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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Majalah Kesehatan Pharmamedika Journal of Sylva Indonesiana Indonesian Journal of Pharmaceutical and Clinical Research Indonesian Journal of Global Health research International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO Jurnal Natural Molekul: Jurnal Ilmiah Kimia
Yuandani
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary

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The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats Syafitri, Anggun; Yuandani, Yuandani; Widyawati, Tri
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.758

Abstract

Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
Immunostimulant Effect Test Of Curcuminoid Extract From Turmeric Rhizome (Curcuma Domestica Val.) In VCO On Rats Induced Cyclophosphamide Againts An Increasing Total Leukocytes And Leukocyte Differential Damayanti, Damayanti; Yuandani, Yuandani; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.852

Abstract

Turmeric (Curcuma domestica Val.) is a traditional Indonesian plant that has many benefits. Curcuminoids are turmeric compounds known to have effects as immunomodulators and have been proven in several in vivo tests. Immunosuppressive drugs such as cyclophosphamide are widely given to improve clinical symptoms in autoimmune patients and cancer treatment which can cause susceptibility to infection.Therefore,this study aimed to determine the immunostimulating effect of curcuminoid extract from turmeric rhizome on cyclophosphamide-induced white rats. Proof of the immunostimulating effect of curcuminoid extracts was by testing the total leukocytes and leukocytesdifferential. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant.
Antibiofilm Formation Activities of Ethanol Extract of Curcuma domestica Val. Rhizome Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani; Abdi Wira Septama; Sony Eka Nugraha; Sufitni
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.883

Abstract

Abstract. Multidrug resistance is still a major health problem worldwide. Biofilm formation was related to the resistance of bacteria mechanism. Acinetobacter baumannii, one of the bacteria that cause nosocomial infections, is given particular attention due to its high prevalence of resistance. The current study address observing the antibacterial activity and antibiofilm formation activity of Curcuma domestica rhizome extract against multidrug-resistant Acinetobacter baumannii (MDR A.baumannii). Curcuma domestica rhizome was macerated by ethanol 96%. Determination of Minimum Inhibitory Concentration (MIC) was carried out by the microdilution method. Antibiofilm formation analysis was determined by standard quantitative using crystal violet-stained assay. Ethanol extract of C. domestica possesses antibacterial activity against MDR A. baumannii with MIC value 250 µg/mL. Additionally, the ethanol extract of C. domestica could inhibit the biofilm formation of MDR A.baumannii, thus percentage of biofilm formed only 23.7% and significance different with control after analyzed using ANOVA post hoc test Tukey. According to these results, ethanol extract of C. domestica revealed antibacterial activity and had the potency in suppressing the biofilm formation of MDR A.baumannii, thus could be utilized in clinical application, especially in MDR A.baumannii infection. Keywords: Antibiofilm, antibacterial, Curcuma domestica, multidrug-resistant, Acinetobacter baumannii
EDUKASI DAN PELATIHAN PEMBUATAN YOGHURT WORTEL SEBAGAI UPAYA PENINGKATAN EKONOMI DAN GIZI MASYARAKAT DI DESA RUMAH BERASTAGI Salim, Emil; Hanum, T. Ismanelly; Yuandani, Yuandani; Syahputra, Hafid; El Farhani Hasti Habibi Samosir, Fauziah; Try Nursylla, Rantyta; Pebrian Siregar, Jonathan; Tree Sabina, Fani; Fitri, Yulia; Glorya Sihaloho, Angelica; Hanna Magdalena Simangunsong, Irene; Kusuma Danny, Faustina; Naja Sakinah, Thara; Bangun, Herianto; Nabila, Nabila
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

