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All Journal Pharmaciana: Jurnal Kefarmasian Window of Health : Jurnal Kesehatan JURNAL PENDIDIKAN TAMBUSAI Jurnal Ilmu Kefarmasian Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Indah Sains dan Klinis Mejuajua Jurnal Pengmas Kestra (JPK) Jurnal Penelitian Pendidikan MIPA Jurnal Indah Sains dan Klinis
Samran, Samran
Institut Kesehatan Medistra Lubuk Pakam
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Utilization Of Corn Starch Amylopectin (Zea mays L.) For Coating Acetylsalicylic Acid Tablets Dalimunthe, Gabena Indrayani; Rani, Zulmai; Fauzi, Ziza Aisyia Putri; Samran, Samran; Nindya Indah Damayanti; Siti Anisa
Window of Health : Jurnal Kesehatan Vol 8 No 2 (April 2025)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v8i2.1380

Abstract

Aspirin or acetylsalicylic acid is a class of NSAIDs stable in dry air, in humid air aspirin will over time hydrolyze or decompose into salicylic acid and acetic acid, with the decomposition of aspirin levels that contained in the preparation will experience degradation. Acetylsalicylic acid needs to be made in the form of thin-coated or film-coated tablets. In this research, the method used was tablet coating, followed by evaluation tests of core tablets and coated tablets. The results of this study indicate that amiloCorn starch pectin can be used as a thin layer and enteric coating. The coated tablet formulation from corn starch amylopectin has evaluation test results, namely the formula 1 tablet hardness test is 4.28 kg, formula 2 is 4.94 kg, formula 3 is 4.63 kg, size uniformity test is the diameter and thickness of formula 1 is 10.93 and 3.67 mm, formula 2 is 11.33 and 3.98 mm, formula 3 was 10.95 and 3.70 mm, average weight uniformity test for formula 1 was 389.5 mg, formula 2 was 399.5 mg, formula 3 was 393 mg, disintegration time test for formula 1 in stomach medium was 13, 31 minutes, formula 2 in the stomach medium 20.25 minutes, formula 3 in the intestinal medium 2.44 minutes, dissolution test for formula 1 in 120 minutes the solubility of the active substance reached 84%, formula 2 was 82%, formula 3 was 3% and intestinal dimedium within 210 minutes. The best formula, namely formula 3, meets the requirements for coated film.
Analisis Sistem Administrasi Klinik Fisioterapi Sultan dalam Meningkatkan Pelayanan dan Kepuasan Pelanggan di Kota Sungai Penuh Provinsi Jambi Melani, Hafzah; Samran, Samran; Gurusinga, Rahmad
Jurnal Pendidikan Tambusai Vol. 9 No. 2 (2025): Agustus
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i2.30443

Abstract

Sistem administrasi yang efektif merupakan elemen penting dalam mendukung pelayanan kesehatan yang berkualitas. Penelitian ini bertujuan untuk menganalisis pengaruh sistem administrasi terhadap tingkat kepuasan pasien di Klinik Fisioterapi Sultan Kota Sungai Penuh, Provinsi Jambi. Penelitian menggunakan pendekatan kuantitatif dengan desain cross-sectional. Data dikumpulkan melalui kuesioner menggunakan model SERVQUAL dan melibatkan 35 responden yang dipilih dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa sebagian besar responden menilai sistem administrasi sudah cukup baik, terutama pada indikator keramahan petugas, kerapihan rekam medis, dan kemudahan pendaftaran. Namun, beberapa aspek seperti kecepatan pelayanan administrasi dan kejelasan informasi masih memerlukan perbaikan. Uji chi-square menunjukkan terdapat hubungan yang signifikan antara efektivitas sistem administrasi dan kepuasan pasien dengan nilai χ² = 11,707 dan p = 0,0035 (p < 0,05). Kesimpulan dari penelitian ini adalah sistem administrasi yang efektif berkorelasi dengan meningkatnya kepuasan pasien. Oleh karena itu, penguatan sistem administrasi melalui digitalisasi proses pendaftaran, pelatihan petugas, serta penyusunan standar operasional prosedur (SOP) yang konsisten perlu dilakukan untuk meningkatkan mutu pelayanan. Penelitian ini diharapkan menjadi referensi dalam pengembangan layanan fisioterapi yang berorientasi pada kenyamanan dan kepuasan pasien.
Association of Pharmacist-Provided Medication Counselingwith Adherence in Outpatients Samran
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/p6jqac58

