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HUBUNGAN KADAR C-REACTIVE PROTEIN DENGAN DERAJAT KEPARAHAN PASIEN COVID-19 YANG DIRAWAT INAP DI RUMAH SAKIT Nuswantoro, Ari; Perdede, Lusi Hernawati; Aulia, Annisa Syafa; Aditia, Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 4 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i4.2026

Abstract

Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) can appear with a varied clinical spectrum, ranging from no symptoms, mild illness, moderate illness, to severe illness. The high mortality rate is closely related to the severity of the disease. One of the laboratory parameters that is thought to be related to the severity of COVID-19 is C-Reactive Protein (CRP). This study aimed to determine the relationship between CRP values and the severity of COVID-19 patients. This research has an analytical observational design with a cross-sectional approach. The samples were COVID-19 patients with moderate and severe symptoms who were hospitalized at RSUD dr. Soedarso West Kalimantan in January - December 2021. The sampling technique was total sampling to obtain medical record data which included CRP values and patient severity levels so that 49 data were obtained. The results showed that 8 respondents (16.3%) had CRP levels of 0.8 mg/dL, 24 respondents (49%) had CRP levels of 1.6 mg/dL, 9 respondents (18.4%) had CRP levels of 3 .2 mg/dL and 8 respondents (16.3%) had CRP levels of 6.4 mg/dL. Based on Kendall's tau-b statistical test, a significance value of 0.001 <0.05 was obtained, which means there is a significant relationship between CRP levels and severity. The correlation coefficient value of 0.708 shows a strong correlation coefficient between CRP levels and severity. This proves that the higher the CRP levels of COVID-19 patients found, the more severe the degree of disease that may be suffered by these patients, so there is a close relationship between CRP levels and the degree of disease of COVID-19 patients.
KORELASI JUMLAH MONOSIT DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA TUBERKULOSIS Nuswantoro, Ari; Astuti, Fitri Mega; Hartati, Fitri Ulya; Aditia, Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 3 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i3.2027

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is still a public health problem throughout the world, including in Indonesia. Monocytes play a role in cellular reactions against MTB bacteria and are considered a marker of active TB spread. C-Reactive Protein (CRP) examination is very useful for diagnosing inflammation or infectious diseases. This study aimed to determine the correlation between monocyte counts and CRP levels in TB patients in North Putussibau. This research was observational analytic with cross-sectional approach and the sampling technique was accidental nonprobability sampling. The sample was TB patients in North Putussibau who were undergoing treatment for 0, 2, and 6 months in 2022, resulting in 36 patients. Monocyte counts were examined using the fluorescence method and CRP levels were examined using the latex agglutination method. At 0 months of treatment, the monocyte count was obtained with an average of 1.096.88cells/µL and average CRP level of 55.13mg/L, at 2 months of treatment the average monocyte count was 742.31 cells/µL and CRP levels were obtained an average of 10.62mg/L, and after 6 months of treatment an average monocyte count was 414.29cells/µL and an average CRP level of 0mg/L. The Kendall's Tau-b test showed a significant value 0.000 (<0.05), which means there was a significant correlation between the number of monocytes and CRP levels in TB patients with a correlation coefficient 0.645 which shows the strength of  strong relationship. This shows that the decrease in the number of monocytes and CRP levels is in line with the length of the TB treatment period.
KORELASI ANTARA RASIO NEUTROFIL/LIMFOSIT DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA TUBERKULOSIS PARU Aufani, Destia; Azzahra, Larasabella; Supriyanto, Supriyanto; Fatayati, Imma; Nuswantoro, Ari
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 2 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i2.2089

