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All Journal JURNAL KIMIA SAINS DAN APLIKASI AKADEMIKA JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Pemberdayaan Masyarakat Madani (JPMM) Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Jambura Journal of Health Sciences and Research Jambura Journal of Food Technology Jambura FIsh Processing Journal Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Mattawang: Jurnal Pengabdian Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Damhil: Jurnal Pengabdian kepada Masyarakat Indonesian Journal of Innovation Multidisipliner Research Jambura Journal of Biomathematics (JJBM)
Yuszda K Salimi
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Deskripsi Kemampuan Kognitif Siswa pada Materi Struktur Atom Ischak, Netty Ino; Domu, Siti Afdianti; Botutihe, Deasy Natalia; Salimi, Yuszda K.; Rumape, Opir; Aman, La Ode; Najmah, Najmah
Jambura Journal of Educational Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jjec.v5i2.12832

Abstract

This research aims to determine the cognitive abilities of students in atomic structure material at SMA Negeri 1 Kabila. This research is descriptive qualitative research. This research was conducted at SMA Negeri 1 Kabila with a research sample of 66 students. Data collection uses instruments in the form of a two-tier multiple choice test. Research describing the cognitive abilities of students at SMA Negeri 1 Kabila on atomic structure material. The percentage of students' cognitive aspect abilities in the high category was (36%), in the medium category was (39%), and in the low category was (31%).
Sociotechnopreneurship As An Alternative For Community Empowerment In Improving The Economy Of Sugar Palm Farmers In Lonuo Village Gorontalo Province Hasanuddin; Mardin, Herinda; Taan, Hapsawati; Salimi, Yuszda K.; Rahmatia
Mattawang: Jurnal Pengabdian Masyarakat Vol. 4 No. 3 (2023)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.mattawang2084

Abstract

economic perspective which can become the main livelihood of the Lonuo village community so that the bioethanol center is a solution to this problem, because the production results can be used to make alcohol which is used for the cosmetics industry. , medicines The method of implementing this program is mentoring through social education activities aimed at providing social strengthening for the sugar palm farming community by providing social motivation Sociotechnopreneurship. Sociotechnopreneurship social motivation activities provide knowledge and insight to the people of Lonuo village to carry out entrepreneurship in turning palm sap into bioethanol products with the awareness that challenges need to be faced by developing ideas, having the ability to create something new, and even being able to escape from the habit of making palm sap into minimum illegal products are prohibited. Through this activity, there was an increase in the insight of the palm farmer participants regarding socio-technopreneurship in managing palm sap.
Non-Linear Function Approximation for Predicting Binding Affinity of PPAR-Targeting Antidiabetic Compounds from Molecular Descriptors La Ode Aman; Widy Abdulkadir; Dizky Papeo; Ariani Hutuba; Teti Tuloli; Mohamad Mustapa; Yuszda Salimi; Hamsidar Hasan; Arfan; Aiyi Asnawi
Jambura Journal of Biomathematics (JJBM) Vol. 7 No. 1: March 2026
Publisher : Department of Mathematics, Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjbm.v7i1.18

Abstract

Diabetes mellitus remains a major global health challenge, necessitating the development of more effective therapeutic agents. The PPAR family plays a crucial role in regulating glucose and lipid metabolism, making it an important target for antidiabetic drug discovery. However, the identification of potent PPAR-targeting compounds is often limited by the high cost and time-consuming nature of experimental approaches. This study aims to develop a non-linear function approximation model to predict docking-derived binding affinity of antidiabetic compounds targeting PPAR using 2D molecular descriptors. A dataset of 3,764 small molecules with IC50 values was curated from the ChEMBL database, followed by data preprocessing to remove duplicates and incomplete entries. Molecular docking simulations were performed using AutoDock Vina to obtain binding affinity scores (kcal/mol), which were used as the target variable. Subsequently, 2D molecular descriptors were calculated from SMILES representations to capture key structural and physicochemical properties of the compounds. These descriptors were used as input features for a Multi-Layer Perceptron (MLP) regression model to approximate the complex non-linear relationship between molecular structure and binding affinity. The model achieved R² values of 0.853 for the training set and 0.632 for the test set, indicating moderate predictive performance and acceptable generalizability. Overall, this approach demonstrates the potential of machine learning as a cost-effective and scalable tool to support early-stage discovery of antidiabetic compounds targeting the PPAR family.
Pemanfaatan Kitosan Dari Kulit Udang (Panaeus Monodon) Sebagai Pengawet Ikan Kembung (Rastrelliger Sp) Bintang Maharani; Astin Lukum; Deasy Natalia Botutihe; Yuszda K. Salimi; La Alio; Hamid Majelis
Indonesian Journal of Innovation Multidisipliner Research Vol. 4 No. 2 (2026): April - Juni
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v4i2.632

