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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Dasar Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat Indonesian Journal of Tropical and Infectious Disease JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Agromedicine and Medical Sciences JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Elkawnie MIX : Jurnal Ilmiah Manajemen The Indonesian Journal of Occupational Safety and Health Majalah Kedokteran Sriwijaya Universa Medicina Paediatrica Indonesiana Jurnal Bioteknologi & Biosains Indonesia (JBBI) Medical Laboratory Technology Journal Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Prima Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Journal of Health Sciences Action Research Literate (ARL) Jurnal Lingkar Mutu Pendidikan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Public Health and Preventive Medicine Archive Berita Kedokteran Masyarakat Jurnal Indonesia Sosial Sains Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ASPIRATOR - Journal of Vector-Borne Diseases Studies NurseLine Journal Jurnal Lingkar Mutu Pendidikan Jurnal Penelitian Pengelolaan Daerah Aliran Sungai (Journal of Watershed Management Research) Journal of Clinical and Translational Medicine
Dini Agustina
Departemen Mikrobiologi Fakultas Kedokteran Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Identifikasi Bakteri Patogen Sungai Bedadung di Jember Indonesia (Identification of Bedadung River Pathogen Bacteria in Jember, Indonesia) Enny Suswati; Dini Agustina; Rini Riyanti; Muhammad Ali Shodikin; Elly Nurus Sakinah; Desi Sandra Sari; Yuliana MDA; Ema Rachmawati
Jurnal Penelitian Pengelolaan Daerah Aliran Sungai (Journal of Watershed Management Research) Vol 8 No 1 (2024): Jurnal Penelitian Pengelolaan Daerah Aliran Sungai (Journal of Watershed Manageme
Publisher : Asosiasi Peneliti dan Teknisi Kehutanan dan Lingkungan Hidup Indonesia (APTKLHI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59465/jppdas.2024.8.1.1-16

Abstract

The Bedadung River is a typical environment where anthropogenic pollution often occurs thus rapidly changing the chemical and biological composition of the sediments and surface water. However, the effects of urbanization on the organization and diversity of the microbial community in rivers have not been adequately studied. A thorough examination of the microbial dispersion in the Bedadung River's surface water is presented. This research aims to determine the type and prevalence of pathogenic bacteria from Bedadung River water samples, Jember Regency. To investigate the prevalence of bacterial contaminants, sixteen sites along the Bedadung River were chosen. Bacterial isolation and identification using chromogenic media, such as Salmonella Chromogenic Agar (SCA) and Mannitol Salt Agar (MSA). Using API E 20 media, the bacteria were identified based on the color of the bacterial colonies in growth. The results indicated that contaminant bacteria isolated from Bedadung River water in Jember were S. aureus (96.67%), E. coli (98.33%), Salmonella sp. (96.67%), Shigella sp. (40%), and Proteus sp. (1.67%). These findings indicate that the river was a significant source of bacteria with a risk potential to humans and the environment that must be addressed. Many actions are needed to reduce fecal contamination of river water.
THE DIFFERENCE OF EOSINOPHIL AMOUNT IN TUBERCULOSIS PATIENTS WITH AND WITHOUT SOIL-TRANSMITTED HELMINTHS CO-INFECTION IN PANTI DISTRICT, JEMBER Nisrina Salsabila Firmansyah; Angga Mardro Raharjo; M. Ali Shodikin; Enny Suswati; Dini Agustina; Yunita Armiyanti
NurseLine Journal Vol. 5 No. 1 (2020): May 2020
Publisher : Program Studi Ilmu Keperawatan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v5i1.60175

