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All Journal Tropical Medicine Journal Scriptura Jurnal Pendidikan Kimia Intuisi Journal of Mathematical and Fundamental Sciences BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) INKUIRI : Jurnal Pendidikan IPA Jurnal SOLMA Chemistry Indonesian Journal of Chemical Research Jurnal Ilmiah Sekolah Dasar Walisongo Journal of Chemistry Jurnal Pembelajaran Sains Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Inovasi Pendidikan dan Sains Panrannuangku Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Bhinneka Student Scientific Creativity Journal Jurnal Ilmiah Pengabdian dan Inovasi Room of Civil Society Development Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Morfologi : Jurnal Ilmu Pendidikan, Bahasa, Sastra dan Budaya Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Biology Education Asian Journal of Environmental Research Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Room of Civil Social Development Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya STEM Education International
Dian Nugraheni
Universitas Negeri Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Tropical Medicine Journal

 1 
The Effect of Bacille Calmette-Guerin (BCG) on the Changes in Number and Functional Activities of Mononuclear Phagocytes in Malaria- infected Mice Model Supargiyono -; Mahardika Agus Wijayanti; Tri Ratnaningsih; Dian Nugraheni
Tropical Medicine Journal Vol 1, No 1 (2011): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/tmj.4569

Abstract

Introduction: Recent studies have indicated that Bacille Calmette-Guerin (BCG) vaccination may have benefi cial eff ect on the survival of infant living in malaria endemic area as well as of malaria-infected mice model. However, the impact of injection of BCG vaccine on the changes in number and functional activities of Mononuclear Phagocytes during malaria-infection in animal model is still poorly understood.Objectives: To evaluate the eff ect of BCG on the changes in number and functional activities of Mononuclear Phagocytes (MPs) during Plasmodium berghei infection.Methods: Two groups of 18 Swiss mice were used. The fi rst group was given 0.1 ml of BCG injection subcutaneously and the second was the control non-BCG group. One week after BCG injection, all mice in both groups were inoculated with 107 Plasmodium berghei infected erythrocytes. The parasitaemia were monitored daily and the number and functional activity of splenic and peritoneal macrophages were tested.Results: The parasites were detected in the blood of both groups on the fi rst day after infection. The parasitaemia in the control group grew slowly until day 3, followed by rapid increased up to 38.96% on day 9. Parasitemia of mouse which still alive on day 12 was 59.6%. The parasitaemia of BCG-injected mice were also increased at lower rate after day 3, and the mice still survive until day 15 after infection. The number of peritoneal macrophages from BCG-injected mice increased to a higher degree compared to the non-BCG injected mice. Moreover, the phagocytic activities of peritoneal macrophages in BCG injected group were increased higher up to twice (200%) of normal levels compared to the non-BCG control group which increase only up to 1,5 times (150%) of the normal levels.Conclusion: The injection of BCG on Plasmodium berghei infected Swiss mice resulted in the extension of survival of the mice until day 15, accompanied by higher increased in number of circulating blood, splenic and peritoneal MPs, and the phagocytic activities of peritoneal MPs up to 137% of the increased in non-BCG mice.Keywords: BCG vaccine, malaria, Plasmodium berghei, macrophages, phagocytosis.
Co-Authors A'yuni, Shahira Qistan Abraham Tiandno Witjaksono Agung Mulyo Setiawan Agus Purwanto Ainul Yaqin Aisyah Az-Zahro Alvi Rohmah Amalia, Berlyana Anggi Arista, Rini Anisa Wuri Kartika Annisa, Nidya Anshori, M. Wildan Antika, Rizky Arief Muttaqiin Arifin, Achmad Saiful Asep Purwo Yudi Utomo Astuti, Nisa Sindi Az-Zahro, Aisyah Az-Zahro, Fatimah Daru Anggara Murty Dewi, Alfina Kusuma Dewi, Kadek Risa Rivana Dikhi Firmansyah Dwi Saryanti Eka Nurul Qomaliyah Elvira Hermawati Erti Hamim Erti Hamimi Evi Nur Mala Sari Fahria, Mila Farah Dhilah Balqis Fardhani, Indra Fatimah Az-Zahro Fatmawati, Fenti Fiel'ardh, Khalifatulloh Fitroh Rafli Firdausi Habiddin Hanandya Rahma Dinda Destriani Hanifiyah, Fitroh Haryati, Titin Hendra Helmanto Husna, Ihda Maf'ulatul Husnayaini, Nida Ilmiatunnisa, Rahmatin Ilmiatunnisa’, Rahmatin Isnanik Juni Fitriyah Jibril Maulana Kusumarini, Shelly Lia Dewi Juliawaty Lina Sinatra Wijaya Maghfiroh Maghfiroh Mahardika Agus Wijayanti Mohammad Iqbal Mabruri, Mohammad Iqbal Muhammad Fajar Marsuki Muhardjito Muhardjito Mulyani, Sri Munzil Nabilah, Wardah Natasya Intania Pertiwi Nida Rufaida Nina Chairani Fatimah Nisa Sindi Astuti Norman Yoshi Haryono Novida Pratiwi Nurul Qomaliyah, Eka Pertiwi, Natasya Intania Prabowo, Himawan Ganjar Pranata, Ivandra Bagus Praptawati, Atika Purnomo Putri Dzakiyyatul Khotimah Putri, Viola Syarwendah Ramadhan, Miftahul Akbar Rini Anggi Arista Riyanto, Obaja Eden Santosa Rosa Fadilla, Silvya Rosita Assyifa Purba Rossi Galih Kesuma Said Hasan Salsabila, Nanda Fitria Santosa, Khalis Nadhira Saryanti, Dwi Setiawan, A. M. Shinta Permata Sari Sri Retno Dwi Ariani SUGIYANTO Sugiyarta Stanislaus, Sugiyarta Supargiyono - Syach, Muhammad Zahran Edlian Tri Ratnaningsih Tunazjah, Savina Ulfi Akhyatussyifa Vianni Nifattien Vrisna Putri Wicaksono, Azizul Widadi, Zahir Widowati, Tamara Rahma widya astuti Wuri Wuryandani Yana Maolana Syah Yayuk Mulyati Yayuk Mulyati Yulianti, Erni Zulfa Fahmy