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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner VALENSI Jurnal Veteriner Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Proceeding International Conference on Global Resource Conservation Indonesian Journal of Pharmaceutical Science and Technology BERITA BIOLOGI Jurnal Ilmiah Kedokteran Wijaya Kusuma Omni-Akuatika FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Journal of Aquaculture and Fish Health Majalah Farmasetika Journal of Parasite Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine al Kimiya : Jurnal Ilmu Kimia dan Terapan Indonesian Journal of Pharmacology and Therapy

Rahminiwati, Min

INSTITUT PERTANIAN BOGOR

Author-ID : 1190825

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Public Health Veterinary Other

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In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent Wendi Nurul Fadillah; Nampiah Sukarno; Dyah Iswantini; Min Rahminiwati; Novriyandi Hanif; Mashuri Waite
HAYATI Journal of Biosciences Vol. 29 No. 1 (2022): January 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.1.76-86

This study aimed to evaluate the potential of marine fungus Purpureocillium lilacinum isolated from an Indonesian marine sponge Stylissa sp. as an anti-obesity agent through pancreatic lipase inhibition assay. The fungus was identified as P. lilacinum through morphological and molecular characteristics. The fungal extract’s inhibition activity and kinetics were evaluated using spectrophotometry and Lineweaver-Burk plots. Ethyl acetate and butanol were used for extraction. Both extracts showed pancreatic lipase inhibition in a concentration-dependent manner. Both crude extracts were then fractionated once. All fractionated extracts showed inhibitory activity above 50%, with the highest activity found in fraction 5 of ethyl acetate at 93.41% inhibition. The best fractionated extract had an IC50value of 220.60 µg.mL-1. The most active fraction of P. lilacinum had a competitive-type inhibitor behavior as shown by the value of Vmax not significantly changing from 388.80 to 382.62 mM pNP.min-1, and the Michaelis-Menten constant (KM) increased from 2.02 to 5.47 mM in the presence of 500 µg.mL-1 fractionated extract. Metabolite identification with LC-MS/MS QTOF suggested that galangin, kaempferol, and quercetin were responsible for the observed lipase inhibition.

Studi agrobiofisik kamandrah (croton tiglium L.) dan penentuan potensi awal kamandrah sebagai larvasida hayati pencegah penyakit demam berdarah dengue Dyah Iswantini; Rosihan Rosman; Upik Kesumawati; Djumali Mangunwidjaja; Min Rahminiwati; Adi Riyadhi
Jurnal Ilmu Pertanian Indonesia Vol. 14 No. 2 (2009): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1308.713 KB)

The aim of the research is to obtain the ecological condition and propagation of kamandrah (Croton tiglium L.) and determination of its potency as biological larvacidal for preventing dengue haemorraghic fever. Agrobiophysic study indicated that Croton tiglium L. plant need full sunlight(> 70 %). low intensity of sunlight could decrease the ability of plant to produce seed. The plant could grow well on podzolic land (30-50 m upon sea surface). Seed of kamandrah from Ampah has growth percentage of 43.8 °/o, height of 27.5 em, stem diameter of 5 em, total leaves of 10, and total primary branches of 2. Phytochemical assay resulted that among other part of Kamandrah, Kamandrah seed has highest alkaloid content. Because alkaloid compound has high larvicidal activity, kamandrah seed has high potency as larvicide. Among all of extracts of part of plant, oil of Croton tiglium L. has the highest potency as biological larvacidal with 863.67 ppm of LC50 for 24 hours of treatment.

Bioprospeksi ekstrak jahe gajah sebagai anti-crd: kajian aktivitas antibakteri terhadap Mycoplasma galliseptikum dan e. coli in vitro Min Rahminiwati; Aulia Andi Mustika P.; Siti Saadah; . Andriyanto; . Soeripto; Unang P.
Jurnal Ilmu Pertanian Indonesia Vol. 15 No. 1 (2010): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (971.752 KB)