Abstract

Tuberculosis is one of the world's health problems, even in Indonesia. The immune response that needed to eliminate TB can be influenced by other infections, such as helminth infection. The helminth infections induce Th2 immune responses and eosinophilia to eliminate the helminths. Meanwhile, the Th2 response and eosinophilia can also suppress the Th1 immune response, which is very important to eliminate the bacterium M. tuberculosis and make a negative impact on the success of TB therapy. Thus, the eosinophil profile can describe the immune response in TB patients with helminth co-infection. This study aims to determine the prevalence of helminthiasis in TB patients and determine the differences in eosinophil amount in tuberculosis patients with and without helminth coinfection. This study was an observational analytic study with a cross-sectional design conducted at Panti local health center in August 2019-January 2020 using fecal and blood samples from 24 research subjects. Helminth co-infection status was obtained from fecal examination with sedimentation and flotation methods while the number of eosinophils was obtained from leukocyte counts. Data analysis used the Mann Whitney U test to determine differences in the number of eosinophils in the two groups. The results showed there was no difference in the number of eosinophils in TB patients with helminth coinfection and without helminth co-infection (p> 0.05). There was no typical picture of the number of eosinophils in both groups so that eosinophils cannot describe the immune response that arose in TB patients with helminth co-infections in Panti district, Jember.Further study is needed to measure IgE and interleukin (IL4 and IL10) to know the immune response in TB patients with helminth co-infection.
Effect of Pesticide Exposure on Respiratory Symptoms in Agroindustrial Farmers: A Systematic Review Siti Zulaikha Risqiyani; Dini Agustina; Jauhar Firdaus; Bagus Hermansyah
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.85

Abstract

Pesticides are a mixture of substances used to control pests, plants, or animals. The inappropriate uses can cause serious problems for farmers. About 3 million cases of global pesticide acute poisoning, 25 million mild acute poisonings, and 300.000 deaths. The inhalation route is the main entry route for chemicals and pesticides. Exposure through inhalation associated with respiratory pathology, can cause respiratory symptoms due to the accumulation of pesticide substances in the respiratory tract. Inhaled pesticides will be stored in the human respiratory tract indicating damage and irritation of respiratory organs, which can cause serious respiratory symptoms. This review aimed to summarize the association between pesticides exposure and respiratory symptoms in agroindustrial farmers. This systematic review was reported based on criteria from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted with electronic databases, such as PubMed, ScienceDirect, Cochrane Library, and Portal Garuda. P-value with the confidence interval (CI) of 95% was used to determine the association between pesticides exposure and respiratory symptoms. Ten studies were included in the qualitative synthesis. The current study showed pesticides exposure increases respiratory symptoms in farmers. Farmers who use pesticides have a greater frequency of respiratory symptoms than other farmers. Organochlorine and organophosphate have a significant risk of causing respiratory problems, such as cough, phlegm, wheezing, and shortness of breath. Conclusion: This systematic review provides valuable evidence suggesting the correlation between pesticides exposure and respiratory symptoms in agroindustrial farmers.
Bacteriological Profile and Risk Factors Among Patients with Recurrent Bacterial Vaginosis at Puskesmas Tanggul Ichlasul Amal; Dita Diana Parti; Dini Agustina; Bagus Hermansyah
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.86

Abstract

Background: Bacterial vaginosis (BV) is the most common vaginal disease affecting approximately 30% of women aged between 15 and 44 years. Bacterial vaginosis (BV) can be caused by anaerobic bacteria, including Gardnerella vaginalis, Prevotella spp., Bacteroides spp., Mobiluncus spp. The current first-line BV therapy is oral metronidazole twice daily for 7 days, but the recurrent rate is more than 50% within 12 months after treatment. Risk factors for BV were associated with racial origin, smoking, level of education, vaginal douching, sexual behavior and hygine behavior. Many microorganisms that cause BV, the high rate of recurrent BV on treatment with metronidazole and the many risk factors for BV were the reasons for this study. Objective: To determine the bacteriological profile and risk factors of recurrent bacterial vaginosis at the Tanggul health center. Method: This study used a descriptive study with etiological data taken from vaginal secretory specimen culture using Vitek 2 Compact, risk factor data taken from interviews and SRQ-20 questionnaire results. Result: A total of 5 specimens of vaginal secretions were identified as E. coli (83.3%) and 1 was identified as K. pneumoniae (16.6%). The description of the risk factors found were age over 46 years (66.7%), work as a housewife (66.7%) and as a farmer (33.3%), high school education level (66.7%), habit of changing underwear <3 times a day (100%), vaginal douching habits (50%), use of hormonal contraceptives (66.7%), frequency of sexual intercourse >2 times a week (33,3%) and high stress levels (66.7%). Conclusion: The etiological species of recurrent BV found were E. coli and K. pneumoniae. The risk factors found were age over 46 years, occupation, education level, habit of changing underpants <3x a day, habit of vaginal douching, use of contraception, frequency of intercourse and high stress level.
Meningococcal Meningitis In Children: A Case Report Muhammad Ali Shodikin; Achmad Haykal Baswedan; Dini Agustina; Diana Chusna Mufida; Enny Suswati; Bagus Hermansyah
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.87

