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All Journal Majalah Kesehatan FKUB Journal Of Vocational Health Studies Klinikal Sains (Jurnal Analis Kesehatan) Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Ners MAHESA : Malahayati Health Student Journal Jurnal EduHealth JURNAL ILMIAH GLOBAL EDUCATION Innovative: Journal Of Social Science Research Jurnal Vokasi Kesehatan Jurnal Laboratorium Khatulistiwa Indonesian Journal of Community Empowerment Media Penelitian dan Pengembangan Kesehatan MEDICA (International Medical Scientific Journal) Jurnal Info Kesehatan ELECTRON (Journal of Science and Technology) Jurnal teknologi Kesehatan Borneo Laboratory Journal of Infectious Diseases
Ari Nuswantoro
Departement Of Medical Laboratory Technology, Poltekkes Kemenkes Pontianak
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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PROFIL LIPID SEBAGAI PREDIKTOR DISFUNGSI GINJAL PADA PASIEN DIABETES MELITUS-HIPERTENSI: STUDI CROSS-SECTIONAL DI KOTA PONTIANAK Triana, Linda; Nuswantoro, Ari; Kamilla, Laila; Aprillia, Dinasti
Majalah Kesehatan Vol. 13 No. 2 (2026): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2026.013.02.2

Abstract

Disfungsi ginjal merupakan komplikasi serius yang sering terjadi pada pasien dengan diabetes melitus dan hipertensi (DM-HT). Beberapa penelitian menunjukkan hubungan antara profil lipid dengan gangguan fungsi ginjal, namun hasilnya masih belum konsisten dan data pada populasi Asia Tenggara masih terbatas. Penelitian ini bertujuan untuk menganalisis hubungan antara parameter lipid dengan penanda disfungsi ginjal pada pasien DM-HT di Kota Pontianak serta mengidentifikasi parameter lipid mana yang paling berpengaruh sebagai prediktor disfungsi ginjal. Penelitian observasional analitik dengan desain cross-sectional ini dilakukan di Unit Pelaksana Teknis Pusat Laboratorium Kesehatan Kota Pontianak selama periode Januari hingga Desember 2024. Sebanyak 469 pasien DM-HT yang tercatat sebagai peserta Prolanis dilibatkan dalam penelitian ini. Data yang dikumpulkan meliputi parameter lipid (kolesterol total, LDL, HDL, trigliserida) dan penanda fungsi ginjal (ureum, kreatinin, mikroalbuminuria). Analisis data dilakukan menggunakan uji korelasi Spearman’s rho untuk menilai hubungan antar variabel dan regresi logistik untuk mengidentifikasi prediktor dominan. Analisis korelasi menunjukkan hubungan negatif yang signifikan antara HDL dengan kreatinin (rho = -0,227; p < 0,001) dan mikroalbuminuria (rho = -0,183; p < 0,001). Hasil regresi logistik mengkonfirmasi bahwa HDL merupakan satu-satunya parameter lipid yang secara signifikan berhubungan dengan penurunan risiko peningkatan kreatinin (OR = 0,933; 95% CI = 0,884-0,978; p = 0,004). Tidak ditemukan hubungan signifikan antara parameter lipid lainnya dengan ureum maupun mikroalbuminuria (semua p > 0,05). HDL merupakan faktor protektif yang signifikan terhadap disfungsi ginjal pada pasien DM-HT di Kota Pontianak. Temuan ini mendukung pentingnya strategi peningkatan kadar HDL dalam tata laksana pasien DM-HT untuk pencegahan komplikasi ginjal. 
Antimicrobial Activity of Endophytic Bacteria Isolated from the Roots of Avicennia marina (Forssk.) Against Escherichia coli Ari Nuswantoro; Diana Novita; Aditia Aditia
Laboratory Journal of Infectious Diseases Vol. 2 No. 1 (2026): Laboratory Journal of Infectious Diseases
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endophytic bacteria are beneficial microorganisms that interact with the host plant without causing damage. This study aimed to determine the antimicrobial activity of endophytic bacteria from the roots of Avicennia marina (Forssk.) against Escherichia coli. Samples were collected using a purposive sampling approach with 9 repetitions. Endophytic bacteria were isolated from root tissues and identified using Gram staining and biochemical tests (Simmons citrate, SIM, TSIA, methyl red, catalase, BAP, and MCA). The antimicrobial activity test used the disc diffusion method with a 100% concentration of endophytic bacterial suspension adjusted to 0,5 McFarland standard; ampicillin served as the positive control. Three bacterial isolates were obtained: Aeromonas sp., Enterobacter sp., and Bacillus sp. The average inhibition zones were 18,78 mm (Aeromonas sp.), 15,1 mm (Enterobacter sp.), and 16,66 mm (Bacillus sp.). Based on the standard for interpreting inhibition zones (≥20 mm = very strong; 10–20 mm = strong), all isolates demonstrated strong antibacterial potential. One-way ANOVA revealed a significant difference among the three isolates (p < 0,001), with Aeromonas sp. showing the highest activity. This study is novel in providing the first comparative evidence that Aeromonas sp. from Avicennia marina (Forssk.) roots exhibits superior antibacterial activity against Escherichia coli growth.
AKTIVITAS ANTIBAKTERI EKSTRAK DAUN KITOLOD (Isotoma longiflora) TERHADAP PERTUMBUHAN BAKTERI Streptococcus pyogenes Ari Nuswantoro; Kartini Kartini
Klinikal Sains : Jurnal Analis Kesehatan Vol. 11 No. 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3343

