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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner VALENSI Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology BIOTROPIA - The Southeast Asian Journal of Tropical Biology Proceeding International Conference on Global Resource Conservation Indonesian Journal of Pharmaceutical Science and Technology Jurnal Sumberdaya Hayati BERITA BIOLOGI Jurnal Ilmiah Kedokteran Wijaya Kusuma Omni-Akuatika FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Journal of Aquaculture and Fish Health Majalah Farmasetika Journal of Parasite Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine al Kimiya : Jurnal Ilmu Kimia dan Terapan Indonesian Journal of Pharmacology and Therapy
Min Rahminiwati
Department Of Anatomy, Physiology And Pharmacology, Faculty Of Animal Medicine, IPB University, Jl. Lingkar Kampus IPB Darmaga, Bogor, West Java 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Public Health Veterinary Other

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POTENSI INHIBITOR α-GLUKOSIDASE EKSTRAK KASAR Streptomyces tendae SEBAGAI PENURUN KADAR GLUKOSA DARAH PADA TIKUS Sprague Dawley DIABETES: The Potency of Streptomyces tendae Crude Extract as an α-Glucosidase Inhibitor in Lowering Blood Glucose Levels of Diabetic Sprague Dawley Rats Aliful Karim; Min Rahminiwati; Yulin Lestari
Jurnal Sumberdaya Hayati Vol. 12 No. 1 (2026): 2026
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.12.1.8-14

Abstract

Diabetes is a disease caused by insulin dysfunction or impaired insulin production, leading to elevated blood glucose levels (hyperglycemia). It is classified into three types: Type 1, Type 2, and Gestational Diabetes Mellitus (GDM). Type 2 diabetes is a condition resulting from insulin resistance. Previous research has identified microorganisms isolated from Ficus deltoidea that produce α-glucosidase inhibitors. This study aims to determine the potential of extracts derived from Streptomyces tendae as an α-glucosidase inhibitor through both in-vitro and in-vivo assessments, specifically evaluating the extract's effectiveness in reducing blood glucose levels in Sprague Dawley rats with Type 2 diabetes. Although the isolates from previous studies showed a decrease in activity, they remained capable of lowering blood glucose levels in the rats. Statistical analysis of the Oral Glucose Tolerance Test (OGTT) provided sufficient evidence to conclude that the combination of time (minutes) and extract administration significantly influenced the reduction of blood glucose levels in diabetic rats (P<0.05). Diabetes was induced in the rats using low-dose streptozotocin. The results showed that "Dose 1" of the extract significantly reduced blood glucose levels compared to control (aquades) treatment starting from the fifth day of administration and was effective in suppressing further increases in blood sugar (P<0.05).
PHYSIOLOGICAL AND METABOLOMIC APPROACH FROM DIFFERENT ACCESSIONS OF MULBERRY TREATED WITH SALT STRESS IN INDONESIA Yasinta Ratna Esti Wulandari; Yohana Caecilia Sulistyaningsih; Agik Suprayogi; Min Rahminiwati; Triadiati Triadiati
BIOTROPIA Vol. 33 No. 3 (2026): BIOTROPIA Vol. 33 No. 3 September 2026
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2026.33.3.2884

