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Media Penelitian dan Pengembangan Kesehatan
Published by Politeknik Kesehatan Kemenkes Bandung
ISSN : 08539987     EISSN : 23383445     DOI : DOI: https://doi.org/10.34011/jmp2k.v34i3.2287
Core Subject : Health, Science, Social,
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Medicine & Pharmacology
Media of Health Research and Development is a journal that was developed to disseminate and discuss scientific papers on health development and other research of health. The journal is intended as a medium of communication for those who were interested to study health, among others, for researchers, educators, students, practitioners Department of Health, Public Health Service, and public generally who have an interest in it. The journal is trying to meet the growing need to study health. Vision: Being a leading national journals in the field of health research and leading a reputable international journals. Mission: Providing scientific communication media in health research in order to advance science and technology in related fields. Publishing scientific journal in the field of medical research that seeks to achieve a high impact factor in the development of science and technology.
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 324 Documents
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Clinical audit of medical records based on clinical pathway: case study Benign Prostatic Hyperplasia (BPH) Sugiarti, Ida; Setiadi, Dedi; Junaedi, Fadil Ahmad; Wahyuni, Ida
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3436

Abstract

Background: Benign Prostatic Hyperplasia (BPH) is a common condition in adult men with a prevalence exceeding 50% by the age of ≥ 60 years. BPH causes symptoms of lower urinary tract infection, which reduces the quality of life and increases the burden of health services through visits, examinations, and medical interventions. BPH service practices still vary between health services, and medical records are still inconsistent and often deviate from clinical guidelines Objective: To examine the implementation of the BPH clinical pathway (CP) through clinical audit and explore its inhibiting factors. Methods: Qualitative research with a case study design in one regional referral service center. Data were collected through three triangulation sources: (1) observation of medical audits of 63 BPH patients' medical records, (2) in-depth interviews with 12 health workers (doctors and nurses), and (3) policy documents related to CP. Thematic analysis was carried out iteratively to identify patterns of CP non-conformity and implementation barriers. Results: Thirty-five percent of medical records did not meet CP criteria. Key obstacles included low awareness of the CP among healthcare workers, limited clinical time, and lack of integration of health information systems. Conclusion: The implementation of the BPH clinical pathway remains hindered by clinical and systemic factors. Evidence-based CP provides strategic solutions to improve service consistency and quality, but supporting policies, ongoing training, and integration of information systems are needed to optimize its application.
PROACTIVE COGNITIVE GAME METHOD FOR PERSONS WITH DISABILITIES TO PREVENT EARLY MARRIAGE IN BOGOR CITY Fitria, Dedes; Nurhayati, Titi; Juariah, Juariah; Djamilus, Fauzia; Mulyati, Sri; Rahayu, Eva Sri; Sasnitiari, Ni Nyoman
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3848

Abstract

Individu dengan disabilitas sering mengalami keterbatasan dalam memahami kesehatan reproduksi akibat rendahnya pendidikan reproduksi serta terbatasnya akses terhadap layanan dan informasi terkait seksualitas. Oleh karena itu, diperlukan metode edukasi yang sesuai dan mudah dipahami. Salah satu pendekatan yang efektif adalah pembelajaran yang bersifat interaktif dan partisipatif, seperti game kognitif proaktif. Penelitian ini bertujuan untuk menganalisis pengaruh edukasi kesehatan reproduksi menggunakan metode game kognitif proaktif terhadap peningkatan pengetahuan remaja penyandang disabilitas di Kota Bogor. Penelitian menggunakan desain kuasi-eksperimen dengan kelompok intervensi dan kelompok kontrol. Studi dilaksanakan pada tahun 2024 di Kota Bogor dengan populasi remaja penyandang disabilitas sebanyak 1.058 orang. Sampel dipilih secara purposive sampling, terdiri atas 60 responden, dengan 30 orang pada kelompok intervensi dan 30 orang pada kelompok kontrol. Kelompok intervensi diberikan edukasi kesehatan reproduksi melalui game kognitif proaktif, sedangkan kelompok kontrol memperoleh edukasi dengan metode konvensional. Pengumpulan data dilakukan melalui observasi dan kuesioner pre-test dan post-test. Analisis data menggunakan uji Mann–Whitney karena data tidak berdistribusi normal. Hasil penelitian menunjukkan adanya pengaruh signifikan edukasi kesehatan reproduksi melalui game kognitif proaktif terhadap peningkatan pengetahuan remaja putri mengenai dampak pernikahan dini. Karakteristik remaja penyandang disabilitas pada dasarnya serupa dengan remaja tanpa disabilitas, dengan tingkat kecerdasan yang setara, meskipun memiliki keterbatasan pada aspek kemampuan verbal. Oleh karena itu, disarankan penggunaan metode edukasi yang interaktif dan menarik untuk meningkatkan efektivitas pendidikan kesehatan pada remaja.
GENETIC STUDY OF HEPATOCYTE NUCLEAR FACTOR-1 ALPHA (HNF-1Α) MUTATIONS IN DIABETES MELLITUS PATIENTS Merdekawati, Fusvita; Rahayu, Ira Gustira; Juliastuti, Aditya; Anhar, Citra Amaniah; Hasan, Zulfikar Ali; Maynar, Larasati Putri
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.4242

