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Rusmini, Hetti
Universitas Malahayati
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Role of Matrix Metalloproteinase-9 in Lung Function Impairment in Patients with Post-Tuberculosis Sequelae Rusmini, Hetti; Soemarwoto, Retno Ariza S; Messah, Anse Diana V; Yunus, Faisal; Dilangga, Pad; Herdarto, Muhammad Junus Didiek; Hendarto, Gatot Sudiro; Ekawati, Diyan
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/3chv8k81

Abstract

Background: Post-tuberculosis (post-TB) sequelae are long-term pulmonary complications that persist despite completion of anti-tuberculosis treatment (ATT). These long-term effects frequently contribute to diminished pulmonary function and a lower quality of life. Matrix metalloproteinase-9 (MMP-9) is thought to be involved in the process of lung tissue injury among individuals recovering from tuberculosis. This study aimed to explore the correlation between serum MMP-9 levels and pulmonary function impairment in post-TB patients. Methods: An observational case-control study was carried out at Dr. H. Abdul Moeloek Hospital in Lampung between April 2023 and March 2024. The study involved 35 post-TB patients (case group) and 35 healthy individuals (control group). Pulmonary function was evaluated using spirometry, while serum MMP-9 concentrations were measured by ELISA. The data were statistically analysed using the Mann-Whitney U test and Spearman's rank correlation. Results: The post-TB group exhibited higher serum MMP-9 levels compared to the control group (1137.7±527.4 vs. 939.5±360.1), though the difference did not reach statistical significance. Post-TB patients showed reduced lung function, particularly in FEV1/FVC, FEV1, and FVC values. There was a significant correlation between MMP-9 levels and pulmonary function parameters, including pre-bronchodilator FEV1/FVC (r = -0.321; P=0.007), post-bronchodilator FEV1/FVC (r = -0.265; P=0.027), and %FEV1 (r = -0.254; P=0.034). Conclusion: Increased serum MMP-9 levels are associated with reduced lung function in post-tuberculosis patients, particularly in cases of obstructive impairment. MMP-9 has the potential to be used as a biomarker for lung injury in individuals with a history of tuberculosis.
Pengaruh Pemberian Calcitriol terhadap Kadar Limfosit pada Tikus Putih (Rattus norvegicus) Galur Wistar Jantan yang Dipapar Asap Rokok Jordy Oktobiannobel; Hetti Rusmini; Retno Ariza Soeprihatini Soemarwoto; Syafa’atun Malihah
Biotropic : The Journal of Tropical Biology Vol. 5 No. 1 (2021): Biotropic, Volume 5 Nomor 1, 2021
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.2021.5.1.29-40

