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Journal : Tropical Animal Science Journal

Molecular Identification, Chemical Composition, and In Vitro Anthelmintic Activity of Sargassum duplicatum Against Haemonchus contortus Sakti, A. A.; Kustantinah; Sofyan, A; Nurcahyo, R. W.; Fidriyanto, R.; Kusnadi, H.; Prasetyo, A.; Putnarubun, C.; Permadi, S.; Pramono; Hartati, L.; Hudaifa, I.; Suwignyo, B.
Tropical Animal Science Journal Vol. 47 No. 2 (2024): Tropical Animal Science Journal
Publisher : Faculty of Animal Science, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5398/tasj.2024.47.2.188

Abstract

The resistance of the Haemonchus contortus, a parasite causing severe anemia in ruminants, to commercial anthelmintics emphasizes the need for alternative bio-anthelmintics. This study aimed to identify the molecular, chemical composition, and in vitro anthelmintic activity of Sargassum duplicatum against H. contortus. Molecular identification employed the Chelex method, with DNA diversity and phylogeny assessed using maximum likelihood in IQ-tree. The analyzed chemical composition included proximate, total flavonoid, and total phenols. Adult worm motility test (AWMT) and egg hatch inhibiting test (EHIT) were conducted at concentrations of 2, 4, and 6 mg/mL of S. duplicatum ethanolic extract. AWMT followed a completely randomized factorial design (5 replications, each with 5 worms), while EHIT used a completely randomized one-way design (5 replications, each with H. contortus egg batches from 3 adult female worms). The cox1 gene sequence revealed the Sargassum sample as S. duplicatum (KP101270.1) with 99.83% similarity. The results indicated that the identified concentrations of S. duplicatum ethanolic extract, and the observation time significantly influenced motility and egg hatchability (p<0.05). Both factors exhibited a significant interaction (p<0.05). Concentrations of 4-6 mg/mL reduced worm motility by up to 50% (LD50) within 6-8 hours, while concentrations of 2-6 mg/mL inhibited egg hatchability by more than 87% during 24 hours of incubation. In conclusion, S. duplicatum holds significant potential as a bio-anthelmintic agent.
Co-Authors A Sofyan A. A. Sakti, A. A. Abdul Harits, Muhammad Abdul Rozzaq Agus Setiyono Ahmad Muzaqi, Safrizal Ahmad Samawi Akbar P, Hamzah Al Aufa, Ibaddurohman Alam, Gentar Alifia Lailatur Rahmi Alwi, Salma Amalia, Andi Nurul Andhini, Asmara Andrian Prasetyo, Yoga Anjarwati, Pipin Annestasya, Khatulistiwa Jihan Anwar, Irana Ardiyanto, Kevin Ardya Putra, Fendi Arif Budi Suryono Aryo Putra Prayoga, Ferdianto Asyhari, Rahayu Atmojo, Fattah Satrio Ayu Rachmawati, Diva Pramesti Aziz Herlambang, Muhammad B. Suwignyo, B. Badzlin, Safira Banjarsanti, SSN Banjarsanti, SSN. Basana Berlian Agustina, Anggun Brilliant Firdaus, Azkha Cahyo Nugroho, Nur Calvin Aditama Novrandika, Orlando Candra Permana, Aditya Choirul Ananda, Naufal Danu Warta, Muchalim Dayyana, Nimas Rokhmatik De Andrade Gusmao, Nelson Desi Eri Kusumaningrum Dhefilyn Wahyu Widia Arini Dhevira Ayu Ashandi Dia U, Ahmad Dita Mahameru Hidayati Mubayinna Dwi Hartanti Edo Eka Putra Emi Kuswanti Eny Nur Aisyah Evania Yafie Fahrunnisa Faradina, Adita Ayu Farid Faqih, Muhammad Farrel Putra Ediansyah Ferdinand Hafith, Daniel Fidriyanto, R. Firdausi Firdausi, Firdausi Galuh, Ajeng Gilang Pramudito, Vincensius Gilang Prasetya Adi Pradana Hafid Krisna Wahyu Wijaya, Muhammad Hari Putranto Hartati, L. Hudaifa, I. I Wayan Sutama Ibayasid Ibnu Ramadhan, Kemal Iftitah, Selfi Lailiyatul Ihza Yuzar Vianda, Rizqi Imanuel Munaiseche, Christian Imron Arifin Indasah Indra Gunawan Indra K, Yohanes Indriyani, Tiara Izzy Gian Anargia, David Jepriani, Sujiati Julizar, Muhammad Rizky Karminto Kartikasari, Amilia Khairuddin, Khairul Farhah Binti Khusnul Ain Kukuh Prihatin Kusnadi, H. Kustantinah Lestari, Sopia Ayu Maryamah, Elisa Maulana Akbar, Reza Maulana S, Ridlo Maulana Sabilla, Chafidz Meilani CA, Farida Afifah Mohammad Hidayat Muh. Arafik Muhamad Ichsan Hidayatullah Muhammad Majid Fadhillah muhammad rizky, muhammad Muhammad Syaifullah, Muhammad Muhammad Syarif, Muhammad Muhammad Yusuf Muhammad, Alfian Muhammad, Ma'ruf Nur Mulyawan, Rizky Rama Munaisra Tri Tirtaningsih Nabila Yudisha Nasha Nabila Maulidya Nibras Faiq Muhammad Nur Anisa Nur Hidayah Nur Rohman, Sofyan Nur Rohmani, Mayda Nurabadi, Ahmad Nurcahyo, R. W. Nurchim Nurchim Octavia Rahmawati, Anin Oktaviana Az Zahra, Erika Permadi, S. Prasetya T.W, Chandra Prasetyo, A. Prastyo, Danang Prayogo, Muhammad Fairuz Suryo Prihatin, Kukuh Putnarubun, C. Putra Ediansyah, Farrel Putra, Yudhitia Dian Putri, Sintya Tiara Raden Bambang Sumarsono Rado Andre Yusa Saka Tory, Alfa Radya Prameswari Putri Reihan Ferdian Utomo, Diva Reza Fauzi Rhafi Arsyan, Hafid Rhemadanu, Andreas Rida , Rizkha Ridho, Taufik Riyadsyah, Deprinico Rizqy Alfiansyah, Rafif Rosyi Damayani Twinsari Maningtyas Rosyidatun Nafi’ah Rudi Susanto Satria Yudha, Rafiq Satrio Atmojo, Fattah Setiawan, Gilar Setiawan, Hiskia Kus Seto Adi, Alfian Setyoko Sidik Prasetyo, Sidik SRI RAHAYU SUPRAYITNO Sutarno Teguh Triwiyanto Tumingan Ully Irma Maulina Hanafiah Umi Nurjanah, Umi Utari, Sindy Mey Dwi Utomo, Duwi Budi Vicka Devira Septhia WIJI LESTARI Wijiyanto Wuri Astuti Yoga Saputra, Muhammad Yuanita FD Sidabutar Yudith Dian Putra Yunardi, Riky Tri Zakharia, Ade Zidan, Rahmat