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All Journal MITRA: Jurnal Pemberdayaan Masyarakat Acta Biochimica Indonesiana Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Bakti Masyarakat Indonesia Jurnal Kesehatan Tambusai Devotion: Journal of Research and Community Service Prosiding Seri Seminar Nasional Jurnal Suara Pengabdian 45 KREATIF: Jurnal Pengabdian Masyarakat Nusantara Jurnal Sehat Indonesia (JUSINDO) Tarumanagara Medical Journal Perigel: Jurnal Penyuluhan Masyarakat Indonesia Jurnal Keperawatan Bunda Delima Jurnal Abdimas Indonesia Jurnal Muara Medika dan Psikologi Klinis Jurnal Pengabdian Masyarakat Nian Tana Panggung Kebaikan : Jurnal Pengabdian Sosial Cermin Dunia Kedokteran
David Limanan
Bagian Biokimia Dan Biologi Molekuler Fakultas Kedokteran Universitas Tarumanagara, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Antioxidant Test, Total Alkaloid Content, Antimitosis Test and HPTLC Test of Chamomile Flower Extract (Matricaria Chamomilla L.) Tantowi, Ferdy; Limanan, David
Devotion : Journal of Research and Community Service Vol. 4 No. 1 (2023): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/dev.v4i1.351

Abstract

Oxygen is one of the supports of multicellular life and is necessary for aerobic metabolism. However, the use of oxygen can produce by-products, one of which is reactive oxygen species (ROS) which can also increase due to external factors such as exposure to ionizing rays, and vehicle smoke. When reactive oxygen species levels are high, the body can experience a condition called oxidative stress, which is a condition that can cause tissue damage. To overcome this, antioxidants are needed, namely compounds that can donate electrons to free radicals to neutralize their effects. Antioxidants are divided into endogenous antioxidants and exogenous antioxidants. Endogenous antioxidants are antioxidants found in the body. Exogenous antioxidants are antioxidants that come from outside the body. Because there is an increase in ROS levels due to external influences, an increase in exogenous antioxidants is needed, one of which is chamomile flowers. This study evaluated qualitative phytochemical levels using the Harnborne method, total antioxidant capacity using the Blois method, total quantitative levels of alkaloids using the Trivedi et al method, BSLT toxicity using the Meyer method, and fingerprint analysis using HPTLC. The obtained chamomile flowers are dried and extracted by maceration using methanol solvent. The test results on chamomile flowers revealed phytochemical content in the form of alkaloids, betasianin, cardioglycosides, coumarins, flavonoids, phenols, quinones, saponins, steroids, tepenoids and tannins. Antioxidant ability 209.27 g/ml; Total alkaloid content of 12.62 g/ml; toxicity 174.39 g/mL; As well as fingerprint analysis chamomile flowers have active ingredients. Therefore, chamomile flowers can serve as a moderate antioxidant with antimitotic activity.
Antioxidant Capacity Test, Total Phenolic, Total Alkaloid, and Toxicity of Marigold Flower (Tagetes Erecta L.) Tenggono Son, Hadinata; Limanan, David
Devotion : Journal of Research and Community Service Vol. 4 No. 1 (2023): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/dev.v4i1.352

Abstract

Antioxidants are a set of compounds that can fight the effects of reactive oxygen species (ROS) so as to eliminate their effects in the form of damage to macromolecules of carbohydrates, fats, proteins, and DNA chains. One source of antioxidants that are easily available and widely available is through herbal ingredients such as marigold flowers (Tagetes erecta L.). Marigold flowers are well known and used as a source of antioxidants, anti-inflammatory, antibacterial, diuretic and accelerate wound healing. This flower is often consumed as an edible flower and is also drunk in the form of tea. This study aims to look for the antioxidant capacity, total phenolic, total alkaloids, and toxicity of marigold flowers. Marigold flower extract is obtained by evaporating the results of methanol maceration from dried marigold flowers. Test antioxidant capacity with DPPH (2,2-diphenyl-1-picrilhydrazyl) using Blois method, total phenolic using Singleton and Rossi method, total alkaloid by method by Trivedi et al, and BSLT toxicity by Meyer method. The antioxidant capacity of marigold flowers is measured in IC50 as much as 74.5 μg/mL which includes active antioxidant levels. The total phenolic content of marigold flowers was obtained as much as 10,350.68 μg/mL. Total alkaloid levels were obtained as much as 13.05 μg/mL. The BSLT toxicity test in LC50 is 162.82 μg/mL which is categorized as moderate toxicity. From the results of this study, marigold flowers can be used as a source of antioxidants and have antimitotic properties.
ANALISIS FITOKIMIA, UJI FENOLIK DAN TOTAL ANTIOKSIDAN EKSTRAK BIJI CHIA METODE FRAP Saerang, Stefanus Handy; Limanan, David; Yulianti, Eny; Ferdinal, Frans
Jurnal Muara Medika dan Psikologi Klinis Vol. 5 No. 1 (2025): Jurnal Muara Medika dan Psikologi Klinis (IN PRESS)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmmpk.v5i1.34477