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi kitosan kulit udang (Penaeus monodon) terhadap daya simpan dan kualitas ikan kembung (Rastrelliger sp) selama penyimpanan. Penelitian dilakukan tahapan, yaitu proses pengawetan ikan menggunakan kitosan serta penggunaan garam sebagai pembanding. Selanjutnya dilakukan karakterisasi kualitas ikan melalui beberapa pengujian, meliputi analisis pH, uji organoleptik, Hasil penelitian menunjukkan bahwa pengawetan ikan menggunakan kitosan mampu mempertahankan daya simpan hingga 14 hari. Pada uji pH, konsentrasi kitosan 2% berada pada kisaran 6,00–7,15 dengan hasil organoleptik terbaik dibandingkan konsentrasi 3% dan 4%. Konsentrasi 3% memiliki kisaran pH 6,45–7,32 dengan kualitas organoleptik lebih baik dibandingkan konsentrasi 4%. Sementara itu, konsentrasi 4% memiliki kisaran pH 6,80–7,90 dengan hasil organoleptik paling rendah.
Gelatin–Alginat Koaservat Berstruktur Nano untuk Meningkatkan Stabilitas Minyak Sacha Inchi dalam Sistem Pangan Yuszda K Salimi; Afrilia Ali; La Alio; Astin Lukum; Arviani Arviani
Jambura Journal of Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v8i1.35601

Abstract

Sacha inchi (Plukenetia volubilis L.) seed oil is rich in polyunsaturated fatty acids, such as alpha-linolenic acid (ω-3) and linoleic acid (ω-6), which are beneficial for health but are susceptible to oxidation. This study aimed to develop a stable and efficient microencapsulation system to protect oil from oxidative degradation using a complex coacervation method with gelatin and sodium alginate as coating materials, and calcium chloride (CaCl2, 2%) as a crosslinking agent. The process was carried out at pH 3.75, with homogenization at 12,000 rpm for 7 minutes, followed by low-temperature drying. Characterization included yield, encapsulation efficiency, moisture content, particle size, and the morphology of the microcapsules. The results showed a yield of 75.00 ± 2.10%, an encapsulation efficiency of 93.85 ± 0.93%, and a moisture content of 11.26 ± 1.37%. Dynamic Light Scattering-based Particle Size Analyzer analysis showed a hydrodynamic diameter of~0.100 µm (PDI 0.321) with good dispersion (88.4% transmittance). In the meantime, Scanning Electron Microscope observations revealed a spherical morphology with a smooth, crack-free surface. The gelatin-sodium alginate combination proved effective as a coating material, yielding microcapsules with high efficiency, good physical stability, and potential applications in functional food products and nutraceutical supplements.
Karakterisasi Cookies Berbasis Tepung Jagung (Zea Mays Ssp.) dan Tepung Ampas Minyak Sacha Inchi (Plukenetia Volubilis L.) Riyanti Utina; Yuszda K Salimi; Arif Murtaqi Akhmad Mutsyahidan; Rahmiyati Kasim
Jambura Journal of Food Technology Vol 8, No 01 (2026): JUNI
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjft.v8i01.35910

