Claim Missing Document
Check
Articles

Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth Nurhayati Bialangi; Mohamad Adam Mustapa; Yuszda Salimi; Weny Musa; Ari Widiyantoro; Agus Malik Ibrahim; Boima Situmeang; Julinton Sianturi
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.74481

Abstract

Plasmodium species are the infectious agents that are responsible for malaria, a disease that claims the lives of approximately 400,000 people annually. The fact that drug resistance against malaria is on the rise suggests that new antimalarial compounds need to be discovered. It is well known that medicinal plants present the best opportunity for the identification of novel antimalaria chemicals. Both the Andrographis paniculata (Burm.f.) and Peperomia pellucida (L. Kunth) species have been tested for their antiplasmodial ability against the Plasmodium falciparum strain. The P. pellucida (L. Kunth) species has also been subjected to in vitro and in vivo biological research. P. pellucida was used to isolate the steroid known as 3-hydroxy-24-ethyl-5,22-cholestadiene (1) and the triterpenoid known as 3-hydroxy-9-lanosta-7,24E-dien-26-oic acid (2). Both compounds were then tested for their activity in vitro. In the mice model, triterpenoid 2 had a substantial chemo-suppressive impact.
Ekstraksi, Analisis Kuantitatif dan Bioaktivitas Virgin Coconut Oil (VCO) Salimi, Yuszda K; Syarbin, Ruslun A. R.; Yusuf, Novalita; Paputungan, Mardjan; Mohamad, Erni
Jambura Journal of Chemistry Vol 5, No 1 (2023): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v5i1.21713

Abstract

Penelitian ini bertujuan untuk mengekstraksi Virgin Coconut Oil (VCO) dengan metode CEVCO (Cold Extaction Virgin Coconut Oil), FEVCO (Fermentation Extraction Virgin Coconut Oil), IEVCO (Inducement Extraction Virgin Coconut Oil), PEVCO (Papaya Extraction Virgin Cococnut Oil) dan NEVCO (Nanas Extraction Virgin Cococnut Oil). Pengujian kualitas berbagai metode ekstraksi VCO secara kuantitatif dianalisis sifat fisikokimia, analisis komposisi asam lemak dengan Kromatografi gas – spektrofotometri Massa (GC-MS), bioaktivitas daya hambat bakteri dengan metode difusi sumuran dan bioaktivitas antioksidan dengan metode diphenil pikril hidrazil (DPPH). Hasil penelitian ini menunjukkan bahwa perlakuan terbaik pada uji fisikokimia dengan metode CEVCO (kadar air 0,0044, asam lemak bebas 0,0029, bilangan peroksida 0,0012, bilangan iod 6,4719, bilangan penyabunan 255,25 dan pH 6) dan metode FEVCO, IEVCO memenuhi syarat standar nasional Indonesia (SNI). Hasil analisis komposisi asam lemak yang terbaik pada metode IEVCO yaitu terdapat asam laurat, asam palmitat, asam kaproat, asam kaprilat dan asam kaprat. Hasil pengujian organoleptik pada metode CEVCO memiliki kualitas yang terbaik dari segi warna, rasa dan aroma. Hasil pengujian daya hambat terhadap bakteri S. aureus sebesar (15,64) dan bakteri E. coli (15,90) pada metode IEVCO dengan konsentrasi 33,33% dan lama waktu 3 jam. Hasil pengujian bioaktivitas antioksidan metode NEVCO memiliki nilai IC50 45 dengan kategori aktivitas antioksidan sangat kuat.
Identifikasi Senyawa Metabolit Sekunder Ekstrak Metanol Batang Katang-katang (Ipomoea Pes-Caprae) dan Uji Aktivitas Antioksidan Salimi, Yuszda K; R Tulie, Wina Zulviana; Bialangi, Nurhayati; Ischak, Netty Ino
Jambura Journal of Chemistry Vol 6, No 1 (2024): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i1.17493

