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All Journal Jambura Journal of Health Sciences and Research Jurnal Prima Medika Sains Journal of Multidisciplinary Applied Natural Science Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Razoki, Razoki
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Pengaruh Tingkat Pengetahuan dan Tingkat Kepatuhan pada Pasien Tuberkulosis di Puskesmas PB Selayang II Kota Medan Arbita Huri; Erida Novriani; Razoki, Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2798

Abstract

Background: Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis.Mycobacterium species, including: M. tuberculosis, M. africanum, M. Bovis, M. Leprae are Acid Resistant Bacteria (BTA). in Indonesia TB reached 842,000 cases in 2018 with a mortality of 107,000 cases. With this data, Indonesia is the country with the third highest TB disease in the world. Objective: To determine the effect of Knowledge Level and Compliance Level on TB patients at PB Selayang II health center in Medan City. Methods: the study used quantitative, cross sectional research design approach. The sample in this study were 36 respondents who were willing to use purposive sampling technique, and data collection using a questionnaire. Research Results: the results of data processing on 21 respondents had a sufficient level of knowledge of 58.3% and as many as 27 respondents had a moderate level of compliance of 75.0%. In the Pearson Chi Square results p = 0.003 The results of the correlation analysis with the Chi-Square test can be interpreted that there is an influence between the level of knowledge and the level of compliance with taking medication for Tuberculosis Patients at the PB Selayang II Health Center, Medan City.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp.) Dengan Metode DPPH Wilson Kanggaran; Razoki, Razoki; Roy Indrianto Bangar Siagian; Hariyadi Dharmawan Syahputra
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2927

Abstract

Bay leaf (Syzygium polyanthum (Wight) Walp.) is known to contain phenolic and flavonoid compounds with potential as natural antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract of bay leaves using the DPPH method and to identify the bioactive compounds through phytochemical screening and simplicia characterization. Extraction was conducted using maceration with 80% ethanol as the solvent. Characterization result showed that the bay leaf simplicial met the standards of the Farmakope Herbal Indonesia. Phytochemical screening revealed positive results for alkaloids, flavonoids, saponins, tannins, and phenols. The antioxidant activity test showed that the ethanol extract of bay leaves had an IC50 value of 15,45 ppm, which falls into the very strong antioxidant category. These findings reinforce the potential of bay leaf as a natural antioxidant source that can be further developed in pharmaceutical and health applications.
Potensi Antioksidan dan Total Fenol Ekstrak Etanol Kunyit Putih dengan Metode DPPH-FRAP Sitorus, Christina Berliana; Razoki, Razoki; Syahputra, Hariyadi Dharmawan; Novriani, Erida
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 6 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i6.4301

Abstract

Stres oksidatif akibat radikal bebas beperan dalam patogenesis penyakit degeneratif, mendorong pemanfaatan antioksidan alami seperti kunyit putih yang kayak fenolik sebagai alternatif yang lebih aman dari sintetis. Penelitian ini mengevaluassi hubungan antara kandungan fenolik dan kapasitas antioksidan kunyit putih menggunakan metode DPPH dan FRAP. Aktivitas antioksidan dan kadar total fenol ekstrak etanol kunyit putih dianalisis menggunakan metode DPPH, FRAP, dan Folin-Ciocalteu. Ekstrak etanol kunyit putih mengandung total fenol 189,21 mg GAE/g dan menunjukkan aktivitas antioksidan sangat kuat dalam menangkal radikal bebas dengan nilai IC50 5,30 ppm (DPPH) dan 24,02 ppm (FRAP).
Identifikasi Drug Related Problems Terhadap Pasien Hipertensi Di Rumah Sakit Royal Prima Marelan Yohanes Dewantoro Situmorang; Razoki, Razoki; Novitaria Br Sembiring
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to assess Drug Related Problems (DRPs) in hypertensive patients hospitalized at Royal Prima Marelan General Hospital during the period January until June 2024. The study was conducted as a descriptive retrospective analysis on 33 patients using medical records and prescription data. The results showed that drug interactions were the most common DRPs (98,51%), with 64 cases classified as moderate severity, 37 as minor, and 12 as major. The most common interactions occurred with the combination of amlodipine and clopidogrel, while major interactions occurred with the combination of candesartan and spironolactone. Regular monitoring of potential drug interactions is crucial to support the safety and effectiveness of treatment.
Gambaran Penggunaan Obat Antibiotik dan Analgetik pada Resep Pasien Poli Gigi di RSUD Muyang Kute Razoki, Razoki; Elvi Sasmi; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.02

