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Suharyo Hadisaputro
Ilmu Penyakit Dalam Universitas Diponegoro Semarang
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Journal : MEDISAINS

 1 
In vivo study of the antihypertensive effect of bidara leaf (Ziziphus spina-christi) during pregnancy Dilla, Tasya Nurlaila; Hadisaputro, Suharyo; Santjaka, Aris
MEDISAINS Vol 19, No 2 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i2.11431

Abstract

Background: Bidara is drought tolerant and very easy to grow in tropical climates such as Indonesia. Bidara contains a combination of calcium, potassium, and magnesium, and active flavonoid compounds, and antioxidant activity that play a role in inhibiting free radical damage, improving endothelial function so that it can potentially lower blood pressure. Previous studies explained that a dose variant of no more than 300mg/kg BW is beneficial while minimizing pathological changes. However, there has been no research related to the effect of bidara leaf in lowering blood pressure, so it is necessary to do related research.Objective: Analyze the effect of bidara leaf extract at a 200 mg/kg BW dose and 300 mg/kg BW on systolic and diastolic blood pressure.Methods: 24 pregnant female Wistar rats induced hypertension, aged 6-8 weeks with a weight of 130-230 grams. The rats were randomized so that they consisted of 2 control groups and two experimental groups, which were given various doses of bidara leaf for nine days. Blood pressure was measured using non-invasive CODA.Results: The blood pressure of rats in the bidara leaf extract group at doses of 200mg/kg BW and 300mg/kg BW decreased systolic and diastolic compared to the control group (p<0.05). The 200mg/kg BW dose group experienced a decrease in blood pressure of 12.3% for systolic and 16.32% for diastolic; the 300mg/kg BW dose group experienced a decrease in blood pressure of 19.99% for systolic and 27.73% for diastolic.Conclusion: Bidara leaf extract can reduce the blood pressure of pregnant rats with hypertension.
Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension Salsabila, Farah; Hadisaputro, Suharyo; Sunarjo, Lanny
MEDISAINS Vol 21, No 2 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i2.17484

Abstract

Background: As a complication of pregnancy, uncontrolled hypertension will continue to be a complication that harms both mother and baby. Pomegranate peel, which contains high antioxidants, is potentially used as an antihypertensive of adjuvant pharmacological therapy. However, there has been no research on the effect of pomegranate extract in lowering blood pressure, so it is necessary to do related research.Purpose: Analyze the effect of pomegranate peel extract on blood pressure and nitric oxide levels in gestational hypertension.Methods: This is a quasi-experiment design pre-post-test with the control group. Through purposive sampling techniques, 32 respondents were divided into two groups. During 14 days, the intervention group received nifedipine 10 mg/day with 500 mg of pomegranate peel extract, while another group was only given nifedipine 10 mg/day.Results: The blood pressure of the intervention group decreased compared to the control group (p<0.05). Meanwhile, the nitric oxide level of the intervention group is increased compared to the control group (p<0.05).Conclusions: Pomegranate peel extract can reduce blood pressure and enhance nitric oxide levels in gestational hypertension.
Calcium supplementation from chicken eggshells to increase nitric oxide levels and control blood pressure in gestational hypertension Rahmah, Aulia Agyanti; Hadisaputro, Suharyo; Ambarwati, Eny Retna
MEDISAINS Vol 20, No 1 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i1.13378