Abstract

Ipomoea pes-caprae merupakan obat tradisional yang termasuk dalam family Convollvulaceae. Tujuan penelitian ini adalah untuk mengetahui kandungan senyawa metabolit sekunder dan aktivitas antioksidan pada ekstrak Ipomoea pes-caprae. Batang Ipomoea pes-caprae diekstraksi menggunakan metode maserasi dan dilakukan uji fitokimia. Hasil fitokimia ekstrak metanol menunjukkan adanya senyawa flavonoid, tanin, dan steroid. Hasil penelitian menunjukkan bahwa isolat yang diperoleh dari Ipomoea pes-caprae berupa kristal amorf. Hasil fitokimia isolat positif mengandung senyawa flavonoid hal ini didukung dengan hasil identifikasi senyawa menggunakan spektrofotometri UV-Vis menghasilkan pita I dan II masing-masing dengan panjang gelombang 257 nm 274 nm. Spektrum IR menghasilkan gugus fungsi ulur O-H pada daerah bilangan gelombang 3195 cm-1. Uluran C-H pada daerah bilangan gelombang 2922 cm-1 dan 2851 cm-1. Uluran C=O muncul pada daerah bilangan gelombang 1716 cm-1. Tekuk C-C streching pada daerah bilangan gelombang 1459 cm-1. Hasil UV-Vis dan IR diduga isolat adalah senyawa flavonoid. Aktivitas antioksidan dengan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil) menunjukkan bahwa ekstrak metanol menunjukkan nilai IC50 sebesar 302,85 ppm yang tergolong dalam kategori lemah.
Education to Strengthen the Economy of the Utilization of Aren Nira Producing Bioetanol in Lonuo Village, Bone Bolango District Hasanuddin; Taan, Hapsawati; Mardin, Herinda; Salimi, Yuszda K.; Rahmatia; Arafat, Muhammad Yasser; Larosa, Esta; Rasyid, Abdul; Ashari, Sri Ayu
Jurnal Pemberdayaan Masyarakat Madani (JPMM) Vol. 8 No. 1 (2024): Jurnal Pemberdayaan Masyarakat Madani (JPMM) (DOAJ & SINTA 3 Indexed)
Publisher : Fakultas Ekonomi dan Bisnis Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JPMM.008.1.03

Abstract

This economic education activity for palm sap farmers aims to provide economic strengthening and build awareness among the public, especially palm sap farmers, that palm sap water can be utilized and made into several products with high economic value, for example bioethanol products. Apart from that, it can also minimize the negative impact of the production of alcoholic drinks made from palm sap in Lonuo village. This activity uses educational methods, socialization and community assistance for sugar palm sap farmers. Empowering sugar palm farmers through product diversification is the key to increasing the quality and quantity of sugar palm sap products into various marketable products such as bioethanol. This economic education activity for palm sap farmers has had a positive impact and response from the Lonuo village community. This can be seen from the enthusiasm of the community in participating in activities at the village office. The community received education well and smoothly and increased public understanding regarding the use of palm sap into products of high economic value such as bioethanol.
Senyawa Triterpenoid dari Ekstrak N-heksana Daun Kelor (Moringa oleifera Lamk.) dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Salimi, Yuszda; Bialangi, Nurhayati; Abdulkadir, Widysusanti; Parulian, Boima Ramses
Indonesian Journal of Chemical Research Vol 7 No 1 (2019): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2019.7-par