Abstract

Maturity-Onset Diabetes of the Young (MODY) merupakan bentuk diabetes monogenik yang sering salah diklasifikasikan sebagai diabetes tipe 1 atau tipe 2, seringkali mengakibatkan penanganan klinis yang kurang optimal. Salah satu penyebab paling umum dari MODY adalah mutasi pada gen HNF1A, yang berperan penting dalam mengatur ekspresi gen di dalam sel beta pankreas. Penelitian ini bertujuan untuk mengidentifikasi mutasi potensial pada gen HNF1A pada pasien yang dicurigai menderita MODY secara klinis menggunakan Sanger sequencing. DNA diisolasi dari dua pasien yang dicurigai menderita MODY sebagai studi molekuler awal untuk mengeksplorasi mutasi potensial pada gen HNF1A, diikuti dengan amplifikasi sepuluh ekson HNF1A menggunakan PCR konvensional. Produk PCR dievaluasi dengan elektroforesis gel agarosa untuk memastikan amplifikasi yang berhasil sebelum dilakukan Sanger sequencing. Data urutan yang dihasilkan kemudian dianalisis menggunakan perangkat lunak BioEdit dan ClustalW untuk mendeteksi variasi nukleotida dengan membandingkannya dengan urutan referensi HNF1A (NM_001306179.2). Ditemukan enam mutasi titik pada gen HNF1A yang tersebar di ekson 7, 9, dan 10, terdiri atas satu mutasi silent (p.Leu459Leu), empat mutasi missense (p.Gln460His, p.Ser486Asn, p.Ser581Gly, dan p.Val705Leu), serta satu mutasi nonsense (p.Trp785*) yang menyebabkan terminasi translasi dini. Mutasi yang ditemukan berpotensi memengaruhi struktur dan fungsi protein HNF1A, termasuk domain transaktivasi yang penting dalam regulasi ekspresi gen target. Penelitian ini menunjukkan bahwa deteksi mutasi genetik, khususnya pada HNF1A, penting dalam mendiagnosis MODY secara akurat dan dapat menjadi dasar pemilihan terapi yang lebih tepat, seperti penggunaan sulfonilurea sebagai alternatif insulin.
SENSITIVITY AND SPECIFICITY OF BLOOD PRESSURE AND WEIGHT GAIN IN PREGNANT WOMEN TO THE INCIDENCE OF PREECLAMPSIA Darwanty, Jundra; Fariji, Ahmad; Mardianti, Ani; Sugiri, Herry; Murni, Hasrah
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.4268

