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Wasrin Syafii
Departemen Hasil Hutan, Fakultas Kehutanan, Institut Pertanian Bogor Kampus IPB Darmaga, Bogor 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Public Health Veterinary

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In-vitro, In-vivo, and In-silico Studies of Insulinotropic Activity and Cytotoxicity of Mahagony Seed Extracts and Its Nanophytosome Hamidi, Zikri; Sari, Rita Kartika; Prayogo, Yanico Hadi; Syafii, Wasrin; Kasmi, Adinda Zahra Marissa; Prasetyo, Bayu Febram; Harlina, Eva; Wahyudi, Setyanto Tri
Communications in Science and Technology Vol 10 No 2 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.2.2025.1676

Abstract

This present study set out with the objective of evaluating the effect of ethanol–water solvent composition on extraction yield, insulinotropic activity (IA), cytotoxicity, and phytochemical profile (PP) of mahogany (Swietenia mahagoni) seed (MS) extracts. It also sought to study in silico and encapsulate the best extract, and to assay the antidiabetic of the extract and its nanophytosome. The extraction of MSs was achieved through the utilization of ethanol, ethanol–water (1:1), and water through ultrasound–assisted extraction. The extracts of IA and cytotoxicity were assayed in vitro using BRIN–BD11 cell lines and analyzed using LC-MS. The most effective extract was identified for its active compounds using molecular docking, encapsulation, characterization, and testing for its antidiabetic properties in vivo. The highest yield was observed in the water extract (MW), followed by the ethanol–water extract (MEW) and the ethanol extract (ME). MEW and MW demonstrated low level of cytotoxicity, with MEW exhibiting the highest level of IA. An in silico study identified four key antidiabetic compounds through the IA mechanism. The study demonstrated that MEW and its nanophytosome (250 mg/kg mouse weight) effectively reduced blood glucose level, and enhanced both erythrocyte function, and insulin secretion. This finding provides a new perspective in the development of natural-based antidiabetic agents through the nanophytosome formulation of mahogany seed extract.
Co-Authors Abdul Aziz Darwis Achmad Achmad Achmad Achmad Adesna Fatrawana Adesna Fatrawana Akhiruddin Maddu Akhirudin Maddu Akhirudin Maddu Akhirudin Maddu Amril Aman Anak Agung Istri Sri Wiadnyani Ani Suryani Anne Carolina Bambang Prasetya Bambang Prasetya Bambang Prasetya Bayu Febram Prasetyo Bintang C. H. Simangunsong Buchari Buchari Buchari Buchari Deded Sarip Nawawi Deded Sarip Nawawi Denny Irawati Desi Melianti Dewi R Agungpriyono E Gumbira Sa, E Gumbira Eka Novriyanti Eka Novriyanti Eko Budi Santoso Eko S Pribadi Elis Nina Herliyana ENDANG SUHENDANG Erdy Santosa Erdy Santosa Eva Harlina Evie Nihayah Fabianus Ranta Fahriya Puspita Sari Faizatul FALAH Fathul Yusro Fauzi Febrianto Gunawan Pasaribu Gunawan Pasaribu Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustini Syahbirin Hamidi, Zikri Herman Siruru Herman Siruru Hikma Yanti Hiroyuki Yamamoto Husni Y Rosadi, Husni Y I MADE ARTIKA I Nyoman Jaya Wistara IGK Tapa Darma Illah Sailah Imam Wahyudi Indrawan, Imam Wahyudi Irmanida Batubara Irnayuli R. Sitepu Irnayuli R. Sitepu Iskandar Z Siregar Istie Rahayu Izza Firdausi Hadiyanto Jemi, Renhart Juliasman Juliasman Karliati, Tati Kasmi, Adinda Zahra Marissa Khaswar Syamsu Kosei Yamauchi Kurnia Sofyan Kurnia Sofyan Kurnia Sofyan Laela N. Anisah Laela Nur Anisah Latifah K. Darusman Latifah K. Darusman Lucky Risanto M. Daud Maggy T Suhartono Maggy T Suhartono Maman Turjaman Maman Turjaman Maya Ismayati Mody Lempang Mody Lempang Mody Lempang Mody Lempang Muflihati Muflihati Muhammad Adly Rahandi Lubis Muhammad Fadli Muhammad Hanafi Nissa Nurfajrin Solihat Norman Razief Azwar Nugraha, Arifin Budiman Nur Adi Saputra Nur Adi Saputra Nur Azizah Prayogo, Yanico Hadi Pudja Mardi utomo Pudja Mardi utomo Purwoko, Agus Rahmi Mauladdini Rahmi Mauladdini Renhart Jemi Rita K Sari Rita Kartika Sari Romi Irka Putra S Heris Anita, S Heris Saat Egra Santiyo Wibowo Santiyo Wibowo Santiyo Wibowo Saptadi Darmawan Saptadi Darmawan Saptadi DARMAWAN Setyanto Tri Wahyudi Simon Taka Nuhamara Simon Taka Nuhamara Siruru, Herman Siti Maemunah Siti Sa'diah Siti Sa'diah Soetrisno Hadi Soetrisno Hadi Sri Familasari Suminar A Achmadi Suminar S Achmadi Syamsul Arifin Tohru Mitsunaga Umi Cahyaningsih Widya FATRIASARI Widya FATRIASARI Widya Fatriasari Yanico Hadi Prayogo Yanotama T Laksana Yanti Hikma Yusup AMIN