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Faisal Anwar
Departemen Gizi Masyarakat, Fakultas Ekologi Manusia (FEMA), Institut Pertanian Bogor, Bogor 16680
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Journal : Medical Laboratory Technology Journal

 1 
Anti-hyperglycemic Effect of Torbangun (Coleus amboinicus Lour) Leaves Extract Through Liver and Muscle Glycogen Deposits in Streptozotocin-induced Hyperglycmic Sprague-Dawley Rats Model Meilla Dwi Andrestian; Rizal Damanik; Faisal Anwar; Nancy Dewi Yuliana
Medical Laboratory Technology Journal Vol. 5 No. 2 (2019): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.547 KB) | DOI: 10.31964/mltj.v5i2.227

Abstract

The association of liver and muscle glycogen deposits with serum insulin levels, β-cells pancreas, and fasting blood glucose (FBG) of streptozotocin (STZ)-induced hyperglycemic rats receiving Torbangun leaves extract (TE) investigated. The intervention performed on 25 8-week-old Sprague-Dawley rats divided into four groups. Seven rats separated as a normal group (N), and other rats injected with streptozotocin (STZ). Confirmation of hyperglycemic was characterized by fasting blood glucose >126 mg/dl. Treatment group which is NG (hyperglycemic rats); N (normal rats); H-IM (62.5 mg/kg BW metformin); and H-IT (620 mg/kg BW TE) for 14 days. This study revealed that TE significantly decreased FBG levels, increased insulin production, and the amount of liver glycogen deposits (a=0.01). However, the intervention did not significantly increase the amount of muscle glycogen deposits. TE administration improves β-cells, increases the liver and muscle glycogen deposits. TE was shown to have antihyperglycemic activity by improving the β-cell, increasing blood serum insulin levels, decreasing blood glucose levels, and increasing the liver glycogen deposits.
Co-Authors . Rimbawa Ade Irawan Adi Teruna Efendi Adi Winarto Adriana Wahyu Rahmani Ahmad Sulaeman Ahmat, Dayu Aji Nugraha Ali Khomsan Amalina Ratih Puspa Aprinia Dian Nurhayati Asih Sulistyorini Uly Damora Budi Setiawan Cesilia M Dwiriani Chica Riska Ashari Clara M. Kusharto Clara Meliyanti Kusharto Dadang Sukandar Desak Putu Yulita Kurniati Desiana Firdaus Dewi Pratiwi Ambari Dewi Ratih Agungpriyono Drajat Martianto Dwi Ariyani Dyan Fajar Christianti Eddy S Mudjajanto Eddy S, Eddy Eddy S. Mudjajanto Eddy Setyo Mudjajanto Eddy Setyo Mudjajanto Eny Palupi Eryasih Setyorini Evy Damayanthi Fachruddin, Kadija Raisa Febriana Ira Dewi Guntari Prasetya Hadi R, Hadi Hadi Riyadi Hakimi Hakimi Hambali Hambali Hardinsyah Hendro Wibowo Herni Yuanda Hutomo, Putra I Made Alit Gunawan Ifanna, Ifanna Ikeu Ekayanti Indah Suryawati Iriyani K Iriyani K Iriyani Kamaruddin Izna Nurdianty Muhdar Joko Widodo jufri, Nurnashriana Julia, Putry Junita, Dini Kartika Musbyarini Kiki Puspasari Kusen, Yustiyani Leily Amalia Lilik Kustiyah M Maman Rohama Mahani Mahani Maizar, Safiratul Maya Sri Maryani Meilla Dwi Andrestian, Meilla Dwi Mira Dewi Muhamad Rizal Martua Damanik N.A. Shofiyyatunnisaak Nancy Dewi Yuliana Naufal Muharam Nurdin Ni Ketut Sutiari Nur Rahman Nurdin Nurdin Nurnashriana Jufri Nurul Hasanah Nuzliah Nuzliah Ploeger, Angelika Putri Julia Putri Julia, Putri Ratika Putriastuti Rian Diana Rian Diana Rimbawan , Risatianti Kolopaking Risatianti Kolopaking, Risatianti Sarah Dilla Nurhidayah SAUDAH SAUDAH Siti Madanijah Siti Madanijah Siti Mutia Rahmawati Solechan - Sri Adiningsih Sri Anna Marliyati Sriyanti Sugeng Riyanto Susi Desminarti Susi Desminarti Susi Nurohmi TATI NURHAYATI Tjahja Muhandri Widya Astuti widya astuti Widya Astuti Yayat Heryatno Yuanda, Merani