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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner VALENSI Jurnal Veteriner Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Proceeding International Conference on Global Resource Conservation Indonesian Journal of Pharmaceutical Science and Technology BERITA BIOLOGI Jurnal Ilmiah Kedokteran Wijaya Kusuma Omni-Akuatika FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Journal of Aquaculture and Fish Health Majalah Farmasetika Journal of Parasite Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine al Kimiya : Jurnal Ilmu Kimia dan Terapan Indonesian Journal of Pharmacology and Therapy
Rahminiwati, Min
INSTITUT PERTANIAN BOGOR
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Public Health Veterinary Other

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Exploring Indonesian Sponge-Associated Marine Aspergillus hortai: Characterization of Bioactive Compounds with Potential Anti-Escherichia coli Properties Fadillah, Wendi Nurul; Sukarno, Nampiah; Iswantini, Dyah; Rahminiwati, Min; Franco, Christopher MM; Zhang, Wei; Hanif, Novriyandi; Waite, Mashuri
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.712-724

Abstract

Sponge-associated marine fungi are potential source for secondary metabolite compounds. The aim of this research was to investigate sponge-associated marine fungus as secondary metabolite producers against Escherichia coli. The fungus was isolated from Indonesian marine sponge Stylissa sp. and identified as Aspergillus hortai through a combination of morphological and molecular characteristics of ITS DNA and β-tubulin genes. The fungus was tested against E. coli using fungal broth and mycelial extracts. The optimized condition was achieved by fungal broth grown in corn meal broth at 6-days of shaking incubation. Fungal extract was produced using three liters of filtered fungal broth and extracted in ethyl acetate. The antibiotic activity of the extract is vulnerable to 45°C heat and basic or acidic conditions. Therefore, the extraction was done at pH 7 with evaporation at 40°C. The extract shows 7 major bands on TLC with 1 band shows activity against E. coli (Rf 0.81) on bioautogram. The band was observed as a yellow color and turned black in short-wave UV and did not show any fluorescence in long-wave UV. This research shows that sponge-associated marine fungi obtained from Indonesia has the potential as anti E. coli worth to be explored for searching new antibiotics.
Anticoagulant effects of combined extracts of Curcuma xanthorrhiza Roxb., Mimusops elengi Linn., and Averrhoa carambola in mice Rahminiwati, Min; Ulandari, Rafika; Hidayat, Rahmat
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.16

Abstract

Background Curcuma xanthorrhiza Roxb. rhizome, the Mimusops elengi Linn. leaves, and Averrhoa carambola leaves contain bioactive compounds such as alkaloids and flavonoids. Flavonoids influence calcium ion levels, which play critical roles in cardiovascular functions, including heart function and blood coagulation. However, the effects of these plant extracts on blood clotting remain unclear. Objective This study aimed to evaluate the anticoagulant effects of a combination of these plant extracts in mice. Methods Twenty-five mice were divided into five treatment groups, receiving either distilled water (0.5 mL/25 g BW), aspirin (0.2 mg/20 g BW), Curcuma xanthorrhiza extract (0.1344 mg/20 g BW), or a combination of the three extracts at two doses (0.63 mg/20 g BW and 2.52 mg/20 g BW). Extracts were administered orally, bleeding and coagulation times were measured at 3-, 6-, and 9-hours post-administration. Results The combined extract significantly prolonged bleeding and coagulation times compared to a single Curcuma xanthorrhiza extract. The most pronounced effect was observed at a dose of 2.52 mg/20 g BW, with the peak effect occurring at the 3rd hour. Conclusion The combination of Curcuma xanthorrhiza, Mimusops elengi, and Averrhoa carambola extracts demonstrated significant anticoagulant activity, with the highest potency observed at a dose of 2.52 mg/20 g BW, surpassing the effects of aspirin. The synergistic interaction between these extracts is suggested to enhance their anticoagulant properties.
Potential Anthelmintic Activity of Pineapple Fruit (Ananas comosus) and Mango Leaves Juice (Mango foliorum) against Ascaridia galli Worms In-Vitro Model Rahminiwati, Min; Martha Arofa Dilla; Nisa Najwa Rokhmah
Journal of Parasite Science Vol. 9 No. 2 (2025): Journal of Parasite Science
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jops.v9i2.63604