Abstract

ARTICLE HIGHLIGHTS- Information on salinity-tolerant mulberry accessions is currently unavailable. This research reveals the discovery of salinity-tolerant mulberry accessions from the exploration of various mulberry accessions in Indonesia.- Salinity-tolerant mulberry accessions can be utilized for sustainable development and biodiversity conservation.- Salinity stress treatment is known to increase secondary metabolites in mulberry plants.- Profiling of secondary metabolites in mulberry plants in response to salinity stress is known.- The integration of metabolomics and ecophysiology offers a new perspective on how plants adapt to stress.ABSTRACTLand salinity in Indonesia continues to increase, therefore research is needed to obtain saline-resistant plants such as mulberries. Mulberry plants are well recognized for their resilience to various abiotic stresses, including salinity. This study aimed to identify tolerant accessions to salinity stress, in accordance with their growth characteristics, and to examine the alterations in secondary metabolites as a reaction to salt stress. The experiment was designed using a factorial randomized block design, which included seven mulberry accessions, identified as MB1 through MB7, and varying NaCl concentrations of 0% (control), 0.2%, 0.3%, and 0.4%. The study’s results showed that MB2-3 accession tolerates high salinity stress by accumulating proline, flavonoid compounds, phenolic and dissolved sugars, as well as secondary metabolites, with increasing NaCl concentration. Based on the results of UHPLC-Q-Orbitrap HRMS analysis of mulberry leaf extract, 100 selected metabolites were obtained. The heat map results showed metabolic substances such as phenylpropanoids, organic acids, lipids, and carbohydrates increased in response to salinity stress. The integration of metabolomics and ecophysiology called ecophysiolomics offers a new perspective on how plants adapt to stress. By analyzing the involvement of metabolites that facilitate tolerance to salinity stress, we can gain a valuable understanding of how mulberry plants endure this environmental challenge..
Co-Authors . andriyanto . Soeripto A.S. Satyaningtijas Achmad Tjahja Ade Sunarma Ade Sunarma Adi Riyadhi Agik Suprayogi Agus Setiyono Ahmad Subhan Ahmad Tjahja Nugraha, Ahmad Tjahja Aliful Karim Amrozi Andriyanto . Andriyanto A Andriyanto Andriyanto Anggraena, Shinta Suci Ani Murtisari April Hari Wardhana Arief Boediono Aryani Satyaningtijas Aswani, Tuti Aulia Andi Mustika Bambang Pontjo Priosoeryanto Budi Wirawan Cantika Zaddana Ceristianto Ceristianto Ceristianto, Ceristianto Chudahman Manan Chudahman Manan Daldiyono Daldiyono Daldiyono Daldiyono Damiana Rita Ekastuti Dede Sukandar Deni Noviana Djumali Mangunwidjaja Dyah Iswantini E Mulyati Effendi, E Mulyati Erni Rustiani Fadillah, Wendi Nurul Fajar Triansyah Gumelar Firman, Gelline Tama Anindia Fitri Dwiputri Franco, Christopher MM Gelline Tama Anindia Firman Gumelar, Fajar Triansyah Hajar Hajar Hambarsika, IGM Antara HANDAJANI, FITRI Hidayanti, Tiyan Huda Shalahudin Darusman IETJE WIENTARSIH Ika Amalia, Ika Ike Yulia Wiendarlina Indriani, Lusi Irmanida Batubara Ita Djuwita Ita Juwita Joshie Ramadhan Juwita, Ita Kusdiantoro Mohamad La Ode Sumarlin La Ode Sumarlin latifah K Darusman latifah K Darusman Latifah Kosim Darusman Lina Novianti Sutardi Livana Dethris Rawung M. Agung Zaim Adzkiya M. Zairin Junior Mahyuni, Siti Martha Arofa Dilla Mashuri Waite Meyliana Wulandari MUHAMMAD AGUS SUPRAYUDI Murtisari, Ani Mutiara, Tia Najwa Rokhmah, Nisa Nampiah Sukarno Neni Nuryani Nhestricia, Nhadira Novriyandi Hanif Oom Komala Rahmania Hanim Rahmat Hidayat Raudhatul Jannah Rosihan Rosman SAEPUDIN RAHMATULLAH Sara Nurmala Shinta Suci Anggraena Sholehah, Akipah Nazla Siti Saadah Siti Sa’diah Sri Budiarti Poerwanto Sri Estuningsih Sri Nuryati Suci Sintya SUMINAR S. ACHMADI Supardi, Arviani Rahmawati Tia Mutiara Triadiati Triadiati Tuti Aswani Ulandari, Rafika Unang P. Unang Patriana Upik Kesumawati Hadi Waite, Mashuri Wasmen Manalu Wei Zhang Wendi Nurul Fadillah Wida Lesmanawati Widia Safitri Yasinta Ratna Esti Wulandari Yohana Caecilia Sulistyaningsih YULIN LESTARI Zaenal Abidin