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All Journal VALENSI Indonesian Journal of Science and Technology Pharmacology and Clinical Pharmacy Research Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Jurnal farmasi UIN Alauddin Makassar Borneo Journal Of Pharmascientech Current Research on Biosciences and Biotechnology Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Pharmaceutical Reports MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Wahyuni Wahyuni
Faculty Of Pharmacy Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : Pharmaceutical Reports

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In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana Hariana; Wahyuni Wahyuni; Suryani Suryani; Ari Sartinah; Maulidyah Maulidyah; Agung Wibawa Mahatva Yodha; La Ode Muhammad Julian Purnama; Adryan Fristiohady
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Co-Authors ,, Suryani . Firdayanti A. N. T. A Mallarangeng Aan Zurniwatih P Abdulkadir Kamaluddin Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agung W. M. Yodha Ajeng Diantini, Ajeng Amaliah Amaliah Andini Sundowo Andryani Ningsih Annisa Fatinah Gani Anwar, Irvan Arfan Arfan Ari Sartinah Asman Sadino Asman Sadino Asniar Pascayantri Asniar Pascayantri Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Astrid Indalifiany Bafadal, Mentarry Baru Sadarun Dayatriana Muthalib Desyandri Desyandri Dewiyanti Madu Dian Afriana Dian Munasari Dian Munasari Dian Munasari Solo Dian Munasari Solo Dwi Arini Jufri Fadhliyah Malik Fahria Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Fery Indradewi Armadany Fery Indradewi Armadany Fery Indradewi Armadany Firasmi Sangadji Fitrawan, La Ode Muhammad Fredy Talebong Fristiohady Adryan Fristiohady, Adryan Gusti Ray Sadimantara Gusti Ray Sadimantara Gusti Ray Sadimantara Halik Halik Hariana Hariana Hasnawati Hasnawati Hendra Febriansyah Herdianawati Ringgu I Sahidin I Sahidin I Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Imran Imran Indri Wulandari Iren Meylani Irnawati Irnawati Irvan Anwar Jumriani Jumriani Junli Hong La Ode MJ Purnama La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Loly Subhiaty Idrus M. Ardianti M. Hajrul Malaka Marianti A. Manggau Masrika, Nur Upik En Maulidyah Maulidyah Mesi Leorita Mesi Leorita Mirda Mirda Mirna Widasri Mohammad Ghozali Mubarak Mubarak Mubarak Mubarak Muh. Azdar Setiawan Muh. Ilyas Yusuf Muhamad Handoyo Sahumena Muhammad Alim Marhadi Muhammad H Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad I. Yusuf Muhammad Ilyas Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Israwan Azis Muhammad Israwan Aziz Muktiarni, Muktiarni Musdalipah Musdalipah N. Nohong Nasrudin Nasrudin Nasrudin Nasrudin Nita Trinovitasari Nur Annisaa Nur Hikmah Nur Illiyyin Akib Nur Indri Rahayu Nur Saadah Daud Nur Syifa Rahmatika Nuralifah Nuralifah, Nuralifah Nurfenti Nurfenti Nurhikma Nurramadhani A. Sida Nurramadhani A. Sida Nurull Hikmah Nurull Hikmah Parawansah Parawansah Parawansah RAHMAT MULIADI, RAHMAT Rathapon Asasutjarit RH. Fitri Faradilla Rina Andriani Rina Andriani Rina Andryani Rina Maryanti Rini Hamsid Rini Hamsidi Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Salsabila, Syefira Saripuddin Saripuddin Seprian Hilman Sernita Sernita Sitti Raodah Nurul Jannah Sofa Fajriah Sri Hutami Lety Grashella Sri Madani Newulasindo Suryani Suryani Tian Amalia Halik Ulan Dwi Shintia Ulfa Ulfa Wa Ode Erna Fitriani Wa Ode Ida Fitriah Wa Ode Nurfinti Wa Ode Salma Wa Ode Siti Zubaydah Wa Ode Sitti Zubaydah Wiwin Holidin Yamin Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yulianti Fauziah Yustian Okwani