Abstract

Background: patient medication adherence is critical for therapeutic success. Pharmacist-provided medication counseling can enhance patients' understanding and adherence to treatment regimens. Objective: this study aimed to assess the relationship between pharmacist-provided counseling and medication adherence among outpatients at RSU. Sembiring Delitua. Research Methods: a quantitative study with a cross-sectional design was conducted. A total of 100 outpatients were selected using purposive sampling. Data were collected using a structured questionnaire evaluating counseling quality and adherence through the MMAS-8 scale. The Chi-square test was used for statistical analysis at a significance level of p<0.05. Results: Sixty percent of patients reported receiving counseling, but only 21% received complete counseling. Medication adherence levels showed that 42% had high adherence. Statistical analysis revealed a significant association between medication counseling and adherence (p=0.002), where patients receiving counseling had higher adherence rates. Conclusion: pharmacist-led medication counseling is significantly associated with higher medication adherence among patients. Hospitals are advised to improve the quality and coverage of medication counseling through continuous pharmacist training and the use of supplementary educational media.
The Impact of Adverse Drug Reaction (ADR) Monitoring Systems on Enhancing Drug Safety Samran
JURNAL KESMAS DAN GIZI (JKG) Vol. 7 No. 2 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/q8zbdw10

Abstract

Background: Adverse drug reactions (ADRs) are a serious concern in drug use, potentially endangering patient safety if not properly monitored. Objective: This study aimed to determine the incidence of ADRs and identify the drugs causing ADRs among hospitalized patients at RSUD Drs. H. Amri Tambunan, Deli Serdang Regency. Research Methods: a descriptive non-experimental study with a retrospective approach was conducted. Data were collected from medical records between September 2022 and February 2023. Analysis was performed descriptively using the Naranjo scale. Results: a total of 139 suspected ADR cases were identified. Based on the Naranjo scale, 1 case (0.72%) was definite, 86 cases (61.87%) were probable, and 52 cases (37.41%) were possible ADRs. Antibiotics (61.87%) were the most common drug class causing ADRs, with ciprofloxacin and levofloxacin being the main drugs. The most common ADR manifestation was redness (23.74%). Dexamethasone (41.73%) was the most frequently administered medication to treat ADRs. Conclusion: The incidence of ADRs at RSUD Drs. H. Amri Tambunan remains relatively high, predominantly linked to antibiotic use. Strengthening the adverse drug reaction monitoring system through enhanced reporting, healthcare worker training, and regular antibiotic use evaluations is crucial to improving patient safety.
FILM COATING FORMULATION FROM AMYLOPECTIN PARK PLAIN SKIN (Musa paradisiacaL.) AS A COATING FOR MEFENAMIC ACID DRUG Rani, Zulmai; Samran, Samran
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2570

