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All Journal Biotika: Jurnal Ilmiah Biologi Bionatura Farmaka Indonesian Journal of Applied Sciences Jurnal Ilmu Dasar Jurnal Natur Indonesia Jurnal Radioisotop dan Radiofarmaka Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication Indonesian Journal of Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Praeparandi : Jurnal Farmasi dan Sains Journal of Pharmaceutical and Sciences. Jurnal Sains dan Kesehatan
Anas Subarnas
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran, Sumedang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
The determination of quercetin in Plectranthus scutellarioides(L.) R.Br. leaves extract and its In SilicoStudy on Histamine H4 Receptor Moektiwardoyo, Moelyono; Levita, Jutti; Sidiq, Syafrudin Purnama; Ahmad, Khoziah; Mustarichie, Resmi; Subarnas, Anas; ., Supriyatna
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.578 KB) | DOI: 10.14499/indonesianjpharm0iss0pp191-196

Abstract

Plectranthus  scutellarioides  (L.)  R.Br.,  or  jawer  kotok,  Family  Lamiaceae, grows  widely  in  Indonesia,  and  has  a  long  history  of  therapeutic  usage  in Indonesian traditional jamuto cure various diseases. The brownish purple leaves of  Plecranthus  contain  alkaloids,  saponin,  flavonoids,  tannin,  volatile  oils,  and quercetin  which  has  been  proven  to  exert  antiinflammatory  activity.  In  this research,  a  determination  of  quercetin  in  Plecranthus  leaves  extract  was performed and followed by a study of its interaction with histamine H4 receptor to  understand its  anti-inflammatory  activity.  The  dry  leaves  were  macerated by using  a  mixture  of  methanol  and  water  (1:1)  for  48  hours  and  the  solvent  was evaporated  at  low  temperature  (40-50oC).  Analysis  of  quercetin  in  the  extract was performed by using reversed-phase HPLC method LC-10AT VP (Shimadzu), Atlantis  Hilicsilica  C18  (Waters®)  150  mm  x  4.6  mm,  5  µm  as  stationary  phase and  a  mixture  of  acetonitrile,  phosphoric  acid,  and methanol  (40:50:10),  flow rate 0.8 mL/minute.  In silicostudy of quercetin with histamine H4 receptor was performed by using AutoDock Tools 3.0.5. Histamine H4 receptor (H4R) belongs to  G  protein-coupled  receptors  which  is  involved  in arthritis,  asthma,  and inflammations.  The  3D  structure  model  of  H4R  was  built  by  using  MODELLER 9v7.  Quercetin  contained  in  Plecranthus  leaves  extract  was  0.05  %.  This compound interacted with H4R viahydrogen bond formation with Lys158 (2.006 Å)  and  Glu182  (2.048  Å),  and  van  der  Waals  interaction  with  Trp90,  Leu91, Asp94, Tyr95, Phe168, Thr178, Ser179, Tyr319, Phe344, and Tyr340, therefore Plecranthus  leaves  extract  might  have  a  chance  to  be  used  as  histamine  H4 receptor inhibitor.Key  words  :   histamine  H4  receptor,  in  silico  study,  Plecranthus  leaves,  Plectranthus scutellarioides, quercetin
Analysis of compounds possessing inhibitory properties on mice locomotor activity from essential oils of Ki Lemo bark (Litsea cubeba lour. Pers) Muchtaridi .; Anton Apriyantono; Anas Subarnas; Slamet Budijanto
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.284 KB) | DOI: 10.14499/indonesianjpharm0iss0pp63-69

