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All Journal Majalah Kesehatan FKUB Journal Of Vocational Health Studies Klinikal Sains (Jurnal Analis Kesehatan) Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Ners MAHESA : Malahayati Health Student Journal Jurnal EduHealth JURNAL ILMIAH GLOBAL EDUCATION Innovative: Journal Of Social Science Research Jurnal Vokasi Kesehatan Jurnal Laboratorium Khatulistiwa Indonesian Journal of Community Empowerment Media Penelitian dan Pengembangan Kesehatan MEDICA (International Medical Scientific Journal) Jurnal Info Kesehatan ELECTRON (Journal of Science and Technology) Jurnal teknologi Kesehatan Borneo
Ari Nuswantoro
Departement Of Medical Laboratory Technology, Poltekkes Kemenkes Pontianak
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Potential of Methanol Extract of Bungli Fruit Seed (Oroxylum Indicum) in Inhibiting the Growth of Escherichia coli Ari Nuswantoro; Natasya Intan Ramadhani
Jurnal teknologi Kesehatan Borneo Vol 2 No 1 (2021): Jurnal Teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v2i1.29

Abstract

Bungli (Oroxylum indicum) has been used for generations in Asia as traditional medicine. The seeds of the bungli are commonly used as traditional medicine to treat typhoid, cough, hypertension, internal fever, fever and diarrhea. The active compounds in this plant are known to have anti-inflammatory, antirheumatic, antifungal and antibacterial activities. Our research on methanol extract of bungli fruit seeds showed its potential to inhibit the growth of Escherichia coli bacteria that causes diarrhea. Bungli seed extract samples with a concentration of 25% showed an inhibition zone with a diameter of 9.22 mm, while at a concentration of 50% the diameter was 11.16 mm and 75% had a diameter of 12.88 mm. This size is indeed smaller than chloramphenicol (26 mm), but this potential can be greater if the extraction is carried out more intensively to extract the active compound, the sample concentration is increased, and the part or age of the plant with the highest content of the active compound is used; so that the Bungli plant is expected to be an alternative in overcoming Escherichia coli infection.
Combination of Aloe Vera and Chocolate to Reduce The Number of The Colony of Staphylococcus Aureus Edy Suwandi; Ari Nuswantoro; Sugito Sugito
Jurnal teknologi Kesehatan Borneo Vol 3 No 2 (2022): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v3i2.197

Abstract

Aloe vera (AV) and chocolate are good examples of functional foods because they contain prebiotics that can help the host defend itself against harmful bacterial infections such as Staphylococcus aureus. Many studies have used AV or chocolate alone to help fight infection, but not much is known about using both together. This study aims to count the number of colonies of S. aureus infected on mice’s skin (Mus musculus) after being given AV and cocoa in certain doses per kilogram of body weight. A total of 35 healthy male mice were infected with S. aureus in the superficial area of ​​the nape of the skin. After that, they were divided into seven groups, each consisting of 5 mice, and given the following treatments: given 50 mg/kg BW AV (group A), 50 mg/kg BW brown (B), 50 mg/kg BW combination of AV and chocolate (C), given 75 mg/kg BW AV (D), given 75 mg/kg BW brown (E), given 75 mg/kg BW combination of AV and chocolate (F), and control (without prebiotic administration), K). Mice that were given 75 mg/kg BW AV/chocolate/AV+chocolate had a better ability to reduce the number of bacteria than those that were given 50 mg/kg BW AV/chocolate/AV+chocolate. In addition, rats that were given AV and chocolate together had a better ability to reduce the number of bacteria than those that were given either only AV or chocolate alone. Prebiotics are both found in AV and chocolate but with different substances. This causes mice given a combination of prebiotics to be considered better than those given only one type of prebiotic source.
Lipid Profile of Prolanis Patients in Pontianak City Ari Nuswantoro; Dinasti Aprillia; Juliana Cristyaningsih
Jurnal teknologi Kesehatan Borneo Vol 4 No 1 (2023): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v4i1.209