CRD is chronic respiratory disease in chicken caused by infection of Mycoplasma gallisepticum (M gallisepticum) and E. coli. Rio-prospective of jahe for controlling the disease was investigated through the study of antibacterial activity against M. gallisepticum of fresh ginger juice extract and fraction of hexan, ethyl acetate, methanol and water against M. gallisepticum and E. coli. The results showed that the juice of fresh ginger inhibited the growth of M. gallisepticum with the minimum inhibitory concentration that could inhibit the growth was 10 °/o. The fractions that effectively inhibited the growth of M. gal/isepticum are hexan fraction and water fraction with the smallest inhibition zone was found at concentration of at least 8 % and 10 % respectivelly.TLC examination results of hexan fraction showed a purple spot with Rf value of 0.9 and a dark blue spot with Rf value of 0.36. Based on Rf values and color reference, the first spot was suggested zingiberen and the second spot was gingerol. All fractions that were examined, did not show any inhibitory activity against thegrowth of E coli. Thus the extract of fresh ginger was only to be used to control the respiratory disease causedby M. gallisepticum but not coli.

Potensi Jarak Pagar (Jatropha curcas) sebagai Larvasida Hayati Pencegah Penyakit Demam Berdarah Dengue Dyah Iswantini; Adi Riyadhi; Upik Kesumawati; Rosihan Rosman; Djumali Mangunwidjaja; Min Rahminiwati
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 1 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (629.563 KB)

Recently, Indonesia has big problem caused by dengue haemorraghic fever with A. aegypti as vector. Potential medicine and vaccine for curing this disease have not been found. The effective method to prevent this disease is the use of A. aegypti larvicidal. The chemical larvicidal has disadvantage for evironmental aspect. To solve this problem, the biological larvicidal has a good chance to develop. Indonesia has megadiversity which can be developed as biological larvicidal. Crude aqueous extracts and ethanol extracts of Jatropha curcas (Jarak pagar) seed and oil of Jatropha curcas were evaluated for larvicidal potential against the Aedes aegypti mosquito. Among all extracts, Jatropha curcas oil possessed a highest activity against the 3th instar larvae of Aedes. LC50 values of Jatropha curcas oil was 1507 ppm for 24 h and 866 ppm for 48 h. It was suggested that the Croton tiglium oil and Jatropha curcas oil possess larvicidal properties that could be developed and used as biological larvicidal.

Ekstrak secang berukuran nano dengan kaolin sebagai pembawa Irmanida Batubara; Zaenal Abidin; Min Rahminiwati
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 2 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1194.765 KB)

Sappanwood extracts reported had antiacne activity with brazilin as active component. To develop antiacne formula from sappanwood extract, nanoparticle sappanwood with kaolin nanosize as carrier was developed. Carrier used was montmorillonite yellow, brown montmorillonite, yellow kaolin from Cicalengka, white kaolin from Cicalengka, kaolin from Bangka Belitung, and kaolin from Wonosari. The best carrier for active components of Sappanwood was selected based on UV-Vis spectroscopy, thin layer chromatography, liquidchromatography tinggi.dan performance antijerawat activity test. The most potent kaolin as Sappanwood carrier was kaolin from Bangka Belitung with percent inhibiton of DPPH scavenging reaction about 78% at 50 mg kaolin.

BIOAKTIVITAS EKSTRAK METANOL DAUN NAMNAM SERTA KOMBINASINYA DENGAN MADU TRIGONA La Ode Sumarlin; Agik Suprayogi; Min Rahminiwati; Achmad Tjahja; Dede Sukandar
Jurnal Teknologi dan Industri Pangan Vol. 26 No. 2 (2015): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