Desa Rumah Berastagi berada di Kecamatan Berastagi, Kabupaten Karo, Sumatera Utara, Indonesia, merupakan desa dengan kekayaan alam berupa sayur dan buah yang melimpah. Dua komoditas tersebut sudah menjadi sumber penghidupan atau mata pencaharian bagi masyarakat sekitar sejak lama. Salah satu sayur yang melimpah tersebut adalah sayur wortel. Menurut Badan Pusat Statistik, produksi wortel di Sumatera Utara pada tahun 2023 sebesar 145,810 ton masuk kedalam kategori produksi besar dibandingkan provinsi lain. Produksi wortel yang melimpah menjadi permasalahan yang dihadapi Masyarakat Desa Rumah Berastagi karena kelebihan sisa panen sehingga tidak memiliki nilai jual sehingga perlu adanya inovasi agar bernilai ekonomi. Wortel merupakan sayur yang dapat dijadikan sebagai bahan inovasi salah satunya rasa yoghurt dengan manfaat dari kandungan yang dimilikinya antara lain vitamin A, vitamin C, E, B, beta karoten. Yoghurt merupakan salah satu bentuk fermentasi dari susu dengan bantuan bakteri yang memecah laktosa dari susu menjadi asam laktat. Selain itu, pembuatan yoghurt juga murah dan mudah. Tujuan kegiatan ini adalah meningkatkan aspek ekonomi dan aspek kesehatan masyarakat melalui edukasi manfaat yoghurt wortel dan pelatihan pada masyarakat dalam pembuatan inovasi yoghurt wortel.  Pemahaman masyarakat dinilai menggunakan pre-test dan post-test. Sebelum kegiatan pengabdian masyarakat dilaksanakan, tingkat pemahaman masyarakat pada uji pre-test adalah 88,57%, sedangkan setelah diberikan edukasi melalui penyampaian materi, pemutaran media visual, dan praktik langsung, tingkat pemahaman masyarakat pada uji post-test meningkat secara drastis menjadi 97,50%. Pengabdian masyarakat yang telah dilaksanakan ini telah menunjukkan bahwa masyarakat Desa Rumah Berastagi dapat memahami manfaat yoghurt dan mampu membuat yoghurt wortel dengan respon yang positif.
Phytoconstituents and Antioxidant Profiling of Avicennia marina (Forsk.) Vierh. Heartwood Extract Sourced from Bagan Kuala: A Novel Natural Source for Radical Scavenging Applications Reveny, Julia; Rahayu, Firdha Sekar; Yuandani
Journal of Sylva Indonesiana Vol. 9 No. 01 (2026): Journal of Sylva Indonesiana
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jsi.v9i01.20826

Abstract

Avicennia marina (Forssk.) Vierh., commonly known as 'api-api' or white mangroves, are woody shrubs and tropical plants that inhabit mangrove ecosystems, which occur at the interface between terrestrial and marine environments. Salinity is a critical environmental factor in mangrove habitats. Plants growing in such extreme conditions exhibit elevated concentrations of specific antioxidant compounds. Various parts of plants, including heartwood, are known to contain an abundance of extractive components compared to sapwood. Objective: This study was the first to evaluate the antioxidant activity of A. marina heartwood extract. Method: The applied method of sample extraction comprises ethanol-based maceration, qualitative phytochemical analysis based on observable visual changes, and the assessment of antioxidant activity employing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay using UV-Vis Spectrophotometry. Result: heartwood extract of Avicennia marina exhibits phytochemical constituents that comprise alkaloids, tannins, saponins, triterpenoids, and flavonoids. The antioxidant capacity of the extract showed strong antioxidant activity with an IC50 value of 61.50 µg/mL (R2 = 0,9962). Conclusion: The current study confirms the promising antioxidant activities of Avicennia marina heartwood sourced from Bagan Kuala. These marine biological resources can be explored further as an ailment for degenerative disease induced by Reactive Oxidative Stress (ROS), which can be made into an oral supplement or topical preparations, thus generating a greater economic value.
Co-Authors . Marianne Abdi Wira Septama Abdi Wira Septama Amanda, Safina Audiva Aminah Dalimunthe Anggreini, Dea Anjelisa Z. Hsb, Poppy BANGUN, HERIANTO Damayanti Damayanti Denny Satria, Denny Dudut Tanjung Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony El Farhani Hasti Habibi Samosir, Fauziah Emil Salim Febriady, Andy Ginting, Junius Gian Glorya Sihaloho, Angelica Hafid Syahputra Hanna Magdalena Simangunsong, Irene Hanum, Tengku Ismanelly HARI PURNOMO Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Julia Reveny Julianti, Maelani Khairunnisa, Nur Aini Kusuma Danny, Faustina Lumban Gaol, Nurahmi Mardaliza, Silvia Marianne Marianne Muhammad Yunus Nabila, Nabila Naja Sakinah, Thara Nasution, Halimah Raina Ningtias, Anggitha Pebrian Siregar, Jonathan Popi Patilaya Prayoga, Andre Rahayu, Firdha Sekar Reza Destri Anggi Rezza Fikrih Utama Rosidah Rosnani Rosnani Simamora, Hengky Simanjuntak, Nerly Juli Pranita Siti Morin Sinaga Sitorus, Panal Sufitni Syafitri, Anggun Syukur Berkat Waruwu Tree Sabina, Fani Tri Widyawati, Tri Try Nursylla, Rantyta Urip Harahap Wira Septama, Abdi Wiryanto Yulia Fitri Ziza Putri Aisyia Fauzi