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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Kedokteran JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Penelitian Farmasi Indonesia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pengabdian Magister Pendidikan IPA GERVASI: Jurnal Pengabdian kepada Masyarakat Jurnal Abdi Insani Community Development Journal: Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Kefarmasian Indonesia
Nisa Isneni Hanifa
Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Preliminary In Vitro Antiplatelet Potential of Ipomoea pes-caprae from North Lombok with Adenosine Diphosphate-Induced Platelet Aggregation Ilsa Hunaifi; Dewi Suryani; Lalu Husnul Hidayat; Muhammad Naufal Farras Ananta; Muhammad Iqbal Farobbi; Nisa Isneni Hanifa; Raisya Hasina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.229-246

Abstract

Background: Cardiovascular diseases, particularly ischemic stroke, remain a global health burden, necessitating potential candidate for further antiplatelet with fewer side effects. Objectives: This study aimed to evaluate the antiplatelet potential of ethanolic extracts from the leaves and stems of Ipomoea pes-caprae (Katang-katang) from North Lombok, Indonesia, through ADP-induced platelet aggregation. Phytochemical screening, total tannin quantification, and in vitro antiplatelet assays were conducted. Methods: The leaves and stems were macerated with 96% ethanol, followed by qualitative phytochemical tests, Folin-Ciocalteu-based tannin analysis, and platelet aggregation inhibition assays using human platelet-rich plasma. Results: The extracts contained alkaloids, flavonoids, and tannins, with higher tannin levels in leaves (4.02 ± 0.02 mgEAT/g) than stems (3.67 ± 0.17 mgEAT/g). Concentration-dependent antiplatelet activity was observed, with leaf extracts showing inhibition (85.9% at 2000 μg/mL) compared to stems (79.5%) and aspirin (77.3%). IC₅₀ values were 727.78 μg/mL (leaves) and 349.95 μg/mL (stems). Statistical analysis confirmed significant differences across concentrations (p < 0.05). Conclusion: These findings demonstrate that Ipomoea pes-caprae exhibits potent antiplatelet activity, attributed to its tannin and phytochemical content, with leaves being more effective. Although these findings suggest preliminary antiplatelet potential, further analysis is required to validate the method using aspirin IC₅₀, and subsequent in vivo and pharmacological investigations are necessary before therapeutic application can be claimed.
Co-Authors Abdillah, Lalu Khairi Aini, Siti Rahmatul Alamanda, Baiq Irzana Putri Aliefman Hakim Amni Hamid Ananta, Muhammad Naufal Farras Angelina, Varelia Anggit Listyacahyani Sunarwidhi Annisa Nurrahman Arinda Eka Muliani Astri Ferdiana Azizah, Hidayatul Bayani, Faizul Candra Eka Puspitasari Dani Syaiful Akbar Dedianto Hidajat Dewi Suryani Dewi Suryani Dinatul Aini Dyke Gita Wirasisya Dyke Gita Wirasisya Dyke Gita Wirasisya Dyke Gita Wirasisya Farobbi, Muhammad Iqbal Febia Arien Lestari Febriyanto Febriyanto Fidrus Affandy Fitri Haryani Fitri Haryani Fradnya Vrianka Praharsini Hajrin, Wahida Halimatussakdiyah Halimatussakdiyah, Halimatussakdiyah Handa Muliasari Happy Elda Murdiana, Happy Elda Hasin, Raisya Hidayati, Agriana Rosmalina Hidayatul Ihsan I Komang Ary Werdhi Widnyana Ilsa Hunaifi Ilsa Hunaifi, Ilsa Iman Surya Pratama Indra Purnomo Istiqamah, Juhratul Istri Bartini Jannah, Syifaul Kania, Nadira Kartika Permatasari Khalil, Luthfi Riza Kurniasih Sukenti Kurniasih Sukenti Laksono Trisnantoro Lalu Husnul Hidayat Lestari, Febia Arien Luthfanto Hafizhuddin Mahacita Andanalusia Mahacita Andanalusia Monika Sofi Nandini Muhamad Haikhal Muhammad Iqbal Farobbi Muhammad Naufal Farras Ananta Mukhlishah, Neneng Rachmalia Izzatul Muliasari, Handa Muliasari, Handa Neneng Rachmalia Izzatul Mukhlishah Ni Made Amelia Ratnata Dewi Nikasius Jonet Sinangjoyo Nmar Dewi Novi Susianti Novisma, Mutia Nuralyza, Imasayu Nurul Istiqomah Ocktaviana Saputri, Legis Oktaviana, Siti Muhsonah Permatasari, Lina Permatasari, Ni Made Ayu Dinda Praditama, Lalu Denendra Pramudia, Cindy Prianggawe, Prianggawe Raisya Hasina Raisya Hasina Ramadhan, Muhammad Arif Ridwan, Sucilawaty Rizka Dwi Rahmitasari Rizkika, Adila Rosmalina, Agriana Septia Budi Utami Setiawan, Wahyu Aldi Siti Muhsonah Oktaviana Sugeng, Santoso Sulthon Annaji Sunarwidhi, Anggit Listyacahyani Surya Febrianto SUSANTI Susanti Susanti Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahyu Widyaningsih Wardani, Ray Haerul Windah Anugrah Subaidah Yayuk Andayani Yohanes Juliantoni Yosua Adi Kristariyanto Zulfiana Fitrianingrum Annas