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All Journal VALENSI Jurnal Farmasi Udayana PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL ILMIAH PERSPEKTIF Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Ilmiah Manuntung Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research JIMR - Journal of Islamic Medicine Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Lentera Acitya Journal Of Health Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Lentera Acitya Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Joni Tandi, Joni
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Effect Of Ethanol Extract Of Kenikir (Cosmos caudatus Kunth.) Leaves in Blood Glucose, Cholesterol and Histopathology Pancreas of Male White Rats (Rattus norvegicus) Tandi, Joni; Claresta, Jong A.; Ayu, Gusti; Irwan, Irwan
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.307 KB) | DOI: 10.15416/ijpst.v1i1.17247

Abstract

The aim of this study was to investigate the effects extract of Kenikir in male rats parameters blood glucose, cholesterol and histopathological of the pancreas. Thirty rats were divided into six groups, and each group consists of five individuals with the details of groups I, II, and III as control groups and groups IV, V, and VI for the experiments. Group I: normal control was given NaCMC 0,5%; Group II: control negative was given Streptozotocin 30 mg/kgBW i.p, high feed fat 25 g/day, and the positive control was given met form in 45 mg/kgBW, and the experimental groups were each given extract of the kenikir leaves with dose 100 mg/kg BW, 200 mg/kgBW , and 400 mg/kg BW. The results showed that there were secondary metabolites contained in the extract of leaves of kenikir. Giving the extract of kenikir leaves at the dose of 200 mg/kg is effective in lowering the blood glucose levels, extract of leaves of kenikir with the dose of 400 mg/kg is effective to reduce the total cholesterol levels and regenerate pancreatic tissue, and extract of leaves of kenikir with the dose of 100 mg/kg BW did not give any maximum impacts to decrease the blood glucose. Keywords: Cholesterol, diabetic, histopathology, kenikir leaves ethanol extract
Effect Of Ethanol Extract Of Kenikir (Cosmos caudatus Kunth.) Leaves in Blood Glucose, Cholesterol and Histopathology Pancreas of Male White Rats (Rattus norvegicus) Joni Tandi; Jong A. Claresta; Gusti Ayu; Irwan Irwan
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.307 KB) | DOI: 10.24198/ijpst.v1i1.17247

Abstract

The aim of this study was to investigate the effects extract of Kenikir in male rats parameters blood glucose, cholesterol and histopathological of the pancreas. Thirty rats were divided into six groups, and each group consists of five individuals with the details of groups I, II, and III as control groups and groups IV, V, and VI for the experiments. Group I: normal control was given NaCMC 0,5%; Group II: control negative was given Streptozotocin 30 mg/kgBW i.p, high feed fat 25 g/day, and the positive control was given met form in 45 mg/kgBW, and the experimental groups were each given extract of the kenikir leaves with dose 100 mg/kg BW, 200 mg/kgBW , and 400 mg/kg BW. The results showed that there were secondary metabolites contained in the extract of leaves of kenikir. Giving the extract of kenikir leaves at the dose of 200 mg/kg is effective in lowering the blood glucose levels, extract of leaves of kenikir with the dose of 400 mg/kg is effective to reduce the total cholesterol levels and regenerate pancreatic tissue, and extract of leaves of kenikir with the dose of 100 mg/kg BW did not give any maximum impacts to decrease the blood glucose. Keywords: Cholesterol, diabetic, histopathology, kenikir leaves ethanol extract
TESTING THE EFFECTS OF PAPAYA LEAF EXTRACT ON THE HISTOPATHOLOGICAL FEATURES OF THE STREPTOZOTOCIN-INDUCED PANCREATIC OF MALE WHITE RATS tandi, joni
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53705