Abstract

Ki lemo barks has been used as traditional spasmolitic (called oils of massage) since a long time by ethnic of Dayak. The odors inhaled is presumed possessing inhibitory on mice locomotor activity. The present research has been done to determine the components in blood plasma of mice after inhalation of essential oil of ki lemo barks, and the possibility of their role in the inhibition on mice locomotor activity.Inhalation of essential oil of ki lemo bark (Litsea cubeba Lour. Pers) at the doses of 0.5 ml inhibit locomotor up to 60,75 %, whereas at the doses of 0.1 ml and 0.3 ml inhibit locomotor activity of 57,44 % and 54,20 %, respectively.Identification and quantification of volatile active compounds in the blood plasma were carried out by GC-MS analysis after half an hour, one hour, and two hours inhalation. The blood plasma of three mice were collected in heparin tube, isolated and concentrated by the C-18 column (100 mg-Seppak Waters) eluted with methanol and bidistilled water (60:40). The major compounds identified were citronellol, citronellal, α-terpineol, and 1,8-cineole. The blood level of those substances was increasing for one hour after inhalation but decreasing after two hours.Key words : essential oil of ki lemo bark (Litsea cubeba Lour. Pers), inhalation, locomotors.
Co-Authors Abdul Mutalib Abdul Mutalib Adang Hardi Gunawan Adryan Fristiohady Afiat Berbudi Agung W.M. Yodha Aji Najihudin ALIF VIRISY BERLIAN AMELIA SUCI PRAFITRI YANI Ami Tjitraresmi Andini Sundowo Ani Haerani ANI HAERANI Anis Chaerunisaa Anis Yohana Chaerunisa ANIS YOHANA CHAERUNISA Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa Anton Apriyantono ASENG RAMLAN Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Aulia Annisa Putri Heri Aulia, Nazela Constantia Hilyatul Belinda, Rahma BRIGITTA TIARA PUTRI PRIYANTONO California, Salma H. Chaerunisaa, Anis Cucu Hadiansyah Dana Nasrullah Dani Sujana Dea A. A. Kurniasih DIAH SITI FATIMAH DIANTINI, AJENG - Dicky Santosa Dida Akhmad Gurnida Dika Destiani Dingse Pandiangan - ELI HALIMAH Eli Halimah, Eli Ellin Febrina Elvan Kamal Endang Sutedja Eri Amalia Euis Julaeha Fauzia Azzahra, Fauzia Fazrina Pratiwi Fransiska Silalahi Henni Djuhaeni Henni Djuhaeni Herri S. Sastramihardja Hesti Renggana Hideo Hayashi Hideo Hayashi Hideo Hayashi Hideo Hayashi HIRALIUS BIMA ARDIKA PUTRA I. Sahidin IIN SUPARTINAH NOER Indradi, Raden Bayu Irma Erika Herawati Iyan Sopyan Joharudin, Ade Juliani Ronike Turang Jutti Levita Karyono - Keri Lestari Khoirunnisa, Afina Khoziah Ahmad, Khoziah Kunkun J. Gurmaya Kurniasih, Dea A. A. Lika Ginanti Febriana Lutfi Sulaiman M. S. Soedjanaatmadja Magdarita Riwu Mardhiani, Yanni Dhiani Marline Abdassah Bratadiredja Martalena Ramli Maulana Yusuf Alkandahri Mega Juliana Moelyono Moektiwardoyo, Moelyono Mohammad Ghozali Muchtaridi Muchtaridi Mutiara, Intan Najihudin, Aji Nasrudin Nasrudin Nela - Simanjuntak NONI CAHYANA Noor Rain Abdullah Noor Rain Abdullah Nor Latifah Norisca Aliza Putriana NUR ALFI KUSUMAH DEWI PARAS WATI Pramesti, Ardhia Kirana Prayudi Ahmad Puja Yanti Raden Maya Febrianti Rano K. Sinuraya Ratu Ralna Ismuha Renggana, Hesti Resmi Mustarichie Riezki Amalia Risrina Nur Ekawati Rizkita Rahmi Esyanti - Ronny Lesmana Salma H. California Shinta Marpaung Sinuraya, Rano K. Siti Saidah Muthmainah Slamet Budijanto Sofa Fajriah Sri Adi Sumiwi Sri Hartini Sriwidodo Sriwidodo Supriyatna ., Supriyatna Supriyatna Supriyatna Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Surachman, Emma Suseno Amien Suwandi, Deden Winda Syafrudin Purnama Sidiq, Syafrudin Purnama Taofik Rusdiana Tati Herlina Tati Herlina Tati Herlina Tati Herlina Tina Rostinawati Triyono Triyono Triyono Triyono Unang Supratman Utami, Putri Antiyani W. Wahyuni Wenny Tilaar - Yohana Chaerunisaa, Anis Yoppi Iskandar Yulianto, Asep Nurrahman Yuni Elsa Hadisaputri