Abstract

 Tujuan dalam penelitian ini yaitu untuk mengetahui karakteristik kimia dan organoleptik Cookies berbasis tepung jagung dan tepung ampas minyak sacha inchi. Metode yang digunakan dalam penelitian ini yaitu Rancangan Acak Lengkap (RAL) dengan 1 faktorial. Yaitu Substitusi tepung jagung dan tepung ampas minyak sacha inchi (P1 100g : 0g, P2 80g :20g, P3 60g : 40g, P4 40g : 60g). Setiap perlakuan diulang 3 kali. Data yang diperoleh dari Hasil pengujian, disajikan dalam bentuk grafik dan dianalisis dengan menggunakan Analisis of Variant (ANOVA) dan dilanjutkan dengan uji banding  DMRTdengan taraf signifikasi 5%. Berdasarkan penelitian yang telah dilakukan bahwa cookies berbasis tepung jagung dan tepung ampas minyak sacha inchi memberikan pengaruh nyata terhadap nilai kadar air, kadar abu, kadar lemak, protein, karbohidrat, kalori, dan uji organoleptik warna, rasa, aroma, dan tekstur. Berdasarkan Hasil pengujian kadar air diperoleh hasil 4,55%-6,07%, kadar abu 1.33%-2,36%, kadar lemak 13,18%-19,13%, protein 9,80%-14,86%, karbohidrat 63,77%-76,55%, kalori 439%-464%, kemudian uji organoleptik warna (suka-netral), rasa (suka-agak tidak suka), aroma, (suka–netral) tekstur (suka–agak tidak suka). 
PEMANFAATAN DAUN SACHA INCHI (Plukenetia volubilis L) DALAM PEMBUATAN TEH HERBAL DENGAN VARIASI SUHU DAN LAMA PENGERINGAN Moh Fahri Mooduto; Rahmiyati Kasim; Yuszda K Salimi; Widya Rahmawaty Saman
Jambura Journal of Food Technology Vol 8, No 01 (2026): JUNI
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjft.v8i01.32705

Abstract

Daun Sacha Inchi (Plukenetia volubilis L) merupakan tanaman rambat yang tumbuh dengan baik di daerah tropis dan subtropis. Daun sacha inchi terkenal dengan kandungan nutrisinya yang tinggi dan banyak senyawa bioaktif yaitu asam lemak, omega-3, serat, alkaloit,flavonoid, triterpenoid,tanin,saponin,dan aktivitas antioksidan.daun sacha inchi memiliki berbagai manfaat kesehatan, seperti meningkatkan sistem kekebalan tubuh, antikanker, dan antibakteri. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh variasi suhu pengeringan terhadap karakteristik kimia dantingkat kesukaan panelis terhadap teh herbal daun sacha inchi. Rancangan yang digunakan pada penelitian ini adalah rancangan acak lengkap (RAL) Faktorial dengan 2 Faktor yang perbedaan suhu dan waktu pengeringan dan 3 ulangan di setiap perlakuan. Data analisis dengan uji statistik Analisis of variance (ANOVA) dan hasil ini menunjukan bahwa, Hasil penelitian nilai kadar air yaitu 4,4%– 9,7%. Pada teh harbal daun sacha inchi mengendung positif tanin, total fenol 6,36–13,27 mgGAE/g. Aktivitas antioksidan 42,81–120,65 ppm. analisis uji organoleptik warna 4,23–5,80 aroma 3,40–5,63, dan rasa 4,40–5,70.maka dilanjutkan dengan uji Dunce Multiple Range Test (DMRT). bahwa Teh Herbal Daun Sacha Inchi memberikan pengaruh nyata terhadap aktivitas antioksidan, total fenol, uji organoleptik warna, aroma, dan rasa tetapi tak berpengaruh nyata terhadap kadar airDaun Sacha Inchi (Plukenetia volubilis L) merupakan tanaman rambat yang tumbuh dengan baik di daerah tropis dan subtropis. Daun sacha inchi terkenal dengan kandungan nutrisinya yang tinggi dan banyak senyawa bioaktif yaitu asam lemak, omega-3, serat, alkaloit,flavonoid, triterpenoid,tanin,saponin,dan aktivitas antioksidan.daun sacha inchi memiliki berbagai manfaat kesehatan, seperti meningkatkan sistem kekebalan tubuh, antikanker, dan antibakteri. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh variasi suhu pengeringan terhadap karakteristik kimia dantingkat kesukaan panelis terhadap teh herbal daun sacha inchi. Rancangan yang digunakan pada penelitian ini adalah rancangan acak lengkap (RAL) Faktorial dengan 2 Faktor yang perbedaan suhu dan waktu pengeringan dan 3 ulangan di setiap perlakuan. Data analisis dengan uji statistik Analisis of variance (ANOVA) dan hasil ini menunjukan bahwa, Hasil penelitian nilai kadar air yaitu 4,4%– 9,7%. Pada teh harbal daun sacha inchi mengendung positif tanin, total fenol 6,36–13,27 mgGAE/g. Aktivitas antioksidan 42,81–120,65 ppm. analisis uji organoleptik warna 4,23–5,80 aroma 3,40–5,63, dan rasa 4,40–5,70.maka dilanjutkan dengan uji Dunce Multiple Range Test (DMRT). bahwa Teh Herbal Daun Sacha Inchi memberikan pengaruh nyata terhadap aktivitas antioksidan, total fenol, uji organoleptik warna, aroma, dan rasa tetapi tak berpengaruh nyata terhadap kadar air
Development of a Differentiated Learning-Based Chemical Bonding Teaching Module to Enhance Scientific Argumentation Skills Wawan Tahir; Yuszda K. Salimi; Akram La Kilo; Lukman Abdul Rauf Laliyo; Astin Lukum; Masrid Pikoli
Jambura Journal of Educational Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjec.v8i1.35112