Abstract

Preeklamsia masih menjadi penyebab utama komplikasi kehamilan di Indonesia. Penatalaksanaan kasus yang tepat selama kehamilan dapat mencegah preeklamsia.  Penelitian bertujuan untuk mengetahui sensitivitas dan spesifisitas tekanan darah, MAP, dan pertambahan berat badan kehamilan terhadap kejadian preeklamsia Desain penelitian eksploratif dengan pendekatan potong lintang. Penelitian dilakukan di Kabupaten Karawang pada Maret sampai Desember 2022.  Sampel 165 responden dari ibu yang mempunyai bayi, dipilih secara acak. Kriteria sampel responden  melakukan pemeriksaan antenatal minimal 6 kali selama kehamilan. Ibu memiliki buku KIA  yang mencatat tekanan darah, berat badan dan tinggi badan serta melahirkan pada cukup bulan. Pengolahan menggunakan SPSS versi 21 dengan uji sensitivitas dan spesifisitas. Hasil analisis sensitivitas sistole dan diastole serta MAP memiliki sensitivitas di atas 90%, kecuali sistole pada kehamilan kurang dari 24 minggu 83% (CI: 1,14-6,85). Spesifisitas tertinggi ditemukan pada diastole kehamilan di atas 24 minggu (0,96). Hasil terbaik  pada sistole kehamilan di atas 24 minggu dengan sensitivitas 92% (CI: 37,12-2427,28). dan spesifisitas 0,96. hasil ini membuktikan  tekanan darah sistole, diastole, dan MAP dapat digunakan sebagai deteksi yang kuat untuk preeklamsia. Disarankan adanya regulasi dan SOP dalam pelaksanaan layanan ini.
SMOKING BEHAVIOR CAN INCREASE CREATININE LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Tarjuman, Tarjuman; Nurfadilla, Selly Dwi Intani; Sasmita, Anah; Hamzah, Ali
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3805

Abstract

Penyakit ginjal kronik (PGK) merupakan penyakit tidak menular dengan angka morbiditas dan mortalitas yang tinggi, sering kali memerlukan terapi hemodialisis. Kadar kreatinin serum berfungsi sebagai indikator utama dalam menilai kerusakan fungsi ginjal. Merokok diketahui dapat mempercepat kerusakan ginjal melalui berbagai mekanisme. Penelitian ini bertujuan untuk mengetahui hubungan antara perilaku merokok dan kadar kreatinin pada pasien PGK yang menjalani hemodialisis. Metode penelitian menggunakan pendekatan kuantitatif dengan desain cross-sectional, melibatkan 57 responden yang dipilih melalui purposive sampling, data kadar kreatinin diambil dari rekam medis pada kondisi  predialisis. Instrumen yang digunakan mencakup kuesioner GN-SBQ dan data laboratorium kadar kreatinin. Hasil menunjukkan seluruh responden merupakan perokok aktif, dengan mayoritas (57,9%) tergolong perokok berat, serta rata-rata kadar kreatinin sebesar 10,90 mg/dL. Uji Spearman menunjukkan hubungan positif yang signifikan antara perilaku merokok dan kadar kreatinin (p = 0,034; r = 0,256). Disimpulkan bahwa terdapat hubungan signifikan dengan kekuatan sedang antara perilaku merokok dan kadar kreatinin. Edukasi berkelanjutan dan konseling berhenti merokok, termasuk pendekatan spiritual, direkomendasikan untuk mencegah kerusakan ginjal kedepannya.
Influence of family and child demographic characteristics on the incidence of stunting Balgis, Balgis; Putri, Anak Agung Alit Kirti Estuti Narendra; Primaningtyas, Widana; Paramesti, Khansa Firyallely
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3326

Abstract

Background: Stunting cases in Surakarta ranked fourth lowest in Central Java. However, the stunting target in Surakarta is zero. Objective: This study aimed to analyze the influence of maternal and child demographic factors on the incidence of stunting at the Gilingan Surakarta Community Health Center. Methods: This research method used analytical observations with a case-control research design. The research subjects were obtained using a simple random sampling method consisting of 38 stunted toddlers and 38 non-stunted toddlers aged 24-59 months at Gilingan Surakarta Community Health Center. Data collection was done by distributing questionnaires to respondents. The statistical test used for bivariate analysis is the chi-square, and multivariate analysis uses multiple logistic regression. Results: Bivariate analysis showed that maternal occupation (p=0.047) and family income (p=0.002) influenced the incidence of stunting. Multivariate analysis then found that maternal occupation and family income were associated with the incidence of stunting (p=0.005). Conclusion: The conclusion in this study was that mothers' occupation and family income significantly influence the incidence of stunting. Therefore, there is a need for assistance in the form of additional food for toddlers from underprivileged families to meet their nutritional needs so that stunting can be prevented.
The impact of postpartum depression symptom on breastfeeding outcomes: a literature review Shafi’ah, Shafi’ah; Indrani, Rahma Sasmita; Shabira, Aghniyya; Adnani, Qorinah Estiningtyas Sakilah; Susiarno, Hadi; Adepoju, Victor Abiola
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3587

