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All Journal Jambura Journal of Health Sciences and Research Jurnal Prima Medika Sains Journal of Multidisciplinary Applied Natural Science JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Jurnal Multidisiplin Sahombu Ranah Research : Journal of Multidisciplinary Research and Development Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Razoki, Razoki
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Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

Abstract

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.
The impact of white turmeric rhizome extract on the histopathological characteristics of the pancreas in male wistar rats with diabetes Lubis, Zahra Khairunnisa; Ongko, Nicolas Xavier; Soekardi, Adi; Razoki, Razoki
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6407

Abstract

This study investigates the potential of white turmeric (Curcuma zedoaria Rosc.) rhizome extract as a cost-effective treatment for managing diabetes, focusing on its impact on pancreatic histopathology and blood glucose levels in diabetic Wistar rats. The research employed a randomized pre-test and post-test control group design, with rats induced with alloxan to simulate diabetes. The treatment groups received varying doses of white turmeric extract (250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW) for 14 days. Histopathological analysis of the pancreas revealed that the white turmeric extract groups showed no signs of edema, inflammation, or necrosis, indicating a protective effect. Blood glucose level measurements demonstrated that the 500 mg/kg BW dose exhibited the most optimal results in lowering blood glucose levels. Statistical analysis using ANOVA and Kruskal-Wallis tests indicated significant differences between groups. These findings suggest that white turmeric extract, particularly at a dosage of 500 mg/kg BW, holds promise as a complementary treatment for managing diabetes by improving pancreatic health and reducing blood glucose levels. Further research is warranted to explore the underlying mechanisms and optimize its application.
An evaluation of patient satisfaction with pharmaceutical services at Munyang Kute Regional General Hospital Bengimiate, Nuriza; Hartopo, Haqi; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7173

Abstract

Patient satisfaction is a crucial indicator for assessing hospital service quality, in which pharmaceutical services play a vital role as a primary point of contact with patients. This study aimed to comprehensively evaluate the satisfaction level of outpatients with the pharmaceutical services at Munyang Kute Regional General Hospital. This research employed a descriptive quantitative design with a cross-sectional approach. A total of 90 respondents were selected through a purposive sampling technique based on predetermined criteria. The research instrument was an adapted questionnaire designed to measure satisfaction across five dimensions of service quality: tangibles, reliability, responsiveness, assurance, and empathy. The collected data were analyzed descriptively using SPSS software. The findings indicated that patients were generally satisfied with the pharmaceutical services they received. The highest level of satisfaction was observed in the responsiveness dimension, with a percentage of 69.72%. The other dimensions, in descending order, were tangibles (32.21%), empathy (27.19%), assurance (19.60%), and the lowest was the reliability dimension (16.00%). Overall, the patient perception of pharmaceutical services at Munyang Kute Regional General Hospital is positive. Nevertheless, there remains room for improvement, particularly in the reliability and assurance dimensions. Continuous quality improvement through enhanced patient education and optimization of facilities is highly recommended.
Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Abstract

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.
Pengaruh Kombinasi Ekstrak Etanol Bawang Putih dan Kunyit terhadap Histopatologi Jantung dan Pankreas Tikus Diabetes Ana Fiske Hotmaida Simanjuntak; Nerly Juli Pranita Simanjuntak; Razoki, Razoki
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6703

Abstract

Diabetes mellitus (DM) is a chronic condition characterized by increased blood glucose levels that require long-term treatment to maintain stable blood sugar levels. Garlic and turmeric rhizomes are known to contain secondary metabolite compounds that have the potential to lower blood glucose levels. This study aims to see how the combination of garlic and turmeric rhizome extracts affects the histopathological picture of the pancreas of male white rats (DM). This study uses an experimental design method with a designposttest only control group involving 30 white male rats divided into five groups: Negative control (K-), positive control (K+), and three treatment groups with extract doses of 100mg/kgBW (F1), 200mg/kgBW (F2), and 300mg/kgBW (F3). The results showed the most significant decrease in blood glucose levels in the 300mg/kgBW group (F3), namely (105mg/kgBW). The histopathological picture of the pancreas showed severe damage in group F1 (75% had necrosis), and moderate damage (50% with necrosis) in F2 and F3. The combination of garlic extract and turmeric rhizome has the potential to reduce blood glucose levels and improve the histopathological picture of the pancreas in DM rats.
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA FRAKSI AKTIF EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum) DAN EKSTRAK IKAN GABUS (Channa striata) PADA TIKUS Salsabila, Dinda Ayu; Razoki, Razoki; Mutia, Maya Sari
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.25985