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and can persist in all parts of the body. Laboratory tests used to determine the level of inflammation in TB sufferers include the neutrophil/lymphocyte ratio (RNL) and C-reactive protein (CRP) levels. The RNL value is the ratio of the absolute number of neutrophils and the absolute number of lymphocytes, while CRP is an acute phase protein produced in the liver, and its levels increase within 6 hours in acute inflammation. The aim of this study was to determine the relationship between RNL and CRP in pulmonary TB patients. This research was a descriptive study with a cross-sectional design carried out from April to June 2021 at the Lung Health Services Integrated Service Unit, West Kalimantan Province. The number of samples was determined using a purposive sampling technique, with the criteria being newly diagnosed TB patients who had positive BTA, positive TCM and positive X-ray results, resulting in 48 samples. CRP levels were measured using the latex agglutination method, while the number of neutrophils and lymphocytes used the impedance method. Analysis was carried out using the Shapiro-Wilk normality test and Kendall's tau b correlation test. Statistical analysis using the Kendall's tau b correlation test obtained a significant value of 0.000 (<0.05), which means there was a relationship between RNL and CRP levels in pulmonary TB patients with a correlation coefficient of 0.489, which means the relationship between the two variables is enough.
EDUKASI PENYAKIT TB PARU DAN SOSIALISASI PENGUMPULAN SAMPEL SPUTUM DIAGNOSIS TUBERCULOSIS Salim, Maulidiyah; Muhammad Ihsan, Bagus; Nuswantoro, Ari; Indrawati, Ratih; Jenny Ratnawati, Gervacia
MAJU : Indonesian Journal of Community Empowerment Vol. 2 No. 2 (2025): MAJU : Indonesian Journal of Community Empowerment, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/maju.v2i2.1075

Abstract

Tuberkulosis (TBC) adalah suatu penyakit menular yang disebabkan oleh kuman Mycobacterium tuberculosis. Kuman tersebut biasanya masuk kedalam tubuh manusia melalui udara pernapasan kedalam paru. Kemudian kuman tersebut dapat menyebar melalui udara pernapasan ke dalam paru, kemudian kuman tersebut dapat menyebar dari paru ke bagian tubuh lainya melalui sistem peredaran darah, sistem saluran limfa, melalui saluran pernapasan atau penyebaran langsung kebagian tubuh lainnya. Tuberkulosis masih merupakan masalah kesehatan masyarakat yang menjadi tantangan global. Secara global kasus baru tuberkulosis sebesar 6,4 juta. Setara dengan 64 % dari insiden tuberkulosis (10 juta). Tuberkulosis tetap menjadi 10 penyebab kematian tertinggi di dunia dan kematian tuberkulosis secara global diperkirakan 1,3 juta pasien. Pengabdian masyarakat ini bertujuan untuk upaya pencegahan dengan melakukan penyuluhan kepada masyarakat masih sangat jarang dilakukan, sementara lingkungan kehidupan para masyarakat berada dalam kelompok masyarakat dengan kepadatan hunian yang tinggi. Pencegahan penyakit dan promosi kesehatan tentang Tuberkulosis merupakan upaya esensial disaat masih tingginya kejadian penyakit menular juga di iringi dengan semakin tinggi masalah penyakit tidak menular. Metode pengabdian kepada masyarakat ini merujuk pada bagian tujuan diatas, Secara umum sasaran yang ingin dicapai dari kegiatan ini banyak melibatkan banyak pihak demi mencapai tujuan diatas. Kegiatan pengabdian ini akan fokus pada pemberian edukasi kepada masyarakat tentang upaya yang dapat dilakukan untuk mencegah penyakit tuberkulosis, cara penularannya serta cara pengambilan spesimen sputum dengan baik dan benar. Kegiatan yang sudah dilakukan adalah Edukasi Penyakit TBC serta Sosialisasi mengenai pengumpulan sampel sputum yang dilakukan di daerah binaan di Desa Rasau Jaya Kabupaten Kubu Raya, kegiatan pengabdian masyarakat ini dihadiri sekitar 35 orang dalam waktu kurang lebih 2 jam dimana pengabdian masyarakat ini dilakukan dalam bentuk penyuluhan dan diskusi tanya jawab.
ANTHOCYANIN-CONTAINING PLANT EXTRACTS AS AN ALTERNATIVE DYE FOR MICROSCOPIC EXAMINATION OF SOIL-TRANSMITTED HELMINTHS Ari Nuswantoro; Riska Alfianita; Fitra Fathuhudin; Veny Veny
Journal of Vocational Health Studies Vol. 8 No. 3 (2025): March 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V8.I3.2025.183-190