Abstract

Perubahan lingkungan, teknologi dan gaya hidup memicu naiknya kasus penyakit tidak menular, seperti diabetes melitus (DM) dan hipertensi (HT), yang bersifat kronis dan membawa risiko kematian terutama di negara berkembang seperti Indonesia. Dua penyakit tersebut dapat dideteksi dengan menilai profil lipid individu dimana kondisi dislipidemia dapat dianggap mengarah pada risiko terjadinya penyakit kardiovaskuler. Pemerintah Indonesia meluncurkan program Prolanis terhadap pasien DM dan HT yang salah satu kegiatannya adalah pemeriksaan profil lipid yang meliputi kadar kolesterol, trigliserida, HDL-kolesterol, dan LDL-kolesterol. Dari hasil pemeriksaan ini dapat dinilai rasio trigliserida terhadap HDL-kolesterol, yang merupakan prediktor paling kuat terhadap penyakit kardiovaskuler. Penelitian ini mengambil data pemeriksaan profil lipid dari 337 pasien Prolanis di Kota Pontianak. Hasil penelitian menunjukkan bahwa pasien DM didominasi oleh orang dengan hiperkolesterolemia (63,03%), trigliserida normal (56,36%), HDL-kolesterol normal (91,51%), LDL-kolesterol tinggi (83,03%), dan rasio trigliserida/HDL-kolesterol normal (60%). Demikian pula pada pasien HT, hiperkolesterolemia dan LDL-kolesterol tinggi dialami sebagian besar pasien (69,76 dan 84,30%), sedangkan trigliserida normal, HDL-kolesterol normal, dan rasio Trigliserida/HDL-kolesterol normal lebih mendominasi dengan persentase 61,61%, 94,19%, dan 68,03%. Hasil penelitian ini menunjukkan bahwa baik pasien DM maupun HT memiliki kecenderungan profil lipid yang normal dan menuju dislipidemia.
Predictors of Dengue Hemorrhagic Fever in the Pediatric Population: Logistic Regression Analysis of Hematological Profile and Demographics Nuswantoro, Ari; Ratulangi, Agus Dimas
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 14, No 1 (2026): EDITION MARCH 2026
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v14i1.8398

Abstract

Dengue Hemorrhagic Fever (DHF) remains a significant public health threat in Indonesia, particularly among the pediatric population. Early diagnosis is crucial for appropriate clinical management, and hematological parameters are routinely available indicators that may aid in predicting dengue infection. However, the independent predictive value of individual hematological parameters for NS1-confirmed dengue in children remains not fully characterized. This study aimed to identify independent predictors of NS1-positive dengue hemorrhagic fever in the pediatric population through logistic regression analysis of hematological profiles and demographic characteristics. A cross-sectional analytical study was conducted using secondary data from medical records of pediatric patients admitted to the pediatric ward of RSUD dr. Soedarso Pontianak between January and December 2023. A total of 203 patients who underwent NS1 antigen testing and complete hematological examinations were included. Data were analyzed using bivariate tests (independent t-test or Mann-Whitney U test) followed by binary logistic regression to identify independent predictors of NS1 positivity. Model performance was evaluated using Receiver Operating Characteristic (ROC) curve analysis. Bivariate analysis revealed that thrombocyte count was significantly lower in NS1-positive patients compared to NS1-negative patients. In multivariate logistic regression analysis, thrombocyte count emerged as a significant negative predictor of NS1 positivity, while erythrocyte count demonstrated a significant positive association. Hemoglobin, hematocrit, leukocyte count, age, and sex did not retain statistical significance in the final model. The combination of thrombocyte and erythrocyte counts yielded acceptable discriminative ability with an area under the ROC curve of 0.68. Thrombocyte count and erythrocyte count are independent predictors of NS1-positive dengue infection in pediatric patients. Low thrombocyte counts and elevated erythrocyte counts increase the likelihood of acute dengue infection and should be considered in diagnostic assessment, particularly in resource-limited settings where immediate NS1 testing may not be available.
Potential of Garlic Filtrate as An Alternative Anticoagulant for Whole Blood Samples Nuswantoro, Ari; Berlianti, Jessica Ningtyas
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.2683

