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All Journal Jurnal Kesehatan The Indonesian Biomedical Journal Nusantara Medical Science Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Jurnal Biologi Tropis Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indian Journal of Forensic Medicine & Toxicology Jurnal Ilmiah Kesehatan (JIKA) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Cangara, Husni
Department Of Anatomical Pathology, Medical Faculty Hasanuddin University, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Cardioprotective of Ethanol Extract of Black Turmeric (Curcuma Caesia Roxb) on Doxorubicin Induced Rats Pratiwi, Nadya; Wahyudin, Elly; Cangara, Muhammad Husni
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Agustus 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i2.496

Abstract

Discovery of black turmeric's anti-radical, anti-inflammatory properties and ability to inhibit the growth of tumor cells. This study aimed to evaluate the cardioprotective effects and identity the effect of black turmeric (Curcuma caesia Roxb) ethanol extract in preventing cardiac damage in mice induced by doxorubicin. The experimental design employed is a pre-post test control group design. The study used male Wistar rats weighing between 150-200 grams, divided into 6 groups, with each group consisting of 4 rats. The first group, serving as the normal group, was only provided with food and water. The second group received Na-CMC as a negative control, while the third group was given Vitamin E as a positive control. The fourth, fifth, and sixth groups were administered suspensions of black turmeric extract at doses of 100, 300, and 500 mg/kg BW, respectively. The rats were induced with doxorubicin at a dose of 5 mg/kg BW once a week for 3weeks. On the final day of treatment, the rats were fasted for 18 hours, anesthetized, and blood samples were taken for analysis. The rats were also secured on a surgical board. Following induction, CKMB and LDH levels were measured again, and histopathological observations were conducted. The results showed CKMB levels indicated significant differences between groups with p<0,05 (0,025), while LDH levels did not show significant differences with p-value>0,05 (0,225). Histopathological examination of the heart revealed improvements in function and structure in the group IV.
Co-Authors A Endang Kusuma Intan Abdul Halim, Musdalifah Abdul Qadar Punagi Achmad, Djumadi Amir, Muzakkir Anak Agung Ayu Niti Wedayani Andi Alfian Zainuddin Ariyandy, Andi Arsyad, M Aryadi Arsyad, Muhammad Aryadi Arsyadi, Gunawan Aslam, Muhammad Cahyono Kaelan, Cahyono Christinahadi, Agnes Dyah Dahlan, Haslindah Desi Dwirosalia Suparman Djabir, Yulia Yusrini Djimahit, Tarsisia Truly Dwi Kesuma Sari Elly Wahyudin Fardah Akil Fatimah Mappanyompa Gina Andyka Hutasoit Ham, Jonathan Ika Yustisia Ilhamjaya Patellongi Ilyasa, Muhammad Riza Ima Arum Lestarini Juniarsih, Juniarsih Makbul, Hidayat Mardiati Mardiati Mardiati Marinati A Manggau Miskad, Upik Nasser, Andi Sitti Halija Diawanti Natsir, Sartini Nelwan, Berti J Nelwan, Berti Julian Ni Ketut Sungowati, Ni Ketut Pieter, Nova Audrey Luetta Pratiwi, Nadya Rahmawani, Surya Ramadhita, Nova Izza Salsa Rasyid, Nur Rahmah Restuningdyah, Novia Andansari Putri Rianti, Andi Marcha Rina Masadah Rosdiana Natsir Sakinah, Andi Irhamnia Sartini Natsir Solly Aryza Sudin, Asmirani Syahrul Rauf Syamsiar, Syamsiar Syarifuddin Wahid talawo, Vivi Yuniarti Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yamin, Amalia Yulia Yusrini Djabir