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All Journal Jurnal Ilmiah Farmasi Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Ilmu Kesehatan Jurnal Farmasi Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Societas : Jurnal Ilmu Administrasi dan Sosial Indonesian Journal of Global Health research Jurnal Health Sains Jurnal Mandala Pengabdian Masyarakat JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Open Access Indonesian Journal of Medical Reviews Jurnal Farmasi Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Jurnal Indonesia Sosial Sains Jurnal Indonesia Sehat (JURINSE) Journal of Health Management and Pharmacy Exploration (JOHMPE) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Indonesian Journal of Global Health Research
Tri Wijayanti
Fakultas Farmasi Universitas Setia Budi Surakarta, Jawa Tengah, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Effectiveness of extract and fraction of robusta coffee beans (coffea canephora) against streptozotosin-nicotinamide induced blood glucose levels of male white mice Risny Oklyan; Tri Wijayanti; Gunawan Pamudji Widodo
Journal of Health Management and Pharmacy Exploration Vol. 4 No. 1 (2026): February 2026
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v4i1.640

Abstract

Robusta coffee bean have compounds flavonoids, alkaloids, saponins and tannins. This compound has the benefit of being an antihyperglycemic which plays a role in inhibiting absorption glucose, preventing the formation of AGEs chains, and increasing the activity of antioxidant enzymes. This research aims to determine the effectiveness of the robusta coffee bean fraction which is effective in reducing blood glucose levels in STZ-NA induced mice. Research conducted is experimental research. Using 30 mice aged 2-3 months with a body weight of 18-25 g and grouped into 6 groups, that is group I negative streptozotocin 5.6 mg/kg weight and nicotinamide 15.4 mg/kg weight, group II positive control was given glibenclamide 0.65 mg/kg weight, Group III was given robusta coffee bean extract 400 mg/kg weight Group IV was given the n-hexane fraction of 42 mg/kg weight, group V was given the ethyl acetate fraction of 38 mg/kg weight, group VI was given the water fraction of 216 mg/kg weight. The data has been analyzed and after 21 days of observation it was found that the ethyl acetate fraction and robusta coffee bean extract decreased blood glucose levels the same as the decrease in blood glucose levels in the positive group test.
Co-Authors Afi Rahmat Slamet Ajeng Cahyarini, Hernita Aldita Cahyani Puspitasari Angga Adi Rahmawan Annisa Ratna Fadilla Purba Ayudia Cipta Khairani Bellatry Maharani Chandra Arifin Cholilah Cholilah Chynthia Iga Saputri Dapot Pardamean Saragih Desmana Mei Yuliyanti Desti Nuryani Sitompul Desti Nuryani Sitompul Deva Yolanda Dwi Nur Azizah Dewi Ekowati Dewi, Lucia Vita Inandha Eko Yudha Prasetyo Erlangga, Juan Erwin Nugraha Purnama Feriani, Pipit Fitri Melati Ganet Eko P Gunawan Firmansyah Gunawan Pamudji Widodo Gunawan Pamudji Widodo Ika Purwidyaningrum Imba, Farhan Inaratul Rizkhy Hanifah Inayati Inayati Ismi Maksalmina Isna Nur Khasanah Jason M. Peranginnangin Jason Merari Peranginangin Jeni Mistya Intan Awani Lukito Mindi Cahyo Maria Nona Adriana Lering Mohammad Febry Andintias Mohammad Febry Andintias Muchromin Muchromin Muhammad Aisy Akbar Firdaus Muhammad Farid Muhammad Mansur Narimo Narimo Nawang Wulan Nago Pitasari Nuraini Harmastuti Nurul Huda Oetari Oetari Opstaria saptarini Pramukantoro, Ganet Eko Priska Juanita Pakingki Putri Rinda Pratiwi RA. Oetari Ransta L. . Lekatompessy Risny Oklyan Rodhi Anshari Satibi Satibi Satibi, Satibi Sisca Latue Sofiah, Siti Asadu Sulanto Saleh Danu Supriyadi Supriyadi Talalab, Silvia Claudia Tri Murti Andayani Tri Murti Andayani Tri Nur Azizah Triyani Triyani Vivin Nopiyanti Wahyu Apriliany Wildayanti Wiwin Herdwiani Wiwin Herdwiani Yovi Pranata Yunilah Sukmadryani Zakiyyah Qurrotul 'Aini Zakiyyah Qurrotul ‘Aini Zorathea Benita