Abstract

Background: Eosin is commonly used for microscopic examination of Soil-Transmitted Helminth (STH) infections, but natural anthocyanin-based pigments remain underutilized. Purpose: This study evaluates the potential of anthocyanins extracted from red beans (Phaseolus vulgaris), hibiscus flowers (Hibiscus rosa-sinensis), and amaranth leaves (Amaranthus tricolor) as eosin alternatives for staining STH eggs in stool smears. Method: Extracts were obtained using 96% ethanol for 24, 48, and 72 hours, with nine replications. Stool preparations were stained with these extracts and compared to eosin, assessing color intensity, contrast, and egg layer clarity. Result: Red bean extracts scored 2.1, 2.7, and 2.8 at 24, 48, and 72 hours, with the latter two showing no significant difference from eosin. Hibiscus flower extracts scored 1.6, 2.2, and 2.8, with the 72 hours extract comparable to eosin. Amaranth leaf extracts scored 1.4, 1.7, and 1.9, all significantly different from eosin. Conclusion: Red bean extracts (48 and 72 hours) and hibiscus flower extract (72 hours) provided staining comparable to eosin, with red bean extract being the most promising alternative. These findings suggest that anthocyanin-based stains can serve as viable substitutes for eosin in diagnosing helminthiasis via stool smear microscopy.
The Effectiveness of Chocolate in Reducing the Number of Methicillin-Resistant Staphylococcus aureus Colonies in Rattus norvegicus Edy Suwandi; Ari Nuswantoro; Sugito Sugito; Desi Wahyumarniasari; Muhammad Reza Setiawan; Dinasti Aprillia; Devi Nurfitri Bintang
JURNAL INFO KESEHATAN Vol 19 No 2 (2021): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol19.Iss2.545

Abstract

Chocolate has long been understood to provide positive emotions and a good mood if consumed in moderation. Chocolate contains prebiotics naturally from its constituent ingredients produced during the production process. Prebiotics, frequently oligosaccharides, are substances which cannot be metabolized by the human digestive system but can be employed by a group of bacteria in the gut, understood as probiotics. The positive relationship among them provides benefits for the host in eliminating pathogens. One of the well-known pathogens which frequently cause infection either in the community or in hospitals is methicillin-resistant Staphylococcus aureus (MRSA). Since it was first identified in 1960, MRSA has caused health problems until today. Research conducted on two groups of Rattus norvegicus infected with MRSA and then fed chocolate revealed a decrease in the average number of bacterial colonies on the skin compared to the control group. In the group fed chocolate at a dose of 50 mg/day, the bacterial colonies decreased to 1.28 x 108 CFU/cm2 in 7 days, lower than in the control group (1.46 x 108 CFU/cm2) at the same time. While those fed 75 mg/day chocolate decreased to 2.70 x 107 CFU/cm2 and the three groups were significantly different (0.000<0.05). Prebiotics fermented by probiotics release short-chain fatty acids (SCFA), which compete with the pathogens for attaching to the epithelial wall so that pathogens lose space and nutrients to survive. However, the adverse effect of chocolate may occur because it contains sugar which is a nutrient for bacteria, but if the balance of normal flora and adequate intake of prebiotics are administered, the pathogen could be eliminated.
APPLICATION OF MUSA BALBISIANA LOTION AGAINST STAPHYLOCOCCUS AUREUS Rezky, Muhammad Andyka; Budhy, Theresia Indah; Nuswantoro, Ari; Tika, Dian; Adawiyah, Rabi’atul
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2818