Abstract

Background: Dental and oral diseases often lead to infections and pain, thus requiring treatment with antibiotics and analgesics. These conditions, if not treated properly, can significantly impact patients' quality of life and may result in further complications. Objective: This study aims to provide an overview of the use of antibiotics and analgesics in prescriptions for dental clinic patients at RSUD Muyang Kute. Method: A descriptive retrospective study was conducted on 80 prescriptions from patients at the Dental Clinic in September 2024. The sampling technique used was random sampling. Results: The majority of patients were female (60%) and within the age range of 26–45 years (37.5%). The most frequently prescribed antibiotic was amoxicillin (92.5%), followed by a combination of amoxicillin and metronidazole (3.75%), lincomycin (2.5%), and cefadroxil (1.25%). The most commonly used analgesic was a combination of paracetamol and dexamethasone (97.5%), followed by mefenamic acid and dexamethasone (2.5%). Conclusion: Amoxicillin and the combination of paracetamol-dexamethasone were the preferred drugs due to their high effectiveness, safety, and relatively affordable cost.
Profil Pelayanan Resep dengan Obat Glibenklamid di Apotek Wilayah Nagan Raya Razoki, Razoki; Friska Rezki Hasibuan
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.04

Abstract

Background: Community pharmacies have shifted from focusing only on products to providing care centered on patients. Pharmacists now have the role of gathering patient information, giving proper counseling, and ensuring medicine labels are clear and correct. This is crucial for chronic diseases like type 2 diabetes mellitus, where drugs such as glibenclamide must be used properly to avoid risks. Objective: This study aimed to describe how pharmacies in Nagan Raya provide prescription services for glibenclamide, especially in terms of patient data collection, counseling, and labeling. Methods: A descriptive study was done using the simulated patient method. A total of 90 pharmacies were randomly chosen. The researcher acted as a patient’s family member and presented a prescription for glibenclamide. Observations were recorded right after each visit using a structured and validated checklist. Results: Of the 90 pharmacies visited, 85 (94.4%) dispensed the medicine. However, only 18.8% asked for the patient's address, and fewer than 10% asked about other key information like user identity or medication history. No pharmacy asked about symptoms, allergies, or comorbidities. For counseling, 64.7% mentioned how often to take the drug, 15.3% explained timing, and just 1.2% discussed side effects. Labels were provided in 65.9% of cases, but some were incomplete or used wrongly. Conclusion: The quality of prescription services for glibenclamide in Nagan Raya is still lacking. Important steps like patient assessment and counseling are often missed. Better training and stronger supervision are needed to improve pharmacy services and ensure patient safety
Profil Pelayanan Resep dengan Obat Glibenklamid di RSUD Muyang kute Bener Meriah Masriani; Razoki, Razoki; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.03