Abstract

Background: Hypertension is one of the highest causes of death in pregnant women. Calcium deficiency can lead to hypertension. Chicken eggshell can be used as a natural calcium supplementation therapy in hypertension.Purpose: Analyze the effect of chicken eggshell on blood pressure through the increased nitric oxide level in gestational hypertension.Methods: This is Quasy experiment research with pretest and posttest with control group design. Respondents were ≥20 weeks pregnant women with gestational hypertension. Determination of respondents by purposive sampling obtained experimental group (n=12) and control group (n=12). 1.1 g/day of eggshell flour was given for 14 days.Result: Mean of systolic and diastolic blood pressure in experimental group decreased 14.25 mmHg or 9.5% (p=0.000) and 12.84 mmHg or 13.04% (p=0.000) after received chicken eggshell flour for 14 days compared to control group mean of systolic and diastolic blood pressure increased 1.92 mmHg or 1.35% (p=0.000) and 0.33 mmHg or 0,34% (p=0.121). Nitrit oxide level of experimental group increased 8.250 μmol/L or 20.93% (p=0.020) and control group decreased 3.083 μmol/L or 7.20% (p=0.488).Conclusion: Chicken eggshell flour affects increasing nitric oxide levels and controls systolic and diastolic blood pressure in gestational hypertension.
The effect of warm water foot bath therapy on the blood pressure and cortisol levels in gestational hypertension Amin, Dewita Rahmatul; Hadisaputro, Suharyo; Isnawati, Muflihah
MEDISAINS Vol 20, No 3 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i3.14899

Abstract

Background: Pregnant women are susceptible to anxiety disorders that result in hypertension. Previous studies that have been carried out with warm water foot bath therapy, which can relax the body, previous research only measured the level of anxiety psychologically and never seen a physiological/molecular increase in blood pressure from the indicator of cortisol levels.Purpose: To analyze the effect of warm footbath therapy on the blood pressure and cortisol levels in gestational hypertension.Methods: This experimental study has a randomized pre-post-test control group design. They involved 40 subjects in two groups. The control group was given 10 mg of nifedipine, while the intervention group was given 10 mg of nifedipine and a warm water foot bath at 40-43oC for 15 minutes for 14 consecutive days. Pre-post cortisol levels were measured with the ELISA method cortisol test.Results: A warm water foot bath therapy effectively decreased systolic blood pressure in the intervention group, which was 43 mm Hg compared to the control group, 19 mm Hg (p<0.05). Diastolic blood pressure in the intervention group was 15.5 mmHg compared to the control group's 6.5 mmHg (p<0.05), and cortisol levels in the intervention group: 48.1 ng/ml compared to the control 14.5 ng/ml (p<0.05).Conclusion: Warm water foot bath therapy at 40-43oC for 15 minutes for 14 consecutive days reduces systolic blood pressure by decreasing cortisol levels in hypertensive pregnant women.
The effectiveness of topical gel formulation extract Centella asiatica and Curcuma domestica to fading striae gravidarum Oktavia, Eva Zuli; Hadisaputro, Suharyo; Rahayu, Sri
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.19130