Abstract

Staphylococcus aureus merupakan bakteri patogen yang dapat menyebabkan berbagai infeksi, terutama pada kulit, seperti bisul, impetigo, dan abses. Infeksi ini sering kali ditandai dengan peradangan, nekrosis, dan pembentukan nanah, yang secara signifikan dapat mengganggu fungsi kulit sebagai pelindung tubuh. Tantangan utama dalam pengelolaannya adalah meningkatnya resistensi antibiotik, termasuk Methicillin-Resistant Staphylococcus aureus (MRSA), sehingga diperlukan alternatif yang efektif, seperti bahan herbal, untuk mengatasi permasalahan ini. Kulit pisang kepok kuning yang sering berakhir sebagai limbah organik, diketahui mengandung senyawa aktif seperti flavonoid, alkaloid, saponin, tanin, dan antioksidan. Senyawa-senyawa tersebut memiliki aktivitas antibakteri yang signifikan, disertai dengan kemampuan melindungi kulit dari kerusakan akibat radikal bebas. Penelitian ini bertujuan untuk menjelaskan perbedaan efektivitas losion berbahan dasar ekstrak kulit pisang kepok kuning dengan tiga konsentrasi berbeda, yaitu formula I (30%), formula II (60%), dan formula III (90%) dalam menghambat pertumbuhan Staphylococcus aureus. Penelitian berbentuk quasi eksperimental desain ini menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa rata-rata diameter zona hambat formula I adalah 5,60 mm, formula II adalah 8,30 mm, dan formula III adalah 8,70 mm. Analisis statistik dengan uji Kruskal-Wallis menunjukkan nilai p = 0,004, yang mengindikasikan adanya perbedaan signifikan antar formula. Kesimpulannya, losion ekstrak kulit pisang kepok kuning menunjukkan efektivitas yang signifikan dalam menghambat pertumbuhan Staphylococcus aureus. Efektivitas ini meningkat secara proporsional dengan konsentrasi ekstrak, sehingga produk ini memiliki potensi untuk digunakan sebagai losion antibakteri.
Relationship between duration of treatment and urine protein in pulmonary tuberculosis patients Sadid, Randy; Salim, Maulidiyah; Nuswantoro, Ari; Yunus, Mohd
ELECTRON (Journal of Science and Technology) Vol. 7 No. 1 (2025): ELECTRON (Journal of Science and Technology)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/electron.v7i1.521

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. TB treatment is an efficient way to prevent the spread of the bacteria. The goals of TB treatment include curing, maintaining the patient's quality of life and productivity, preventing death from active TB or its sequelae, preventing relapse, reducing transmission to others, and preventing drug resistance. Most TB patients complete treatment without significant side effects, but a minority experience significant side effects. The duration of drug consumption can affect other organs such as the kidneys. Proteinuria is a condition in which there is protein in the urine beyond normal limits. The purpose of this study was to determine the relationship of length of treatment to urine protein in TB patients in Meliau District. This research method is analytical observational with a cross-sectional approach and consecutive sampling technique, with a total sample of 47 respondents. The results showed 10 respondents (21.27%) experienced proteinuria, while 37 respondents (78.73%) did not. Chi-Square analysis showed a relationship between length of treatment and urine protein in TB patients in Meliau District, as evidenced by a p-value of 0.015 (<0.05). In conclusion, there is a relationship between length of treatment and urine protein in TB patients in Meliau District.
Resistance Profile Antibiotics Pathogenic Bacteria from SWAB Wounds of Pontianak City Diabetes Treatment Clinic Patients azura, Azura; Sri Tumpuk; Ari Nuswantoro
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (DM) is a type of metabolic disorder where the sufferer has high blood sugar levels due to the body's failure to respond or produces insufficient amounts of insulin, or a metabolic disorder caused by hyperglycemia due to abnormalities in insulin secretion and insulin action or both. One of the complications of diabetes is ulcers, where a superficial infection occurs on the sufferer's skin and becomes a strategic location for bacterial growth. Most of the drugs that are widely used to inhibit or kill bacteria that cause infections in humans are antibiotics which carry the risk of drug resistance. Antibiotic resistance is a growing problem in many parts of the world. Antibiotic resistance can occur due to inappropriate or excessive use of antibiotics. This study aims to determine the susceptibility of pathogenic bacteria to several antimicrobial agents or antibiotics and to determine the percentage of antibiotic resistance in diabetes mellitus patients who experience complications, which will make it easier to choose the right antibiotic for healing. This research uses a descriptive method using samples of bacterial isolates which have been identified as 11 samples of Staphylococcus aureus bacterial isolates, 11 samples of Pseudomonas aeruginosa isolates and 39 samples of Klebsiella pneumoniae bacterial isolates. Antimicrobial susceptibility test (AST) disk diffusion method (Kirby & Bauer test) using Mueller Hinton media. With eight different types of antibiotics, this test was carried out to prove antimicrobial activity by measuring the diameter of the antimicrobial activity inhibition zone. Resistance test results were obtained in Staphylococcus aureus experiencing the highest resistance to the antibiotic Gentamycin (CN) at 63.63%, in Pseudomonas aeruginosa experiencing high resistance to the antibiotic Ampicillin (AMP) at 54.54%, and in Klebsiella pneumoniae experiencing the highest resistance. against the antibiotic Ampicillin (AMP) was 41.02%. Preventing antibiotic resistance in wound healing is very important to ensure antibiotics remain effective in treating infections. Therefore, this research was carried out in order to determine the correct type of antibiotic for healing wounds in diabetes mellitus sufferers.
Potensi Air Perasan Batang Bayam Merah (Amaranthus Tricolor L) Sebagai Alternatif Pewarnaan Telur Cacing Soil Transmitted Helminth Artanti, Lina Yunda; Sungkawa, Hendra Budi; Djohan, Herlinda; Nuswantoro, Ari; Alfianita, Riska
Innovative: Journal Of Social Science Research Vol. 4 No. 4 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i4.13043

