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All Journal Jurnal Kedokteran Brawijaya Molecular and Cellular Biomedical Sciences (MCBS) Pendas mahakam : jurnal pendidikan dan pembelajaran Sekolah Dasar Jurnal Keperawatan Padjadjaran JIMR - Journal of Islamic Medicine Research Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Kebidanan Mutiara Mahakam Jurnal Kesehatan Pasak Bumi Kalimantan Jurnal Pengabdian kepada Masyarakat Nusantara Narra J Jurnal Pengabdian Kepada Masyarakat Mulawarman Jurnal Medika: Karya Ilmiah Kesehatan Jurnal Pengabdian Kreativitas Pendidikan Mahakam (JPKPM) Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Yarsi Dental Journal Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Indonesian Journal of Pharmacology and Therapy
Fikriah, Ika
Department Of Pharmacology, Faculty Of Medicine, Mulawarman University, Samarinda, Indonesia.
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Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Agustina Rahayu Magdaleni
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.146

Abstract

Coptosapelta flavescens Korth. is a liana plant from the Rubiaceae family. In East Kalimantan, it is also known as “Akar Tambolekar” or “Merung”, it is called “akar” or root as its trunk spreads like a root. The plant’s stems are used by ethnic Dayak in East Kalimantan to overcome high blood pressure and it has been proven to induce vasorelaxation on blood vessels, but the its action mechanism in the endothelial or vascular smooth muscle cells (VSMC) are unknown. Vasorelaxation on the blood vessels could be mediated by endothelial or by the VSMC. This research aims to study in vitro which of them is the mechanism of action of Coptosapelta flavescens Stems (CFS) extract. CFS were taken from the secondary forest in Paser Regency, East Kalimantan Province. Its simplicia were macerated with methanol solvent for three days and twice repeated. Vasorelaxation activity of the blood vessels was tested with rats’ isolated thoracic aorta with endothelial and with the endothelial removed (endothelium-denuded). Both aorta of 3 mm length were soaked into Krebs-Henselheit solution at 37°C, pH 7.4 and aerated with carbogen gas. After they have acclimatized, both aortas were contracted with phenylephrine solution, after reaching peak contraction and plateau, the solution of extract or its solvent (Control) was administered in cumulatively increasing doses. The results show that CFS extracts induce vasorelaxation both in the endothelial-intact aorta and in the endothelial-denuded aorta. At high concentrations, the vasorelaxation activity in the endothelial-intact aorta was weaker than that on endothelial-denuded aorta. This study proves that action mechanism of blood vessels’ vasorelaxation induced by the methanol extract of CFS were more dominantly mediated by the blood vessels smooth muscle; and at high concentrations the endothelial actually weakened the VSMC vasorelaxation activity. Further study is necessary on the mechanism of action vasorelaxation through the modulation of intracellular or extracellular calcium ion channels of VSMC Keywords: Coptosapelta flavescens, vasorelaxation, extract, aorta, in vitro
Evaluation of Synergistic Effect of Kaempferia galanga L. Rhizome Extracts on the Antibiotic Activity Antibiotics against Bacterial Pathogens Almira Fahrinda; Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Yuniati Yuniati
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i3.148

Abstract

Background: aromatic ginger rhizome (Kaempferia galanga L.) is a member of Zingiberaceae family, has been known to have an antibacterial effect is used for everyday cooking spices, but the synergistic effect on broad spectrum antibiotics was unknown. Objective: this research was conducted to find out the synergistic effect of Kaempferia galanga L. Rhizome extract (KGR) on some broad-spectrum antibiotics against gram positive and negative bacterial pathogens in vitro. Method: KGR was taken from farmers in Samarinda City, East Kalimantan Province, Indonesia. Extraction by maceration with ethanol solvent. Antibacterial activity test of KGR ethanol extract, antibiotic and synergistic effect using Mueller-Hinton agar, Kirby-Bauer disc diffusion method on ampicillin, cefuroxime, chloramphenicol, ciprofloxacin, and meropenem antibiotics against Staphylococcus aureus and Escherichia coli. Results were expressed in percentage increase of the inhibition zone. Statistical test with t-test, significantly different if p<0.05. Results: KGR ethanol extract showed increase the percentage of antibiotic inhibition zone, ampicillin being the highest and the weakest of ciprofloxacin in E. coli; meropenem being the highest and the weakest of ciprofloxacin in S. aureus, statistically significant different tests on antibiotic ampicillin (E. coli), meropenem and cefuroxime. Conclusion: KGR ethanol extract showed synergistic effect on antibiotic ampicillin (E. coli), meropenem and cefuroxime in S. aureus and E. coli.
Acute Toxicity Assay from Seeds and Flesh of Tarap Fruit (Artocarpus odoratissimus Blanco) Ethanolic Extract against Daphnia magna Larvae Crissty Magglin; Ika Fikriah; Khemasili Kosala; Hadi Kuncoro
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.240

