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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Jurnal Perikanan dan Kelautan Pharmaciana: Jurnal Kefarmasian Kreano, Jurnal Matematika Kreatif-Inovatif Journal of Environmental Engineering and Sustainable Technology The Journal of Pure and Applied Chemistry Research Jurnal Pilar INDONESIAN JOURNAL OF PHARMACY Agricore: Jurnal Agribisnis dan Sosial Ekonomi Pertanian Unpad Edukasi: Jurnal Pendidikan Jurnal Penelitian Pendidikan IPA (JPPIPA) Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Biologi Tropis Proceeding Simposium Nasional Kelautan dan Perikanan Jurnal Perikanan Universitas Gadjah Mada Indonesia Journal of Halal Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Techno-Fish PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat GERVASI: Jurnal Pengabdian kepada Masyarakat JURNAL PEMBELAJARAN DAN MATEMATIKA SIGMA (JPMS) Jurnal Abdi Insani Indonesian Journal of Global Health research Mosharafa: Jurnal Pendidikan Matematika Berkala Penelitian Hayati Jumper : Jurnal Mahasiswa Pendidikan Olahraga Juwara : Jurnal Wawasan dan Aksara Indo-MathEdu Intellectuals Journal Jurnal Desain Komunikasi Visual Nirmana Journal of Indonesian Rural and Regional Government (JIRReG) Jurnal Komputer Teknologi Informasi Sistem Komputer (JUKTISI) Journal of Comprehensive Science Jurnal Inovasi Pendidikan dan Teknologi Informasi (JIPTI) Proceedings Series of Educational Studies Jurnal Inovasi Pendidikan dan Pengajaran International Research Journal of Business Studies Jurnal Buana Kata: Pendidikan, Bahasa, dan Ilmu Komunikasi Fajar: Media Komunikasi dan Informasi Pengabdian Kepada Masyarakat Media Pendidikan Matematika
Muhamad Firdaus
Fakultas Perikanan Dan Ilmu Kelautan, Universitas Brawijaya, Malang
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Journal : INDONESIAN JOURNAL OF PHARMACY

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Effects of brown algae extract to function of aorta endothelium cell in diabetic rats Muhamad Firdaus; Made Astawan; Deddy Muchtadi; Tutik Wresdiyati; Sarwono Waspadji; Setyawati S. K.
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.495 KB) | DOI: 10.14499/indonesianjpharm0iss0pp151-157

