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All Journal International Journal of Public Health Science (IJPHS) JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Althea Medical Journal Jurnal Keolahragaan Journal of Biomedicine and Translational Research Jurnal Penelitian Pendidikan IPA (JPPIPA) IJEMS (Indonesian Journal of Environmental Management and Sustainability) JOURNAL SPORT AREA Journal of Dedicators Community PREPOTIF : Jurnal Kesehatan Masyarakat Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Eduvest - Journal of Universal Studies Jurnal Keperawatan Indonesian Journal of Biomedicine and Clinical Sciences
Muniroh, Muflihatul
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Development of the Indonesian sexual quality of life scale for women (ISQOL-W) Hadiprajitno, Peter I.; Ediati, Annastasia; Ariani, Mahayu D.; Muniroh, Muflihatul; Juniarto, Achmad Z.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1073

Abstract

Sexual quality of life is greatly influenced by sexual function, yet thorough measures remain limited and vary across regions.  In Indonesia, diverse cultural and religious contexts notably shape sexual quality of life. Thus, it is important to have a tool that considers both internal and external aspects. The aim of this study was to develop a valid and reliable scale that specifically measures Indonesian sexual quality of life for women (ISQOL-W), considering cultural and social factors. A total of 228 participants were recruited from April 30, 2023, to September 30, 2023. The ISQOL-W was developed through two phases: item generation and psychometric evaluation. In the first phase, 68 items were drafted based on definitions and dimensions of sexual quality of life. In the second phase, exploratory factor analysis resulted in 34 items with a loading factor greater than 0.4 (ranging from 0.41 to 0.84) which were categorized into four domains/factors: sexual-related emotion, sexual fantasy, sexual arousal, and sexual relationship. The Cronbach’s α coefficient for the overall questionnaire was 0.915, with subscale reliability ranging from 0.826 to 0.903. Further analysis revealed significant differences in ISQOL-W scores across relationship status, educational level, history of last sexual activity, and type of sexual activity. In conclusion, the ISQOL-W demonstrated robust psychometric properties, supporting its use in future studies. This study represents the first effort to develop and validate a sexual quality of life scale specifically for Indonesian women.
Striped catfish oil and turmeric extract reduces inflammation in metabolic syndrome rats Mambaya, Helvi Desi; Muniroh, Muflihatul; Afifah, Diana Nur; Anjani, Gemala; Pramono, Adriyan; Sulchan, Mohammad
International Journal of Public Health Science (IJPHS) Vol 14, No 2: June 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i2.24984

Abstract

Metabolic syndrome is a growing global health problem. Long-term treatment for metabolic syndrome causes side effects. Therefore, the use of nutraceuticals could also be considered. This study analyzed the effect of the administration of striped catfish oil and turmeric extract on tumor necrosis factor-α (TNF-α) levels and homeostasis model assessment of insulin resistance (HOMA-IR) in metabolic syndrome rats. Metabolic syndrome was induced in rats by administration of high fat fructose diet (HFFD) containing 3 g pork fat (15%), 2 g duck egg yolk (10%), 15 g standard diet (75%), and 2 ml fructose (1%). Thirty rats were randomized into five groups: C1 (normal control group), C2 (metabolic syndrome control group without treatment), P1 (striped catfish oil at 0.08 ml/200 g BW/day), P2 (turmeric extract at 5.04 mg/kg BW/day), P3 (combination of striped catfish oil at 0.08 ml/200 gBW/day and turmeric extract at 5.04 mg/kg BW/day). There was a significant decrease (p<0.05) in TNF-α levels and HOMA-IR in treatment groups (P1, P2, P3) compared to C2. The P3 group had the lowest TNF-α levels. Treatment groups had the same potential effect in reducing HOMA-IR. Striped catfish oil, turmeric extract, and their combination reduce inflammation and insulin resistance in metabolic syndrome rats.
COMPARISON OF THE EFFECTS OF CORE EXERCISE AND BALANCE STRATEGY EXERCISE ON WALKING SPEED AND FRAILTY LEVEL IN THE ELDERLY Utami, Arini; Muniroh, Muflihatul; yuniati, Renni
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.38507