Abstract

The health impact for active and passive smokers is damage to the organs and respiratory tract. The body organs initially experience inflammation which increases the number of white blood cells, one of which is an increase in lymphocytes. One of the efforts to reduce the damage caused free radical by cigarette smoke is by consuming Calcitriol. Objective: To determine the effect of presenting Calcitriol on lymphocyte levels in male Wistar rats (Rattus norvegicus) exposed to cigarette smoke. Methods: This type of research is a pure experimental (true-experiment) using a pre and post-test research design with a control group design to check lymphocyte levels in male Wistar rats (Rattus norvegicus). 24 rats were divided into 6 groups simultaneously. Random, namely the control group 1 (exposed to cigarette smoke and not given Calcitriol), group 2 (exposed to cigarette smoke and not given Calcitriol), placebo control group (exposed to cigarette smoke and given olive oil), treatment 1 (exposed to cigarette smoke and given Calcitriol with a dose of 0.25 µgr / head), treatment 2 (exposed to cigarette smoke and given Calcitriol at a dose of 0.5 µgr / head) and treatment 3 (exposed to cigarette smoke and given Calcitriol at a dose of 1 µgr / head). Results: Paired t-test lymphocyte levels showed evidence that stated (p <0.05) in the K2 group (p = 0.014), the K3 group (p = 0.049), the P1 group (p = 0.012) and the P3 group (0.001) . Meanwhile, group K1 (p = 0.115) and group P2 (p = 0.066) had no statistical difference. Conclusion: Calcitriol administration can reduce lymphocyte levels in male Wistar rats exposed to cigarette smoke.
Co-Authors Abriyanti, Okta Ade Maria Ulfa Aditya Aditya Adityo Wibowo, Adityo Agus Dwi Susanto Alfarisi, Ringgo Andri Baedowi Apri Lyanda Arif Widiyantoro Aryana, Wayan Ferly Asmia Djunishap Aulyya Rahmah Azka, Laisa Bima Taruna Sakti Boby Suryawan Boby Wijaya Chanita Sari Manulang Chicy WIdya Morfi Chintya Mutiara Cindi Anggraeni Dalfian Dalfian David Tongon Silaen Desty Monica Ramadayanti Dhani Risandy Dilangga, Pad Dimas Rizki Oktavian Dinda Rachma Syarifah Dita Fitriani Djunishap, Asmia Dwi Marlina Efrida Warganegara Ekawati, Diyan Erumbia, lham Akbar Esteria Maharyuni Fadhillah Amanda Fahmi Fathul Rahman Faisal Yunus Farra Hayka Salsabilla Febianti Febianti Febri Anindita Suralaga Febriani Putri, Devita Febrianti Febrianti Febrihartati, Isura Festy Ladyani Mustofa Fitriani, Dita Fransisca Sinaga Fransisca Sinaga Fransisca Sinaga Fransisca Sinaga Fransisca TY Sinaga Fransisca TY Sinaga Friska Novira Maya Galang Kharisma Putra Gatot Sudiro Hendarto, Gatot Sudiro Ghina Gabrilla Yusuf Gusti Rizka Khairunnida Hafiratul Fitri Hanif, Muhammad Fikri Henri Setiawan Herdarto, Muhammad Junus Didiek Hermawan, Dessy Hidayat Hidayat Hidayat I Gusti Agung Ngurah Maha Yudha Ida Maya Meika Sari Indah Islalia Intan Putri Permata Hati Jordy Oktobiannobel Jordy Oktobiannobel Latief, Adhi Nugraha Lolita Putri Nanda Utami Lulu' Rifatunnissa Lutfi Indah Rahayu Mardheni Wulandari Maria Ulfa, Ade Megantara, Gilang Kukuh Messah, Anse Diana V Mia Esta Poetri Afdal Faisal Miftahul Jannah Gafar Mita Azzalia Morfi, Chicy Widia Muhammad Fikri Hanif Muhammad Nurly Nuha Naufal Muhammad Odis Nursyhabudin Nadya Febriani Nasruddin, Sigit Pratama Iustitia Naufal, Muhammad Nuriy Nuha Nia Triswanti Nina Herlina Nopi Sani Nuke Indrawati Nur Rahayu Permana Sari Nurlis Mahmud nurmalasari, yesi Nurul Halimah Nu’syadiyah Nurul Jannah Octa Reni Setiawati Okta Abriyanti Prasetia , Toni Primadiamanti, Annisa Purwaningrum, Ratna Putranta, Naufal Rafif Putri Lestari Rakhmi Rafie Rakhmi Rafie Rakhmi Rafie Ratna Purwaningrum Ratna Purwaningrum Redho Citra Cendana Rena Octavia Retno Ariza Retno Ariza S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soemarwoto Retno Ariza Soemarwoto Retno Ariza Soemarwoto Retno Ariza Soemarwoto Retno Ariza Soeprihatini Soemarwoto Retno Pinasrsih Reza Febriyantara Ricki Gustiawan Rina Kriswiastiny Risna Hidayanti Rita Agustina Rizki Putra Sanjaya Romi Yuansah Rossy Meliyana Salman Alfarisi Komara Sandayanti, Vira Saputra, Tetra Arya Shelfi Aprilia Ningsih Sinaga, Fransisca TY Soemarwoto, Retno Ariza S Soemarwoto, Retno Ariza S. Supriyati Supriyati Syafa’atun Malihah Syamsiatul Ma’rifah Syazili Mustofa Theng, Luther Toni Prasetia Trisia Dira Yuniar Tusy Triwahyuni Wisnu Galih Prayoga Wisnugroho, Cahyo Yessi Nurmalasari Yuliana Wildani Marek Yulistiawati, Novitri Zahra Shafa Anisa Zam Zanariah Ibrahim Zulfian Zulfian Zulfian Zulfian Zulfian