Abstract

Kelor plant (Moringa oleifera Lamk) is a plant that grows naturally in a tropical climate. During this decoction of pirdot leaves plants are used by the people as antimicroba. The purpose of this study was to isolate triterpenoid compound from ethyl acetate extract of kelor leaves. The sample extraction was performed by maceration method using methanol as a solvent. Fractionation used n-hexana and etil asetat as a solvent. The separation and purification of the compound was carried out by column chromatography method followed by stain pattern analysis with thin layer chromatography (TLC). Characterization and elucidation of pure compound structures using UV, IR, 1H-NMR, 12C-NMR, HSQC, HMBC, and 1H-1H COSY, and compared with various literatures. Based on the result of structural elusidation, the pure isolate obtained is a pentacyclic triterpenoid group compound with the molecular formula C30H50O and the name of 3-hydroxy, 20 (29) -en, lupenol. The triterpenoid compound of 3-hidroxy, 20 (29) -en, lupenol is the first isolated and reported from leaves of kelor plant.
Karakteristik Kimia Dan Organoleptik Asap Cair Tempurung Kelapa Dalam Menurunkan Cemaran Logam Timbal (Pb) Pada Ikan Cakalang (Katsuwonus pelamis) Djalil, Jhodi Pratama; Salimi, Yuszda K; Iyabu, Hendri; Bialangi, Nurhayati; Mohamad, Erni; Kunusa, Wiwin Rewini
Jambura Fish Processing Journal Vol 6, No 1 (2024): VOLUME 6 NOMOR 1, JANUARY 2024
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jfpj.v6i1.21715

Abstract

This research aims to determine the chemical characteristics of coconut shell liquid smoke and analyze the effectiveness of using liquid smoke in reducing Pb metal contamination in skipjack tuna (Katsuwonus Pelamis). Grade 2 liquid smoke from coconut shells is produced by the Pulubala IKM center through the stages of pyrolysis and distillation. This study employs a completely randomized design (CRD) with two replications. To determine the chemical characteristics of the liquid smoke, the analyzed methods include pH measurement, phenol content, total acidity, protein content, organoleptic value, and the chelating power of heavy metal Pb with variations in the concentration of liquid smoke test solutions AC (undiluted liquid smoke), AC2, AC4, AC6, and AC10 (liquid smoke with the addition of distilled water at 2%, 4%, 6%, and 10%). The results show that the best treatment is obtained from coconut shell liquid smoke with AC concentration (undiluted liquid smoke) having the best characteristics, namely a pH value of 4, phenol content of 1.6469%, total acidity of 14.94 mg/mL, protein content of 0.6083%, and a chelating power for heavy metal Pb of 97.32%. The results of the organoleptic test indicate that overall, the highest score was obtained with a neutral value at the concentration of AC2 (liquid smoke with the addition of 2% distilled water).
Pemberdayaan Masyarakat dalam Pemanfaatan Air Nira Menjadi Produk Bioetanol di Desa Lonuo Kecamatan Tilongkabila Kabupaten Bone Bolango Moh Izwarto Piyohu; Wiwin Rewini Kunusa; Astin Lukum; La Alio; Yuszda K Salimi
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 1, No 1: June 2022
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/damhil.v1i1.15405

Abstract

Bioetanol merupakan etanol (etil alkohol) yang proses produksinya menggunakan bahan baku alami dan proses biologis, berbeda dengan etanol sintetik yang diperoleh dari sintesis kimiawi senyawa hidrokarbon. Tujuan kegiatan pelaksanaan KKNT membangun desa di Desa Lonuo adalah meningkatkan pengetahuan masyarakat tentang pengolahan pohon nira dan limbahnya menjadi produk yang bernilai ekonomi tinggi, Mendorong terwujudnya desa berkembang dan mandiri, serta kolaborasi pedesaan dan perkotaan melalui pengembangan kawasan pedesaan secara berkelanjutan, Mendorong tumbuh dan berkembangnya investasi desa dan pedesaan, daerah tertinggal dan kawasan transmigrasi dan Memberikan pengalaman kepada mahasiswa khususnya untuk dapat mengimplementasikan keilmuannya kepada khalayak di luar prodi dan dapat meningkatkan keterampilan keilmuannya dari pembelajaran dan penerapan secara langsung di lapangan. Waktu Pelaksanaan :15 Maret  2022 – 15 Juli 2022. Produk yang dihasilkan adalah bioetanol dari Air Nira. Kelompok Kerja Mahasiswa KKNT MBKM 2022 Sukses dalam Program Pengembangan Potensi UMK Berbasis Bahan Lokal (Pohon Nira) untuk Meningkatkan Perekonomian Masyarakat di Desa Lonuo.
Pemberdayaan Masyarakat dalam Mengenal Pewarna dan Pemanis Sintetik Berbahaya Yuszda K Salimi; Opir Rumape; Najmah Najmah
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 2, No 1: June 2023
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/damhil.v2i1.20797

