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Journal : Pharmacon

Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don) Fadhli, Haiyul; Ikhtiarudin, Ihsan; Lestari, Putri
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.9846

Abstract

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50  of 327,01µg/mL.
Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don) Haiyul Fadhli; Ihsan Ikhtiarudin; Putri Lestari
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.9846

Abstract

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50  of 327,01µg/mL.
Co-Authors Abdi Wira Septama Adel Zamri Adriani Susanty agistia, nesa Agustini, Tiara Tri Ainun Nurain Nurdin Ainun Nurain Nurdin Alfayutia, Windi Allaya, Regina Alpasiri, Ikhsan Mauludi Ananto, Deswita Sandra Tsalsabila Andika Bharada Rizky Soeharto Anggraeni, Ica Winanda Anggraini, Silvana Anita Lukman Apriko Jauwahir Arif Arsaf, Mohammad Armon Fernando Arsaf, Mohammad Arif Arsaf, Muhammad Arif Azizah, Wahyu BENNI ISKANDAR Dachriyanus Devi Safitri Dewi, Erna Puspita Difa, Faradini Ramsanjami DINA FITRIYAH Dwi Winarsih Emma Susanti Emma Susanti Emma Susanti Emrizal Enda Mora Erenda Yuneistya Erna Puspita Dewi Fadhila, Qonita Nur Fadillah, Ma’isyatul Fatma Sri Wahyuni Fatmalia, Anggun Fellysya, Nadya Safha Feriansyah, Robby Fina Aryani, Fina Fitriah, Dina Frasesa, Roscha Ulfa Furi, Mustika Ginta Rio Maranti Hazimah Hazimah, Hazimah Husnawati Husnawati Husnawati Ihsan Ikhtiarudin Iriani, Revy Islamia, Elmas Ghalis Nur Jasril Jasril Jumadila, Ikhsal Mukri Khoiriah, Anisah Maqfiroh, Wirdarani Mardianti, Tengku Shella Maspat, Rinta Meiriza Djohari, Meiriza Melzi Octaviani Miftahul Jannah Muhtadi, Wildan Khairi Musyirna Rahmah Nst Muti’ah, Try Hadirah Nadilla Alfitri Nasution, Musyirna Rahmah Neni Frimayanti Ningsih, Yozi Fiedya Nofri Hendri Sandi Noveri Rahmawati Noviana Suhery, Wira Nur Fitria Rohmatul Ummah Nurul fadillah, Nurul Pedro Anugrah Aswan Pratiwi, Amanda Putri Pratiwi, Erniza Putra, Diova Yuswidia Putri Lestari Putri Lestari, Putri Putri Pratiwi, Amanda Putri, Hefriza Putri, Rusnita Putri, Sella Hilmalia Nur Al Rahayu Utami Rahayu Utami Rahayu Utami Utami Rahima Rahma Dona Rahma Dona, Rahma Rahmatunnur, Siti Rahmayanı, Wıky Rahmiwati Hilma Ricardo, Nadira Atiqah Rifani, Mhd Rizki Wulandari Robiatun Adawiyah Rodhia Ulfa Ruska, Shinta Liana Sajja Wanda, Taqqia Sandra Tsalsabila Ananto, Deswita Sari, Rinita Septi Muharni Siregar, Lisa Andriyani Sitanggang, Sarah Dianora Sumbarita, Silvia Trihardiyanto, Agus Tyasakti Viryana Ulfa Frasesa, Roscha Ulfa, Rodhia Veithzal Rivai Zainal Viryana, Tyasakti Winda Tria Safitri Winda Yusma Ameliah Windarti Windarti Wira Noviana Suhery Wulandari, Venny Yanwirasti Yanwirasti Yuneistya, Erenda Yuswidia Putra, Diova Zamri, Wiedya Alfitrya