Abstract

Ascaridia galli is a worm that infects the chickens' digestive tract, leading to various problems such as worsening feed efficiency, slowing poultry growth, and increasing mortality. Mango leaves and pineapple fruit were reported to have anthelmintic activity against A. galli. These two plants contain secondary metabolites that were suggested to have synergistic effects. This study aimed to determine the potential activity of combining arumanis mango leaf and pineapple juice against A. galli and evaluate their interaction based on anthelmintic activity profile. The activity of 40% pineapple fruit juice (PA) added with different concentrations of arumanis mango leaf juice (AM) from 0.13%, 0.26%, and 0.52% v/v, and pineapple fruit juice at concentrations 20, 40% v/v were mixed with 0.26% arumanis mango leaf juice. as well as NaCl 0,9%  as negative control and pyrantel pamoate 0.2; 0.4; 0.8 % b/v as a positive control respectively were determined. Observation on worm mortality was conducted in 15-minute intervals for 300 minutes. The time-a cumulative mortality rate of worm curve exposed to PA 40 %   was shifted to the left in the presence of AM, and AM 0.26 % curve in the presence of PA. The best, LC50, LT50, and L100 were found in AM 0.52 % combined with PA 40%. This finding showed the potential activity of pineapple fruit juice at 40% combined with arumanis mango leaf juice at 0.52 %  as the best combination in which anthelmintic activity occurs due to synergism interaction between arumanis mango leaf juice and pineapple fruit juice.
Enhancement of α-Glucosidase Inhibitory Activity, Antioxidant Activity, and Antioxidant Compounds in Mulberry Leaves Under Salinity Stress Wulandari, Yasinta Ratna Esti; Sulistyaningsih, Yohana Caecilia; Suprayogi, Agik; Rahminiwati, Min; Triadiati, Triadiati
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.87-94

Abstract

Salinity stress disrupts redox homeostasis in plants, leading to notable changes in the levels of bioactive compounds. These compounds are recognized for their significant role in inhibiting the α-glucosidase enzyme, which is relevant in glycemic control. Detailed insights into how salinity stress modulates α-glucosidase inhibition in mulberry leaves remain scarce. This study aims to investigate the effects of salinity stress on α-glucosidase inhibitory activity in mulberry leaf extracts, and to identify accessions exhibiting the most potent inhibitory properties. In vitro assays were employed to conduct qualitative phytochemical analyses and to quantify total phenolic content, total flavonoid content, and α-glucosidase enzyme activity. The results demonstrate that high salinity stress enhances the inhibitory activity of mulberry leaf extracts against the α-glucosidase enzyme. Notably, the MB2-3 sample exhibited the most favorable IC50 value (0.59 µg/mL), coupled with a substantial phenolic content (141.9 mg GAE/g extract) and the highest content of flavonoid observed among all tested samples (619.56 mg QE/g extract). Collectively, these findings highlight the capacity of salinity stress to augment both the inhibitory potential of mulberry extracts against α-glucosidase and the accumulation of phenolic and flavonoid compounds, with sample MB2-3 displaying auspicious attributes.
Antidimentia activity of instant granule containing a combination of Brassica oleracea L. Var. Italica and Centella asiatica L. Urban extracts in male mice (Mus musculus) model of dementia Erni Rustiani; Suci Sintya; Min Rahminiwati
Indonesian Journal of Pharmacology and Therapy Vol 6 No 2 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.17391

