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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Media Ilmu Kesehatan Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Poltekita : Jurnal Ilmu Kesehatan Health and Medical Journal Jurnal Dunia Gizi Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Jurnal Riset Ilmiah Neurona Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Eva Decroli
Endocrinology And Metabolic Subdivision, Division Of Internal Medicine, Dr. M. Djamil General Hospital/ Medical Faculty Of Andalas University, Padang, West Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Neurona

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ANALISIS KADAR AMILOID BETA PLASMA DENGAN GANGGUAN KOGNITIF PADA DIABETES MELITUS TIPE 2 Syafrita, Yuliarni; Amir, Darwin; Decroli, Eva; Susanti, Restu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.38

Abstract

   ANALYSIS OF PLASMA LEVELS OF BETA AMYLOID WITH COGNITIVE IMPAIRMENT IN TYPE 2 DIABETES MELLITUSABSTRACTIntroduction: Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease are two kind of neurodegenerative disease that related with age. Patients with DM show a tendency to develop Alzheimer’s disease, but there is no single marker for predicting a DM case will develop into Alzheimer’s disease. Amyloid cascade beta disturbance is one factor involved in the pathogenesis of DM disease as well as in Alzheimer’s disease, and still believed to be the main factor causing Alzheimer’s dementia.Aims: This research was aimed to determine the correlation between beta amyloid plasm level and demographic factors with the occurrence of cognitive dysfunction in type 2 diabetes mellitus patients.Methods: This was a cross-sectional design study on patients with DM in special DM clinic at M Djamil and Ibnu Sina hospital, Padang, between August—October 2016. Cognitive function was examined using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Beta amyloid level was measured by enzyme-linked immunosorbent assay (ELISA) technique. Beta amyloid diagnostic ability was analyzed by using receiver operating characteristics (ROC). The correlation between the variables were analyze by using Chi-square, and p value p<0.05 was considered to be significant. To determine the strongest variables which correlated to cognitive dysfunction, logistic regression analysis were performed.Result: 65 subjects included in this study, where cognititve dysfuntion were present in 35 patients (58.3%). There were significant correlation between disease duration and low levels of 42 beta amyloid in plasma (Aβ42) with the occur- rence of cognitive dysfunction. The multivariate analysis showed that the disease duration, followed by low levels of Aβ42 and education level were the variables correlated with cognitive dysfunction.Discussion: There were a correlation between low levels of 42 beta amyloid in plasma with the occurrence of cog- nitive dysfunction in type 2 diabetes mellitus patients.Keywords: Beta amyloid, cognitive impairment, demographic factors, type 2 DMABSTRAKPendahuluan: Penyakit diabetes melitus tipe 2 (DM) dan penyakit Alzheimer adalah dua penyakit neurodegeneratif yang sering berhubungan dengan usia. Pasien dengan DM menunjukkan kecenderungan untuk menderita penyakit Alzheimer, namun belum ada satupun penanda untuk memprediksi kasus DM yang akan berkembang menjadi penyakit Alzheimer. Gangguan kaskade amiloid beta merupakan faktor yang terlibat pada patogenesis penyakit DM maupun pada penyakit Alzheimer, dan sampai sekarang masih dipercaya sebagai faktor utama yang menyebabkan demensia Alzheimer.Tujuan: Mengetahui hubungan kadar amiloid beta plasma dan faktor demografi dengan gangguan fungsi kognitif pada penderita DM.Metode: Penelitian dengan desain potong lintang ini, terhadap pasien DM yang berobat di Poliklinik khusus diabetes RSUP Dr. M Djamil dan RS Islam Ibnu Sina, Padang, pada periode Agustus–Oktober 2016. Penilaian gangguan kognitif menggunakan Montreal Cognitive Assesment versi Indonesia (MoCA-Ina), dinyatakan terganggu jika nilai <26.Kadar amiloid beta diperiksa dengan metode enzyme-linked immunosorbent assay (ELISA) dan kemampuan diagnostik amiloid beta dianalisis dengan receiver operating characteristics (ROC). Hubungan antar variabel diuji dengan Chi- square, dikatakan bermakna bila nilai p≤0,05. Dilakukan analisis regresi logistik untuk menentukan variabel yang paling kuat hubungannya dengan gangguan fungsi kognitif.Hasil: Didapatkan 65 subjek dengan rerata usia 61,62+7,6 tahun dan sebanyak 53,8% mengalami gangguan fungsi kognitif. Didapatkan hubungan yang bermakna antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif. Pada analisis multivariat diketahui bahwa urutan kekuatan variabel yang berhubungan dengan terjadinya gangguan fungsi kognitif adalah lama sakit, rendahnya kadar Aβ42 plasma, dan tingkat pendidikan.Diskusi: Terdapat hubungan antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif pada penderita DM.Kata kunci: Amiloid beta, DM tipe 2, faktor demografi, gangguan kognitif
Co-Authors Adang Bachtiar Ade Chandra Afriwardi Afriwardi Ahmad, Armen Al Hafiz Alexander Kam Alexander Kam Alexander Kam Alexander Kam Alfitri, Maura Salsabila Andi Fadilah Yusran Putri Antoni, Adi Aprilia, Dinda Asman Manaf Aulia, Salsabila Syafna Auliangi Tamayo Brian Sri Prahastuti Darwin Amir, Darwin Deddy Saputra Delmi Sulastri Dessy Arisanty Dinda Aprilia Dinda Aprilia Dinda Aprilia Dinda Aprilia Dwitya Elvira, Dwitya Efendi, Nursyirwan Efendi, Yanne Pradwi Ellyza Nasrul Eryati Darwin Eti Yerizel Fadella, Annesa Fadrian, Fadrian Fahrurozi, R. Ifan A. Fauzar Fauzar Fereshti Lailani Finisia Noviyanti Firdawati Firdawati Garri Prima Decroli Genta Pradana, Genta Hafni Bachtiar Hardisman Harie Satria ES Husna Yetti Jannah, Lidya Raudhatul Jonggara Oktaviandra Siahaan Kam, Alexander Linosefa Linosefa Martini, Rose D Meliza Wahyuni Mudjiran Muhammad Luthfi Muharramah, Disa Hijratul Murni, Arina W Mustafa Noer Muthia Faurin Nada Utami Prahastiwi Nadila Andam Astari Namanda Putri, Athari Fadhila Nining Kurniawati Nur Indrawati Lipoeto Nurhayati Nurhayati Prayitno, Irwan Putri Deas Hadilofyani Putri Sri Lasmini Putri, Biomechy Oktomalio Putri, Septia Harma Putri, Vidola Yasena Rahayuningsih, Sri Puji Restu Susanti Risviani, Darayani Ritonga, Sukhri Herianto Robby Satria Putra Roza Kurniati Roza Mulyana Saptino Miro Saptino Miro, Saptino Sheila Jihan Safira Sofiani, Dinda Putri Suci Berlian Hemilton Sukri Rahman Susila Sastri Syafril Syahbuddin Syafril Syahbuddin Syafril Syahbuddin Tamayo, Auliangi Try Rahmi Lussii Karsuita Ulvyana, Vyora Viotra, Deka Yanne Pradwi Efendi Yanne Pradwi Efendi Yoga, Vesri Yulia, Dwi Yuliarni Syafrita Yusrawati Yusrawati Yustini Alioes Zelly Dia Rofinda