Abstract

Macro and microvascular disease are currently the principal causes of morbidity and mortality in diabetes mellitus patients. Loss of the modulatory role of  the  endothelium  may  be  a  critical and  initiating factor  in  the  development of diabetic  vascular  disease.  Polyphenol is known behave protective active compound to function endothelium cell.  Polyphenol that contained in brown algae was phlorotannin.  The  aim  of  the  present  study  was  to  investigate  the effects  of  S.  echinocarpum extract  on  endothelial  dysfunction  in  aorta  of streptozotocin  diabetic  rats.  This experiment was conducted by complete randomized design in 2 months old of male albino Sprague Dawley strain of rats, 125-150 grams body weight. The rats divided in fivegroups, each group consist of  6  rats.  First  group:  normal  which  is  given  1  mL  of  extract  vehicle  orally; second  group:  diabetic  rats  which  is  given  1  mL  of  extract  vehicle  orally;  third group:  diabetic  rats  which  is  treated  extract  150  mg/kg  BW  dose  orally;  fourth group: diabetic rats which is treated extract 300 mg/kg BW dose orally; and fifth group: diabetic rats which is treated extract 450 mg/kg BW orally. Diabetic rats prepared by injection of 45 mg/kg  streptozotocin  intraperitoneally.  Extract was given to diabetic rats during 90 days.  The  result  showed  that  brown  algae extract  rearrange  endothelium  cell  function  of  diabetic  rats  by  increasing relaxation,  releasing  of  EDRF  and  decreasing  of  MDA.  Based on these observations,  it  was  concluded  that  S.  echinocarpum extract  recovers  the endothelial  dysfunction  associated  with  diabetes.  This effect appears to be  due to its antioxidant properties.Key words: diabetes, EDRF, endothelial dysfunction, MDA, S. Echinocarpum
Co-Authors Abdillah Abdillah Abdillah Abdul A. Jaziri Abdul Aziz Jaziri, Abdul Aziz Abdur Razzaq, Abdur Al-Farezi, Gilang Alghafihqi, Denny Ali Imron Alifiani, Alifiani Amel Yanis Andriati, Novi Anggraeni, Pangestuty Yeni Anies Chamidah Anies Chamidah Annafi Riski Nurcholis Asep A Prihanto Asep Awaludin Prihanto Asep Wahyudin Astiti, Ayu Dewi Astriyani, Serly Astuti - Astuti, Retno Tri Atiek Iriany Aulia Savira Awang, Mohd Azrie Bin Bambang Dwi Argo Bambang Semedi Budiutami, Aryanti Diah Ayu Cahyo, Retno Nur Candra Adi Intyas Chamidah, Anies D S Sari Danang Ariyanto Darmawan, Hendy Widya Deddy Muchtadi DEDDY MUCHTADI Delima, Meita Putri Denny Alghafihqi Dewi Liesnoor Setyowati Dhanny Septimawan Sutopo Djamaludin, Heder Dwi Anggraini Puspitasari Dwi Oktaviana Dwi Setijawati Dwi Setijawati Eddy Suprayitno Eka Puji Lestari Erliza Noor Faizul Amam Fauzi, Adnan Fazira, Ira Firyal Hanifah Florensia, Flofida Gardenia Akhyar Genda, Agustina Hakiki, Muhammad Hakim, Dedi Budiman Hambali, Yudi Ahmad Hardiansyah, Rendi Hardoko Hardoko Hartono Hartono Hendri Hendri Irvandi, Wandra Islamy, R Adharyan Iwit Prihatin Karimah Karimah Kartikaningsih, Hartati Lestari, Rizka Febry MADE ASTAWAN Mahara, Fenny Amilia Mahmuddin Mahmuddin Marhen Andan Prasetyo Mesa Rahmi Stephani, Mesa Rahmi Muhammad Amri Muhammad Nur Akbar Rasyid Muzakky, Mohamad Irvan Ningsih, Omega Tantia Noer Rahmi Ardiarini, Noer Rahmi Nugraha, Muhamad Yudistira Nugraha, Muhammad Reno Dwi Nunik Cokrowati Nunik Cokrowati Nur Aliya Nabila Zsalzsabil Nurcholis, Annafi Riski Nurrohmah, Maulida Salasa Pangestuty Yeni Anggraeni Putri, Natasya Adelia Rahman Haryadi, Rahman Rahmi Nurdiani Rasim Rasim, Rasim Rendi Hardiansyah Ridho Dedy Arief Budiman Sapto Jumono Sari, Fitra Bona Sarwono Waspadji Sarwono Waspadji Setyawati S. K. Setyawati S. Karyono Sika, Monika Siregar, Herbert Siti Yulaikah Sitti Mania Soffyana, Soffyana Sri Andayani Sri Andayani Sujoko, Anang Sumarno, Gano Suryanata, Widya Adi Susilawati, Susilawati Sutisna, Dadang Suyono Suyono Syarif Firmansyah Tambunan, Jenny Ernawati Tutik Wresdiyati Utin Desy Susiaty Vindo Feladi, Vindo Wafa, Moh. Ali Wicaksono, Achmad Nizar Widagdo, Supriyatno Widya Adi Suryanata Yahya Yahya Yasmin, Putri Yenny Risjani Yudi Darma Yulaikah, Siti Yunita Eka Puspitasari Zulfaidah Penata Gama Zulkifli, Akmal