ayu Misuari Puja Ayu Misuari Putra, Wisnu Pratama Putut Laksminto Emanuel Rini Purbowati Rini Purbowati Sakri, Brian Manggala Satya Yudhayana Satya Yudhayana Sianny Suryawati, Sianny Sudarmika, Kadek Adi Sukma Sahadewa, Sukma Syeira Rigita Noptavia Theodora Theodora Titiek Sunaryati Titiek Sunaryati Wahyuni Dyah Parmasari, Wahyuni Dyah