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Journal : Indonesian Journal of Science and Technology

Antiangiogenesis Activity of Indonesian Local Black Garlic (Allium Sativum ‘Solo): Experiments and Bibliometric Analysis Retno Arianingrum; Nurfina Aznam; Sri Atun; S. Senam; Alya Rizkita Irwan; Nida Qurbaniah Juhara; Nadiya Fitri Anisa; Latifah Kurnia Devani
Indonesian Journal of Science and Technology Vol 8, No 3 (2023): (ONLINE FIRST) IJOST: December 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v8i3.63334

Abstract

Cancer is still one of the leading causes of death in the world. Angiogenesis is the formation of new blood vessels, which plays a vital role in the growth of cancer cells. As a result, inhibition of proangiogenic factors such as vascular epidermal growth factor (VEGF) could be used as a cancer treatment strategy. Black garlic (BG) is processed fresh garlic (Allium sativum L.) for several days under controlled high temperature and humidity. The research aims to investigate the effect of Indonesian local BG on antiangiogenic activity through in vivo and in silico studies. The in vivo test was carried out by observing the formation of new blood vessels using the Chorio-Allantoic Membrane Assay (CAM). The in silico study was performed by docking analysis of BG bioactive compounds on the VEGF receptor (VEGFR). The results showed that ethanol extract, ethyl acetate fraction, and n-hexane fraction of BG inhibit new vessel blood formation, with n-hexane fraction having the highest efficacy. The molecular docking assay indicated some similarities in the amino acids involved in the interaction between the BG bioactive compounds and the native ligand in binding to VEGFR. This similarity may lead to interference with VEGFR resulting in angiogenesis inhibition. The study suggests that BG has the potential to be developed as an anticancer agent, which might be through the mechanism of inhibiting the angiogenesis process
Co-Authors Abas Susilo Ade Sofiana Suryani Agusta, Fauji Alfin, Riandi Althaaf, Nabila Tsabita Alya Rizkita Irwan Aminatun, Tien Ana Siti Nurjanah Anak Agung Gede Sugianthara Anisa Nur Khakim Anna Rakhmawati Anugrah Anang Respati Apriani, Nuni Arifudin Idrus Arthamena, Vegha Dwi Artina Diniaty Artina Diniaty, Artina Astuti Lestari Ayubi, Mizzan Azeeza, Sabira Nurul Azizah, Fidasari Nur Bian Ihda An Naila Buhera, Rusdiman Darmono Dessy Kurniasari Dewi ANGGRAENI Dewi Anggraini Emilio L Ghisalberti Erlina Erlina Euis Holisotan Hakim Fajar Naqsyahbandi Fapriyan Wijoyo Mulyopratikno Ghabby Maharani P Hadibah Kalor Heru Kuswanto Hurrahman, Mifta Ika Rosdiani Indah Puspita Sari, Mega Insih Wilujeng Jumaiyah, Wati Kamari, Azlan Kasyfi Rifqi Mouromadhoni Laila, Erni Latifah Kurnia Devani Lia Dewi Juliawaty Luthfi Fitri Frindryani Luthfia Ulva Irmita Maemonah, Maemonah Mamluaturrahmatika, Annisa Marpaung, Aisyatur Radhwa Masatake Niwa Mouromadhoni, Kasyfi Rifqi muhamad arif nur rokhman Muhammad Ikhsan Muhammad Ikhsan Mukti Syarifah Mulyopratikno, Fapriyan Wijoyo Nadiya Fitri Anisa Nafakoti, Nadia Naffa Afkarina Izzata Dini Naqsyahbandi, Fajar Nelly Fadliyani Ni Putu Laksmi Cintya Dewi, Ni Putu Laksmi Cintya Nida Qurbaniah Juhara Niwa Masatake Nova Irawati Simatupang Nova Irawati Simatupang, Nova Irawati Nurfina Aznam Oky Pamungkas Pamungkas, Oky Purnamaningsih, Nur Aini Rahman, Nanang Rania Nur Farida Ratri Panggih Pangastuti Rayasari, Fitrian Retno Arianingrum RISHA KURNIA DWI HARTANTI Romadhoni, Siti Dzakiya Royani, Elmi S. Senam Sa'adah, Siti Imroatus Sabar Nurohman Sabar Nurohman Sangal, Aditi Sari, Winda Putri Permata Sarip, Muhamad Satriya, M. Agung Senam Senam Simbolon, Doly siswanti ningsih Siti Aisyah SITI NUR'AINI Sitorus, Patar Ariyanto Sjamsul Arifin Achmad Sogen, Jasintah Tagan Sri Lestari Sujangka, Arsyad Suryadi Prasetyo Susila Kristianingrum Suyanta Suyanta Tia Rachmatika Wahyuni Tonapa, Nely Unayah, Habibatul Wijoyo Mulyopratikno, Fapriyan Yana Maolana Syah Yani Sofiani Yasaroh, Sabila Yunitri, Ninik