Namnam (Cynometra cauliflora L) and trigona honey are two natural ingredients that are potential to be developed in Indonesia. However, scientific evidence of its active compounds and bioactivity is still rarely found, particularly the combination of these two materials. Therefore, this research is to explore their active ingredients of combination of these two materials such as total phenolic, flavonoids, vitamin C and β-carotene and bioactive capabilities such as antioxidant activity and antibacterial activity. The analysis showed that antibacterial activity of methanol extract of Namnam leaves (EMDN) and trigona honey either in their sole form or combined form has antioxidant and antibacterial activity. The EMDN was more sensitive to Staphylococcus aureus (23.7±3.3 mm) than to Escherichia coli, while the Trigona honey (MT) more sensitive to Escherichia coli (32.6±4.4 mm) than Staphylococcus aureus (16.6±4.1 mm). Similarly, the combination of EMDN and MT was more sensitive to Escherichia coli (23±1.9 mm) than Staphylococcus aureus (17.6±2.6 mm). Analysis of the antioxidant activity also showed that EMDN provided the highest activity (IC50 0.0048±0.000 mg/mL), a combination EMDN and MT (IC50 0.0085±0.000 mg/mL) and MT (IC50 3.736±0.112 mg/mL). Moreover, this analysis also showed thatsole samples of MT and EMDN have total phenolic content, flavonoids, and vitamin C that were higher than the combination of MT and EMDN. However, the content of β-carotene in the combined form of MT and EMDN was higher. Thus trigona honey, methanol extract of leaves Namnam (Cynometra cauliflora L) in a single form or in a combination are potential to be utilized and developed as a source of antioxidants and antibacterial in the form of functional food.

Aktivitas Larvasida Biji Bengkuang sebagai Insektisida Nabati terhadap Larva Lalat Crysomya bezziana Aulia Andi Mustika; Upik Kesumawati Hadi; April Hari Wardhana; Min Rahminiwati; Ietje Wientarsih
Acta VETERINARIA Indonesiana Vol. 4 No. 2 (2016): Juli 2016
Publisher : IPB University

Bengkuang merupakan salah satu tanaman obat yang berpotensi sebagai bioinsektisida. Penelitian ini bertujuan mengetahui efektivitas biji bengkuang sebagai insektisida nabati terhadap larva lalat Crysomya bezziana (C. bezziana) agen penyebab miasis secara in vitro. Penelitian ini terbagi menjadi 5 kelompok perlakuan. Masing-masing sebanyak 20 Larva instar 1 (L1), Larva instar 2 (L2), dan Larva instar 3 (L3) C.bezziana digunakan untuk pengujian in vitro menggunakan pot plastik yang berisi media larva dan ekstrak ethanol biji bengkuang dengan konsentrasi bertingkat 0,06, 0,12, dan 0,25%. Coumaphos 0,06% dan akuades steril digunakan sebagai kontrol positif dan negatif. Hasil penelitian menunjukkan bahwa pada konsentrasi 0,25% mampu menyebabkan 100% kematian larva dan 100% pupa tidak menetas. Pengujian L3 menunjukkan bahwa ekstrak ethanol biji bengkuang mampu menyebabkan penurunan daya tetas pada semua konsentrasi. Pengujiaan L1 dan L2 untuk mengindikasikan efektifi tas ekstrak sebagai racun perut, sedangkan pengujian pada L3 sebagai indikasi racun kontak. Biji bengkuang memiliki daya larvasida terhadap beberapa jenis larva serangga C. bezziana.

Inovasi Formula Produk Hand Rub Berbasis Alkohol sebagai Upaya Efisiensi Pengelolaan Sediaan Farmasi di Rumah Sakit Ahmad Subhan; Wasmen Manalu; Min Rahminiwati; Huda Salahudin Darusman
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25891

