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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research Indonesian Journal of Global Health research International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO Jurnal Natural Molekul: Jurnal Ilmiah Kimia
Yuandani
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Evaluation of Antyhipercholesterolemic Effect of Allium cepa L. var cepa in Atherogenic Induced Rats Lumban Gaol, Nurahmi; Yuandani; Sitorus, Panal
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5381

Abstract

Fermented onion is a type of onion that produced by heating onion bulbs at high temperature for 15 days by fermenter machine. This research is expected to produce new alternatives therapy for reducing cholesterol from onions especially Allium cepa L. var cepa. In this experimental laboratory used 25 male white rats that divided into five groups, group I: negatif control, group II: positif control (Atorvastatin), group III: 100 mg/Kg body weight (bw) of fermented onion extact, group IV: 200 mg/Kg bw of fermented onion extract and group V: 300 mg/Kg bw of fermented onion extract. The Rats was feeding by an atherogenic diet to makes them hypercholesterolemia before treatment for 7th days, 14th days and 21st days. All of data were analyzed by ANOVA method (significant 0,05). The result concludes that of all the doses tested, fermented onion extract of Allium cepa L. var cepa with a dose of 200 mg/Kg bw has the highest effect in decreasing total cholesterol levels of hypercholesterolemia rats (Rattus novergicus).
Antibacterial Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Staphylococcus aureus and Escherichia coli Prayoga, Andre; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6169

Abstract

One of the medical needs whose demand continues to increase is wound dressings. The wound cover must also be non-toxic, non-allergenic, made of widely available biomaterials, and have antibacterial properties that can prevent infection of the wound. Chitosan is known to have wound healing activity by acting as a blood-clotting agent and stimulating the formation of new tissue, and silver nanoparticles have good antibacterial activity. Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles is 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0. Then the antibacterial activity was tested against Staphylococcus aureus and Escherichia coli to find the best formula for antibacterial activity. The analysis showed that the SNCCN patch with a ratio of 9:1 had the best antibacterial activity against Staphylococcus aureus (13.8±0.05 mm) and Escherichia coli (12.5±0.05 mm). It can be concluded that patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) have good antibacterial activity at a concentration of 9:1 in the category of strong inhibition (10-20 mm).
Teratogenic Toxicity of Ethanol Extract of Mahkota Dewa Fruit Flesh (Phaleria macrocarpa (Scheff.) Boerl) Julianti, Maelani; Yuandani; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8733

Abstract

Mahkota Dewa is known as one of the medicinal plants in Indonesia. It contains bioactive compounds and potentially has pharmacological activity. This study aimed to determine the possible toxic effects of Mahkota DewaThe ethanol extract of Mahkota Dewa fruit flesh was given to rats. Group I (control 0.5% Na-CMC), groups II, III and IV as a treatment group (Mahkota Dewa at doses of 100, 500 and 1000 mg/kg bw, respectively). Group V as a control satellite (Na-CMC 0, 5%) and group VI as a satellite of the ethanol extract at a dose of 1000 mg/kg bw., Each groups were treated on day 6 to 15 of gestational. On the 19th day getation, the rats were dissected and observed the skeletal malformations. The data were analyzed using one-way ANOVA followed by a post-hoc tukey. The results toxicity showed that no fetuses had external malformations. On fetal skeletal appearance, all skeletal bone preparations were normal. Based on the study, the ethanolic extract of Mahkota Dewa Fruit Flesh did not cause a teratogenic effect on the fetus during the organogenesis period at doses of 100 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw  
Uji Antibakteri Formula Liposom Minyak Atsiri Kulit Jeruk Kasturi (Citrus microcarpa) Dan Kulit Jeruk Lemon (Citrus limon) Gaol, Budianto Lumban; Yuandani, Yuandani; Wiraseptama, Abdi
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51551

Abstract

Komponen utama senyawa bioaktif dari minyak atsiri yang dihasilkan oleh kulit buah jeruk berupa senyawa d–limonene, -pinene, γ-terpinene, dan linalool diketahui memiliki aktivitas antibakteri dan antioksidan. Adanya keterbatasan minyak atsiri seperti kelarutan rendah dalam air, volatilitas tinggi dan ketidakstabilan terhadap oksidasi dan suhu dapat menghambat efektivitas minyak atsiri sehingga diperlukan sistem penghantaran yang dapat melindungi dan mengoptimalkan kinerja bioaktif dari minyak atsiri tersebut, salah satunya adalah liposom. Tujuan penelitian ini adalah untuk mengetahui ada tidaknya daya hambat terhadap bakteri Salmonella thypi dan Bacillus cereus dari formula liposom dengan bahan utama minyak atsiri yang diperoleh dari kulit jeruk kasturi dan lemon. Metode penelitian berupa metode eksperimental dengan tahapan pengambilan minyak atsiri dengan cara destilasi uap air, dilakukan uji karakteristik minyak atsiri dan dibuat dalam bentuk formula liposom dengan konsentrasi yang berbeda, kemudian dilakukan uji karakterisasi lipososm serta diuji daya hambat terhadap bakteri dengan metode difusi cakram. Hasil karakteristik minyak atsiri kulit buah jeruk kasturi dan lemon menghasilkan nilai bobot jenis sebesar 0,837 dan 0,842; nilai indeks bias yaitu 1,462 dan 1,470. Hasil karakteristik formula liposom memenuhi syarat liposom. Liposom minyak atsiri memiliki daya hambat terhadap pertumbuhan bakteri Salmonella thypi dan Bacillus cereus. Kata Kunci: Minyak Atsiri, Citrus microcarpa, Citrus limon, Liposom, Antibakteri.
Co-Authors . Marianne Abdi Wira Septama Abdi Wira Septama Amanda, Safina Audiva Aminah Dalimunthe Anggun Syafitri Anjelisa Z. Hsb, Poppy Damayanti Damayanti Dea Anggreini Denny Satria Denny Satria, Denny Dudut Tanjung Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony Febriady, Andy Gaol, Budianto Lumban Ginting, Junius Gian Halimah Raina Nasution Hari Purnomo Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Julianti, Maelani Khairunnisa, Nur Aini Lumban Gaol, Nurahmi Mardaliza, Silvia Marianne Marianne Muhammad Yunus Nasution, Halimah Raina Ningtias, Anggitha Popi Patilaya Prayoga, Andre Reza Destri Anggi Rezza Fikrih Utama Rosidah Rosnani Rosnani Simamora, Hengky Simanjuntak, Nerly Juli Pranita Siti Morin Sinaga Sitorus, Panal Sufitni Syukur Berkat Waruwu Tri Widyawati Urip Harahap Wira Septama, Abdi Wiraseptama, Abdi Wiryanto Ziza Putri Aisyia Fauzi