Abstract

Senyawa flavonoid dan tanin pada daun salam serta protein pada ikan gabus dapat membantu menurunkan kadar gula darah. Kebaruan  penelitian ini adalah kombinasi komponen alami dari tumbuhan (daun salam) dan hewan (gabus) sebagai agen antihiperglikemik. Tujuan penelitian ini adalah untuk mengetahui efektivitas fraksi aktif ekstrak etanol daun salam (FAEEDS) dan ekstrak ikan gabus (EIG) dalam menurunkan KGD pada tikus yang diberi glukosa 40% secara oral. Penelitian menggunakan 30 ekor tikus yang dibagi menjadi enam kelompok perlakuan. Kelompok 1 mendapat akuades, kelompok 2 mendapat FAEEDS 250 mg/kg bb, kelompok 3 mendapat EIG 250 mg/kg bb, dan kelompok 4 mendapat FAEEDS 250 mg/kg bb dan EIG 250 mg/kg bb, kelompok 5 mendapat FAEEDS 500 mg/kg dan EIG 250 mg/kg bb, kelompok 6 mendapat FAEEDS 750 mg/kg bb dan EIG 250 mg/kg bb. Sebelum pengobatan, tikus diberi dosis oral glukosa 40%. Hasil penelitian yang dilakukan menunjukkan bahwa FAEEDS dan EIG mampu menurunkan kadar gula darah pada tikus. Tingkat persentase pengurangan setelah 120 menit adalah ↑18,81%, ↓68,18%, ↓57,00%, ↓71,07%, ↓71,33%, dan ↓70,14% pada kelompok perlakuan. Dari persentase tersebut dapat disimpulkan bahwa kelompok 5 merupakan dosis optimal untuk menurunkan KGD pada tikus. 
UJI AKTIVITAS ANTIOKSIDAN DARI FRAKSI ETIL ASETAT EKSTRAK METANOL DAUN KERAI PAYUNG (Filicium decipiens) Manao, Merlianasari; Karo, Reh Malem Br; Razoki, Razoki
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.26222

Abstract

Indonesia memiliki banyak jenis tumbuhan yang dapat digunakan sebagai bahan obat. Kerai payung (Filicium decipiens) adalah salah satu tanaman yang berpotensi sebagai tanaman obat karena mengandung senyawa kimia seperti alkaloid, tanin, steroid, flavonoid, terpenoid dan saponin yang berfungsi sebagai antioksidan. Tanaman ini dapat digunakan dalam berbagai bidang, seperti Kesehatan, lingkungan, pertanian dan industri makanan. Kebaruan dalam penelitian ini adalah menguji aktivitas antioksidan dari fraksi etil asetat ekstrak metanol daun kerai payung karena penelitian terdahulu masih sebatas meneliti uji antibakteri pada sampel yang sama. Tujuan penelitian adalah untuk melakukan Uji aktivitas antioksidan  di dalam fraksi etil asetat ekstrak metanol daun kerai payung. Penelitian ini menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil) dengan alat spektrofotometer UV-Vis (Ultraviolet-Visible) pada panjang gelombang 515 nm dan vitamin C sebagai pembanding. Hasil penelitian menunjukkan bahwa Aktivitas antioksidan dapat ditentukan dengan menghitung Nilai ICâ‚…â‚€. Nilai IC50 fraksi etil asetat ekstrak metanol daun kerai payung adalah 19.97 ppm sedangkan nilai ICâ‚…â‚€. Vitamin C sebagai pembanding adalah 3,19 ppm. Kesimpulan bahwa fraksi etil asetat ekstrak metanol daun kerai payung memiliki aktivitas antioksidan sangat kuat.
Evaluation of Microencapsulated Preparation Formulation of Ethanol Extract of Moringa Leaves (Moringa Oleifera) Nazla Deswita Siregar; Razoki, Razoki; Refi Ikhtiari
Jurnal Multidisiplin Sahombu Vol. 6 No. 01 (2026): Jurnal Multidisiplin Sahombu, January 2026
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia has abundant natural resources, one of which is the moringa plant (Moringa oleifera), known as “The Miracle Tree” due to its high nutritional content and pharmacological properties as an antioxidant, antimicrobial, and anti-inflammatory agent. This study aims to formulate ethanol extract of moringa leaves into microencapsulated preparations to improve the stability of active compounds and protect the active ingredients from stomach acid. The extract was obtained through maceration using 96% ethanol solvent with a yield of 24.42%. The characterization of the crude drug met the Indonesian Herbal Pharmacopoeia standards, and phytochemical screening showed the presence of alkaloids, flavonoids, triterpenoids, steroids, and tannins. The microencapsulation formulation was made using a combination of sodium alginate polymer and chitosan coating with CaCl2 hardening agent in four different extract concentrations. The evaluation of the preparations included stability testing (cycling test), moisture content testing, and buoyancy testing (floating). The stability test results showed that the preparation remained organoleptically stable without significant physical changes during 6 cycles. All formulas met the <5% moisture content requirement, with the 0.75% concentration formula (F4) having the lowest moisture content of 0.26%. In the adhesion test using rat gastric mucosa, the preparation showed good mucoadhesive ability, where the interaction of chitosan in an acidic environment prolonged the retention time of the microcapsules in the stomach. This study concluded that microencapsulation of moringa leaf extract has great potential as a stable and effective drug delivery system.
Antibacterial activity of dali ni horbo protein extract modified with citrus and pineapple juice Tesa, Catrin Angelica Putri; Razoki, Razoki; Piska, Finna
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7889

