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Ruslin Ruslin
Universitas Halu Oleo
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antidepressant Potential of Etlingera Calophrys in Mice Tail Suspension Test and Forced Swim Test Ni Kadek Ayu Berlian; Ruslin Ruslin; Asriullah Jabbar; Irnawati Irnawati; Adryan Fristiohady; Sahidin Sahidin
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1967

Abstract

Depression is a mood disorder characterized by feelings of sadness, loss of interest, and decreased activity, and is associated with neurotransmitter imbalance and oxidative stress. The use of conventional antidepressant drugs still has limitations so that alternatives from natural ingredients such as Etlingera calophrys are needed which are known to contain potential bioactive compounds. This study aims to determine the antidepressant potential of methanol extract of Etlingera calophrys rhizome in mice (Mus musculus) using the Tail Suspension Test (TST) and Forced Swim Test (FST) methods. This study used the Chronic Mild Stress (CMS) model in mice which were divided into several treatment groups, namely normal control, negative control, positive control (amitriptyline 25 mg/kgBW), and extracts with doses of 100, 200, and 300 mg/kgBW. The parameters observed were the duration of immobility in the TST and FST tests. Data were analyzed using One Way ANOVA followed by the Tukey HSD test. Phytochemical screening results showed the presence of alkaloids, flavonoids, tannins, saponins, and terpenoids. In vivo tests showed that all doses of the extract were able to reduce the duration of immobility compared to the negative control, with a dose of 300 mg/kgBW providing the most significant effect and approaching the positive control (p < 0.05). The methanol extract of Etlingera calophrys rhizome has significant antidepressant activity, with a dose of 300 mg/kgBW being the most effective dose. These findings indicate that the methanolic extract of Etlingera calophrys rhizome exhibits significant antidepressant activity, which may be attributed to the synergistic effects of its bioactive compounds through modulation of monoaminergic neurotransmission and antioxidant mechanisms. In conclusion, Etlingera calophrys rhizome has promising potential as a natural antidepressant candidate, warranting further investigation at the molecular and clinical levels.
Optimization of Anti-Bacterial Gel from Ethyl Acetate Fraction of Purple Sweet Potato Leaves (Ipomoea Batatas L.) Using Hydroxy Propyl Methyl Cellulose (HPMC) and Testing Its Activity Against Staphylococcus Epidermidis Bacteria Muhamad Luthfid Anando Aly Roza; Fery Indradewi Armadany; Wahyuni Wahyuni; Ruslin Ruslin; Adryan Fristiohady Lubis; Nur Illiyyin Akib
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2075

Abstract

Bacterial infections are a significant global health challenge because they can attack various body tissues and cause illnesses ranging from mild to severe. Staphylococcus epidermidis is a bacterium that often causes various infections. Infection by Staphylococcus epidermidis can slow down the wound healing process and carry the risk of serious complications if not properly managed. This study aims to formulate and optimise an antibacterial gel from the ethyl acetate fraction of purple sweet potato leaves (Ipomoea batatas L.) as a natural alternative for treating skin infections caused by the bacterium Staphylococcus epidermidis. Using the I-optimal mixture design method in Design-Expert software, the optimization analysis was performed by evaluating several responses, including pH, viscosity, spreadability, and adhesion of the gel formulation. The experimental data were fitted to an appropriate polynomial model and analyzed using ANOVA to determine the significance of the model and mixture components. Numerical optimization was then carried out by setting the desired criteria for each response to obtain the optimum formulation. The optimal formulation consisted of 2% HPMC and 13% propylene glycol, with a desirability value of 0.964. The results showed that this formulation met all the criteria for a good and stable gel, including organoleptic properties (semi-solid, brownish-green, characteristic odour, homogeneous), pH (5.81), viscosity (2316.52 cPs), spreadability (6.4 cm), and adhesion time (2.18 seconds). The optimal formulation for an antibacterial gel containing the ethyl acetate fraction of purple sweet potato leaves (Ipomoea batatas L.) was achieved using a 2% HPMC concentration and 13% propylene glycol, with a desirability value of 0.964, , this gel formulation is also effective and falls into the category of being highly potent in inhibiting the growth of Staphylococcus epidermidis, as evidenced by the formation of an inhibition zone of 23 mm.
Insight on Estrogen Receptor Alpha Modulator from Indonesian Herbal Database: An in-silico analysis Muhammad Arba; Nadhifatul Aslikah; Arfan Arfan; Ruslin Ruslin; Arry Yanuar
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 17 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7592