Abstract

Kitolod is a plant that is easy to grow in the tropics, including Indonesia. Kitolod leaves contain flavonoids, alkaloids, tannins, saponins and terpenoids that have the potential to be used as antibacterial agents to inhibit the growth of pathogenic bacteria such as Streptococcus pyogenes. This study aims to determine the antibacterial activity of kitolod leaf extract on the growth of Streptococcus pyogenes. This research is quasi-experimental with purposive sampling technique. Kitolod leaves were extracted by maceration method using ethanol then dissolved in 15% DMSO to obtain concentrations of 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, and 90%. Each concentration was replicated three times, and the control used the antibiotic bacitracin. After carrying out the antimicrobial sensitivity test using the Kirby-Bauer diffusion method, the results obtained were inhibition zones of 17.66 mm (sensitive), 18.16 mm (sensitive), 18.50 mm (sensitive), 19 mm (sensitive), 19. 83 mm (sensitive), 21.16 mm (sensitive), 21.83 mm (sensitive), 22.33 mm (sensitive), and 23.83 mm (sensitive) respectively, while the bacitracin control was 17.5 mm (sensitive). Thus, kitolod leaf extract proved to have antibacterial activity against the growth of Streptococcus pyogenes.
PERBEDAAN HASIL HITUNG BERBAGAI JENIS LEUKOSIT PADA PASIEN COVID-19 YANG ISOLASI MANDIRI DENGAN ISOLASI DI RSUD KABUPATEN MELAWI Nur Reza; Edi Santoso; Ari Nuswantoro; Ratih Indrawati; Etiek Nurhayati; Aditia Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 3 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i3.1886

Abstract

COVID-19 infection causes various clinical manifestations so the treatment method is also different for each individual. Patient isolation is one of the treatments to break the chain of transmission of COVID-19. Asymptomatic to moderate symptomatic patients are usually asked to self-isolate, while those with severe and critical symptoms are isolated in hospital. Leukocyte examination is an important parameter and plays a role in determining patient follow-up. The aim of this study was to find out whether there were differences in leukocyte differential-counts in COVID-19 patients who were self-isolating and those isolated at Melawi Regional Hospital. This study had a cross-sectional design by taking data from medical records of COVID-19 patients at Melawi Regional Hospital during October 2021 to July 2022. The data taken were from 399 COVID-19 patients, consisting of 182 patients are self-isolating and 217 patients are isolating at Melawi Regional Hospital. In self-isolated patients, the average value of leukocyte count was 7.04 x 10³ cells/µL, and the leukocyte differential-counts was neutrophils 58.45%, lymphocytes 21.81%, monocytes 13.84%, eosinophils 1.52%, and basophils 4.38%. In isolated patients at Melawi Regional Hospital, the average value of leukocyte count was 9.89 x 10³ cells/µL, and the leukocyte differential-counts was neutrophils 75.09%, lymphocytes 12.97%, monocytes 8.38%, eosinophils 0.46%, and basophils 3.11%. The Mann-Whitney U test obtained a significance value of 0.000 (p < 0.05), which means there is a significant difference in the results of leukocyte counts between self-isolated patients and those isolated at Melawi Regional Hospital.
KORELASI JUMLAH MONOSIT DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA TUBERKULOSIS Ari Nuswantoro; Fitri Mega Astuti; Fitri Ulya Hartati; Aditia Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 3 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i3.2027

