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All Journal JURNAL GIZI INDONESIA Nexus Kedokteran Klinik Nexus Biomedika Jurnal Gizi dan Kesehatan Ilmu Gizi Indonesia Indonesian Journal of Medicine Abdimas Universal Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings Narra J Journal of Multidisciplinary Applied Natural Science Sehat Rakyat: Jurnal Kesehatan Masyarakat Journal of International Conference Proceedings Biocaster : Jurnal Kajian Biologi JAMAS: Jurnal Abdi Masyarakat Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Paramasari Dirgahayu
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Journal : Journal of Multidisciplinary Applied Natural Science

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Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride Sahara, Nita; Mudigdo, Ambar; Wasita, Brian; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Cilmiaty, Risya
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.370

Abstract

Benign prostatic hyperplasia (BPH) progression is critically influenced by the androgen receptor (AR), Fibroblast growth factor-2 (FGF-2), and transforming growth factor-β (TGF-β) signaling axis. Although finasteride (FIN) is the standard therapeutic agent, its use is limited by adverse effects. This study evaluated the efficacy of Cosmos caudatus (CC) extract, administered alone or in combination with FIN, in modulating the AR–FGF-2–TGF-β axis in a testosterone-induced BPH rat model. Rats were divided into five groups (n = 6): Normal (N), BPH control (KN), FIN (KP; 0.44 mg/kg), CC extract (P1; 250 mg/kg), and combination (P2; CC 250 mg/kg + FIN 0.44 mg/kg). Prostatic AR, FGF-2, and TGF-β expression was analyzed using immunohistochemistry (IHC) with H-score quantification. Both KP and P1 significantly reduced AR (KP: 112 ± 15; P1: 105 ± 12 vs KN: 195 ± 18, p < 0.05) and FGF-2 (KP: 98 ± 14; P1: 92 ± 11 vs KN: 180 ± 20, p < 0.05), approaching normal values (AR N: 90 ± 10; FGF-2 N: 85 ± 9). In contrast, combination therapy (P2) failed to suppress AR (188 ± 17, p = 0.936) and FGF-2 (175 ± 19, p = 0.870) and induced a significant increase in TGF-β (P2: 145 ± 16 vs KN: 110 ± 12, p < 0.05). All treatment groups showed reduced epithelial thickness and prostate index (p < 0.05). These findings indicate that CC extract alone exerts therapeutic effects comparable to FIN by modulating the AR–FGF-2 axis, whereas combining it with FIN disrupts pathway regulation and promotes a pro-fibrotic response. The study supports the potential of CC extract as an effective alternative for BPH management without pharmacologic complications.
Co-Authors Adi Magna Patriadi Nuhriawangsa Adi Prayitno Amandha Boy Timor Randita Ambar Mudigdo Annang Giri Moelyo Annang Giri Moelyo Antonius Christanto Aryanda Widya Tazkagani Salsabila Aulia Nadhiasari Bambang Purwanto Bambang Sukilarso Sakiman Betty Saptiwi Brian Wasita Brian Wasita Budiyanti Wiboworini Christanto, Antonius Dani Redhono Haryoputro Dewi Okta Anggraini Dhani Redhono, Dhani Dono Indarto Dwi Surya Supriyana Endang Listyaningsih Suparyanti Eti Poncorini Pamungkasari Fadila, F Hanifa, Shafira N. Hartono Hartono Ida Nurwati Ilyas, Muhana F. Irma Suryani Lilik Wijayanti Lukas, Graciella A. Ma'rufah, Siti Made Setiamika Mashuri, Yusuf Ari Muchsin Doewes Nabila Adib Sungkar Nabila Adib Sungkar Nanang Wiyono Negara, Khesara Sastrin Prasita Pamungkasari, Eti P. pasa, chusairil Pradipto Subiyantoro Putri, Mahendri Deayu Rahma, Annisa A. Ratih Dewi Yudhani Ratih Puspita Febrinasari Risya Cilmiaty Risya Cilmiaty, AR Risya Cilmiaty, Risya Sahara, Nita Setiamika, Made Slamet Riyadi Sopianti, Densi Selpia Sri Haryati Sumandjar, Tatar Sundari, Isti Surya Dewi Primawati Sutartinah Tamaulina Br Sembiring Triniputri, Winastari Y. Umi Mahmudah Widia Susanti Wijayanto, Matthew A. Windayani, Komang Wulandari, Anggraini Yanita Listianasari