Abstract

Additives as food additives that are intentionally added in small quantities for food quality and are available in natural and synthetic ingredients. Synthetic dyes and sweeteners are widely circulating in the community, synthetic food ingredients are in great demand in terms of taste and attractive color appearance without regard to nutritional and health values. Community empowerment aims to increase understanding and knowledge about harmful synthetic dyes and sweeteners in food in the surrounding environment. Community service activities were carried out in Molotabu Village, Kabila sub-district, Bone Bolango Regency, Gorontalo Province. The method used is socialization including the delivery of material by resource persons and followed by discussion. The participants were PKK mothers in Molotabu village, the outreach activities went well from the beginning to the end of the activity the participants were very enthusiastic, the participants got to know additives and various synthetic dyes and sweeteners that are harmful to health and their negative impacts, the knowledge and insight of the community increased regarding the additives used hazardous to health so that participants are vigilant and selective in choosing and buying food and drinks that indicate synthetic dyes and sweeteners in their surroundings.
Penerapan Teknologi Tepat Guna Pada Masyarakat Kayubulan Kabupaten Gorontalo Melalui Pengolahan Limbah Organik, Anorganik dan Eceng Gondok Nita Suleman; Yuszda K Salimi; Netty I Ischak; Jhodi Pratama Djalil
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 1, No 2: December 2022
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/damhil.v1i2.17368

Abstract

The problem of hyacinths in the Limboto lake of Gorontalo Regency has not yet been resolved, causing silting of the lake. Organic and inorganic waste also aggravated the silting. The application of appropriate technology to the Kayubulan community aims to educate the public through organic, inorganic, and hyacinth waste treatment technology. The stages of activities are in the form of community education, consultation, diffusion of science and technology, training, mediation, science and technology simulation, substitution of science and technology, advocacy. The results of this activity provide an understanding to the community about the use of hyacinth, plastic waste, garbage and livestock manure intop roduk in the form of organic solid fertilizer, liquid fertilizer, briquettes, bioethanol, and handicrafts. This activity has a positive impact on increasing the knowledge and skills of the target partners of the young people of the Kayubulan community.
Pemberdayaan Masyarakat Desa Tabongo Timur Melalui Pengolahan Produk Berbasis Kelapa dan Sacha Inchi untuk Mendukung Pencapaian SDGs Bait, Yoyanda; Salimi, Yuszda K.; Zubair, Mohammad; Rahmatia, Siti; Suleman, Delvi
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/linov.v9i4.2393

