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Yuandani
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Simanjuntak, Nerly Juli Pranita; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4303

Abstract

Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.
Immunomodulator Activity of Puguntano (Picria fel-terrae Lour.) Extract in White Male Mice By Carbon Clearance Method Rezza Fikrih Utama; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4306

Abstract

Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.
Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period Reza Destri Anggi; Yuandani; Dalimunthe, Aminah
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4311

Abstract

The purpose of the research was to evaluate the teratogenic effect caused by theprovision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml withpositive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. Themeasurement parameters in this study are the appearance of reproduction, externalmalformations and scalal malformations. The results in this study found that theadministration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /kg bb caused an abnormality in the reproductive appearance of weight loss and body length,whereas for extrenal malformation and scalal malforation no abnormalities were found ineach administration of the solution Arabica coffee and caffeine.  
Evaluation of Waiting Time for Outpatient Prescription Services at the Pharmacy Installation at the Universitas Sumatera Utara Hospital Muhammad Yunus; Wiryanto; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4430

Abstract

The pharmacy installation is one of the units in the hospital that provides. service products and services in the form of prescription services. Prescription service asthe front line of pharmacy services to patients must be managed properly becausethe quality of pharmaceutical prescription service which is generally associated with the speed ingiving service. This research is a descriptive type of research with prospective data collection from March-June 2019 to evaluate the waiting time for outpatient prescription services at the Hospital Pharmacy Installation of the Universitas Sumatera Utara. The data taken were 357 outpatient prescriptions.The results of this study indicate the total average length of time waiting for outpatients for the provision of non-fake drugs at the Pharmacy Installation of Outpatients at the University of Sumatera Utara Hospital at 09.00 - 11.00 is 29.10 minutes, at 11.00 - 13.00 is 34.44. minutes and at 13.00 - finished 42.60 minutes. The average length of waiting time for outpatients for the provision of compound drugs at the Outpatient Pharmacy Installation of the University of Sumatera Utara Hospital at 09.00 - 11.00 is 51.67 minutes, 11.00 - 13.00 hours is 62.27 minutes and at 13.00 - completion was 65.71 minutes. The waiting time for prescription services is ≤ 60 minutes.Based on the results of research conducted at the Outpatient Pharmacy Installation at the University of Sumatera Utara Hospital, non-concocted prescription drugs meet the requirements if the service time speed is ≤ 30 minutes and the concocted drug prescription fulfills the requirements if the service time speed is ≤ 60 minutes.
Poguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes Ningtias, Anggitha; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5378

Abstract

Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.
Evaluation of Antyhipercholesterolemic Effect of Allium cepa L. var cepa in Atherogenic Induced Rats Lumban Gaol, Nurahmi; Yuandani; Sitorus, Panal
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5381

Abstract

Fermented onion is a type of onion that produced by heating onion bulbs at high temperature for 15 days by fermenter machine. This research is expected to produce new alternatives therapy for reducing cholesterol from onions especially Allium cepa L. var cepa. In this experimental laboratory used 25 male white rats that divided into five groups, group I: negatif control, group II: positif control (Atorvastatin), group III: 100 mg/Kg body weight (bw) of fermented onion extact, group IV: 200 mg/Kg bw of fermented onion extract and group V: 300 mg/Kg bw of fermented onion extract. The Rats was feeding by an atherogenic diet to makes them hypercholesterolemia before treatment for 7th days, 14th days and 21st days. All of data were analyzed by ANOVA method (significant 0,05). The result concludes that of all the doses tested, fermented onion extract of Allium cepa L. var cepa with a dose of 200 mg/Kg bw has the highest effect in decreasing total cholesterol levels of hypercholesterolemia rats (Rattus novergicus).
Antibacterial Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Staphylococcus aureus and Escherichia coli Prayoga, Andre; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6169

Abstract

One of the medical needs whose demand continues to increase is wound dressings. The wound cover must also be non-toxic, non-allergenic, made of widely available biomaterials, and have antibacterial properties that can prevent infection of the wound. Chitosan is known to have wound healing activity by acting as a blood-clotting agent and stimulating the formation of new tissue, and silver nanoparticles have good antibacterial activity. Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles is 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0. Then the antibacterial activity was tested against Staphylococcus aureus and Escherichia coli to find the best formula for antibacterial activity. The analysis showed that the SNCCN patch with a ratio of 9:1 had the best antibacterial activity against Staphylococcus aureus (13.8±0.05 mm) and Escherichia coli (12.5±0.05 mm). It can be concluded that patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) have good antibacterial activity at a concentration of 9:1 in the category of strong inhibition (10-20 mm).
Teratogenic Toxicity of Ethanol Extract of Mahkota Dewa Fruit Flesh (Phaleria macrocarpa (Scheff.) Boerl) Julianti, Maelani; Yuandani; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8733