Abstract

Dementia is a progressive cognitive impairment characterized by cognitive decline and memory loss. Acetylcholine levels in dementia patients decrease due to increased levels of acetylcholinesterase which breaks down acetylcholine into choline and acetate. Gotu kola (Centella asiatica L. Urban) contains asiaticoside,while broccoli (Brassica oleracea L. Var Italica) contains glucosinolate. Both compounds are believed to have acetylcholinesterase inhibitor activity. This study aimed to evaluate the antidementia activity of instant granules of a combination of B. oleracea and C. asiatica extracts in male white mice model of dementia. Thirty-five male mice were used in this experimental divided into seven group with five mice in each group. All groups were induced with hyoscine butylbromide intraperitoneally except the normal control group (group I). Group II (negative control) was given Na CMC 0.5% orally, and group III (positive control) was given piracetam intraperitoneally. Groups IV to VII were given instant granules with different formulation, namely namely group IV (25 mg :190 mg dose 1x), group V (25 mg : 190 mg dose 2x), group VI (190 mg : 190 mg dose 1x) and group VII (190 mg : 190 mg dose 2x). Y-maze test for mice was carried out for 5 min by allowing mice to explore the three arms of the Y-maze freely. A significant difference in antidementia activity between groups given the instant granules was observed (p <0.05). The instant granules combination with a ratio of B. oleracea andC. asiatica extracts (190 mg : 190 mg) had a higher antidementia activity than that combination of 25 mg : 190 mg. The instant granules combination with a ratio of B. oleracea and C. asiatica extracts (190 mg : 190 mg) at dose 2x had a higher antidementia activity than at dose 1x. In conclusion, the instant granules combination of B. oleracea and C. asiatica have a potential antidementia activity.
Co-Authors , Triadiati . andriyanto . Soeripto A.S. Satyaningtijas Achmad Tjahja Ade Sunarma Ade Sunarma Adi Riyadhi Agik Suprayogi Agus Setiyono Ahmad Subhan Ahmad Tjahja Nugraha, Ahmad Tjahja Amrozi Andriyanto . Andriyanto A Anggraena, Shinta Suci Ani Murtisari April Hari Wardhana Arief Boediono Aryani Satyaningtijas Aswani, Tuti Aulia Andi Mustika Bambang Pontjo Priosoeryanto Budi Wirawan Cantika Zaddana Ceristianto Ceristianto Ceristianto, Ceristianto Chudahman Manan Chudahman Manan Daldiyono Daldiyono Daldiyono Daldiyono Damiana Rita Ekastuti Dede Sukandar Deni Noviana Djumali Mangunwidjaja Dyah Iswantini E Mulyati Effendi, E Mulyati Erni Rustiani Fadillah, Wendi Nurul Fajar Triansyah Gumelar Firman, Gelline Tama Anindia Fitri Dwiputri Franco, Christopher MM Gelline Tama Anindia Firman Gumelar, Fajar Triansyah Hajar Hajar Hambarsika, IGM Antara HANDAJANI, FITRI Huda Shalahudin Darusman IETJE WIENTARSIH Ika Amalia, Ika Ike Yulia Wiendarlina Irmanida Batubara Ita Djuwita Ita Juwita Joshie Ramadhan Juwita, Ita Kusdiantoro Mohamad La Ode Sumarlin La Ode Sumarlin latifah K Darusman latifah K Darusman Latifah Kosim Darusman Lina Novianti Sutardi Livana Dethris Rawung Lusi Indriani M. Agung Zaim Adzkiya M. Zairin Junior Mahyuni, Siti Martha Arofa Dilla Mashuri Waite Meyliana Wulandari MUHAMMAD AGUS SUPRAYUDI Murtisari, Ani Mutiara, Tia Najwa Rokhmah, Nisa Nampiah Sukarno Neni Nuryani Nhestricia, Nhadira Novriyandi Hanif Oom Komala Rahmania Hanim Rahmat Hidayat Raudhatul Jannah Rosihan Rosman SAEPUDIN RAHMATULLAH Sara Nurmala Shinta Suci Anggraena Sholehah, Akipah Nazla Siti Saadah Siti Sa’diah Sri Budiarti Poerwanto Sri Estuningsih Sri Nuryati Suci Sintya Sulistyaningsih, Yohana Caecilia SUMINAR S. ACHMADI Supardi, Arviani Rahmawati Tia Mutiara Tiyan Hidayanti Tuti Aswani Ulandari, Rafika Unang P. Unang Patriana Upik Kesumawati Hadi Waite, Mashuri Wasmen Manalu Wei Zhang Wendi Nurul Fadillah Wida Lesmanawati Widia Safitri Yasinta Ratna Esti Wulandari Yohana Caecilia Sulistyaningsih YULIN LESTARI Zaenal Abidin