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All Journal ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Veteriner Veterinary Biomedical and Clinical Journal Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pusat Inovasi Masyarakat Jurnal Veteriner dan Biomedis Current Biomedicine Asian Journal of Social and Humanities Indonesian Journal of Jamu
Lina Noviyanti Sutardi
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Veterinary

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Antitumor activity of Typhonium flagelliforme Ethanol Extract Nanoemulsion in DMBA-Induced Sprague Dawley Rats Rini, Dian Cipta; Priosoeryanto, Bambang Pontjo; Riki Siswandi; Sutardi, Lina Noviyanti
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.167-174

Abstract

Tumors are a leading cause of disease-related deaths in humans and companion animals, including dogs and cats. Typhonium flagelliforme, recognized in Indonesian traditional medicine, exhibits notable antitumor properties, such as inhibiting tumor cell proliferation and enhancing immune response. This study aimed to formulate T. flagelliforme into a nanoemulsion to improve its antitumor eflects and assess its efficacy in Sprague Dawley rats induced with the carcinogen 7,12-dimethylbenz (a) anthracene (DMBA). The nanoemulsion was formulated using the inversion phase method, and its particle size and stability were analyzed using SEM. Phytochemical screening identified active compounds, and toxicity was assessed using the brine shrimp lethality test. In vivo experiments involved five rat groups: untreated (NTC), nanoemulsion solvent (Solv), and three treatment groups receiving 25 μg/kg (TF25), 50 μg/kg (TF50), and 100 μg/kg (TF100) doses of the nanoemulsion, administered via intralesional injection. Results showed significant tumor size reduction in treatment groups compared to controls (p<0.05), with TF25 exhibiting the most eflective antiproliferative activity. Increased body weight across groups indicated low toxicity. The study concludes that T. flagelliforme nanoemulsion eflectively reduces tumor size and angiogenesis, demonstrating its potential as an antitumor agent. 
Studi Kasus: Terapi Prostatitis Disertai Urolithiasis pada Anjing Lokal Diaz, Fariz Arrachman; Nurdiansyah, Rio Dwi Haryadi; Bachmid, Salma Safitri; Mufida, Anis Arifatu; May, Ng U; Purwono, Rini Madyastuti; Fitri, Arni Diana; Budiono, Novericko Ginger; Prasetyo, Bayu Febram; Sutardi, Lina Noviyanti; Anisa, Rahma
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.43-47.

Abstract

Prostatitis pada anjing dapat disertai dengan urolithiasis. Keduanya dapat disebabkan oleh adanya infeksi bakteri yang masuk melalui saluran kemih. Anjing bernama Momo yang merupakan pasien RSHP IPB University datang dengan keluhan stranguria, hematuria, muntah, dan susah makan di malam sebelumnya. Pemeriksaan dilakukan dengan pemeriksaan fisik dan pemeriksaan penunjang ultrasonography (USG). Hasil pemeriksaan menunjukkan bahwa Momo menderita urolithiasis disertai prostatitis. Sediaan Cefixime, Batugin® Elixir, Meloxicam, Glucosamine, Asam Traneksamat, dan pakan Royal Canin Urinary® diberikan sebagai penanganan. Kumpulan sediaan tersebut diberikan dalam rangka terapi kausatif dan simptomatik dari kasus urolithiasis disertai prostatitis.
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Maret Daulay, Lingga Surya; Wientarsih, Ietje; Esfandiari, Anita; Sutardi, Lina Noviyanti; Asmilia, Nuzul
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
The In Silico Toxicity of Serai Wangi (Cymbopogon nardus) and Mimba (Azadirachta indica anggraeni, Henny endah; Purwono, Rini Madyastuti; Sutardi, Lina Noviyanti; Mustika, Aulia Andi; Manalu, Wasmen; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.278-285

Abstract

Natural active-ingredient-based shampoos offer an effective and eco-friendly solution for maintaining the skin and hair health of companion animals. This study aimed to predict the toxicity of phytochemical compounds from citronella oil (Cymbopogon nardus) and neem oil (Azadirachta indica) using an in silico approach with the ProTox-II platform. The analyzed compounds included limonene, farnesene, eucalyptol, menthol, oleic acid, p-cymene, indole, (9Z)-9- octadecenamide, amylbenzene, p-cresol, camphor, and dieugenol, selected based on LC-MS/MS analysis. The evaluated toxicological parameters comprised oral acute toxicity (LD50), hepatotoxicity, immunotoxicity, genotoxicity (cytotoxicity, mutagenicity, carcinogenicity), as well as nuclear receptor signaling and stress response pathways. The results revealed that p-cymene exhibited the highest toxicity (LD50 = 3 mg/kg, class I), followed by oleic acid (LD50 = 48 mg/kg, class II), whereas amylbenzene was classified as non-toxic (LD50 = 6430 mg/kg, class VI). All compounds were predicted to be non-hepatotoxic and non-immunotoxic; however, p-cymene, indole, and amylbenzene showed potential carcinogenicity. Limonene was predicted to be active against AhR, ER, MMP, and ATAD5 receptors, while dieugenol was active against nrf2/ARE, HSE, and MMP. These predictions suggest that most compounds are safe for shampoo applications, except for p-cymene, which requires further evaluation. This study provides preliminary insights for the development of safe and effective natural-based shampoos.
A comparison of the Hematology Profiles from Preventive and Curative Tests on Lissachatina fulica Snail Mucin Cream for Atopic Dermatitis Supiyani, Atin; Manalu, Wasmen; Sutardi, Lina Noviyanti; Subangkit, Mawar; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.296-302