Abstract

Sasar penelitian ini ialah untuk mengetahui dosis terbaik untuk histologi pankreas dan metabolits sekunders pada konsentrat etanolik daun pepaya (Carica papaya L). Penelitian ini merupakan percobaan laboratorium dengan 30 ekor tikus sebagai hewan uji. Hewan uji di bagi menjadi enam kelompok perlakuan masing-masing lima ekor tikus. Suspensi Na-CMC diberikan pada kelompok 2 (control negatif), glibenklamid diberikan pada kelompok 3 (control positif), dan 100, 200, dan 300mg/kgBB konsentrat etanol daun pepaya (Carica papaya L) diberikan pada kelompok 4, 5, dan 6. Konsentrat etanol daun pepaya mengandung senyawa metabolits sekunders antara lain alkaloids, flavonoids, saponins, dan tanins, sesuai temuan. Pepaya Etanol daun pepaya secara bermakna mempengaruhi gambaran histopatologi pankreas, Etanol daun pepaya terpisah pada porsi 300mg/kgBB merupakan bagian yang mempengaruhi gambaran histopatologi pankreas dengan skor tipikal 1,2.
Aktivitas Hepatoprotektif Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) pada Tikus Diabetes Melitus Tandi, Joni
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.50555

Abstract

Tanaman binahong (Anredera cordifolia (Ten.) Steenis) merupakan salah satu tumbuhan herbal yang memiliki khasiat sebagai tanaman bahan obat yang digunakan untuk berbagai penyakit sepeti kerusakan hati, diabetes, jantung, tekanan darah tinggi, muntah darah. Tujuan dari penelitian ini adalah mengetahui kadar metabolit sekunder dengan spektrofotometri UV-Vis dan uji antioksidan  serta aktivitas hepatoprotektif daun binahong. Metode yang digunakan dalam penelitian ini adalah spektrofotometri UV-Vis dan DPPH serta uji lanjut Kruskal-Wallis dan uji ManWhitney terhadap hepar tikus diabetes melitus. Hasil analisis kualitatif Ekstrak Daun binahong mengandung senyawa metabolit sekunder seperti Alkaloid, Flavonoid, Saponin dan Tanin. Pada Uji kuantitatif diperoleh kadar total untuk flavonoid adalah 0,2433% b/b, saponin 0,1631% b/b, tanin 0,2512% b/b dan alkaloid 0,0350% b/b dan aktivitas antioksidan ekstrak etanol daun binahong diperoleh hasil berdasarkan nilai IC50 sebesar 61,9 ppm termasuk dalam kategori antioksidan kuat. Pada histopatologi hewan uji diinduksi dengan streptozotocin dan diberikan perlakuan masing-masing kelompok kontrol normal yang tidak diinduksi, kontrol negatif Na CMC 0,5%, kontrol positif  Metformin, kelompok uji yang diberikan ekstrak masing-masing dengan dosis 25, 50 dan 100 mg/kg BB. Pada penelitian ini ekstrak daun binahong  memiliki aktivitas sebagai hepatoprotektor pada dosis 100 mg/BB tikus diabetes melitus.
Co-Authors Afriani S Afrizal Agustinus Widodo Alaydrus, Syafika Alfia Dewi Anita Purwantari Asrifa Asrifa Astuti, Dewi Qurrotul Ayu Martina Ayu Wulandari AYU WULANDARI Ayu Wulandari Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dhitania Ivana Harliwong Dian S. Waruwu Diana Pratiwi, Franciska Erdy Prasetyo Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Feiverin Tibe Ficanata Adhiguna Toding Gabriella Bamba Ratih Lintin Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Tien Wahyu Handayani, Tien Wahyuni Hastuti L I Made Dipayana Ida Yanti Palinggi Irwan Irwan Islamiati, Utami Jong A. Claresta Kiki Rizki Handayani Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Marsella, Mimi Marzela Dewi Meike Rachmawati Moh Rizky Moh. Roem Muhammad Agus Muljanto Muthi’ah H Z Na'i, Alpina Nadila Nadila Nadira Nani Astria Ni Made Irma Mariani Ni Putu Intan Riani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Novalia Merue Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Puspita Dewi, Niluh Putu Intan R, Yana Novika Rahmawati D Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Rio Mariani Risna Yanti Rivani Tampang Rizaldy Lalu Ronaldy Nobertson Ruterlin, Valen Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Sririzqi Muthmainnah Stely Gracia Bengkati Suarsana, I Made Agus Surat, Megawati R. surisna, surisna Syafika Alaydrus Tamunu, Jeine Sweet Natasya Tarusu, Fikhta Agnesya Tiara Anastasya Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Utami Islamiati Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Viani Anggi Vidya Christin Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wayan Wirawan Wirawan W Wirawan, Resky Chandra Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah