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Deteksi Radiologis Dini Osteoartritis Genu sebagai Upaya Preventif dalam Menurunkan Risiko Disabilitas Tjie Haming Setiadi; Santoso, Alexander Halim; Dwiana, Alya; Jeffrey Jeffrey; Limanan, David
Nusantara: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2026): Februari: NUSANTARA Jurnal Pengabdian Kepada Masyarakat
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/nusantara.v6i1.7967

Abstract

Knee osteoarthritis (OA) is one of the leading causes of disability among the elderly population. This degenerative joint disease is characterized by progressive damage to the articular cartilage and structural alterations of the knee joint, resulting in pain, reduced mobility, and diminished quality of life. This Community Service Program (PKM) aimed to promote early detection of knee OA through simple radiological screening as a preventive strategy to reduce the risk of musculoskeletal disability. The activity was conducted at Asisi Church, South Jakarta, involving 87 participants aged 54–87 years (mean 70.77 ± 7.32 years). Radiological examination was performed using standard anteroposterior knee X-rays, and results were classified according to the Kellgren–Lawrence grading system. Findings revealed that 98.9% of participants exhibited radiological signs of OA, predominantly grade II (60.9%), followed by grade III (21.8%), grade I (11.5%), and grade IV (4.6%), while only 1.1% showed normal results. Female participants (74.7%) predominated across all OA grades, indicating hormonal and biomechanical influences on disease progression. The mean age increased with OA severity, supporting the degenerative theory that aging leads to decreased chondrocyte function and cartilage elasticity. In addition to screening, participants received education on weight management, muscle strengthening exercises, and injury prevention. The results demonstrate that simple radiological screening is an effective, practical, and cost-efficient community-based approach for early detection of knee OA. Integrating such preventive strategies within primary care systems could significantly reduce the burden of disability among the elderly population.
ANALISIS FITOKIMIA DAN KAPASITAS ANTIOKSIDAN EKSTRAK DAUN ALPUKAT (PERSEA AMERICANA MILL) DENGAN METODE DPPH Daiva Pattra Yoe; David Limanan; Frans Ferdinal; Eny Yulianti
Ebers Papyrus Vol. 31 No. 2 (2025): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/4js9n196

Abstract

Produksi berlebihan Reactive Oxygen Species (ROS) dapat memicu stres oksidatif yang membuat kerusakan pada biomolekul penting seperti lipid, protein, dan asam nukleat. Daun alpukat (Persea americana Mill.) telah menarik perhatian sebagai sumber potensial antioksidan alami karena kandungan senyawa aktif biologisnya yang melimpah. Tujuan penelitian ini adalah untuk mencari tahu kandungan fitokimia dan menilai kinerja antioksidan dari ekstrak daun alpukat menggunakan metode uji DPPH. Analisis kandungan fitokimia menunjukkan bahwa berbagai kelompok metabolit sekunder teridentifikasi, termasuk alkaloid, flavonoid, kardioglikosida, saponin, kumarin, fenolik, kuinon, betasianin, steroid, terpenoid, tanin, antosianin, dan glikosida. Senyawa-senyawa ini diyakini berperan dalam pertahanan antioksidan melalui mekanisme seperti transfer atom hidrogen, stabilisasi radikal bebas, dan pengikatan ion logam. Penilaian aktivitas antioksidan dilakukan menggunakan teknik uji DPPH (2,2-difenil-1- pikrilhidrazil), yang menunjukkan aktivitas penangkap radikal yang signifikan dari ekstrak, dengan nilai IC₅₀ sebesar 31,563 µg/mL. Secara keseluruhan, hasil penelitian ini menyoroti sifat antioksidan kuat dari daun alpukat dan menunjukkan potensinya sebagai bahan alami dalam pengembangan formulasi antioksidan berbasis herbal.
Effect of Penta Herbs Forte on Antioxidant Capacity and Cardiac Protein Carbonyl Levels in a Hypoxia-Induced Rat Model Sentanu Widiarto; Shirly Gunawan; David Limanan; Frans Ferdinal; Eny Yulianti
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.304

Abstract

Introduction. Hypoxia, a state of inadequate oxygen supply in tissues, can induce the generation of reactive oxygen species (ROS), leading to oxidative stress and damage to biomolecules such as proteins. This damage can be quantified by measuring protein carbonyl levels. Penta Herbs Forte (PHF), a polyherbal formulation composed of Andrographis paniculata, Blumea balsamifera, Phyllanthus urinaria, Zingiber officinale, and Curcuma xanthorrhiza, is rich in bioactive compounds with known antioxidant properties. This study aimed to evaluate the antioxidant activity of PHF extract and its effects on cardiac protein carbonyl levels in hypoxia-induced rats. Methods. This experimental study included 32 male Sprague-Dawley rats, divided into eight groups: control and treatment groups under normoxia, 1-day hypoxia, 7-day hypoxia, and 14-day hypoxia, either with or without PHF extract administration. Antioxidant capacity was determined using the ABTS and DPPH assays, and cardiac protein carbonyl levels were measured using a spectrophotometer. Results. PHF extract showed an antioxidant activity yielding LC50 values of 22.135 μg/mL (ABTS) and 105.04 μg/mL (DPPH), indicating strong antioxidant potential. PHF-treated groups exhibited lower cardiac protein carbonyl levels than their respective controls across all hypoxic durations. Conclusion. Administration of PHF extract reduced cardiac protein carbonyl levels via its antioxidant activity, suggesting its potential as an exogenous antioxidant source to protect against hypoxia-induced oxidative damage.
Phytochemical Profile and Antioxidant Activity of Green Onion (Allium fistulosum L.) Extract Lis Diana Husni Putri; David Limanan; Eny Yulianti; Frans Ferdinal
International Journal of Psychology and Health Science Vol. 4 No. 3 (2026): International Journal of Psychology and Health Science (July - September 2026)
Publisher : Greenation Publisher & Yayasan Global Research National

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/ijphs.v4i3.2199

Abstract

Oxidative stress plays a pivotal role in the progression of various degenerative diseases due to excessive production of reactive oxygen species (ROS) that overwhelms the body's antioxidant defense system. Green onion (Allium fistulosum L.) is an herbal plant known to contain diverse bioactive compounds with potential as natural antioxidants. This study aimed to analyze the phytochemical profile and antioxidant activity of green onion extract in vitro. Extraction was performed using the percolation method with methanol. Qualitative phytochemical analysis was conducted using specific reagents. Antioxidant capacity was subsequently evaluated using DPPH, ABTS, and FRAP assays, each referenced against Trolox as the standard compound. Results showed that the extract had a yield of 20.36% and contained alkaloids, betacyanins, cardiac glycosides, glycosides, coumarins, flavonoids, phenols, quinones, saponins, steroids, terpenoids, and tannins. Antioxidant activity yielded IC₅₀ values of 185.86 µg/mL (DPPH), 91.60 µg/mL (ABTS), and 15.39 µg/mL (FRAP). These findings indicate that green onion extract possesses considerable potential as a natural antioxidant source for further development.
Skrining dan Edukasi Pencegahan Dini Penyakit Tidak Menular pada Masyarakat Urban Tomang David Limanan; Susy Olivia
Jurnal Pengabdian West Science Vol 5 No 02 (2026): Jurnal Pengabdian West Science
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/jpws.v5i02.3106

Abstract

Penyakit Tidak Menular (PTM) merupakan masalah kesehatan utama di masyarakat urban, dengan obesitas sentral dan gangguan kardiometabolik sebagai faktor risiko dominan. Rendahnya kesadaran masyarakat terhadap faktor risiko PTM serta keterbatasan pengetahuan mengenai kegawatdaruratan kardiovaskular menjadi tantangan dalam upaya pencegahan dini. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan kesadaran masyarakat terhadap faktor risiko PTM melalui skrining kesehatan yang terintegrasi dengan edukasi pencegahan dan pelatihan Bantuan Hidup Dasar (BHD). Kegiatan dilaksanakan pada Rabu, 7 Januari 2026 dengan metode skrining dan edukasi berbasis komunitas pada 66 peserta. Pemeriksaan meliputi indeks massa tubuh, lingkar perut, tekanan darah, kadar gula darah sewaktu, kolesterol total, dan asam urat. Hasil menunjukkan rerata usia peserta 32,79 ± 10,45 tahun, dengan mayoritas berjenis kelamin laki-laki (93,9%). Rerata IMT sebesar 26,14 ± 4,65 kg/m², dengan 65,2% peserta memiliki lingkar perut tinggi. Kadar kolesterol total normal ditemukan pada 77,3%, gula darah sewaktu normal pada 83,3%, dan kadar asam urat tinggi pada 48,5% peserta. Kegiatan ini menunjukkan bahwa masyarakat mitra memiliki berbagai faktor risiko PTM, terutama obesitas sentral, dan bahwa skrining kesehatan yang diintegrasikan dengan edukasi PTM dan BHD berpotensi meningkatkan kesadaran serta kesiapsiagaan masyarakat dalam menghadapi kegawatdaruratan kardiovaskular.
Antioxidant activity of Crescentia cujete extract: effects on oxidative stress in the hearts of hypoxic rats David Limanan; Brandon Alexander Setiady; Belinda Sentosa; Alfred H Alphanto; Selly Herlia Rudianti; Frans Ferdinal
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.201

Abstract

Background: The heart is highly susceptible to oxidative stress. Hypoxia can induce oxidative stress in the heart, leading to cardiac damage. Objective: This study investigated the antioxidant effects of Crescentia cujete extract on oxidative stress in hypoxic rat hearts. Methods: Antioxidant capacity was evaluated using DPPH assay. Sprague Dawley rats were divided into eight groups: four received C. cujete extract (400 mg/kg/day for 14 days) and four served as controls. Hypoxia was induced for 3, 7, and 14 days using a hypoxic chamber (8% O₂, 92% N₂). Heart tissue was analyzed for malondialdehyde (MDA), glutathione (GSH), and catalase activity. Results: C. cujete extract demonstrated moderate antioxidant capacity (IC50 = 158.45 µg/mL). In extract-treated rats, MDA levels were significantly lower compared to controls, while catalase activity was significantly higher. GSH levels were higher in treated groups but not statistically significant. Histopathological analysis revealed less cardiac necrosis in extract-treated groups. Conclusion: C. cujete extract demonstrates protective effects against hypoxia-induced cardiac oxidative stress. These findings suggest potential as complementary therapy for oxidative cardiac damage, although further studies are needed to establish clinical efficacy and safety.
Efek Pemberian Penta Herbs Forte Terhadap Aktivitas Spesifik Enzim Katalase Hati Tikus Sprague Dawley Yang Diinduksi Hipoksia Sistemik Kronik Viola Ananda Jerika Putri; David Limanan; Frans Ferdinal; Eny Yulianti
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 1 (2026): Volume 13 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i1.21171

Abstract

Hipoksia sistemik dapat memicu stres oksidatif akibat peningkatan reactive oxygen species (ROS) yang berpotensi mengganggu fungsi hati. Enzim katalase berperan penting dalam sistem pertahanan antioksidan endogen melalui penguraian hidrogen peroksida (H₂O₂). Penelitian ini bertujuan mengamati aktivitas enzim katalase hati pada tikus Sprague Dawley yang dipaparkan hipoksia sistemik dengan durasi berbeda serta menilai kecenderungan perubahan aktivitas enzim setelah pemberian Penta Herbs Forte (PHF), suatu formulasi herbal kombinasi dari lima tanaman obat. Sebanyak 32 ekor tikus jantan Sprague Dawley dibagi ke dalam delapan kelompok berdasarkan durasi hipoksia (normoksia, 1 hari, 7 hari, dan 14 hari) serta perlakuan (kontrol dan PHF). Induksi hipoksia dilakukan menggunakan hypoxia chamber dengan paparan 24 jam per hari. Aktivitas enzim katalase hati diukur menggunakan metode spektrofotometri. Hasil menunjukkan bahwa paparan hipoksia dengan durasi yang lebih lama cenderung diikuti oleh penurunan aktivitas enzim katalase pada kelompok kontrol. Pada kelompok yang menerima PHF, aktivitas enzim katalase secara umum berada pada nilai yang lebih tinggi dibandingkan kelompok kontrol pada berbagai durasi hipoksia, meskipun sebagian besar perbedaannya tidak bermakna secara statistik (p 0,05). Temuan ini menunjukkan adanya kecenderungan bahwa PHF berpotensi mendukung aktivitas sistem antioksidan hati pada kondisi hipoksia sistemik. Namun, interpretasi hasil masih terbatas pada konteks eksperimental dan memerlukan penelitian lanjutan.
Peningkatan Kesadaran Pemantauan Tekanan Darah melalui Edukasi Kesehatan Kerja pada Pekerja Usia Produktif di Jakarta Barat Susy Olivia; David Limanan
Jurnal Pengabdian Sosial Vol. 3 No. 3 (2026): Januari
Publisher : PT. Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/sp9jga27

Abstract

Hipertensi merupakan faktor risiko utama penyakit kardiovaskular yang semakin banyak ditemukan pada pekerja usia produktif, khususnya di wilayah perkotaan. Kegiatan Pengabdian kepada Masyarakat ini bertujuan meningkatkan kesadaran pemantauan tekanan darah serta mempromosikan aktivitas fisik sederhana sebagai upaya promotif–preventif hipertensi pada komunitas pekerja di Jakarta Barat. Kegiatan dilaksanakan secara tatap muka pada 7 Januari 2026 melalui edukasi kesehatan kerja, promosi aktivitas fisik sederhana, simulasi pemantauan tekanan darah mandiri, serta pemeriksaan tekanan darah menggunakan tensimeter digital. Sebanyak 66 peserta mengikuti kegiatan ini dengan rerata usia 32,8 ± 10,5 tahun, dan mayoritas merupakan laki-laki. Hasil pemeriksaan menunjukkan bahwa sebagian besar peserta berada pada kategori prehipertensi dan hipertensi, yang mengindikasikan adanya risiko gangguan kardiovaskular pada kelompok pekerja usia produktif. Edukasi kesehatan kerja yang dikombinasikan dengan pemeriksaan tekanan darah dan promosi aktivitas fisik sederhana terbukti meningkatkan pemahaman peserta mengenai pentingnya deteksi dini hipertensi dan penerapan perilaku hidup sehat di lingkungan kerja. Kegiatan ini diharapkan dapat mendukung pencegahan hipertensi melalui pendekatan promotif–preventif berbasis komunitas kerja di wilayah perkotaan.
Penta Herbs Forte: The Effect of PHF Extract on Superoxide Dismutase Activity in Hypoxic Sprague Dawley Rat’s Heart Jessie Farica Gunardi; Noer Saelan Tadjudin; Frans Ferdinal; David Limanan; Eny Yulianti
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.382

Abstract

Hypoxia is a condition in which tissues receive insufficient oxygen, leading to increased production of reactive oxygen species (ROS) and triggering oxidative stress that can cause heart damage. Penta Herbs Forte (PHF), a combination of Blumea balsamifera, Curcuma xanthorrhiza, Zingiber officinale var. rubrum, Phyllanthus niruri, and Andrographis paniculata, contains bioactive compounds with antioxidant properties that may help strengthen the body’s defense against oxidative injury. This study aimed to evaluate the effect of PHF extract on the activity of the antioxidant enzyme Superoxide Dismutase (SOD) in the hearts of hypoxia-induced Sprague Dawley rats. The research included in vitro assessments (total phenolic content, BSLT toxicity, and FRAP assays) and in vivo experiments involving eight groups of rats receiving PHF extract with different hypoxia exposure durations (0, 1, 7, and 14 days). Heart tissues were processed into homogenates, and SOD activity was measure by spectrophotometry, followed by statistical analysis using the Mann-Whitney and Kruskal-Wallis tests. Although PHF groups showed higher SOD activity, significant differences between control and treated groups were observed only at 1-day hypoxia. These findings suggest that PHF may help protect the heart from hypoxia-related oxidative stress by enhancing antioxidant enzyme activity.
EKSPLORASI KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA LAWANG (ILLICIUM VERUM) Muhammad Novtyan Putra Ramadhan; Shirly Gunawan; David Limanan; Frans Ferdinal; Eny Yulianti
Ebers Papyrus Vol. 32 No. 1 (2026): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ep.v32i1.36990