Abstract

Meningococcal meningitis is brain membrane (meninges) inflammation caused by Neisseria meningitidis (Meningococcus) bacteria. In the child population, meningococcal meningitis is a rapid-onset disease with high morbidity and mortality rates. In this case, a 7-year-old boy admitted to the Emergency Room of dr. Soebandi Hospital, Jember, presented with seizure, decreased of consciousness, fever, and positive meningeal signs. The results of laboratory and radiological investigations showed bacterial meningitis caused by Neisseria meningitidis bacteria. This patient was treated with antibiotics, symptomatic and supportive medication, which gave a good result. It is important to publish all clinical findings, laboratory examinations, and management of this case so that health workers are aware of the spread possibility of meningococcal meningitis.
Bacterial Co-Infection In Covid-19 Patient: A Systematic Review Dini Agustina; Bagus Hermansyah; Yehuda Tri Nugroho Supranoto
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.88

Abstract

Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. The course of the disease often has more severe clinical symptoms if accompanied by a bacterial infection, known as co-infection or secondary bacterial infection. Apart from having a clinical impact, it also causes the use of more antibiotics, increasing antibiotic resistance. To overcome this, we need data showing the most frequent etiologic agents of bacterial coinfection in patients with COVID-19. This systematic review aims to determine the etiologic agent of the most common secondary bacterial infection in COVID-19. This systematic review is presented based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) criteria. The electronic databases used for the literature search are; PubMed, ScienceDirect, CochraneLibrary, and Google Scholar. Keywords used in the electronic database are described using Boolean operators as follows: (("SARS-CoV-2 Infection" OR "Coronavirus Disease 19" OR "COVID-19") AND ("Secondary Bacterial Infection" OR "Bacterial Co-infection”)). All literature was selected taking into account the eligibility criteria and reference standards. The protocol of this review has been registered in International Prospective Register of Systematic Reviews (PROSPERO) with the registration number is CRD42022331998. Eleven studies were included in the qualitative synthesis. The results of the study showed that Gram-negative bacteria were the most common etiologic agents. These bacteria include Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. This systematic review provides valuable evidence of the most frequent etiologic agents of secondary bacterial infection in COVID-19 patients.
Ventilator Associated Pneumonia (VAP) Antibiogram of Dr. Soebandi Hospital, Jember In 2019 Dini Agustina; Nidia Nursafitri; Arswendo Ika Murthy; Bagus Hermansyah
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.89

