Article Per Year (5 Year)
p-Index From 2021 - 2026
3.208
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Biotechnology Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional The Indonesian Biomedical Journal Majalah Farmaseutik Indonesian Journal of Chemistry Indonesian Contemporary Nursing Journal (ICON Journal) Indonesian Journal of Cardiology Journal of Community Empowerment for Health Devotion: Journal of Research and Community Service The Avicenna Medical Journal Engagement: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacology and Therapy
Dwi Aris Agung Nugrahaningsih
*) Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada; *) Herbal Medical Center, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Devotion: Journal of Research and Community Service

 1 
Relationship between Lead Exposure and Genotoxic Effect in Paint Industry Workers Rahman, Intan Nur’azizah; Oginawati, Katharina; Ismawati, Yuyun; Buftheim, Sonia; Nugrahaningsih, Dwi Aris Agung
Devotion : Journal of Research and Community Service Vol. 4 No. 7 (2023): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v4i7.517

Abstract

Lead-based paint is a main source of lead exposure to paint industry workers and causes an imbalance of Reactive Oxygen Species (ROS) and antioxidants, causing a genotoxic effect. Pb in the blood (PbB) level and DNA damage are frequently used as exposure and effect biomarker of lead. The purpose of this study to determine the relationship between PbB level and DNA damage due to occupational lead exposure in paint industry workers. The research design uses a cross-sectional epidemiological study involving 52 workers from three paint manufacturers in Indonesia. Blood samples were taken for PbB analysis using ICP-MS, while DNA damage was analyzed using the Comet Assay method. The PbB average obtained was 4.36±1.60 µg.dL-1, where 17 workers (32.69%) exceeded the safe limit value of PbB (5 µg.dL-1). Meanwhile, the influential factors of PbB are the working period and alcohol consumption (p=0.029). The level of DNA damage was represented as Tail DNA (%), and the average was 9.62±0.19 %. All respondents in this study were categorized as under low damage (Class 2). There was no significant relationship between PbB and Tail DNA (%) and has a negative correlation (p=0.878; r=-0.022). The study concludes that there was no difference in Tail DNA (%) between PbB ≥ 5 µg.dL-1 and PbB < 5 µg.dL-1 (p=0.876). It means that lead exposure in this finding has not reached a level that can significantly cause DNA damage. However, it is necessary to monitor PbB levels in workers to minimize genotoxic or other effects.
Co-Authors Abdul Karim Zulkarnain Ade Saputri Ade Saputri ADITYA NUGRAHA Aditya Nugraha Aflifia Birruni Sabila Ahmad Hamim Sadewa Ajib Diptyanusa Akhmad Kharis Nugroho Amira Fawwaz Tsabitah Andina Setyawati, Andina Andrew Limavanady Andrew Limavanady Ani Kristiyani Ari Wibowo Arta Farmawati Astika Widy Utomo, Astika Widy Asysyifa, Azzahra Atmaja, Sarah Aurelia Priscilla Regita Putri Budi Mulyaningsih Budi Mulyaningsih Buftheim, Sonia Caroline Caroline Christantie Effendy Christine Patramurti Denny Agustiningsih Dicky Moch Rizal Dicky Moch Rizal Dimas Adhi Pradana Dita Maria Virginia Dwi Cahyani Ratna Sari Dwi Liliek Kusindarta E. Elsa Herdiana Murhandarwati eko purnomo Eko Purnomo Ellsya Angeline Rawar Emilia Vivi Arsita Erna Kristin Ernaningsih Ernaningsih Eti Nurwening Sholikhah Eti Nurwening Sholikhah Foe, Kuncoro Gloria Evita Thalia Gloria Evita Thalia Hanggoro Tri Rinonce Hendy Wijaya Hera Nirwati Herzan Marjawan Hevi Wihadmadyatami I Made Andika Bara Kusuma Ibeneme, Sam Ikhsan Nur Salim Ikhsan Nur Salim Ismawati, Yuyun Iwan Dwiprahasto Januar Rizqi Jaya, Sudi Indra Jonathan J Jonathan J Jumina Jumina Jumina Jusak Nugraha Katharina Oginawati Ketut Shri Satya Wiwekananda Kwok, Yasmeen Mae Sri Hartati Wahyuningsih Mahatma Sotya Bawono Mia Munawaroh Yuniyanti Mia Munawarroh Yuniyanti Mia Munawarroh Yuniyanti Mosa Rini Nurul Hidayati Mosa Rini Nurul Hidayati Mubarika Haryana, Sofia Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Ngatidjan Ngatidjan Ni Luh Made Noviana Dewi Nico Jafet Nilasari, Fita Nur Arfian Nurrahma, Bira Arumndari Oryza Chrisantia Pamungkas Bagus Satriyo Prasetyastuti Prasetyastuti Pratiwi, Woro Rukmi Probosuseno Probosuseno Raden Sumiharto Rahman, Intan Nur’azizah Rahmi Ayu Wijayaningsih Rahmi Ayu Wijayaningsih Rahmi Ayu Wijayaningsih Rasya Mayora Rasya Mayora RATNA SARI Ratna Sari Rina Susilowati Rizki Awaluddin Rocca, Matteo Ronny Martien Rul Afiyah Syarif Senny Yesery Esar Setyawan Bekti Wibowo Setyo Purwono Setyo Purwono Siswanto Siswanto Sitti Rahmah Umniyati Sitti Rahmah Umniyati Sofia Mubarika Haryana Srikanth Karnati Süleyman Ergün Syarifa, Cut Alima Teguh Triyono Tety Hartatik Titien Budhiaty Titik Nuryastuti Tri Baskoro Tunggul Satoto Tri Ratnaningsih Widodo, Irianiwati Widya Wasityastuti Woro Rukmi Pratiwi Wuryanto Hadinugroho Yahiddin Selian Yasmeen Kwok Yudy Tjahjono Yufita Ratnasari Wilianto Yuliani, Fara Silvia Yuniyanti, Mia Munawaroh Zafrullah, Umar Farooq