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Suharyo Hadisaputro
Ilmu Penyakit Dalam Universitas Diponegoro Semarang
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Journal : Global Health Management Journal

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Potential of garlic (Allium sativum) essence in changing blood lipid profile of hypertension patients with hypercholesterolemia Hadi, Hadi; Hadisaputro, Suharyo; Ramlan, Djamaluddin
Global Health Management Journal Vol 3, No 1 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: As like hypertension, hypercholesterolemia is a major risk factor for cardiovascular disease and hypertension and its complications are one of the highest causes of death in the world.Aims: This study aims to determine the potential of garlic essence (Allium sativum) mixed with honey in changing blood pressure and lipid profile of blood in the hypertension patients with hypercholesterolemia, and to compare the effectiveness with those who received Simvastatin, the most preferred pharmacological treatment of hyperlipidemia.Methods: This research is a quasy experiment study with a Nonequivalent control group design. There were 22 hypercholesterolemia outpatients purposively selected from local health centers. The respondents were then divided equally to (a) a control group where the patients were provided with generic Simvastatin 10 mg single dose taken once in the afternoon, and (b) an intervention group where the respondents received a non-pharmacological supplement of garlic essence in 2 grams honey. The blood pressure and the blood lipid profile were examined before (Pretest) and at the Day 22 after the treatment (Posttest). The collected data was then analyzed using a T-test to define the significant mean difference between two groups, and a Cohen’s effect was measured to interpret the size of changes.Results: Either the additions of Simvastatin or the provision of garlic essence mixed with honey decreased the blood pressure (systole and diastole) and the cholesterol, triglyceride, and LDL cholesterol, but increased the HDL cholesterol. While significant difference was observed for all parameters at the intervention group, the improvement at the control group for triglyceride was not significant (p value = 0.041). Overall, by the Cohen's effect size effect, we can interpret that the changes was moderate for diastole and systole blood pressure, and also triglyceride and DLD-cholesterol; however the effect size was low for Cholesterol and HDL-cholesterol. Conclusion: The findings show the importance of the garlic essence mixed with honey to be offered as a nutritional supplement for hypertensive patients with hypercholesterolemia.  Keywords: Garlic (Allium sativum) essence, Simvastatin, Hypertension, Hypercholesterolemia, Blood pressure, Blood lipid profile.
The effect of chocolate consumption (Theobroma cacao L.) on level of blood cholesterol and triglyceride in hypertension patients at Jatiroto Health Center, Indonesia Ulkhasanah, Muzaroah Ermawati; Hadisaputro, Suharyo; Pujiastuti, Rr. Sri Endang
Global Health Management Journal Vol 3, No 1 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Hypertension is influenced by lifestyle factors such as high fat intake which has the potential for high blood cholesterol level. Cocoa products, which are rich sources of flavonoids, have been shown to reduce blood pressure and the risk of cardiovascular disease.Aims: The purpose of this research is to examine the dark chocolate consumption in decreasing the level of blood cholesterol and triglyceride in hypertension patients.Methods: This research is a quasi-experiment study with pre and post and control group design. There were thirty two (32) hypertensive patients selected from Jatiroto Health Center in June-July 2018 using a random sampling technique. The respondents were then divided to (1) a control group where patients were prescribed to a popular non-pharmacological therapy