Telah dilakukan penelitian dalam rangka inovasi produk hand rub alcohol base. Hand rub adalah sediaan antiseptik yang digunakan untuk membersihkan tangan tanpa menggunakan air. Formula yang digunakan dalam penelitian ini adalah kombinasi Etanol 96%; H2O2 3% ; Gliserol 98% ; Aqua Steril ad. total volume. Tujuan penelitian ini untuk menciptakan sediaan hand rub alcohol base yang bermutu dan terjangkau (efisien) dibandingkan dengan produk pabrikan yang ada di Indonesia. Metode yang digunakan dengan hand rub dibuat dalam prosedur bersih, dalam sediaan akhir 500 mL. kadar akhir kandungan alcohol sediaan hand rub harus minimal >80%. Untuk mengetahui mutu sediaan handrub dilakukan dengan uji percentage kill, dengan menggunakan sampel bakteri : Escherichia Coli; Staphylococcus epidermidis; Pseudomonas aeruginosa; Methicillin resistance staphylococcus aureus (MRSA). Pembuatan produk hand rub dilakukan di Instalasi Farmasi RSUP Fatmawati; pengujian percentage kill dilakukan di Laboratorium mikrobiologi Universitas Indonesia (UI) Jakarta. Berdasarkan hasil uji percentage kill diketahui bahwa pada menit kontak ke 1;2 dan 5, untuk bakteri Escherichia Coli diketahui mengalami eradikasi 99,90%. Begitu juga untuk Staphylococcus epidermidis, diketahui untuk waktu kontak pada menit ke 1;2 dan 5, nilai percentage kill adalah 99,90%. Untuk bakteri Pseudomonas aeruginosa diketahui pada waktu kontak menit ke 1;2 dan 5, nilai percentage kill adalah 99,90%. Sama halnya dengan bakteri MRSA, diketahui pada waktu kontak menit ke 1;2 dan 5, nilai percentage kill adalah 99,90%. Hal ini menunjukkan bahwa hasil kualitas produk hand rub adalah baik, karena berdasarkan hasil Uji percentage kill diperoleh nilai untuk tiap waktu kontak ≥90%. Nilai Efisiensidiketahui, harga produk hand rub alcohol base dengan kadar akhir alcohol >80%. Di e-catalogue LKPP tahun 2018 sebesar Rp.78.750/botol 500 mL. Diketahui untuk biaya yang dihabiskan dalam pembuatan sediaan hand rub inovasi produk ini sebesar Rp.30.500/botol 500 mL. Untuk selama periode tahun 2018, hand rub yang digunakan di RSUP Fatmawati sebanyak 15.600 botol 500 mL, dengan rata-rata penggunaan tiap bulan adalah 1.300/botol 500 mL. Sehingga dengan diimplementasikannya produk ini di RSUP Fatmawati Jakarta maka nilai efisiensi yang diperoleh selama tahun 2018 adalah Rp.752.700.000 (tujuh ratus lima puluh dua juta tujuh ratus ribu rupiah).

Evaluasi In Vitro Kemampuan Penyerapan Glukosa oleh Ekstrak Daun Namnam (Cynometra cauliflora) pada Otot Diafragma Tikus La Ode Sumarlin; Agik Suprayogi; Min Rahminiwati; Aryani Satyaningtijas
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Diabetes Melitus (DM) adalah kelompok gangguan metabolisme yang ditandai oleh hiperglikemia akibat kerusakan pada sekresi insulin, kerja insulin atau keduanya. Penderita Diabetes Melitus Tipe 2 (DMT2) mencapai 90-95% dari keseluruhan populasi penderita diabetes tersebut. Salah satu tanaman yang potensial sebagai alternatif obat antidiabetes adalah tanaman namnam (Cynometra cauliflora). Pada penelitian ini kemampuan penyerapan glukosa oleh otot diafragma yang diisolasi dari tikus non diabetes Sprague Dawley oleh ekstrak metanol daun namnam (C. cauliflora) pada berbagai konsentrasi ditentukan. Gugus fungsi senyawa dominan pada ekstrak menggunakan FTIR (Fourier Transform Infrared). Hasilnya menunjukkan bahwa terjadinya peningkatan penyerapan glukosa oleh diafragma ketika konsentrasi ekstrak daun namnam (C. cauliflora) meningkat dan tertinggi pada konsentrasi 450 mg/mL dengan serapan 0.4254 ± 3.23 mg/mL/30 menit dengan peningkatan sebesar 373.72% dibandingkan kontrol air. Diduga kemampuan ekstrak tanaman C. Cauliflora menyerap glukosa disebabkan keberadaan golongan flavonoid. Oleh karena itu daun tanaman namnam (C. cauliflora) memiliki potensi sebagai obat antidiabetes DMT2 melalui mekanisme peningkatan penyerapan glukosa ke dalam sel.DOI:http://dx.doi.org/10.15408/jkv.v4i1.7345

Reproductive Performances and Egg Qualities in African Catfish (Clarias gariepinus) Broodstocks Supplemented with Curcumin and Thyroxine Hormone Livana Dethris Rawung; Damiana Rita Ekastuti; Muhammad Zairin Junior; Min Rahminiwati; Ade Sunarma; Wasmen Manalu
Journal Omni-Akuatika Vol 16, No 1 (2020): Omni-Akuatika May
Publisher : Fisheries and Marine Science Faculty - Jenderal Soedirman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.oa.2020.16.1.696