Abstract

Radikal bebas dapat didefinisikan sebagai suatu senyawa yang bersifat tidak stabil karena memiliki elektron tidak berpasangan, menjadikannya sangat mudah bereaksi dan berpotensi merusak struktur biologis tubuh, sehingga berpotensi merusak struktur biologis dalam tubuh. Apabila jumlah pembentukan radikal bebas melebihi kapasitas sistem tubuh untuk menetralkan radikal bebas, maka dapat memicu kondisi stres oksidatif, yang berhubungan erat dengan berbagai gangguan kronis seperti diabetes, kanker, penyakit kardiovaskular, dan gangguan ginjal. Antioksidan memiliki peran penting dalam menetralisir radikal bebas, yang pada akhirnya berperan dalam menjaga sel agar tidak mengalami kerusakan. Biji chia (Salvia hispanica L.) diketahui memiliki senyawa aktif seperti fenolik dan flavonoid yang berpotensi bertindak menjadi antioksidan alami. Penelitian ini dilaksanakan untuk menilai jumlah keseluruhan senyawa fenolik serta kemampuan antioksidan, dan profil senyawa aktif dari ekstrak biji chia melalui pendekatan in vitro. Proses analisis meliputi identifikasi senyawa aktif menggunakan skrining fitokimia, pengukuran kadar fenolik total dilakukan dengan metode Folin–Ciocalteu, dan untuk pengujian aktivitas antioksidan dilakukan melalui metode FRAP (Ferric Reducing Antioxidant Power). Pengujian fitokimia mengindikasikan bahwa ekstrak biji chia memiliki berbagai senyawa, di antaranya steroid, terpenoid, dan alkaloid, fenol, flavonoid, kuinon, saponin, tanin, kumarin, betasianin, dan kardioglikosida. Kandungan total fenolik mencapai 46,79 mg GAE per gram, mencerminkan tingginya konsentrasi senyawa fenolik. Sementara itu, uji FRAP menunjukkan nilai kapasitas antioksidan sebesar 15,885 µg/mL, yang menandakan bahwa kemampuan antioksidannya tergolong sangat tinggi. Temuan ini memperkuat dugaan bahwa ekstrak biji chia berpotensi digunakan sebagai antioksidan alami dan kandidat bahan aktif untuk mendukung pencegahan penyakit akibat stres oksidatif.
Co-Authors Alexander Halim Santoso Alexander Halim Santoso Alexander Halim Santoso Alphanto, Alfred H Alya Dwiana Andrea Bianca Castafiore Kusuma Angela Aprilia Adinda Annisaa Nurrahma Ardyati Ardhita Felicia Tanuhariono Asyraf, Muhammad Zain Alwi Audina Leonita Clareta Vero Patricia Widya Darma, Timothy Halomoan E Efrany E Yulianti Edbert, Bruce Edwin Destra Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti, Eny Erics Efrany Ezra, Pasuarja Jeranding F Wandy Farell Christian Gunaidi Fariz Azril Khaidar Akhmad Felicia Tanuhariono, Ardhita Ferdian Ferdian Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Fransiska Iriani Dewi Freddy Ciptono Gita Manerlin Kasihita Simatupang Grace Madeleine Halomoan Darma, Timothy Helmi Rizal Helmi Heri Yanto Putra Ivany Lius Pangestu Jap, Ayleen Jeffrey Saputra Kawi Jessica Geselda Salim Julianty, Eny Karinnia Karinnia Kevin Arya Lim Lulu Lina Azzahrotin Fairuza M Lirendra Marcella E. Rumawas Marcella E. Rumawas Marcella, Agnes Marcellino Marcellino Maria Christina Dwiyanti Meilani Kumala Michael Chen Muhammad Fikri Dzakwan Natasha Olivia Christian Nawaika Shafira Putri Ngestinuari Salim NO Christian R Benettan Rizky Putri Agustina Rudianti, Selly Herlia Rumengan, Peterjohn Andrew Benhard Saerang, Stefanus Handy Salim, Melanie Santoso, Alexander Sari Mariyati Dewi Nataprawira Sentosa, Belinda Setiady, Brandon Alexander Shafira Putri, Nawaika Sidarta, Erick Stanislas Kotska Marvel Mayello Teguh Stephanie Amadea Susy Olivia Susy Olivia Susy Olivia Lontoh Susy Olivia Lontoh Tantowi, Ferdy Teguh, Stanislas Tenggono Son, Hadinata Timotius Timotius Tjie Haming Setiadi Triyana Sari Triyana Sari Wijayadi, Linda Julianti Yesan Suci Paramitha