Abstract

Background: Postpartum depression is among the most prevalent mental health conditions during the postpartum period. Postpartum depression is regarded as detrimental to breastfeeding. Depressed mothers may experience a diminished interest and attraction towards their infants. Ultimately, the mother is incapable of adequately caring for her infant, including the inability to breastfeed directly. Objective: Consequently, we performed a literature analysis to rigorously assess the evidence regarding the correlation between postpartum depressive symptoms and breastfeeding habits. Methods: A literature review utilized the PubMed, Scopus, and Science Direct databases, referencing selected publications published between 2019 and 2024. A total of 9,146 articles were obtained from the specified databases and subsequently analyzed using the PRISMA. Results: The review of 22 selected articles revealed a strong correlation between postpartum depression symptoms and decreased breastfeeding success. Depressed mothers tend to have lower breastfeeding initiation rates. In addition, other factors influence breastfeeding success, such as the benefits of breastfeeding, societal and ecological assistance, malnutrition, insomnia, social and demographic characteristics, psychological factors, and patterns of breastfeeding. Conclusion: Postpartum depression symptoms correlate with breastfeeding success. Health practitioners should implement mental health evaluation in breastfeeding programs to identify maternal risk, which can be treated early. This enhances the rates of successful breastfeeding practices and supports the mother's and child's health.
Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Detection of the Murine Double Minute2 (MDM2) gen in formalin-fixed tissue samples using PCR Sanita, Hanifah Velda; Sayekti, Fitria Diniah Janah
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3605

Abstract

Background: Tissue preservation is a crucial procedure in pathological studies to maintain cellular and structural integrity, commonly performed through formalin fixation. However, formalin fixation may cause DNA degradation, posing challenges for molecular analysis. Detection of cancer biomarker genes, such as Murine Double Minute 2 (MDM2), can be performed using Polymerase Chain Reaction (PCR), a technique for amplifying specific DNA fragments. Objective: This study aimed to determine the presence of the MDM2 gene in formalin-preserved tissues stored for different periods using PCR. Methods: A descriptive qualitative design with random sampling was employed. The study was conducted at the Anatomical Pathology and Molecular Biology Laboratories of Sekolah Tinggi Ilmu Kesehatan Nasional. Samples included 10 hair and nail tissues as controls, and formalin-fixed tissues stored for 2 days, 1 month, 2 months, and 8 years. DNA isolation was performed using the Geneaid gSYNC™ DNA Extraction Kit. DNA quality was assessed by 1.5% agarose gel electrophoresis, while concentration and purity were measured using a UV-Vis spectrophotometer. DNA concentrations ranged from 320–420 ng/µL, with purity ratios between 0.8 and 1.125. Results: The results showed that the MDM2 gene (178 bp amplicon) was detectable in tissues stored for up to 2 months but was not detected in tissues stored for 8 years. Conclusion: These findings indicate that storage duration affects the success of gene detection in formalin-fixed tissues.
Effectiveness of the Edinburgh Postnatal Depression Scale (EPDS) as an early screening tool for detecting depression and anxiety in postpartum women Khairiah, Rahayu; Yanti, Rizky; Hikmah, Nurul; Surahman, Heny
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3932

Abstract

Background: Depression and anxiety in postpartum women have a significant impact on the health of the mother, infant, and family. Early detection is essential to prevent long-term psychological complications. Objective: This study aimed to evaluate whether completing the Edinburgh Postnatal Depression Scale (EPDS), followed by a 20-minute brief education session delivered by midwives, could reduce EPDS scores among postpartum women within two weeks after the intervention. Methods: A quasi-experimental non-randomized controlled pre–post design was conducted at Pondok Bambu 1 Primary Health Center (intervention) and Pondok Gede District Hospital (control) using purposive sampling. A total of 52 postpartum women participated, with 26 assigned to the intervention group and 26 to the control group. The intervention consisted of EPDS screening followed by a brief education session on perinatal mental health, while the control group received routine care only. Results: Results showed that the mean EPDS score in the intervention group decreased from 13.23 ± 2.50 to 6.96 ± 2.18 (Δ = 6.27; 95% CI [−6.89; −5.65]; p < 0.001; d = 2.07), whereas the control group showed no significant change. The post-intervention Mann–Whitney test indicated a significant difference between groups (p = 0.021). Conclusion: These findings highlight that EPDS screening followed by brief education by healthcare providers is effective in reducing psychological distress in postpartum women. Integration of this program into postnatal care services is highly recommended to improve maternal and infant mental health outcomes.

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