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is still a public health problem throughout the world, including in Indonesia. Monocytes play a role in cellular reactions against MTB bacteria and are considered a marker of active TB spread. C-Reactive Protein (CRP) examination is very useful for diagnosing inflammation or infectious diseases. This study aimed to determine the correlation between monocyte counts and CRP levels in TB patients in North Putussibau. This research was observational analytic with cross-sectional approach and the sampling technique was accidental nonprobability sampling. The sample was TB patients in North Putussibau who were undergoing treatment for 0, 2, and 6 months in 2022, resulting in 36 patients. Monocyte counts were examined using the fluorescence method and CRP levels were examined using the latex agglutination method. At 0 months of treatment, the monocyte count was obtained with an average of 1.096.88cells/µL and average CRP level of 55.13mg/L, at 2 months of treatment the average monocyte count was 742.31 cells/µL and CRP levels were obtained an average of 10.62mg/L, and after 6 months of treatment an average monocyte count was 414.29cells/µL and an average CRP level of 0mg/L. The Kendall's Tau-b test showed a significant value 0.000 (<0.05), which means there was a significant correlation between the number of monocytes and CRP levels in TB patients with a correlation coefficient 0.645 which shows the strength of  strong relationship. This shows that the decrease in the number of monocytes and CRP levels is in line with the length of the TB treatment period.
Predictors of Dengue Hemorrhagic Fever in the Pediatric Population: Logistic Regression Analysis of Hematological Profile and Demographics Ari Nuswantoro; Agus Dimas Ratulangi
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 14, No 1 (2026): EDITION MARCH 2026
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v14i1.8398

Abstract

Dengue Hemorrhagic Fever (DHF) remains a significant public health threat in Indonesia, particularly among the pediatric population. Early diagnosis is crucial for appropriate clinical management, and hematological parameters are routinely available indicators that may aid in predicting dengue infection. However, the independent predictive value of individual hematological parameters for NS1-confirmed dengue in children remains not fully characterized. This study aimed to identify independent predictors of NS1-positive dengue hemorrhagic fever in the pediatric population through logistic regression analysis of hematological profiles and demographic characteristics. A cross-sectional analytical study was conducted using secondary data from medical records of pediatric patients admitted to the pediatric ward of RSUD dr. Soedarso Pontianak between January and December 2023. A total of 203 patients who underwent NS1 antigen testing and complete hematological examinations were included. Data were analyzed using bivariate tests (independent t-test or Mann-Whitney U test) followed by binary logistic regression to identify independent predictors of NS1 positivity. Model performance was evaluated using Receiver Operating Characteristic (ROC) curve analysis. Bivariate analysis revealed that thrombocyte count was significantly lower in NS1-positive patients compared to NS1-negative patients. In multivariate logistic regression analysis, thrombocyte count emerged as a significant negative predictor of NS1 positivity, while erythrocyte count demonstrated a significant positive association. Hemoglobin, hematocrit, leukocyte count, age, and sex did not retain statistical significance in the final model. The combination of thrombocyte and erythrocyte counts yielded acceptable discriminative ability with an area under the ROC curve of 0.68. Thrombocyte count and erythrocyte count are independent predictors of NS1-positive dengue infection in pediatric patients. Low thrombocyte counts and elevated erythrocyte counts increase the likelihood of acute dengue infection and should be considered in diagnostic assessment, particularly in resource-limited settings where immediate NS1 testing may not be available.
Potential of Garlic Filtrate as An Alternative Anticoagulant for Whole Blood Samples Ari Nuswantoro; Jessica Ningtyas Berlianti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.2683