Abstract

Estrogen receptor α (ERα) is liable for regulating transcription factors which are an important part of hormonal signaling in breast cancer. This study intends to find hit compounds that are considered capable of inhibiting ERα by utilizing structure-based pharmacophores and molecular docking. Pharmacophore of the original ERα ligand (E4D600) has one hydrogen bond acceptor and three hydrogen bond donors which are used to select compounds from the Indonesian herbal database. This pharmacophore model had an Area under Curve of the Receiver Operating Characteristics (AUC-ROC) value is 0.80 and the Goodness of Hits (GH) value is 0.81. The selection process generated 330 compounds which proceed to the molecular docking stage to analyze their binding energy and interactions to ERα. The results indicated potential hit compounds seen from their binding energies in the range -5.42 to -10.01 kcal/mol. four of the best compounds including Lig57/(-)-Bidwillon A, Lig47/Quercetin 3-(6''-galloylgalactoside), Lig197/Multifloroside and Lig83/Erythrabyssin II provide promising information for their detailed analysis as ERα inhibitors.
Co-Authors ,, Suryani ., HALIK Abdi Nipangeran Adnan Haerun Adryan Fristiohady Lubis Agustina Agustina Aisyah Nelpin Mangidi Anastasyah Putri Anwar, Irvan Arba, Muhammad Arfan Arfan Ari Sartinah Arry Yanuar Asniar Pascayantri Asriullah Jabar Asriullah Jabbar Bafadal, Mentarry Defi Liestiawati Phinhaer Dian Munasari Solo Efi Triolni Elza Apriliyanti Endang Endang Fery Indradewi Armadany Fitrawan, La Ode Muhammad Fitri Handayani Fristiohady, Adryan Ghais S. Daud Hairul Nisi Hamdani Sapuan Hasnawati Hasnawati Intan Permata Putri Irnawati Irnawati Julfitar Julfitar Kasmawati, Henny La Aba La Ode Muhammad Diman La Ode Muhammad Julian Purnama Loly Subhiaty Idrus Mawarni Mawarni Mega Nurjanah Mozarivky Salsabilla Javanni Muamal Gadapi Mubarak Mubarak Muh. Ilyas Y Muhamad Luthfid Anando Aly Roza Muhammad Ilyas Y Muhammad Ilyas Y Nadhifatul Aslikah Nasrudin Nasrudin Natalia Christiani Putri Ni Kadek Ayu Berlian Nirwati, Nurwati Nita Trinovitasari Nur Afrianingsih Pasaeno Nur Aviarahma Sihani Nur Illiyin Akib Nur Illiyyin Akib Nur Isnawati Nurbaida Nurbaida Nurramadhani A. Sida Nursavhira Ramadhani Putu Sintya Permani Rachma Malina Rahma Nur Aliza RAHMAT MULIADI, RAHMAT Rahmi Nurul Insani Rina Andriyani Rini Apriani Ruslan Ruslan Sabarudin Sabarudin Sahidin Sahidin Siti Hayati Siti Rahmawati Ondjo Sumi Wally Sunandar Ihsan Sunandar Ihsan Suriany Suriany Syahabudin Syahabudin Tissa Filiany Mangari Uswatun Khasanah Wa Ode Amanah Wa Ode Ifan Mustikawati Wa Ode Mirawanti Wa Ode Mulyana Wahyuni Wahyuni Wd. Nurmila Yamin, Y Yusniati Dwi Pemudi Yuyun Suria