Abstract

Penuaan menyebabkan perubahan fisiologis dan biomekanik, termasuk penurunan otot, berkurangnya panjang langkah, kecepatan berjalan lebih lambat, dan peningkatan risiko jatuh. Studi ini membandingkan efek latihan inti dan keseimbangan pada kecepatan berjalan dan tingkat kelemahan pada orang tua. Ini menggunakan Desain Kelompok Kontrol Pra dan Pasca Tes dengan 40 responden yang dibagi secara acak menjadi dua kelompok. Satu kelompok melakukan latihan inti, sementara yang lain berlatih latihan strategi keseimbangan, keduanya dilakukan tiga kali seminggu selama empat minggu. Kecepatan berjalan diukur menggunakan tes kecepatan berjalan 4 meter, dan kelemahan dinilai dengan Indeks Kelemahan. Hasil penelitian menunjukkan bahwa pada kelompok inti, kecepatan berjalan pasca-tes rata-rata 1,27 m/s, meningkat dari 0,98 m/s (p=0,00), sedangkan pada kelompok keseimbangan, meningkat dari 1,03 m/s menjadi 1,14 m/s (p=0,004). Skor Indeks Kelemahan kelompok inti menurun dari 1,55 menjadi 0,6 (p=0,00), sedangkan skor kelompok keseimbangan menurun dari 1,6 menjadi 1,4 (p=0,046). Tidak ditemukan perbedaan signifikan antara kelompok dalam peningkatan kecepatan berjalan (p=0,051), tetapi latihan inti secara signifikan mengurangi kelemahan lebih banyak daripada latihan keseimbangan (p=0,00). Sebagai kesimpulan, kedua jenis latihan tersebut meningkatkan kecepatan berjalan dan mengurangi kelemahan pada lansia. Namun, meskipun latihan inti dan latihan keseimbangan memiliki efek yang sama pada kecepatan berjalan, latihan inti secara signifikan lebih efektif dalam menurunkan tingkat kelemahan.
Penyuluhan Osteoporosis dalam Upaya Pencegahan Komplikasi Tulang pada Pasien Talasemia Mayor di Kabupaten Rembang dan Grobogan Widyastiti, Nyoman Suci; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta; Ngestiningsih, Dwi; Partiwi, Rina; Muniroh, Muflihatul; Naviati, Elsa; Afriana, Rizky Dyas
Journal of Dedicators Community Vol 7, No 3 (2023)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v7i3.3577

Abstract

Background Osteoporosis is a complication that often occurs in thalassemia major patients. This complication is still not widely known. This community service program aims to increase the knowledge of families of major thalassemia patients in Rembang Regency and Grobogan Regency regarding the complications of osteoporosis in thalassemia patients. Methods Education about osteoporosis, risk of osteoporosis in thalassemia patients, and prevention of osteoporosis. Extension method with presentation and discussion. The activity was attended by 20 thalassemia families in the Rembang Regency and 21 families of thalassemia patients in the Grobogan Regency. Before and after counseling, pretest and posttest questionnaires were completed to measure the knowledge of families of thalassemia major patients regarding bone complications in thalassemia patients. Results and Discussion Nearly half (46.34%) of respondents did not know the risk of osteoporosis in thalassemia. After counseling, 82.93% of respondents knew the risk of osteoporosis in thalassemia, but there were still 17.07% of respondents who still did not know this risk. Conclusion There is a significant increase in family knowledge of thalassemia major patients about the risk of osteoporosis in thalassemia. Further efforts to increase knowledge are needed with written information media (leaflets) given to families of thalassemia major patients
The Relationship Between Hair Zinc Levels, Feeding Patterns, and Infectious Diseases on The Incidence of Stunting in Children Aged 24-59 Months in The City of North Jakarta, Province of DKI Jakarta Fitry, Febriana Ramadhani; Margawati, Ani; Syauqy, Ahmad; Muniroh, Muflihatul; Kartini, Apoina
Eduvest - Journal of Universal Studies Vol. 4 No. 10 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i10.1749

