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Ermayanti, Sabrina
Universitas Andalas
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Journal : respiratory science

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Accuration of Circulating Tumor DNA (ctDNA) in Detection of Epidermal Growth Factor Receptor (EGFR) Mutation in Lung Cancer Patient Type Adenocarcinoma in M Djamil Hospital Padang Yandra Darusman; Sabrina Ermayanti; Sari Nikmawati; Afriani Afriani
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.6

Abstract

Background: ctDNA is an alternative test for detecting mutation of EGFR in lung cancer type adenocarcinoma if the tissue speciment can not be carried out. Sensitivity, specificity and accuration of ctDNA test is stil varied. This study is aimed to acknowledge sensitivity, specificity and accuration of ctDNA in detecting EGFR mutation in patient with lung cancer type adenocarcinoma in M Djamil Hospital. Methods: Design this study a diagnostik test comparing ctDNA to tissue speciment in detection EGFR mutation of 42 patients with lung cancer type adenocarcinoma in M Djamil Hospital. Sample was selected through consecutive technique. Results: Incidence of EGFR mutation in patients with lung cancer type adenocarcinoma from tissue speciment was higher than ctDNA ((42,9% vs 28,6%; p=0,031). There was significant diffierence of EGFR mutation detection between sex, smoking status, and TNM staging based on tissue/cytology examination and ctDNA (p=0,031). EGFR mutation in sitologic test and ctDNA was more likely detected in male patient (66.7% and 58.3%), ex-smoker (50% and 41.7%) and stage IV (88.9% and 91.7%). The results of sensitivity, specificity positive prediction value (PPV) and Negative prediction value (NPV) in ctDNA test to detect EGFR mutation were 66,7%, 100%, 100% dan 80% according to sitology test as gold standard. Furthermore, the ctDNA accuration was measured according to AUC score 0.833 (SE 0,072, CI 95%, 0,693-0,974, p=0.0001). Conclusion: ctDNA test have a good accuration with sensitiviy 66.7% and specificity 100% in detecting EGFR mutation in patients with lung cancer type adenocarcinoma.
Co-Authors Abdiana Abdiana Adrial Adrial, Adrial Afriani Afriani Afriani Afriani Afriani Sandra Afriwardi Afriwardi Ahmad Junaidi Amelin, Fitrisia Amellya Sucieta Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andika Chandra Putra Andreas Infianto Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Arifani, Adinda Rizky Arina Widya Murni Armiza Ashal, Taufik Dessy Mirzati Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dhiaulhaq, Zalva Indira Dian A. Juwita Dian Citra Dimas Bayu Firdaus Dolly Irfandy Duyen, Natalie Dwi Rizki Fadhilah Elisna Syahruddin Elsa Purnama Sari Elsesmita Fadhilah, Dwi Rizki Fenty Anggraini Fenty Anggraininy Fenty Anggrainy Ferry Dwi Kurniawan Fika Tri Anggraini Hamni Tanjung Hanif, Muhammad Alfin Hansen Nasif Hanum, Fathiya Juwita Haryati Haryati Haryati Haryati Hendris Utama Citra Wahyudin Herman, Deddy Husna Yetti Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Intan, Shinta Ayu Iqbal Maulana Irvan Madison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Isnaniyah Usman Jasminarti, Ida Ayu Julizar Julizar Kornelis Aribowo Kurniawan, Ferry Dwi Laisa Azka Laksmi Wulandari Lestari, Rahmi Liandhu Hakim, Sonya Lili Irawati Lilik Sulistyowati Lim, Darren Wan-Teck Mahata, Liganda Endo Masrul Basyar Masrul Basyar Maulana Muharam Meta Zulyati Oktora Miftah Irramah Mirtha Anggraeni Mizarti, Dessy Moulid Hidayat Muhammad Bagus H.S. Muhammad Farhan Ramadhan Muhammad Zakki Al-Fajri Nathaniel Aditya Nixon, Poety Elberta Husna Noni Novisari Soeroso Nora Harminarti Novita Andayani, Novita Nurul Sari Octavia, Fatharani Nabila Oea Khairsyaf Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putri, Biomechy Oktomalio Rahmat Akbar Rian Rizki Ananda Rini Gusya Liza, Rini Gusya Rizki Amrika Russi lawati Russilawati, Russilawati Santoso, Andintia Aisyah Sari Nikmawati Sari Nikmawati Setyawan, Ungky Agus Sita Andarini Sri Melati Munir Sri Melati Munir Sukri Rahman Sur Yastri Suyastri Suyastri Syandrez Prima Putra Vildania, Nisrina Yandra Darusman Yati Ernawati Yenita Yessy Setiawati Yessy Susanty Sabri Yogi Himawan Yori Yuliandra Yulia, Dwi Yulistini, Yulistini Zaini, Jamal