Abstract

Background: Optimal pharmaceutical services are essential in chronic disease management, particularly in diabetes mellitus, where glibenclamide is frequently prescribed. Inadequate dispensing practices and lack of patient information can compromise treatment outcomes. Objective: This study aimed to evaluate the profile of prescription services involving glibenclamide at RSUD Muyang Kute Bener Meriah, focusing on drug availability, patient information gathering, medication counseling, and labeling practices. Methods: A descriptive observational design was applied using the simulated patient method. Researchers visited the pharmacy unit with a standardized prescription scenario involving glibenclamide. Data were collected using an observation checklist immediately after each interaction. Results:The majority of pharmacy staff did not actively collect essential patient information. Counseling was limited to usage instructions, with no mention of adverse effects or drug interactions. Labels were incomplete, often missing key components such as patient name, drug name, or preparation date. However, the availability of glibenclamide remained consistent during the observation period. Conclusion: Prescription services for glibenclamide at RSUD Muyang Kute are still below optimal standards. Improvements in patient assessment, communication, and labeling practices are necessary to enhance medication safety and treatment effectiveness
Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Hotvera Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Abstract

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.
Review Article: Pharmacological Activities and Bioactive Potential of Chinese Betel Leaf (Peperomia pellucida L. (Kunth.)) Razoki, Razoki; Lister, INE; Mutia, Maya Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1000

Abstract

Background: Peperomia pellucida L. Kunth (sirih cina) is a traditional medicinal plant used to treat various ailments. Its broad pharmacological potential needs to be consolidated from various publications to provide a comprehensive overview. Objective: This review aims to analyze and synthesize recent scientific evidence on the pharmacological activities, bioactive compounds, and potential applications of Pperomia pellucida. Methods: This systematic review was conducted by searching electronic databases (Google Scholar, PubMed, ScienceDirect, Scopus) using relevant keywords. From the search results, 21 original research articles published between 2015-2025 that met the inclusion criteria were analyzed descriptively and qualitatively. Results: The analysis revealed that Peperomia pellucida possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, antifungal, antioxidant, anticancer, antidiabetic, antihypercholesterolemic, and osteogenic effects. These activities are supported by bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. Its ethanolic extract has proven effective in in vitro and in vivo tests, including in topical formulations like creams and acne serums. Preliminary safety profiles indicate non-toxic properties. Conclusion: Peperomia pellucida shows great potential as a natural raw material for developing herbal medicines and cosmetics. Further research, such as human clinical trials and the development of technology-based formulations, is necessary to ensure its long-term safety and efficacy.
Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v1i2.2689

Abstract

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.
Co-Authors Adek Amansyah Ana Fiske Hotmaida Simanjuntak Arbita Huri Astriani Natalia Br Ginting Bengimiate, Nuriza Binarwan Halim br. Sembiring, Novitaria br. Silalahi, Aancel Budi, Andre Chiuman, Linda Edlin, Edlin Elvi Sasmi Erida Novriani Fioni Fioni Fioni, Fioni Friska Rezki Hasibuan Ginting, Astriani Natalia Br Ginting, Chrismis Novalinda Hanjaya, Hanjaya Harahap, Halimah Hariyadi Dharmawan Syahputra Hartopo, Haqi Hotvera Merianis, Hotvera Hutauruk, Rico Halim Iksen, Iksen Lister, INE Lubis, Zahra Khairunnisa Manao, Merlianasari Masriani . Merianis, Hotvera Meutia, Rena Mutia, Maya Sari Nardi, Leo Nasution, Chairul Radjab Nerly Juli Pranita Simanjuntak Neswita, Elfia Novita, Cut Elvira Novitaria Br Sembiring Novriani, Erida Ongko, Nicolas Xavier Piska, Finna Reh Malem br Karo Roy Indrianto Bangar Siagian Salsabila, Dinda Ayu Samin, Buter Septia, Evianti Dwi Simanjuntak, Nerly Juli Pranita Sinaga, Ade Putra Fratama Sitorus, Christina Berliana Soekardi, Adi Syahputra, Hariyadi Dharmawan Tanjung, Fahrul Azmi Tarigan, Antje Irmella Tarigan, Susiani Vera Estefania Kaban Wijaya, Johanna Fransiska Wilson Kanggaran Yohanes Dewantoro Situmorang