Simvastatin and (2) an intervention group where the respondents were prescribed with Simvastatin and also received an additional dark chocolate 60gr/day (given twice a day, each 30gr) for 15 days. A spectrophotometer glycerol phosphate oxidase (GPO-POD) with 546 nm wavelength was employed to measure the levels of blood cholesterol and triglyceride. The significant mean difference between pre and posttest, and the changes between control and intervention group were defined by statistical analysis T-test.Results: This study acknowledged that the prescribed simvastatin alone presents a significant contribution to decrease the cholesterol level at 14.40 point (p value = 0.041), however, the generic is not enough to deliver a significant effect to the decrease of triglyceride level in the hypertension patients (p value = 0.361). A great contribution to the depression of cholesterol and triglyceride level in the hypertensive respondent was observed if simvastatin prescription was combined with a provision of 60 gram dark chocolate, respectively to the level of 57.06 and 38.41 mg/dL with p value = 0.001. The addition of dark chocolate in the simvastatin prescription will significantly reduce the blood cholesterol level (p value = 0.020), but not really effective to reduce the triglyceride (p value = 0.560).Conclusion: The findings suggest that giving dark chocolate to the hypertensive patients who receive simvastatin prescription will decrease the cholesterol and triglyceride levels greater than the consumption of simvastatin drugs alone. Keywords: Dark chocolate, Simvastatin, Hypertension, Cholesterol, Triglyceride
Co-Authors Abdul Ghofur Adam, Oktaviana Thresia Monika Barbara Ag Soemantri Agus Suwandono Agustinus Soemantri Amin, Dewita Rahmatul Andriana, Andriana - Ani Margawati Anies Anies Anies Annastasia Ediati Arfan, Iskandar Ari Budi Himawan Ari Suwondo Aris Santjaka Arwani Arwani Astuti, Ismi Puji Awan Hariyanto, Awan Ayu Diana Meilantika Azzahra, Ilya Nur Aulia Bagoes Widjanarko Banundari Rachmawati Bedjo Santoso Kadri Dilla, Tasya Nurlaila Diyah Fatmasari Djamaluddin Ramlan, Djamaluddin Djamil, Masrifan Djokomoeljanto Djokomoeljanto Dwi Pudjonarko Endah Aryati Eko Ningtyas Eny Retna Ambarwati Fajri, Umi Nur Fara, Yetty Dwi Farah Salsabila, Farah Ganda Gumilar, Argo Gumilar, Argo Ganda Gustiya, Sherly Dwi Hadi Hadi Hamdan, Yusuf Lensa Harfaina, Harfaina Haryana, Chyntia Haryono, Nathasia Elga Henry Setyawan Susanto Henry Setyawan Susanto Heri Nugroho Herliani, Emy Herman Kristanto Hikmah, Kholisotul Imam Djamaluddin Mashoedi Iswari Setianingsih Jaleha, Jaleha Jayawarsa, A.A. Ketut Julian Dewantiningrum K. Heri Nugroho HS, K. Heri Kamilah Budhi Rahardjani, Kamilah Budhi Khabib Mualim, Khabib Kumorwulan, Suryati Kurniawati, Erna Yovi Ladyvia, Fiyola Lestariningsih Lestariningsih Lukmono, Djoko Tri Hadi Lukmono, Djoko Trihadi Maria Mexitalia Marludia, Melani Agis Martinus, Ishak Mateus Sakundarno Adi, Mateus Sakundarno Melyana Nurul Widyawati Moedrik Tamam Muflihah Isnawati Muhammad Saleh Muliawati, Ratna Munasik Munasik Muzaroah Ermawati Ulkhasanah Nafi’ah, Eka Apriadi Farkhati Nildawati . Noor Pramono Nur Djanah, Nur Nurjanah, Fatihah Wari Nurul Aeni Oktavia, Eva Zuli Oktaviarini, Eka Onny Setiani Parera, Lodri Pratiwi, Meilicha Anggraini Pratiwi, Tia Purwanti, Sumy Hastry Pusaka, Semerdanta Rahatina, Vilianti Eka Fitri Rahmah, Aulia Agyanti Rasipin Rasipin Resty Ryadinency Rini Astuti Rini, Sulistio Roesipin, Sri Wahyuningsih Rohisotul Laily Rr. Sri Endang Pujiastuti Safira, Rahma Salma, Baiq Desi Sayono Sayono Selamat Budijitno Setyawan S, Henry Shofa Chasani Siti Patimah Soejoenoes, Ariawan Soejoenoes, Ariawan Sofro, Muchlis AU Sri Rahayu Sri Sumarni Sri Wahyuni Sudiyono Suprihati - Supriyadi - Supriyana Supriyana, Supriyana Suryati Kumorowulan Sutaryo Sutaryo Thaariq, Nurul Aziza Ath Tjokorda Gde Dalem Pemayun Triana Sri Hardjanti, Triana Sri Untung Sujianto Widiastuti Samekto Widjarnarko, Bagoes Yunie Armiyati