Abstract

Mahkota Dewa is known as one of the medicinal plants in Indonesia. It contains bioactive compounds and potentially has pharmacological activity. This study aimed to determine the possible toxic effects of Mahkota DewaThe ethanol extract of Mahkota Dewa fruit flesh was given to rats. Group I (control 0.5% Na-CMC), groups II, III and IV as a treatment group (Mahkota Dewa at doses of 100, 500 and 1000 mg/kg bw, respectively). Group V as a control satellite (Na-CMC 0, 5%) and group VI as a satellite of the ethanol extract at a dose of 1000 mg/kg bw., Each groups were treated on day 6 to 15 of gestational. On the 19th day getation, the rats were dissected and observed the skeletal malformations. The data were analyzed using one-way ANOVA followed by a post-hoc tukey. The results toxicity showed that no fetuses had external malformations. On fetal skeletal appearance, all skeletal bone preparations were normal. Based on the study, the ethanolic extract of Mahkota Dewa Fruit Flesh did not cause a teratogenic effect on the fetus during the organogenesis period at doses of 100 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw  
Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Putri Aisyia Fauzi, Ziza; Harahap, Urip; Yuandani, Yuandani; Berkat Waruwu, Syukur; Purnomo, Hari; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Isolation of Chitosan From Dogol Shrimp Skin (Parapenaeopsis sculptilis) Anggreini, Dea; Yuandani, Yuandani; Sinaga, Siti Morin
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.737

Abstract

In Indonesia, shrimp underwent a "cold storage" process where the heads, tails, and shells were discarded as waste. This shrimp waste could pollute the environment around the factory so it needed to be utilized. So far, shrimp shells had only been used as ingredients for making crackers, shrimp paste, and animal feed supplements. The remaining shrimp shells that had been separated were made into chitosan which was then subjected to characterization tests. The three steps of the chitosan isolation process were deproteinization, demineralization, and deacetylation. The analytical tests carried out were testing the water content, ash content, and functional groups contained in chitosan which were identified using the Fourier Transform Infra Red (FT-IR) Spectrophotometer. Based on the test results, there was a moisture content of 9.27% ??and an ash content of 1.69% in the chitosan samples made from shrimp shells. Functional groups of shrimp shell chitosan were identified using FT-IR characteristics. The -NH- group, which was represented by the N-H and O-H stretching groups, could be seen in the absorption band 1456.26 in the wave range 3000–30500. The conclusion of this study was that chitosan could be extracted from shrimp shells and meet the characterization criteria.
Co-Authors . Marianne Abdi Wira Septama Abdi Wira Septama Amanda, Safina Audiva Aminah Dalimunthe Anggreini, Dea Anjelisa Z. Hsb, Poppy BANGUN, HERIANTO Damayanti Damayanti Denny Satria, Denny Dudut Tanjung Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony El Farhani Hasti Habibi Samosir, Fauziah Emil Salim Febriady, Andy Ginting, Junius Gian Glorya Sihaloho, Angelica Hafid Syahputra Hanna Magdalena Simangunsong, Irene Hanum, Tengku Ismanelly HARI PURNOMO Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Julia Reveny Julianti, Maelani Khairunnisa, Nur Aini Kusuma Danny, Faustina Lumban Gaol, Nurahmi Mardaliza, Silvia Marianne Marianne Muhammad Yunus Nabila, Nabila Naja Sakinah, Thara Nasution, Halimah Raina Ningtias, Anggitha Pebrian Siregar, Jonathan Popi Patilaya Prayoga, Andre Rahayu, Firdha Sekar Reza Destri Anggi Rezza Fikrih Utama Rosidah Rosnani Rosnani Simamora, Hengky Simanjuntak, Nerly Juli Pranita Siti Morin Sinaga Sitorus, Panal Sufitni Syafitri, Anggun Syukur Berkat Waruwu Tree Sabina, Fani Tri Widyawati, Tri Try Nursylla, Rantyta Urip Harahap Wira Septama, Abdi Wiryanto Yulia Fitri Ziza Putri Aisyia Fauzi