Abstract

Synthetic anticoagulants such as heparin, citric, and ethylenediaminetetraacetic acid (EDTA) are commonly used to prevent blood clots. In contrast, its widespread use in clinical laboratories is still constrained by price, its toxic nature, and its short shelf life. Therefore, an alternative material that is relatively cheap, non-toxic, and easy to obtain and process in a ready-to-use form is needed. Garlic contains allicin and ajoene, which are anti-platelet and anti-thrombogenic. This study’s aim is to explore the potential of garlic filtrate as an alternative anticoagulant.  Blood from 16 individuals was used and separated into four groups: non-anticoagulant, 50 μL/mL garlic filtrate, 100 μL/mL garlic filtrate, and 150 μL/mL heparin, for a total of 64 treatments. The Lee and White method showed that non-anticoagulated blood had normal clotting times (mean 8 minutes and 56 seconds), whereas heparin plasma and garlic filtrate plasma had longer clotting times (more than 20 minutes); and this is statistically different based on the ANOVA test with a significance value (p) of 0.000 < 0.05. On spectrophotometric measurements, the levels of calcium ions in heparinized plasma and serum were 8.66 mg/dL and 8.52 mg/dL, respectively, while in garlic plasma filtrate of 50 μL/mL and 100 μL/mL were 4.13 mg/dL and 3.58 mg/dL, respectively; this is also statistically different based on the ANOVA test with a significance value of 0.000 < 0.05. The differences indicate that garlic filtrate can extend clotting time and reduce calcium ions therefore it is worth reviewing as an alternative anticoagulant.
PROFIL LIPID SEBAGAI PREDIKTOR DISFUNGSI GINJAL PADA PASIEN DIABETES MELITUS-HIPERTENSI: STUDI CROSS-SECTIONAL DI KOTA PONTIANAK Triana, Linda; Nuswantoro, Ari; Kamilla, Laila; Aprillia, Dinasti
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Disfungsi ginjal merupakan komplikasi serius yang sering terjadi pada pasien dengan diabetes melitus dan hipertensi (DM-HT). Beberapa penelitian menunjukkan hubungan antara profil lipid dengan gangguan fungsi ginjal, namun hasilnya masih belum konsisten dan data pada populasi Asia Tenggara masih terbatas. Penelitian ini bertujuan untuk menganalisis hubungan antara parameter lipid dengan penanda disfungsi ginjal pada pasien DM-HT di Kota Pontianak serta mengidentifikasi parameter lipid mana yang paling berpengaruh sebagai prediktor disfungsi ginjal. Penelitian observasional analitik dengan desain cross-sectional ini dilakukan di Unit Pelaksana Teknis Pusat Laboratorium Kesehatan Kota Pontianak selama periode Januari hingga Desember 2024. Sebanyak 469 pasien DM-HT yang tercatat sebagai peserta Prolanis dilibatkan dalam penelitian ini. Data yang dikumpulkan meliputi parameter lipid (kolesterol total, LDL, HDL, trigliserida) dan penanda fungsi ginjal (ureum, kreatinin, mikroalbuminuria). Analisis data dilakukan menggunakan uji korelasi Spearman’s rho untuk menilai hubungan antar variabel dan regresi logistik untuk mengidentifikasi prediktor dominan. Analisis korelasi menunjukkan hubungan negatif yang signifikan antara HDL dengan kreatinin (rho = -0,227; p < 0,001) dan mikroalbuminuria (rho = -0,183; p < 0,001). Hasil regresi logistik mengkonfirmasi bahwa HDL merupakan satu-satunya parameter lipid yang secara signifikan berhubungan dengan penurunan risiko peningkatan kreatinin (OR = 0,933; 95% CI = 0,884-0,978; p = 0,004). Tidak ditemukan hubungan signifikan antara parameter lipid lainnya dengan ureum maupun mikroalbuminuria (semua p > 0,05). HDL merupakan faktor protektif yang signifikan terhadap disfungsi ginjal pada pasien DM-HT di Kota Pontianak. Temuan ini mendukung pentingnya strategi peningkatan kadar HDL dalam tata laksana pasien DM-HT untuk pencegahan komplikasi ginjal. 
Co-Authors Adawiyah, Rabi’atul Aditia Aditia Aditia, Aditia Affifatuzahara Affifatuzahara Affifatuzahara, Affifatuzahara Al-qorifah, Fahma Ajeng Alfianita, Riska Anisya Nur Shafitri Anjelica, Benedikta Aprilia, Dinasti Ardhani, Adha Riesta Arifah, Rizki Zanuba Artanti, Lina Yunda Astuti, Fitri Mega Aufani, Destia Aulia, Annisa Syafa Azura, Azura Azzahra, Larasabella Bagus Muhammad Ihsan Benedikta Anjelica Berlianti, Jessica Ningtyas Desi Wahyumarniasari Devi Nurfitri Bintang Dinasti Aprillia Djohan, Herlinda Edi Santoso Emilda Sari Fadilla, Alda Nur Fahma Ajeng Al-qorifah Fahrani, Chantika Lailatussa'adah Fitra Fathuhudin Grovindo Grovindo Hartati, Fitri Ulya Hendra Budi Sungkawa, Hendra Budi Herlinda Djohan Ihsan, Bagus Muhammad Imma Fatayati Indah Purwaningsih Indah Purwaningsih Indrawati, Ratih Jordan, Aristo Juliana Cristyaningsih Kartini Kartini Laila Kamilla Laila Kamilla Linda Triana Linda Triana Liza Harum Nur Annisa Maretalinia Maretalinia Maretalinia, Maretalinia Maulidiyah Salim Merda Sri Rahayu Monalita, Ria Muhammad Ihsan, Bagus Munardi, Fhatia Natasya Natasya Intan Ramadhani Natasya Intan Ramadhani Nurhayati, Etiek Nurul Uq'ma P Purwanto Panyada Cholsakhon Perdede, Lusi Hernawati Pratiwi, Tarisya Fitri Rahayu, Merda Sri Ramadan, Aditiya Ratnawaty, Gervacia Jenny Ratulangi, Agus Dimas Reza Setiawan Reza, Nur Rezky, Muhammad Andyka Riska Alfianita Rizki Zanuba Arifah Rizki, Sri Yuniarti Romadi Romadi Sadid, Randy Samwidya, Veronika Sriayu Sen, Sharen Shafitri, Anisya Nur Slamet Slamet Sri Tumpuk Sugito Sugito Sugito Sugito Sutriswanto Sutriswanto Suwandi, Edy Syahdilla, Ade Syopingi Syopingi Syopingi, Syopingi Tantri Rahmatika Theresia Indah Budhy Sulisetyawati Tika, Dian Tumpuk, Sri Uq'ma, Nurul Veny Veny Wahdaniah Wahyudi Wicaksono, Didik Yunus, Mohd