Abstract

This study aimed to develop a differentiated teaching module to enhance students' scientific argumentation skills on chemical bonding material. The method used was Research and Development (R&D) with the 4D model (Define, Design, Develop, Disseminate). Validation results from experts showed that the developed differentiated teaching module was highly valid (92% and 94%), very practical (100% and 97%), and effective, with more than 80% of students achieving the minimum competency standard (KKM) and an average score of 88. The improvement in scientific argumentation skills was reflected in the average pre-test score of 64, which increased to 80 in the post-test. Specifically, the indicators of scientific argumentation showed improvement: claims increased from 62.9% to 75.4%, data from 66.3% to 84%, warrants from 67.8% to 82.1%, and backings from 68.4% to 79.4%. The increase in scientific argumentation scores from pre-test to post-test indicates that the developed teaching module was effective in helping students hone their argumentative skills. However, the ability to formulate claims and backings still requires reinforcement, as they demand a more complex understanding. Nevertheless, this improvement suggests that the differentiated teaching module created and implemented can strengthen students' scientific argumentation skills in understanding chemical bonding material, making it recommended for broader application, especially in science education.
IDENTIFIKASI TURUNAN ASAM KARBOKSILAT AKAR Acalypha indica SEBAGAI KANDIDAT INHIBITOR GFAT MELALUI LC-HRMS DAN STUDI IN SILICO Arviani; Yuszda K. Salimi; Nurhayati Bialangi; Ahmad Chandra Lakasan; Zifran Nur Rahman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2828

Abstract

Diabetes mellitus remains a major global health challenge, prompting the exploration of natural products as sources of safer antidiabetic agents. This study aimed to identify bioactive compounds from the roots of Acalypha indica and evaluate their potential as inhibitors of glutamine–fructose-6-phosphate amidotransferase (GFAT), an enzyme involved in glucose metabolism. Compound profiling was conducted using liquid chromatography–high resolution mass spectrometry (LC-HRMS), while the inhibitory potential against GFAT was assessed through in silico docking. This integrated approach has not been previously reported. Metabolite profiling using LC-HRMS tentatively identified thirteen carboxylic acid derivatives, including hydroxycinnamic acid, gluconic acid, trans-aconitic acid, and glucoheptonic acid. molecular docking analysis revealed strong binding affinities of several compounds toward GFAT.  Glucoheptonic acid exhibited the lowest binding energy (−8.0 kcal/mol), followed by xylaric acid A (−7.9 kcal/mol) and trans-aconitic acid (−7.5 kcal/mol). These compounds interacted with key active-site residues Gln421, Ser420, Ser422, and Lys675, suggesting a potential enzyme inhibition mechanism. In silico pharmacokinetic analysis indicated that 2-hexylpentanedioic acid exhibited favorable ADME properties, with high gastrointestinal absorption, no major inhibition of CYP450, and low predicted acute toxicity risk. These findings highlight Acalypha indica roots as a promising source of bioactive carboxylic acid derivatives, with glucoheptonic acid emerging as the most promising candidate for further in vitro evaluation as a GFAT inhibitor
Karakterisasi Kitosan dari Cangkang Sotong (Sepia officinalis) dari Pantai Tanjung Kramat Kota Gorontalo: Characterization of Chitosan from Cuttlefish Shells (Sepia officinalis) from Tanjung Kramat Beach, Gorontalo City Stasya Anggriani Talib; Nurhayati Bialangi; Arviani; Yuszda K. Salimi; Deasy Natalia Botutihe
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Oktober 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i10.8866