Abstract

Beberapa tumbuhan memiliki potensi efek antioksidan untuk mencegah terjadinya kerusakan yang disebabkan stres oksidatif. Antioksidan eksogen dapat diperoleh dari sumber alami, salah satunya tanaman herbal seperti bunga lawang (Illicium verum). Tanaman ini banyak tumbuh di pegunungan Maluku dan telah lama dipakai dalam pengobatan tradisional misalnya sebagai antiseptik. Penelitian ini bertujuan untuk mengevaluasi kandungan metabolit sekunder, aktivitas antioksidan, serta tingkat toksisitas bunga lawang. Ekstrak bunga diperoleh melalui metode maserasi dengan menggunakan pelarut metanol. Pengujian fitokimia dilakukan dengan pendekatan semikualitatif. Uji aktivitas antioksidan dilakukan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis-(3-ethylbenzothiazoline)-6-sulfonic acid), dan FRAP (Ferric Reducing Antioxidant Power). Uji toksisitas dilakukan dengan metode BSLT (Brine Shrimp Lethality Test). Pengujian fitokimia didapatkan hasil ekstrak bunga lawang mengandung senyawa alkaloid, flavonoid, fenolik, saponin, kumarin, kuinon, antosianin, betasianin, glikosida, kardioglikosida, steroid, terpenoid, dan tanin. Pada pengujian kapasitas antioksidan ekstrak bunga lawang dengan metode DPPH didapatkan IC50 = 206,918 µg/mL, dengan metode ABTS didapatkan IC50 = 16,135 µg/mL, dengan metode FRAP didapatkan IC50 = 23,711 µg/mL. Penelitian ini menunjukkan potensi ekstrak bunga lawang sebagai antioksidan yang kuat.
Co-Authors Akhmad, Fariz Azril Khaidar Alfred H Alphanto Andrea Bianca Castafiore Kusuma Angela Aprilia Adinda Annisaa Nurrahma Ardyati Ardhita Felicia Tanuhariono Asyraf, Muhammad Zain Alwi Audina Leonita Belinda Sentosa Brandon Alexander Setiady Clareta Vero Patricia Widya Daiva Pattra Yoe Darma, Timothy Halomoan Destianti , Erika Dwiana, Alya E Efrany E Yulianti Edbert, Bruce Edwin Destra Eldy Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti, Eny Erics Efrany Ezra, Pasuarja Jeranding F Wandy Farell Christian Gunaidi Felicia Tanuhariono, Ardhita Ferdian Ferdian Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Frans Ferdinal Fransiska Iriani Dewi Freddy Ciptono Gaofman, Brian Albert Gita Manerlin Kasihita Simatupang Grace Madeleine Halomoan Darma, Timothy Helmi Rizal Ivany Lius Pangestu Jap, Ayleen Jeffrey Jeffrey Jeffrey Saputra Kawi Jessica Geselda Salim Jessie Farica Gunardi Julianty, Eny Karinnia Karinnia Kevin Arya Lim Kusuma, Andrea Bianca Castafiore Lis Diana Husni Putri Lulu Lina Azzahrotin Fairuza M Lirendra Maharani, Ismi Ikrima Makarau, Erick Marcella E. Rumawas Marcella, Agnes Marcellino, Marcellino Maria Christina Dwiyanti Meilani Kumala Michael Chen Mohammad Syawal Athallah Harun Muhammad Fikri Dzakwan Muhammad Fitrianur Ramadansyah Muhammad Novtyan Putra Ramadhan Natasha Olivia Christian Nawaika Shafira Putri Ngestinuari Salim NO Christian Noer Saelan Tadjudin Prasasti Marsya Ayu Palupi Putri, Nawaika Shafira R Benettan Resta Emelia Rejoltri Tumon Rizky Putri Agustina Rumawas, Marcella E Rumawas, Marcella E. Rumengan, Peterjohn Andrew Benhard Saerang, Stefanus Handy Salim, Melanie Santoso, Alexander Santoso, Alexander Halim Sari Mariyati Dewi Nataprawira Selly Herlia Rudianti Sentanu Widiarto Septiana, Devqa Nur Shafira Putri, Nawaika Shirly Gunawan Shirly Gunawan Shirly Gunawan Sidarta, Erick Sindy Merliyani Stephanie Amadea Susy Olivia Susy Olivia Susy Olivia Susy Olivia Susy Olivia Lontoh Susy Olivia Lontoh Tantowi, Ferdy Tanuhariono, Ardhita Felicia Teguh, Stanislas Teguh, Stanislas Kotska Marvel Mayello Tenggono Son, Hadinata Timotius Timotius Tjahyanto, Teddy Tjie Haming Setiadi Tjie Haming Setiadi Triyana Sari Viola Ananda Jerika Putri Wijayadi, Linda Julianti yanto, heri Yesan Suci Paramitha