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Journal : Biotropika

Effect of Elephantopus scaber.L and Polyscias obtusa Leaf Extract for CD8+ and CD8+CD62L+ T Cell Modulation in Balb/c Mice Faizah, Nurul; Djati, Muhammad Sasmito
Biotropika: Journal of Tropical Biology Vol 2, No 3 (2014)
Publisher : Biotropika: Journal of Tropical Biology

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Abstract

Medicinal herbal is highly recommended especially for pregnant women with bacterial infection to reduce the consumption of synthetic antibiotics that are harmful to their body and also fetus. E. scaber and P. obtusa are believed to increase the number of imunocompetent cells such as CD8+ and CD8+CD62L+ T cell cause both plants have biochemical compound such as saponin and flavonoid. These plants good for immune system, but optimum dose of mixture extracts from both leaves to increase the number of CD8+ and CD8+CD62L+ T cell in mice is doesnt know yet. This study to determine effect of E. scaber and P. obtusa leaf extract by compared the number of CD8+ and CD8+CD62L+ T cell between control mice and treated mice. E. scaber and P. obtusa leaf extract can not reduce relative number of CD8+ T cells compared with control mice after 14 days treatment and 18 days. Even it show little different number but it was not significantly different, whereas the number of CD8+ decreased in K2 control mice also not significantly different than other treatments. K1 group is always show the highest number of CD8+ T cell compared to other treatments. CD8+ was decreased by increasing the doses of P. obtusa leaf extract. Key word: E. scaber, CD8+ T cell, CD8+CD62L+ T cell, P. obtusa, Salmonella typhimurium.
Co-Authors A. Mustika Abidin Abror Achmad Dwitama Karisma Adha, Munirah Fatimah Agustina, Melinda Ahmad Zuhdi Andari, Fadhilah Nur Antari, Gladeva Yugi Ardiana Aribaat, Salma Khoirotunnisa Armenia, Ivan Gustra Manca Aulia, Kunni Rofiqotul Ayu , Sadriana AYU LESTARI Badrud Tamam BAMBANG SURATMAN Br.Tarigan, Dinda Florentina Rania Burhanuddin Burhanuddin Dewandono, Wiranto Aji Diah Ratna Widiarti Eti Setiawati, Eti Fairuzia Khaidaroh, Hilda faizah, Nurl Faridah, Mutiah Fatahillah, Fatahillah Febrianda, Sony Difa Febriani, Putri Indah Firdiansyah, Firdiansyah Fitri Andriani Fatimah Fitria Wahyuni Hardianti, Laily Harun Al-Rasyid Hasanudin, Muhammad Nurul Hasna, Oktavia Hikmah, Harisna I Ketut Suatha I Wayan Batan Indrawadi, Junaidi Indrowaty, Sri Aju - Isa Anshori Joang Ipmawati Kalloka, Sultan Hendra Mahardi Kartini Kartini Kartini, Dyan Nurwita Khasanah, Indayati Lailatul Qomariyah, Lailatul Lestari, Ida Puji Listiana Hidayati M. Yusuf Amin Nugroho M.Imamuddin, M.Imamuddin Maria Montessori Moch Sasmito Djati MOCHAMMAD YASIR Muali, Chusnul Mufsiroh, Istijabah Ifti Muhammad Alfian, Muhammad Mukhlisa, Dian Murtadlo Murtadlo Mustofa Mustofa Ngulum, Mochamad Bahrul Noviyanti Watman, Ika Nugroho, Muhammad Yusuf Amin Nur Aisyah Pratiwi , Ika Ari Putra, Nicky Rahmana Qomaria, Nur Rabbani, Sulthan Raden Bambang Sumarsono Rahman, K.A Rahmat Aryandi Ramlah Retnoningrum, Sri Murti Rivani, Sinta Rohman, Miftahur romdhoni, muhammad wildan Sa'adah, Rizki Amalia Sachputra, Sofyan Sukrian Safutri, Lhutfia Wahyu Saijun, Saijun Saputri, Nadia Elga Setiyadi, Bradley Shabrina, Amalina Shafina, Shafina Siti Ummi Masruroh Slamet Suyanto Sri Aju Indrowaty Suryanef Suryanef Syamsiarna Nappu, Syamsiarna Tsaqifah, Ainun Wawan Shokib Rondli Widayanti, Agnisa Wifaq Kholidiyah, Ananda Wiwin Puspita Hadi Yahya Nur Ifriza Yenita Roza Yhustien, Dhea Yogananda, Amrina Amalia Zulfatun Ruscitasari Zulkipli Lessy