Abstract

Kitosan, biopolymer kationik alami dari deasetilasi kitin eksoskeleton hewan laut, memiliki sifat biokompatibilitas, biodegradabilitas, dan non-toksisitas yang menarik untuk berbagai aplikasi. Penelitian ini bertujuan untuk mengkarakterisasi kitosan yang diisolasi dari limbah cangkang sotong yang diperoleh dari Pantai Tanjung Kramat, Kota Gorontalo dengan focus rendemen, kadar air, dan analisis Fourier Transform Infrared (FITR). Proses isolasi melibatkan tahap demineralisasi, deproteinasi, dan deasetilasi. Hasil penelitian menunjukkan rendemen kitosan tertinggi 28% pada perlakuan HCl 5%, sedangkan kadar air seluruh sampel berkisar antara 2,00-2,21% dan memenuhi standar SNI 7949:2013 (?12%). Analisis FTIR mengidentifikasi gugus fungsi utama dan derajat deasetilasi (DD) tertinggi mencapai 80,17% pada perlakuan HCl 7%, memenuhi standar mutu (?75%). Penelitian ini memberikan wawasan penting mengenai potensi cangkang sotong sebagai sumber kitosan berkualitas.
Co-Authors Abdul Rasyid Abidin, Khoirul Afrilia Ali Agus Malik Ibrahim Ahmad Chandra Lakasan Ahmad, Halid S. Aiyi Asnawi Akram La Kilo Alimuddin Alimuddin Alwi S. Hasan Anna Y. Pomalingo Arafat, Muhammad Yasser Arfan Ari Widiantoro Ari Widiyantoro Ariani Hutuba Arifasno Napu Arviani Arviani Arviani Arviani Arviani Arviani Astin Lukum Bintang Maharani Boima Ramses Situmeang Bumulo, Nuraini Citron S Payu Deasy N Botutihe Deasy Natalia Botutihe Delvi Suleman Dizky Papeo Djalil, Jhodi Pratama Domu, Siti Afdianti Dr. Apt. Hamsidar Hasan S.Si.,M.Si Erni Mohamad Hamid Majelis Hapsawati Taan Haris Munandar Hartati Inaku Hendri Iyabu Herinda Mardin Ibrahim, Yusni Irwan irwan Ishak Isa Jafar La Kilo Jhodi Pratama Djalil Julhim S Tangio Julinton Sianturi Jumarni Kamarudin Karim, Fadila La Alio La Ode Aman Laliyo, Lukman A.R Lanto Ningrayati Amali Larosa, Esta Lisna Ahmad Lukman A. R. Laliyo M. Yogi Riyantama Isjoni Mangara Sihaloho Mardjan Paputungan Masrid Pikoli Melizubaida Mahmud Moh Adam Mustapa Moh Fahri Mooduto Moh Izwarto Piyohu Moh. Karmin Baruadi Mohamad Adam Mustapa Mohamad Mustapa Mohammad Zubair Hippy Murniati . Muti, Nurfadila Mutsyahidan, Arif Murtaqi Akhmad Najmah Najmah Najmah, Najmah Netty I Ischak Netty Ino Ischak Nita Suleman Noka, Isara Abda Novianti, Rani Nurhayati Bialangi Nurkhaliq, Nurkhaliq Opir Rumape Parulian, Boima Ramses Podungge, Muhamad Ramdhan Pomuato, Sasmita R Tulie, Wina Zulviana Rahmatia Rahmiyati Kasim Riyanti Utina Said, Sriyanti S Saiman Saiman Siti Aisa Liputo Siti Rahmatia Machieu Solang, Sriwanda Van Sri Ayu Ashari Stasya Anggriani Talib Suleman Duengo Sunarty Suly Eraku Suryanto Suryanto Syarbin, Ruslun A. R. Tahir, Wawan Teti Tuloli Umar Sako, Umar Wawan Tahir Weny J.A Musa Weny Musa Widy Abdulkadir Widy Susanti Abdulkadir Widya Rahmawaty Saman Wisna Taniyo Wiwin Rewini Kunusa Yayurulia Hadju Yoyanda Bait Yuliyanti Kadir Yusni Ibrahim Yusuf, Novalita Zaenul Wathoni Zifran Nur Rahman