Abstract

Globally, stunting is a severe public health concern, especially in low- and middle-income nations like Indonesia. It is typified by stunted growth and development due to recurrent infections and chronic malnutrition. North Jakarta has a 19.8% stunting incidence, according to the 2023 Indonesian Health Survey. This indicates the critical need for additional research into the factors contributing to stunting, such as hair zinc levels, dietary habits, and infectious infections. This study employs an observational case-control design conducted in North Jakarta in March 2024. Stunting incidence and hair zinc levels are significantly correlated (p=0.000), affecting 87.5% of children with low hair zinc levels. Stunting is also correlated considerably (p=0.000) with incorrect feeding patterns; 75.7% of children who exhibit these patterns are stunted. On the other hand, there was no statistically significant correlation (p=0.806) between the incidence of stunting and a history of infectious illnesses. The mother's level of education, the child's age, gender, and family income did not significantly correlate with stunting.
Striped Catfish Oil and Turmeric Extract-Reduce Inflammation and Insulin Resistance on Metabolic Syndrom: A Review Mambaya, Helvi Desi; Muniroh, Muflihatul; Sulchan, Muhammad; Afifah, Diana Nur
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.7440

Abstract

Metabolic Syndrome is continuing to grow worldwide. Indonesia is no exception. High-calorie diets and physical inactivity trigger several pathways involved in metabolic syndrome. These include inflammation and insulin resistance. Associated with type 2 diabetes mellitus, cardiovascular disease, and death, metabolic syndrome is important. There is therefore a need for early intervention to reduce the complications of this disease. Striped catfish (Pangasius hypophthalmus) is one of the freshwater fish farmed in Indonesia. Turmeric (Curcuma longa Linn.) is also widely used in Indonesian food preparations. This review aims to focus on striped catfish oil and turmeric extract that positively affect inflammation and insulin resistance in the intervention of metabolic syndrome. This review shows that striped catfish oil contains omega-3 fatty acids (EPA and DHA), while turmeric extract contains flavonoids, tannins, and saponins. Based on the results of the review, it is known that bioactive compounds found in catfish oil and turmeric extract can be used as nutraceutical ingredients to intervene in metabolic syndrome.
Exploring the effects of ursodeoxycholic acid-probiotic combination on Lactobacillus and liver enzyme levels for cholestasis management: An experimental study Nur, Muhammad Hasbi; Lestari, Endang Sri; Budiono, Bernadus Parish; Prasetyo, Sigit Adi; Muniroh, Muflihatul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art10

Abstract

Background: Cholestasis arises from compromised bile secretion due to hepatocyte dysfunction, leading to liver impairment. Available treatments show limited efficacy, with ursodeoxycholic acid (UDCA) being a primary option. Cholestatic conditions influence gut microbiota; therefore, probiotic therapy emerges as a potential approach. Objective: This investigation aimed to evaluate the impact of combined administration of probiotics and UDCA on Lactobacillus levels, as well as the levels of the enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in rats with restricted common bile ducts .Methods: A total of 35 male Sprague Dawley rats were randomly assigned to 7 groups, each comprising 5 members: K1 (healthy control), K2 (negative control with cholestasis), K3 (positive control with cholestasis given UDCA), K4 (cholestasis given 36 mg probiotics), K5 (cholestasis given 18 mg probiotics and UDCA), K6 (cholestasis given 36 mg probiotics and UDCA), and K7 (cholestasis given 54 mg probiotics and UDCA). The treatment duration was 21 days, during which blood samples were collected for AST and ALT analysis. Lactobacillus count was determined by quantitative polymerase chain reaction (PCR) analysis of fecal samples.Results: When UDCA and probiotics were given together in three different dosages, the Lactobacillus count significantly increased (p<0.05) compared to the other groups. Furthermore, compared to the other treatment groups, the UDCA-probiotic combination group exhibited noticeably lower AST and ALT values.Conclusion: Combining UDCA and probiotics elevated Lactobacillus count and decreased AST and ALT levels in cases of cholestasis more effectively than single therapy.
Exploring the remarkable effect of ursodeoxycholic acid and Allium sativum combination on MMP-9 and TIMP-1 levels in cholestatic rat’s model Sekartaji, Anindhita Dyah; Prasetyo, Sigit Adi; Muniroh, Muflihatul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art5