Abstract

Background: The global rise in antibiotic resistance highlights the urgent need to identify novel, natural antimicrobial agents. Fermented dairy products represent potential sources of bioactive peptides with inherent antibacterial properties. Dali ni horbo is a traditional fermented buffalo milk product from North Sumatra, Indonesia. This study aimed to evaluate the in vitro antimicrobial activity of a crude protein extract from dali ni horbo, modified with orange and pineapple juice, against selected pathogenic microorganisms. Methods: This experimental laboratory study employed disk diffusion and well diffusion methods on agar media to assess the extract’s activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Propionibacterium acnes, and Candida albicans. Results: The results showed no inhibition zones for any treatment against all tested microorganisms. The absence of detectable antimicrobial activity may be attributed to the low concentration or biological activity of antibacterial compounds in the crude extract, the possible degradation of bioactive peptides during extraction, and the limited diffusion capacity of high‑molecular‑weight proteins in solid agar media. Conclusion: In conclusion, under the experimental conditions and methods applied, the crude protein extract of dali ni horbo did not exhibit antimicrobial activity against the tested bacterial and fungal species. Further studies involving protein purification, bioactive peptide isolation, and alternative liquid-based susceptibility assays are recommended.
Penentuan Kadar Total Fenol dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) dengan Metode DPPH Manullang, Lampita Bellina; Razoki, Razoki; Bangar, Roy Indrianto
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.214

Abstract

This study aimed to determine the total phenolic content and evaluate the antioxidant activity of the ethanolic extract of Moringa oleifera L. Extraction was carried out using the maceration method with 96% ethanol. Total phenolic content was determined using the Folin–Ciocalteu method with gallic acid as the standard, while antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH. assay and expressed as IC₅₀ values. The results showed that the ethanolic extract of Moringa oleifera leaves contained an average total phenolic content of 69.126 mg gallic acid equivalents per gram of extract. The antioxidant activity test yielded an IC₅₀ value of 92.04 ppm, indicating strong antioxidant activity. The high phenolic content contributed to the extract’s ability to scavenge free radicals. These findings suggest that the ethanolic extract of Moringa oleifera leaves has potential as a natural antioxidant source.
Co-Authors Adek Amansyah Ana Fiske Hotmaida Simanjuntak Arbita Huri Astriani Natalia Br Ginting Bangar, Roy Indrianto Bengimiate, Nuriza Binarwan Halim br. Sembiring, Novitaria br. Silalahi, Aancel Budi, Andre Chiuman, Linda Edlin, Edlin Elvi Sasmi Erida Novriani Finna Piska Fioni Fioni Fioni, Fioni Friska Rezki Hasibuan Ginting, Astriani Natalia Br Ginting, Chrismis Novalinda Hanjaya, Hanjaya Harahap, Halimah Hariyadi Dharmawan Syahputra Hartopo, Haqi Hotvera Merianis, Hotvera Hutauruk, Rico Halim Iksen, Iksen Lister, INE Lubis, Zahra Khairunnisa Manao, Merlianasari Manullang, Lampita Bellina Masriani . Merianis, Hotvera Meutia, Rena Mutia, Maya Sari Nardi, Leo Nasution, Chairul Radjab Nazla Deswita Siregar Nerly Juli Pranita Simanjuntak Neswita, Elfia Novita, Cut Elvira Novitaria Br Sembiring Novriani, Erida Ongko, Nicolas Xavier Refi Ikhtiari Reh Malem br Karo Roy Indrianto Bangar Siagian Salsabila, Dinda Ayu Samin, Buter Sari, Cindy Kurnia Septia, Evianti Dwi Simanjuntak, Nerly Juli Pranita Sinaga, Ade Putra Fratama Sitorus, Christina Berliana Soekardi, Adi Syahputra, Hariyadi Dharmawan Tanjung, Fahrul Azmi Tarigan, Antje Irmella Tarigan, Susiani Tesa, Catrin Angelica Putri Vera Estefania Kaban Wijaya, Johanna Fransiska Wilson Kanggaran Yohanes Dewantoro Situmorang