Abstract

Synthetic anticoagulants such as heparin, citric, and ethylenediaminetetraacetic acid (EDTA) are commonly used to prevent blood clots. In contrast, its widespread use in clinical laboratories is still constrained by price, its toxic nature, and its short shelf life. Therefore, an alternative material that is relatively cheap, non-toxic, and easy to obtain and process in a ready-to-use form is needed. Garlic contains allicin and ajoene, which are anti-platelet and anti-thrombogenic. This study’s aim is to explore the potential of garlic filtrate as an alternative anticoagulant.  Blood from 16 individuals was used and separated into four groups: non-anticoagulant, 50 μL/mL garlic filtrate, 100 μL/mL garlic filtrate, and 150 μL/mL heparin, for a total of 64 treatments. The Lee and White method showed that non-anticoagulated blood had normal clotting times (mean 8 minutes and 56 seconds), whereas heparin plasma and garlic filtrate plasma had longer clotting times (more than 20 minutes); and this is statistically different based on the ANOVA test with a significance value (p) of 0.000 < 0.05. On spectrophotometric measurements, the levels of calcium ions in heparinized plasma and serum were 8.66 mg/dL and 8.52 mg/dL, respectively, while in garlic plasma filtrate of 50 μL/mL and 100 μL/mL were 4.13 mg/dL and 3.58 mg/dL, respectively; this is also statistically different based on the ANOVA test with a significance value of 0.000 < 0.05. The differences indicate that garlic filtrate can extend clotting time and reduce calcium ions therefore it is worth reviewing as an alternative anticoagulant.
Co-Authors Adawiyah, Rabi’atul Aditia Aditia Aditia, Aditia Affifatuzahara Affifatuzahara Affifatuzahara, Affifatuzahara Agus Dimas Ratulangi Al-qorifah, Fahma Ajeng Alfianita, Riska Anisya Nur Shafitri Anjelica, Benedikta Aprilia, Dinasti Ardhani, Adha Riesta Arifah, Rizki Zanuba Artanti, Lina Yunda Aufani, Destia Aulia, Annisa Syafa Azura, Azura Azzahra, Larasabella Bagus Muhammad Ihsan Benedikta Anjelica Desi Wahyumarniasari Devi Nurfitri Bintang Diana Novita Dinasti Aprillia Djohan, Herlinda Edi Santoso Emilda Sari Etiek Nurhayati Fadilla, Alda Nur Fahma Ajeng Al-qorifah Fahrani, Chantika Lailatussa'adah Fitra Fathuhudin Fitri Mega Astuti Fitri Ulya Hartati Grovindo Grovindo Hendra Budi Sungkawa, Hendra Budi Herlinda Djohan Ihsan, Bagus Muhammad Imma Fatayati Indah Purwaningsih Indah Purwaningsih Indrawati, Ratih Jessica Ningtyas Berlianti Jordan, Aristo Juliana Cristyaningsih Kartini Kartini Laila Kamilla Laila Kamilla Linda Triana Linda Triana Liza Harum Nur Annisa Maretalinia Maretalinia Maretalinia, Maretalinia Maulidiyah Salim Merda Sri Rahayu Monalita, Ria Muhammad Ihsan, Bagus Munardi, Fhatia Natasya Natasya Intan Ramadhani Natasya Intan Ramadhani Nur Reza Nurhayati, Etiek Nurul Uq'ma P Purwanto Panyada Cholsakhon Perdede, Lusi Hernawati Pratiwi, Tarisya Fitri Rahayu, Merda Sri Ramadan, Aditiya Ratnawaty, Gervacia Jenny Reza Setiawan Reza, Nur Rezky, Muhammad Andyka Riska Alfianita Rizki Zanuba Arifah Rizki, Sri Yuniarti Romadi Romadi Sadid, Randy Samwidya, Veronika Sriayu Sen, Sharen Shafitri, Anisya Nur Slamet Slamet Sri Tumpuk Sugito Sugito Sugito Sugito Sutriswanto Sutriswanto Suwandi, Edy Syahdilla, Ade Syopingi Syopingi Syopingi, Syopingi Tantri Rahmatika Theresia Indah Budhy Sulisetyawati Tika, Dian Tumpuk, Sri Uq'ma, Nurul Veny Veny Wahdaniah Wahyudi Wicaksono, Didik Yunus, Mohd