An experiment was designed to study the effects of curcumin and thyroxine hormone supplementation in the diet to improve the reproductive performance of catfish broodstock by improving egg quality that eventually increases the production of seedlings. Catfish used in this experiment were supplemented with curcumin and thyroxine hormone through their feeds for 12 weeks. The results showed that there was no significant difference (p > 0.05) in the hepatosomatic index (HSI), gonadosomatic index (GSI), percentage of gonad maturity, total cholesterol concentration in the spawned eggs, high density lipoprotein (HDL) concentration in the spawned eggs, fertilization rate of spawned eggs, and hatching rate of fertilized eggs. However, there were significant differences (p < 0.05) in the concentration of vitellogenin in the spawned eggs, egg diameter of the spawned eggs, and the triglycerides contents of spawned eggs. It was concluded that curcumin and thyroxine supplementations of African catfish increased vitellogenin concentrations and diameters of spawned eggs that have great potential to improve the reproductive performance.

Co-Authors , Triadiati . andriyanto . Soeripto A.S. Satyaningtijas Achmad Tjahja Ade Sunarma Ade Sunarma Adi Riyadhi Agik Suprayogi Agus Setiyono Ahmad Subhan Ahmad Tjahja Nugraha, Ahmad Tjahja Amrozi Andriyanto . Andriyanto A Anggraena, Shinta Suci Ani Murtisari April Hari Wardhana Arief Boediono Aryani Satyaningtijas Aswani, Tuti Aulia Andi Mustika Bambang Pontjo Priosoeryanto Budi Wirawan Cantika Zaddana Ceristianto Ceristianto Ceristianto, Ceristianto Chudahman Manan Chudahman Manan Daldiyono Daldiyono Daldiyono Daldiyono Damiana Rita Ekastuti Dede Sukandar Deni Noviana Djumali Mangunwidjaja Dyah Iswantini E Mulyati Effendi, E Mulyati Erni Rustiani Fadillah, Wendi Nurul Fajar Triansyah Gumelar Firman, Gelline Tama Anindia Fitri Dwiputri Franco, Christopher MM Gelline Tama Anindia Firman Gumelar, Fajar Triansyah Hajar Hajar Hambarsika, IGM Antara HANDAJANI, FITRI Huda Shalahudin Darusman IETJE WIENTARSIH Ika Amalia, Ika Ike Yulia Wiendarlina Irmanida Batubara Ita Djuwita Ita Juwita Joshie Ramadhan Juwita, Ita Kusdiantoro Mohamad La Ode Sumarlin La Ode Sumarlin latifah K Darusman latifah K Darusman Latifah Kosim Darusman Lina Novianti Sutardi Livana Dethris Rawung Lusi Indriani M. Agung Zaim Adzkiya M. Zairin Junior Mahyuni, Siti Martha Arofa Dilla Mashuri Waite Meyliana Wulandari MUHAMMAD AGUS SUPRAYUDI Murtisari, Ani Mutiara, Tia Najwa Rokhmah, Nisa Nampiah Sukarno Neni Nuryani Nhestricia, Nhadira Novriyandi Hanif Oom Komala Rahmania Hanim Rahmat Hidayat Raudhatul Jannah Rosihan Rosman SAEPUDIN RAHMATULLAH Sara Nurmala Shinta Suci Anggraena Sholehah, Akipah Nazla Siti Saadah Siti Sa’diah Sri Budiarti Poerwanto Sri Estuningsih Sri Nuryati Suci Sintya Sulistyaningsih, Yohana Caecilia SUMINAR S. ACHMADI Supardi, Arviani Rahmawati Tia Mutiara Tiyan Hidayanti Tuti Aswani Ulandari, Rafika Unang P. Unang Patriana Upik Kesumawati Hadi Waite, Mashuri Wasmen Manalu Wei Zhang Wendi Nurul Fadillah Wida Lesmanawati Widia Safitri Yasinta Ratna Esti Wulandari Yohana Caecilia Sulistyaningsih YULIN LESTARI Zaenal Abidin

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