Abstract

Program pemberdayaan masyarakat ini bertujuan untuk meningkatkan keterampilan dan pengetahuan masyarakat desa Tabongo Timur dalam pengolahan produk berbasis kelapa dan Sacha Inchi. Permasalahan utama yang dihadapi masyarakat adalah rendahnya nilai tambah produk, keterbatasan teknologi, dan kurangnya akses pasar. Untuk meningkatkan nilai tambah produk dilakukan kegiatan dengan metode pelatihan berbasis praktik, transfer teknologi sederhana seperti fermentasi dan sentrifugasi untuk Virgin Coconut Oil (VCO) digunakan untuk memisahkan minyak murni dari kelapa, serta metode cold pressing untuk memastikan kualitas omega 3 minyak sacha Inchi. Program ini melibatkan 20 peserta dari berbagai kelompok masyarakat, termasuk kelompok tani, PKK, BUMDes, dan pemuda desa. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan, ketrampilan dan pendapatan. Hasil evaluasi menunjukkan peningkatan pemahaman dan ketrampilan rata-rata skor post-test sebesar 35%, kualitas produk yang memenuhi standar pasar karena sudah ada hasil uji dan sertifikat PIRT, dan peningkatan pendapatan masyarakat hingga 30%. Temuan ini mendukung pencapaian tujuan Sustainable Development Goals (SDGs), seperti pengentasan kemiskinan, pekerjaan layak, dan konsumsi serta produksi yang bertanggung jawab. Program ini menjadi best practice yang relevan untuk direplikasi di komunitas lain dengan potensi serupa. Empowering the Tabongo Timur Community Through Coconut and Sacha Inchi Processing to Support Sustainable Development Goals (SDGs) Abstract This community empowerment program aims to improve the skills and knowledge of the East Tabongo village community in processing coconut-based products and Sacha Inchi. The main problems faced by the community are low added value of products, limited technology, and lack of market access. To increase the added value of the product, activities were carried out with practice-based training methods, simple technology transfer such as fermentation and centrifugation for Virgin Coconut Oil (VCO) used to separate pure oil from coconut, as well as cold pressing methods to ensure the quality of omega 3 sacha Inchi oil. The program involved 20 participants from various community groups, including farmer groups, PKK, BUMDes, and village youth. The results showed an increase in knowledge, skills and income. The evaluation results showed an increase in understanding and skills of the average post-test score by 35%, product quality that meets market standards because there are already test results and PIRT certificates, and an increase in community income by 30%. These findings support the achievement of Sustainable Development Goals (SDGs), such as poverty alleviation, decent work, and responsible consumption and production. This program is a relevant best practice to be replicated in other communities with similar potential.
Co-Authors Abdul Rasyid Abidin, Khoirul Agus Malik Ibrahim Ahmad, Halid S. Akram La Kilo Alimuddin Alimuddin Alwi S. Hasan Anna Y. Pomalingo Arafat, Muhammad Yasser Ari Widiantoro Ari Widiyantoro Arifasno Napu Arviani Arviani Astin Lukum Astin Lukum Boima Ramses Situmeang Bumulo, Nuraini Citron S Payu Deasy N Botutihe Deasy Natalia Botutihe Delvi Suleman Djalil, Jhodi Pratama Domu, Siti Afdianti Erni Mohamad Hapsawati Taan Haris Munandar Hartati Inaku Hasanuddin Hendri Iyabu Herinda Mardin Ibrahim, Yusni Irwan irwan Ishak Isa Jafar La Kilo Jhodi Pratama Djalil Julhim S Tangio Julinton Sianturi Jumarni Kamarudin Karim, Fadila La Alio La Ode Aman Laliyo, Lukman A.R Lanto Ningrayati Amali Larosa, Esta Lisna Ahmad Lukman A. R. Laliyo Mangara Sihaloho Mardjan Paputungan Masrid Pikoli Melizubaida Mahmud Moh Adam Mustapa Moh Izwarto Piyohu Moh. Karmin Baruadi Mohamad Adam Mustapa Mohammad Zubair Hippy Murniati . Muti, Nurfadila Najmah Najmah Najmah, Najmah Netty I Ischak Netty Ino Ischak Nita Suleman Novianti, Rani Nurhayati Bialangi Nurkhaliq, Nurkhaliq Opir Rumape Opir Rumape Parulian, Boima Ramses Podungge, Muhamad Ramdhan Pomuato, Sasmita R Tulie, Wina Zulviana Rahmatia Rahmiyati Kasim Said, Sriyanti S Saiman Saiman Siti Aisa Liputo Siti Rahmatia Machieu Solang, Sriwanda Van Sri Ayu Ashari Suleman Duengo Sunarty Suly Eraku Suryanto Suryanto Syarbin, Ruslun A. R. Tahir, Wawan Umar Sako, Umar Weny J.A Musa Weny Musa Widy Susanti Abdulkadir Wisna Taniyo Wiwin Rewini Kunusa Yayurulia Hadju Yoyanda Bait Yuliyanti Kadir Yusni Ibrahim Yusuf, Novalita Zaenul Wathoni