Abstract

Asam mefenamat adalah obat turunan asam antranilat yang banyak digunakan oleh masyarakat sebagai salah satu obat pilihan untuk pengobatan analgesik, antiinflamasi dan antipiretik. Asam mefenamat mempunyai efek samping terhadap saluran cerna antara lain: dispepsia, iritasi mukosa lambung dan diare. Pada penelitian ini metode yang digunakan adalah penyalutan kaplet lalu dilanjutkan dengan uji evaluasi kaplet inti dan kaplet salut yang meliputi uji organoleptis, ujikekerasan, uji keregasan, uji keseragaman ukuran, uji keseragaman bobot, uji waktu hancur, uji kenaikan bobot kaplet salut, uji disolusi, uji kadar air kaplet salut. Hasil penelitian ini menunjukkan bahwa amilopektin pati kulit pisang raja dapat dijadikan sebagai salut lapis tipis serta enterik atau film coating yaitu dengan hasil karakteristik uji organoleptik yaitu bentuk serbuk halus seperti tepung, tidak berbau, berwarna putih dan tidak ada benda asing, kadar abu sebesar 1.3%, kadar air sebesar 4,6%. Amilopektin pati kulit pisang raja kekerasan kaplet yang diperoleh pada formula 1 sebesar 7.927 kg, formula 2 sebesar 8.705 kg, formula 3 sebesar 8.1668 kg, uji keregasan kaplet formula 1 sebesar 0,47%, formula 2 sebesar 0,1%, formula 3 sebesar 0,6%, uji keseragaman ukuran yaitu memnuhi syarat, uji keseragaman bobot rata-rata juga memenuhi syarat, uji waktu hancur formula 1 dimedium lambung 3 menit, formula 2 dimedium lambung 5 menit, formula 3 dimedium usus 1.20 menit, uji disolusi untuk F1 dalam waktu 120 menit mencapai 60.75%, F2 yaitu 52.35%, F3 yaitu 7.9% dan dimedium usus dalam waktu 210 menit F1 yaitu 57.95%, F2 yaitu 101.63% dan F3 yaitu 76.62%.
Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Abstract

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.
Analysis of Factors Affecting the Availability of Medication at UPT Puskesmas for BPJS Patients Andriana Saragih, Mona; Samran; Rahmad Gurusinga
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 1 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mm8cg981

Abstract

Background: The availability of medicines at UPT Puskesmas Silalahi for BPJS patients is influenced by drug procurement, pharmacy management, and BPJS policies. Although the BPJS e-catalogue system aims to improve efficiency, the mismatch between supply and patient needs remains a major issue, affecting the quality of healthcare services at the Puskesmas. Research Objective: This study aims to analyze the factors affecting the availability of medicines at Puskesmas Silalahi and to find solutions to improve the existing drug procurement system. Research Method: This research uses a descriptive qualitative approach with interviews, observations, and documentation. The research informants consist of Puskesmas management, BPJS officers, and the head of pharmacy. Research Results: The results indicate that drug procurement at Puskesmas Silalahi is hindered by delayed BPJS payments, discrepancies between the e-catalogue medicines and actual needs, and limited budgets. These factors affect the smooth delivery of healthcare services and the availability of medicines. Conclusion: More efficient drug procurement management, increased budgets, and better coordination between BPJS and drug suppliers are necessary to ensure timely availability of medicines for BPJS patients at Puskesmas Silalahi.
Evaluation of the Implementation of Regional Regulation Number 1 of 2019 on the Rehabilitation of Victims of Narcotics, Psychotropic Substances, and Other Addictive Substances Abuse Taufik Ismail, Muhammad; Samran; Sri Melda Br Bangun
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 1 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmavwf81

Abstract

Background: The abuse of Narcotics, Psychotropic Substances, and Other Addictive Substances (NAPZA) in North Sumatra Province has become a serious issue. To address this, Regional Regulation Number 1 of 2019 was enacted, aiming to improve the rehabilitation of NAPZA victims. However, the implementation of this policy still faces challenges, such as ineffective intersectoral coordination, limited funding, and insufficient training for rehabilitation staff. These issues hinder the effectiveness of rehabilitation programs and the social reintegration of former NAPZA users. Research Objectives: This study aims to analyze the implementation of Regional Regulation Number 1 of 2019, identify the barriers in rehabilitating NAPZA victims in North Sumatra, and provide policy alternatives to address these barriers and improve the effectiveness of rehabilitation programs. Research Methodology: This research uses Grounded Theory with a qualitative approach. Data were collected through interviews with government officials, rehabilitation staff, and relevant committees. To determine priority policies, the researcher also employed the Analytical Hierarchy Process (AHP). Research Findings: The findings show that weak intersectoral coordination, limited funding, and insufficient training for rehabilitation staff are the main barriers. Additionally, social stigma towards former NAPZA users exacerbates their social reintegration. Conclusion: Enhancing intersectoral coordination, increasing funding, and providing continuous training for rehabilitation staff are necessary to improve the implementation of the regulation. The post-rehabilitation program, based on economic empowerment, must be strengthened to support better social reintegration.
Tablet Kompresi Langsung Ekstrak Etanol Daun Salam (Syzygium polyanthum) Muhammad Gunawan; Suprianto; Samran; Cut Fatimah; Debi Melani; Sumardi
Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i3.31