Abstract

Tarap (Artocarpus odoratissimus Blanco) is one of the plants in the tropics that are consumed by dayak tribe in East Kalimantan. Toxicity tests on seeds and bark have been done but there is no data regarding the acute toxicity of Artocarpus odoratissimus Blanco seeds and flesh of fruit causing the need for acute toxicity tests. This Research to know the acute toxic effects of tarap (Artocarpus odoratissimus Blanco) seed and flesh extracts on larvae of Daphnia magna. Tarap seeds and flesh (Artocarpus odoratissimus Blanco) was taken from dayak market in Samarinda, is East Kalimantan, Indonesia. The seeds and flesh of the tarap fruit are extracted by maceration with ethanol solvent. An acute toxicity test was performed by exposing Dapnia magna larvae aged ? 24 hours with a solution of the experimental group and the control group for 48 hours. Toxicity test results are expressed in percentage of immobilization of larvae of Daphnia magna calculated by probit test to obtain EC50 (Half maximal effective concentration) values. Extracts are toxic if the EC50 value > 1000ppm. EC50 Ethanol extract of tarap seeds obtained values ( 3922,301 ± 324,590 ) for EC50 24h and ( 2964,498 ± 412,498 ) for EC50 48h. The EC50 value of ethanol extract from flesh of tarap fruit is ( 12224.514 ± 2186. 899 ) EC50 24h and ( 6165,235 ± 1940,006 ) EC50 48h.Ethanol extract of tarap fruit and flesh is non toxic to larvae of Daphnia magna.
Pengaruh Sikap Higiene Tidur Terhadap Kejadian Insomnia Pada Mahasiswa Universitas Mulawarman Adheya Putrindashafa; Denny J. Rotinsulu; Ika Fikriah
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.161

Abstract

Insomnia is difficulty starting or maintaining sleep. There are several factors that are considered to be able to trigger and perpetuate insomnia, one of which is the sleep hygiene, which is included in the moderation factor. However, there is some controversy regarding the involvement of insufficient sleep hygiene towards insomnia. This study aims to determine the effect of sleep hygiene attitudes on the incidence of insomnia and a description of the incidence of insomnia and sleep hygiene in Mulawarman University students. The design of this study was observational analytic with a cross-sectional method, which consisted of 140 Mulawarman University students from 14 faculties. The sampling technique used is consecutive sampling. The data taken is primary data in 14 faculties of Mulawarman University. The research instrument used was the Insomnia Rating Scale questionnaire from the Kelompok Studi Psikiatri Biologi Jakarta and the Sleep Hygiene Index. The results of the study used the Chi-Square test and the Kolmogorov-Smirnov test obtained p value> 0.005. Based on the degree of insomnia, found 65% of respondents suffer from mild insomnia. The frequency of the sexes of women who suffer from insomnia more than men. Based on the degree of sleep hygiene attitudes, it was found that 78.6% of respondents had moderate sleep hygiene attitudes. This study concluded that there was no effect of sleep hygiene attitudes on the incidence of insomnia in Mulawarman University students.
Gambaran Pola Pengobatan Antipsikotik pada Pasien Skizofrenia yang Mengalami Efek Samping Ekstrapiramidal di RSJD Atma Husada Mahakam Samarinda: Description of Antipsychotic Treatment Patterns in Schizophrenia Patients Experiencing Extrapyramidal Side Effects at Atma Husada Mahakam Mental Hospital, Samarinda Fatwa, Nur; Fikriah, Ika; Abdullah, Yenny
Jurnal Medika : Karya Ilmiah Kesehatan Vol 10 No 1 (2025): Jurnal Medika : Karya Ilmiah Kesehatan
Publisher : ITKES Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/jmkik.v10i1.1748

Abstract

Schizophrenia is a chronic mental disorder with a combination of psychotic symptoms such as hallucinations, delusions, motivational and cognitive dysfunction. Effective pharmacological therapy for treating schizophrenia is antipsychotic drugs. Side effects from the use of antipsychotic drugs can affect medication adherence in schizophrenia patients. Non-compliance with taking medication can result in a higher risk of recurrence rates. This study aims to determine the pattern of antipsychotic treatment in schizophrenic patients who experience extrapyramidal syndrome at RSJD Atma Husada Mahakam Samarinda. The research design used in this research is descriptive observational. The research data came from medical records of schizophrenia patients at RSJD Atma Husada Mahakam Samarinda for the inpatient period January 2022October 2023 using a purposive sampling method. A total of 86 samples were obtained consisting of 43 schizophrenia patients with extrapyramidal syndrome and 43 schizophrenia patients who did not experience extrapyramidal syndrome. The results of the study showed that the most common pattern of antipsychotic treatment in EPS patients was polytherapy treatment (69.8%).
Pemberdayaan Keluarga Pembuatan Makanan Fungsional Fortikasi Tepung Ikan Nila Masyarakat Desa Perjiwa, Kalimantan Timur Rahayu, Hanis Kusumawati; Khotimah, Siti; Fikriah, Ika; Sulistiawati, Septiana
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 6 No. 1 (2025): Jurnal Pengabdian kepada Masyarakat Nusantara Edisi Januari - Maret
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v6i1.4899