Abstract

in the examination of worm eggs uses 2% eosin. However, eosin has shortcomings because it is not easily decomposed, so an alternative coloring that is more environmentally friendly is needed. Red spinach plants have the potential to be used as a natural dye because they contain anthocyanin compounds. This study aims to determine the potential of red spinach stem juice (amaranthus tricolor L) as an alternative to staining soil transmitted helminth eggs. Research design of quasi experiment with purposive sampling technique. Samples used red spinach stem juice (amaranthus tricolor L) in a ratio of 1:1, 1:2, 1:3, 1:4, and 1:5 by direct method and repeated 5 times. Based on the results of the research, the juice of red spinach stems in the ratio of 1:1 showed 60% results, the ratio of 1:2 showed 53% results, the ratio of 1:3 showed 53% results, the ratio of 1:4 showed 40% results and the ratio of 1:5 showed 40% results. The conclusion of this study is that the concentration of 1: 1 has the highest quality which is considered to have potential as an alternative coloring.
Co-Authors Adawiyah, Rabi’atul Aditia Aditia Aditia, Aditia Affifatuzahara Affifatuzahara Affifatuzahara, Affifatuzahara Al-qorifah, Fahma Ajeng Alfianita, Riska Anisya Nur Shafitri Anjelica, Benedikta Aprilia, Dinasti Ardhani, Adha Riesta Arifah, Rizki Zanuba Artanti, Lina Yunda Astuti, Fitri Mega Aufani, Destia Aulia, Annisa Syafa Azura, Azura Azzahra, Larasabella Bagus Muhammad Ihsan Benedikta Anjelica Berlianti, Jessica Ningtyas Desi Wahyumarniasari Devi Nurfitri Bintang Dinasti Aprillia Djohan, Herlinda Edi Santoso Emilda Sari Fadilla, Alda Nur Fahma Ajeng Al-qorifah Fahrani, Chantika Lailatussa'adah Fitra Fathuhudin Grovindo Grovindo Hartati, Fitri Ulya Hendra Budi Sungkawa, Hendra Budi Herlinda Djohan Ihsan, Bagus Muhammad Imma Fatayati Indah Purwaningsih Indah Purwaningsih Indrawati, Ratih Jordan, Aristo Juliana Cristyaningsih Kartini Kartini Laila Kamilla Laila Kamilla Linda Triana Linda Triana Liza Harum Nur Annisa Maretalinia Maretalinia Maretalinia, Maretalinia Maulidiyah Salim Merda Sri Rahayu Monalita, Ria Muhammad Ihsan, Bagus Munardi, Fhatia Natasya Natasya Intan Ramadhani Natasya Intan Ramadhani Nurhayati, Etiek Nurul Uq'ma P Purwanto Panyada Cholsakhon Perdede, Lusi Hernawati Pratiwi, Tarisya Fitri Rahayu, Merda Sri Ramadan, Aditiya Ratnawaty, Gervacia Jenny Ratulangi, Agus Dimas Reza Setiawan Reza, Nur Rezky, Muhammad Andyka Riska Alfianita Rizki Zanuba Arifah Rizki, Sri Yuniarti Romadi Romadi Sadid, Randy Samwidya, Veronika Sriayu Sen, Sharen Shafitri, Anisya Nur Slamet Slamet Sri Tumpuk Sugito Sugito Sugito Sugito Sutriswanto Sutriswanto Suwandi, Edy Syahdilla, Ade Syopingi Syopingi Syopingi, Syopingi Tantri Rahmatika Theresia Indah Budhy Sulisetyawati Tika, Dian Tumpuk, Sri Uq'ma, Nurul Veny Veny Wahdaniah Wahyudi Wicaksono, Didik Yunus, Mohd