Abstract

Background: The incidence of striae gravidarum in Indonesia is 95%, and 79.7% are primigravida. Striae gravidarum is not a direct physical health risk but is associated with body image and decreased self-confidence. Curcuma domestica contains curcumin and vitamin C, which can stimulate the synthesis of type IV collagen. In contrast, the Centella asiatica plant contains triterpenoids and saponins, which can stimulate the synthesis of type I collagen, which helps regenerate skin cells and improve skin elasticity. However, it is necessary to see the effectiveness of the two herbs, Centella asiatica and Curcuma domestica, in fading striae gravidarum. Purpose: To prove the effectiveness of topical gel formulation extract Centella asiatica and Curcuma domestica for fading of striae gravidarum.Methods: This is a quasi-experimental study with a pretest-posttest control group design. The sample consisted of 32 primigravida pregnant women divided into two groups: the intervention group was given a combination of Curcuma domestica and Centella asiatica gel at a dose of 5 mg twice a day for 14 days, and the control group was given a mineral oil gel at a quantity of 5 mg twice a day for 14 days—measurement of striae gravidarum using Davey score. The statistical test used the Friedman and Wilcoxon test.Results: The average fading of striae gravidarum in the intervention group was more significant than in the control group, 11.44±4.131 to 4±3.033 vs.12.19±5.788 to 8.56±4.320 treatment on the 14th day. The analysis results showed that the topical gel formulation of Centella asiatica and Curcuma domestica was more effective in fading striae gravidarum than the placebo gel (p<0.001).Conclusion: Administering topical gel containing 12% Centella asiatica extract and a 10% Curcuma domestica dose of 5 mg twice a day for 14 days affected the fading of striae gravidarum.
Co-Authors Abdul Ghofur Adam, Oktaviana Thresia Monika Barbara Ag Soemantri Agus Suwandono Agustinus Soemantri Amin, Dewita Rahmatul Andriana, Andriana - Ani Margawati Anies Anies Anies Annastasia Ediati Arfan, Iskandar Ari Budi Himawan Ari Suwondo Aris Santjaka Arwani Arwani Astuti, Ismi Puji Awan Hariyanto, Awan Ayu Diana Meilantika Azzahra, Ilya Nur Aulia Bagoes Widjanarko Banundari Rachmawati Bedjo Santoso Kadri Dilla, Tasya Nurlaila Diyah Fatmasari Djamaluddin Ramlan, Djamaluddin Djamil, Masrifan Djokomoeljanto Djokomoeljanto Dwi Pudjonarko Endah Aryati Eko Ningtyas Eny Retna Ambarwati Fajri, Umi Nur Fara, Yetty Dwi Farah Salsabila, Farah Ganda Gumilar, Argo Gumilar, Argo Ganda Gustiya, Sherly Dwi Hadi Hadi Hamdan, Yusuf Lensa Harfaina, Harfaina Haryana, Chyntia Haryono, Nathasia Elga Henry Setyawan Susanto Henry Setyawan Susanto Heri Nugroho Herliani, Emy Herman Kristanto Hikmah, Kholisotul Imam Djamaluddin Mashoedi Iswari Setianingsih Jaleha, Jaleha Jayawarsa, A.A. Ketut Julian Dewantiningrum K. Heri Nugroho HS, K. Heri Kamilah Budhi Rahardjani, Kamilah Budhi Khabib Mualim, Khabib Kumorwulan, Suryati Kurniawati, Erna Yovi Ladyvia, Fiyola Lestariningsih Lestariningsih Lukmono, Djoko Tri Hadi Lukmono, Djoko Trihadi Maria Mexitalia Marludia, Melani Agis Martinus, Ishak Mateus Sakundarno Adi, Mateus Sakundarno Melyana Nurul Widyawati Moedrik Tamam Muflihah Isnawati Muhammad Saleh Muliawati, Ratna Munasik Munasik Muzaroah Ermawati Ulkhasanah Nafi’ah, Eka Apriadi Farkhati Nildawati . Noor Pramono Nur Djanah, Nur Nurjanah, Fatihah Wari Nurul Aeni Oktavia, Eva Zuli Oktaviarini, Eka Onny Setiani Parera, Lodri Pratiwi, Meilicha Anggraini Pratiwi, Tia Purwanti, Sumy Hastry Pusaka, Semerdanta Rahatina, Vilianti Eka Fitri Rahmah, Aulia Agyanti Rasipin Rasipin Resty Ryadinency Rini Astuti Rini, Sulistio Roesipin, Sri Wahyuningsih Rohisotul Laily Rr. Sri Endang Pujiastuti Safira, Rahma Salma, Baiq Desi Sayono Sayono Selamat Budijitno Setyawan S, Henry Shofa Chasani Siti Patimah Soejoenoes, Ariawan Soejoenoes, Ariawan Sofro, Muchlis AU Sri Rahayu Sri Sumarni Sri Wahyuni Sudiyono Suprihati - Supriyadi - Supriyana Supriyana, Supriyana Suryati Kumorowulan Sutaryo Sutaryo Thaariq, Nurul Aziza Ath Tjokorda Gde Dalem Pemayun Triana Sri Hardjanti, Triana Sri Untung Sujianto Widiastuti Samekto Widjarnarko, Bagoes Yunie Armiyati