Abstract

Background: Cholestasis is a disturbance in the production or flow of bile that causes excessive accumulation of bile fluid and damage in the liver. Chronic liver damage will lead to liver fibrosis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloprotease-1 (TIMP-1) play a critical role in liver fibrosis formation. Although ursodeoxycholic acid (UDCA) and Allium sativum extracts have long been renowned for improving liver function, their combination in alleviating liver fibrosis through the MMP-9 and TIMP-1 inhibitory pathways has yet to be studied.Objective: This study was conducted to assess the efficacy of UDCA and Allium sativum extract combination in altering MMP-9 and TIMP-1 levels, which are the main factors in the progression of liver fibrosis.Methods: We performed an experimental study with a post-test-only control group on 36 Sprague-Dawley rats, which were randomly grouped into healthy, negative, positive, and three treatment groups with UDCA (13.5 mg) and graded doses of Allium sativum extract (3.6 mg; 7.2 mg; and 14.4 mg). Cholestasis induction was done by a choledochal duct ligation, and treatment was given for 14 days. Levels of MMP-9 and TIMP-1 were analyzed after treatment.Results: Combining UDCA and Allium sativum improved the MMP-9 levels significantly in cholestatic rats, compared to administrating UDCA only (p <0.05). Combining UDCA and Allium sativum increased the TIMP-1 level (p < 0.05). Although the MMP-9 level results were under our existing hypothesis, TIMP-1 results showed surprising results. Matrix metalloproteinase-9 levels were strongly negatively correlated with TIMP-1 levels, with a r-value= 0.981.Conclusion: Combining Allium sativum and UDCA alleviates liver fibrosis progression through lowering levels of MMP-9 and increasing levels of TIMP-1.
In vivo assay of Gigantochloa apus shoot extract as biolarvicide for myiasis-causing fly larvae Sadana, Aqsa Aufa Syauqi; Istiadi, Hermawan; Halleyantoro, Ryan; Muniroh, Muflihatul
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.16307

Abstract

The use of synthetic insecticides in treating myiasis is associated with adverse side effects and potential disruption of metabolic systems, prompting interest in natural alternatives. This study investigated the in vivo larvicidal efficacy of Gigantochloa apus bamboo shoot extract, formulated as a spray gel. Twenty-five Wistar rats were randomly divided into 5 groups: a negative control group, a positive control (ivermectin), and 3 treatment groups receiving of 1%, 3%, and 5% G. apus bamboo shoot extract. Myiasis was induced by introducing fly larvae into standardized wounds. Treatments were applied topically twice daily for 32 hr, and larval mortality was assessed every 8 hr. Phytochemical screening and GC-MS analysis revealed the presence of bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and hydrogen cyanide, all of which are known for their larvicidal, neurotoxic, and antiproliferative properties. The 5% extract group showed the highest mortality rate (100%) at 32 hr. The LC50 and LC95 values were determined at 1.43% and 6.01%, respectively. Compared to the standard ivermectin treatment, the 5% extract demonstrated a shorter lethal time and more rapid larval death. Morphological examination revealed darker abdominal segments in the dead larvae, indicating a potential interaction with the digestive tract. These findings indicate that G. apus bamboo shoot extract has potential larvicidal activity and can be an effective natural alternative for treating myiasis.
Co-Authors - Anggorowati Adriyan Pramono Afriana, Rizky Dyas Ahmad Syauqy Ani Margawati Anjani, Gemala Annastasia Ediati Annisa Pratiwi, Annisa Apoina Kartini Ardyarini, Hikmatunnisa Tri Ariani, Mahayu D. Ariosta Ariosta Awal Prasetyo Besari Adi Pramono Bintang, Francisca Natalia Budiono, Bernadus Parish Diana Nur Afifah, Diana Nur Djuara P Lubis Elsa Naviati Endang Sri Lestari Etika Ratna Noer Fitry, Febriana Ramadhani Hadiprajitno, Peter I. Halleyantoro, Ryan Hardhono Susanto Hermawan Istiadi Julian Dewantiningrum Juniarto, Achmad Z. Karlowee, Vega Kesuma, Erlangga Hadi Kesumayadi, Irfan Kis Djamiatun Mambaya, Helvi Desi Mohammad Sulchan Muhammad Nur Muhammad Sulchan Nani Maharani Natalia Dewi Wardani Nugraha, Eka Djatnika Nur, Muhammad Hasbi Nyoman Suci Widyastiti Partiwi, Rina Perdanawati, Mia Qolby, Qonita Nur Renni Yuniati Retnoningrum, Dwi Sadana, Aqsa Aufa Syauqi Sekartaji, Anindhita Dyah Septiani, Bernadeta Novita Sigit Adi Prasetyo, Sigit Adi Sri Achadi Nugraheni Untung Sujianto Utami, Arini Veni, Rizka Widyastuti, Trioni Yetty Movieta Nency, Yetty Movieta Yora Nindita Yosef Purwoko Zetta, Adelia Paradya