Abstract

Ventilator-Associated Pneumonia (VAP) is a type of nosocomial infection that occurs after 48-72 hours of endotracheal intubation with a high mortality rate and is most commonly seen in hospital ICUs The high mortality rate in VAP cases could, among other things, be caused by the emergence of multidrug resistant (MDR) species that may be caused by irrational use of antibiotics. The existence of an antibiogram is expected to solve the problem. This study aimed to form a VAP antibiogram of dr. Soebandi Hospital in Jember City, East Java, Indonesia, can be used to reference rational therapy.This research is a descriptive study using secondary data obtained from medical records. The data will be collected and analyzed in a univariate manner, and then the analysis results will be displayed in graphs and tables. The number of samples used was 37 medical record data that matched the criteria and obtained 39 isolates. Of the 39 isolates, 22 different types of bacteria were obtained. These bacteria come from 7 different families. In addition, of the 39 identified types of bacteria, 29 of them were Gram-negative bacteria (74%), the remaining 10 were Gram-positive bacteria (26%). The antibiotics with the most useful and have a sensitivity level of more than 50% in this study were amikacin (77%), piperacillin-tazobactam (65%), and cephalexin (54%). These three antibiotics are also available in the parenteral form be used as empirical therapy for VAP.
Co-Authors Achmad Haykal Baswedan Ali Santosa Alyatul Himma Anaditya Wahyu Kumudhaningsih Anastasia Citra Purwani Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Aprilya Pratiwi, Nadilla Arief Subhan Arswendo Ika Murthy Aryasatya, Dimas Widyadhana Bhanu Astuti Setyawardani Bagus Dwi Kurniawan Bagus Dwi Kurniawan Bagus Hermansyah Bagus Hermansyah Budi Suharjo Cahyaningrum, Endiningtyas Cholis Abrori, Cholis Cicih Komariah De Rorna, Masrahma Reinataya Denaneer Rahmadatu Desi Sandra Sari Desie Dwi Wisudanti Diana C. Mufida Diana Chusna Mufida Diana Chusna Mufida Dina Helianti Dion Krismashogi Dharmawan Dita Diana Parti Dua , Mikhael Dwita Aryadina Rachmawati El Milla, Kardiana Izza Ellen Ocktavironita Elly N Sakinah Elly Nurus Sakinah, Elly Nurus Elvia Rahmi Marga Putri Ema Rachmawati Enny Suswanti Enny Suswati ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Fitri, Nadya Eka Gama Wisnu Sanjaya Habib Mustofa Habibbur Rochman Salim Habibi, Ali Hamzah, Salsabilla Maula Zalfa El Hanifa Rizki A.S. Hibatulloh, Muhammad Farhan Hidayat Hidayat I Nyoman Semita Ichlasul Amal Iftinan, Karenzha Ika Rahmawati Sutejo Intan Palupi Irawan Fajar Kusuma Jamalullail, Jamalullail Jauhani, Muhammad Afiful Jauhar Firdaus Kirana Nadyatara Kristianningrum Dian Sofiana Kusiyanto Taslim, Fitranda Laila Rizqi Kurniawati Lailatis Shofia Laksmi Indreswari M. Ali Shodikin Mei Liana Wati Miftakhul Huda Muhammad A. Shodikin Muhammad Ali Shodikin Muhammad Dimas Arya Candra Permana Mukhamad Najib Napitupulu , Frengki Nastiti Bekti Utami Nidia Nursafitri Nihayah Lukman Nisrina Salsabila Firmansyah Nita Alfianti Noorhamdani AS Noorhamdani AS Nugraha, Bima Setia Sandya Nurul Indah Saffanah Nurul Indah Saffanah Nurus Saffana Yulianto Pralampita, Pulong Wijang Primadana, Aditya Putra Uta, Diego Rafi Putra, Muhamad Dwi Eka Putra, Yudha Ananta Khaerul Ramadhani, Alfiyah Regina Finka Rinda Yanuarisa Rini Riyanti Rony Prasetyo Rosita Dewi Rustono - Ryan Ravi Is Syahputra S.Pd. M Kes I Ketut Sudiana . Sa'adah, Ajeng Samrotu Salsabila, Yuna Annisa Salsabilla Maula Zalfa El Hamzah Saputra, Antonius Dwi Sarah Marsa Tamimi Semita, I Nyoman septa surya wahyudi, septa surya Setyawardani, Astuti Sheilla Rachmania, Sheilla Shodikin, M. Ali Shofia, Lailatis Siti Marissa Aisyah Siti Zulaikha Siti Zulaikha Risqiyani Sumarno Retoprawiro Supangat Supangat Syahputri, Siti Ananda Hardita Tristianti, Farmitalia Nisa Udi Rusadi Ulfa Elfiah Ulin Nuha Jazmin Widaningsih, Titi Widhiasari Normaningtyas Wiwien Sugih Utami Yehuda Tri Nugroho Supranoto Yudha Nurdian Yuli Hermansyah Yuli Rahmantia, Vania Yuliana MDA Yuna Annisa Salsabila Yunita Armiyanti