Abstract

Malnutrisi kronis yang ditandai dengan asupan gizi yang tidak memadai dalam jangka panjang telah secara signifikan berkontribusi terhadap tingginya prevalensi stunting di Indonesia, dengan Kalimantan Timur menjadi salah satu wilayah yang terdampak paling besar. Program pengabdian masyarakat ini dilakukan di Desa Perjiwa, Tenggarong Seberang, untuk memberdayakan keluarga melalui edukasi dan pengembangan makanan fungsional. Program ini berfokus pada produksi biskuit fortifikasi berbahan dasar tepung ikan lokal (ikan nila / Oreochromis niloticus).) sebagai sumber protein untuk mengatasi kekurangan gizi yang terkait dengan stunting. Kegiatan meliputi edukasi kesehatan, skrining antropometri, dan demonstrasi langsung pembuatan makanan fungsional. Hasil menunjukkan peningkatan signifikan dalam pengetahuan peserta tentang gizi seimbang, seperti yang ditunjukkan oleh skor pre-test dan post-test (skor rata-rata: 2,3 vs. 4,6). Selain itu, uji organoleptik menunjukkan penerimaan positif terhadap rasa, tekstur, aroma, dan warna biskuit fortifikasi. Program ini menyoroti potensi makanan fortifikasi berbahan lokal untuk mengatasi stunting, serta menekankan pentingnya pemberdayaan masyarakat yang berkelanjutan dan edukasi dalam mengatasi malnutrisi.
The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report Ismail, Sjarif; Fikriah, Ika; Tandirogang, Nataniel; Kosala, Khemasili
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.4567

Abstract

The hepatitis B virus (HBV) causes acute and chronic liver infections which can be treated by using interferon and antiviral. However, the treatment is relatively expensive. We reported here a case of a patient with chronic hepatitis B who had negative seroconversion without interferon (IFN) and antiviral treatment after herbal consumption. A retrospective investigation showed that the patient consumed Curcuma xanthorrhiza rhizome and Camelia sinensis green tea. These herbs were widely both in vitro and in vivo studied for their effects against HBV infection, although the clinical studies are limited. This case reported the effect of C. xanthorrhiza rhizome and C. sinensis green tea consumption in a patient with chronic hepatitis B. A female patient with chronic hepatisis B infection at the age of 32 y.o. had been taking neuro vitamins regularly for a year before infection detected. She was an asymptomatic patient with normal limits liver function, positive HBsAg and negative anti-Hbs. At the age of 45, she started taking C. xanthorrhiza rhizome simplicia equivalent to 5mg of curcumin twice daily and drinking C. sinensis green tea regularly. Six years later, HBsAg was not detected and her liver function remained within normal limits and Anti-HBs were detected 5 years later. In conclusion, the consumption of C. xanthorrhiza rhizome and C. sinensis green tea can against chronic hepatisis B infection by eliminate HBV dan induce anti-HBs.
Co-Authors Abdullah, Yenny Adheya Putrindashafa Agustina Rahayu Magdalena Almira Fahrinda Aman S. Panggabean Anik Puji Rahayu Arfian Deny Prakoso Bakhtiar, Rahmat Bilqis Faiqotun Nabilah Dilan Cicih Bhakti Purnamasari Crissty Magglin Denny J. Rotinsulu Endang Sawitri Eva Marliana, Eva Evi Fitriany Hadi Kuncoro Handono Kalim Handy Wiradharma Handy Wiradharma Hanis Kusumawati Rahayu Idris, Fagil Rananda Imran Irsyal Irsal, Imran Iwan Samsugito Jaya Mualimin Khemasili Kosala Khemasili Kosala Kim, Soo-Ya Kim, Yong-ung Krispinus Duma Kusuma, Irawan W. Lilies Anggarwati Astuti Magdaleni Agustina Rahayu Maina, Annin Dya Masruhin, Muhammad A. Meiliati Aminyoto Meilinda Meilinda Miftahul Jannah Miharja, Ediyar Nabiela An’nisa Putri Nadhifa Reynanda Naina Naina Nanda, A. Luthfiah Nataniel Tandirogang Novia Fransisca Novia Fransiska Ngo Nur Fatwa, Nur Nursaci Mardania Pipi Surianti Putri, Nabiela Annisa Rachman, Syarifah Awwaliyyah Rahayu, Anik Puji Rahmat Bakhtiar Rahmat Bakhtiar Respati Suryanto Dradjat Ridwan, Muhammad Thoyib Rifqiya Faiza, Mita Maulida Salsabila, Naila Cantika Sanjaya, Regina Anastasia Sapta Rahayuning Ratri Saputra, Rudi Septiana Sulistiawati Sholichin Sholichin Sinar Yani Siti Khotimah Siti Khotimah Siti Rahmadhani Siti Rahmadhani Sjarif Ismail Subagio, Kiki Jayapratama Sudarso, Sulistiawati Sulistiawati Sudarso Sulistiyawati Sulistiyawati Swandari Paramita Ulyah, Rochimah Thul Yadi Yadi Yuliana Kartika Ningrum Yuniati Yuniati