Abstract

Indonesia's natural wealth that is efficacious in suppressing cholesterol, hypertension, diarrhea, gastritis and blood sugar is one of the bay leaves (Syzygium polyanthum Wight.). Tablets are preparations that are practical to use, easy to produce, pack, and distribute. The research was directed to make tablets of bay leaf ethanol extract (EEDS) by direct compression. EEDS tablets were made into four formulas with various fillers of lactose and Avicel PH 102, each 200 mg : 135 mg A); 250 mg : 105 mg (B); 300 mg : 55 mg (C); and 350 mg : 5 mg (D). The study showed that all formulas met the preformulation test requirements and tablet evaluation, D as the best formula. EEDS is made into tablets by direct compression.
Evaluasi Konsentrasi Karboksimetilselulosa Alginat Formula Pasta Gigi Antiseptik Ekstrak Etanol Daun Seledri (Apium graveolens L.) Samran; Suprianto; Muhammad Gunawan; Melati Yulia Kusumastuti
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.45

Abstract

Maceration of Celery leaves using 96% ethanol solvent was used to make the extract. Toothpaste is formulated with carboxymethylcellulose and alginate binders. The active ingredient in the form of ethanol extract from Celery leaves has the potential for antibacterial. This study was to evaluate the concentration of carboxymethylcellulose alginate in the preparation of antiseptic toothpaste of ethanol extract from Celery leaves. Evaluation of production results consisted of organoleptic, homogeneity, spreadability, foam formation, acidity and viscosity. The higher the concentration of carboxymethylcellulose, the lower the foam and spreadability and the higher the viscosity, while the alginate concentration is the opposite. Carboxymethylcellulose alginate affects the evaluation parameters of antiseptic toothpaste preparations ethanol extract of Celery leaves
Co-Authors Adek Chan Adinda Seftia Ahmad Hafizullah Ritonga Alam Suhada Alam Suhada Andilala Andraini, Galuh Andriana Saragih, Mona Arifin Putra Zai Ayuning Putri Julian Bambang Sumantri Cahya, Cucu Arum Dwi Chan, Adek Cut Fatimah Cut Fatimah Cut Fatimah De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dian Zulkarnain Lubis Effendy De Lux Putra, Effendy De Lux Elvy Oktima Elvy Oktima Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitriani Nasution Fitriani, Enny Gabena Indrayani Dalimunthe Herliana Ika Julianti Tambunan Jansen Silalahi Joko Wibowo Kanne Dachi Karsono Karsono* Kusumastuti, Melati Yulia Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lisa Angrayani Lumbangaol, Sik Fikal M.T SIMANJUNTAK Melani, Hafzah Melati Yulia Kusumastuti Melati Yulia Kusumastuti Muhammad Gunawan Muhammad Gunawan Nasution, Lely Fitri Handayani Nindya Indah Damayanti Pranata, Chandra Purba, Rini Armaida Rahmad Gurusinga Rahmad Gurusinga Ruseni Safitri Saragih Safriana Safriana Sembiring, Hedni Febrianty Shita Tiara Sindy Andriani Siregar, Riwandi Siti Anisa Siti Fatima Hanum Siti Muliani Julianty siti muliani julianty Siti Nurbaya Siti Nurbaya Sofia Rahmi Sri Melda Br Bangun Sumardi Sumardi Sumardi . Suprianto Suprianto Suprianto Syarifuddin, Aminah Nur Taufik Ismail, Muhammad Ziza Putri Aisyia Fauzi Zulmai Rani