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Continuous use of topical NSAIDs in AD cases has been shown to cause adverse effects. Lissachatina fulica mucin (LFM) cream, a natural alternative, has been used for wound healing and can be used as a preventative or curative agent in AD. The objective of this study is to assess the efficacy of LFM cream, exploring its potential as a preventative and curative measure in AD. A total of 36 male BALB/c mice were divided into three cream dosage groups: 0%, 5%, and 10%. The two treatments were preventive and curative, and the two testing times were 0 and 5 days, with three replicates each. Mice were induced with atopic dermatitis by applying 1% DNCB to a 1x1 cm area on their dorsal area for seven days. The preventive group used LFM cream for seven days before DNCB, while the curative group used it after DNCB. Blood samples were collected on days 0 and 5 of the treatment period and analyzed using a hematology analyzer. The data were analyzed using a two-way ANOVA with GraphPad Prism 10, followed by Tukey's test at a 95% confidence level. The toxicity test confirmed that the LFM cream is non-toxic and safe for topical use. The DNCB compound 1% exhibited four main symptoms of atopic dermatitis: pruritus, erythema, excoriation, and lichenification. LFM cream was highly effective, significantly suppressing AD symptoms, with the ADSI score remaining below 2 (p<0.05). Specifically, the curative efficacy was demonstrated by a significant decrease in the ADSI score on day 5 (p<0.05). Hematological analysis revealed statistically significant differences (p<0.05) in the number of lymphocytes, neutrophils, and thrombocytes across groups. The LFM cream is effective and safe for preventative use and successfully treats acute AD at 5% concentration.
Co-Authors Adi Winarto Alifin Wisnu Ananta Alpayet, Rahmat Amaq Fadholly Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Anggraeni, Henny Endah Anggraini, Lutvi Anisa Rahma, Anisa Anisa, Rahma Anita Esfandiari April Hari Wardhana April Hari Wardhana Ardi Sandriya Aulia Andi Mustika Aulia Andri Mustika Aulia Mustika Bachmid, Salma Safitri Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Budiono, Novericko Ginger Christina Clarice Leksono Deni Afrizal Dhiya Puja Ramadhan Diah Nugrahani Pristihadi Diaz, Fariz Arrachman Dodi Darmakusuma Dodi Darmakusumah Ekowati Handharyani Elpita Tarigan Elpita Tarigan Elpita Tarigan Esti Dhamayanti Eva Harlina Fedik Abdul Rantam Fitri Ariyani Fitri, Arni Diana Guna Prajanto Gunanti . Hadri Latif Hamdika Yendri Hamdika Yendri Hamdika Yendri Putra Hamdika Yendri Putra IETJE WIENTARSIH Inayati ilmi Kamilatun Nisa Khonsa Khonsa Kusdiantoro Mohamad Kusdiantoro Muhamad Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Widi Leliana Widi Lingga Surya Maret Daulay Madyastuti, Rini Maret Daulay, Lingga Surya May, Ng U Mufida, Anis Arifatu Muhammad Bintang Nababan, Ratna Kristiani Nabilah, Avida Shahnaz Nina Indria Afifah Nisrina Nurmahfuzhah Nurdiansyah, Rio Dwi Haryadi Nuzul Asmilia Nuzul Asmilia Purohita, Adwisto Saktika Rachmi Ridho Raphaella widiastuti Rasyid, Baharun Ridi Arif Riki Siswandi Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rini, Dian Cipta Riski Rostantinata Riski Rostantinata Rizki Rostantinata Safitri, Nadiya Santosa, Alfian Shabrina Marsha Shabrina Rizki Ahadiah Silmy Kamila Widyanti Siti Rabi’ah SM Leluala Subangkit, Mawar Supiyani, Atin Sus Derthi Widhyari Trioso Purnawarman Utami Idha Pangesti Waras Nurcholis Wasmen Manalu Wiwin Winarsih Yessy Anastasia Yusa Irarang Yusa Irarang Yusa Irarang