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All Journal Jurnal Ilmiah Farmasi LITE: Jurnal Bahasa, Sastra, dan Budaya LiNGUA: Jurnal Ilmu Bahasa dan Sastra Jurnal Pendidikan Dasar Nusantara JAM : Jurnal Aplikasi Manajemen VIVID Journal of Language and Literature Nazharat: Jurnal Kebudayaan Pedagogia: Jurnal Pendidikan INDONESIAN JOURNAL OF PHARMACY InfoTekJar : Jurnal Nasional Informatika dan Teknologi Jaringan JURNAL BIOLOGI INDONESIA DWIJA CENDEKIA: Jurnal Riset Pedagogik Jurnal Bidang Pendidikan Dasar Jurnal Moral Kemasyarakatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ELSE (Elementary School Education Journal) : Jurnal Pendidikan dan Pembelajaran Sekolah Dasar Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Indonesian Journal of Chemistry International Journal of Elementary Education JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Onoma: Pendidikan, Bahasa, dan Sastra Jurnal Manajemen Informatika dan Sistem Informasi LINGUA : Jurnal Bahasa, Sastra, dan Pengajarannya TSAQOFIYA : Jurnal Pendidikan Bahasa dan Sastra Arab Abdi Laksana : Jurnal Pengabdian Kepada Masyarakat Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Teknologi Sistem Informasi dan Sistem Komputer TGD Journal of Arabic Literature (Jali) Jurnal Sociopolitico Prosiding Seminar Nasional Program Pengabdian Masyarakat Online Learning in Educational Research Jurnal Pembelajaran, Bimbingan, dan Pengelolaan Pendidikan Jurnal Bangun Abdimas QISTINA: Jurnal Multidisiplin Indonesia Biocaster : Jurnal Kajian Biologi Innovative: Journal Of Social Science Research PKM Maju UDA Jurnal Ilmiah Pangan Halal Jurnal PKM Agri Hatantiring Journal of Electrical Engineering, Energy, and Information Technology ENRICH: Jurnal Pendidikan, Bahasa, Sastra dan Linguistik Jurnal Pengabdian Kepada Masyarakat Hanif Journal of Information Systems Journal of Innovative and Creativity (ETTLI) LISANIA: Journal of Arabic Education and Literature Al-Bidayah : jurnal pendidikan dasar Islam Jurnal Multidisiplin Indonesia NOBEL : Journal of Literature and Language Teaching JURNAL NERACA Indonesian Journal of Economics, Business, Accounting, and Management Jurnal Bakti UPPR Jurnal Abdimas Nusantara
Arief Rahman Hakim
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : JURNAL BIOLOGI INDONESIA

 1 
Efek Penghambatan Terhadap Pertumbuhan Tumor Paru dan Uji Ketoksikan Akut Ekstrak Kapsul Chang Sheuw Tian Ran Ling Yao Pada Mencit (Mus musculus) dan Tikus (Ratus tanezumi) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.692 KB) | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It’s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
Co-Authors ., Purwantiningsih ., Purwantiningsih A.A. Ketut Agung Cahyawan W Abadi Sanosra Afdayeni, Melia Afitri, Windy Dwi Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Ahmad Syukri Aji Jumiono Akhmad Kharis Nugroho Akhmad Syarif Alva Hendi Muhammad Ananda , Dhimas Aryo Vipha ANDIKA GUTAMA, ANDIKA Anindita, Jessica Arief Nurrochmad Asro Laelani Indrayanti Astini, Siluh Made Yuni Auliana, Diah Fitrotul bin Yahaya, Mohd Firdaus Br Tarigan, Maya Sari Br Tarigan, Yuni Franciska Budi Eko Soetjipto Butarbutar, Maria Haryanti Chaerani, Ika Tania Cicilia Ika Rahayu Nita Daeli, Abiyudin Dedy Suryadi Diana, Ratna Dion Notario Djohar, Hasnul Insani Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Agus Setiawan DWI CAHYONO dwi yasa, arnelia Edy Budi Harjono, Edy Budi Edy Meiyanto Endang Lukitaningsih Eny Masruriati Eny Susilowati Fadhil Hasan R, Hans Mokhammad Fadhli, Khairul Fajar Rakhmatullah Faradilla, Aina Noor Ade Farida Nur Kumala Fathul Jannah Fauzi, Soni Fitri, Hidayatul Fotriyodi, Rivon Hakim, Lukman Hakim, Lukman Hanifa, Lulu Fadlina Hanurawan, Fattah Harefa, Sepakat Jaya HARI PURNOMO Hariani, Pipit Putri Haryadi, Nicko Haryanti Butarbutar, Maria Hasibuan, Ahmad Riady Hasibuan, Bulkis Hayati, Farida Helmi Haris Hidayat, Alvonsius Bambang Hulu, Safira I Nyoman Sudana Degeng Ida Ayu Putu Sri Widnyani Idsan, Rakha Satya Imelda Mardayanti Imono Argo Donatus, Imono Argo Indah Purwantini Intan Intan Iratutisisilia, Iratutisisilia Iryanti, Nurlista Iskandar Ladamay, Iskandar Juwita, Dewi Ratna Kasih, Nirvane Zefanya Khusniyah, Farikhatul Kristini, Wanda Kusuma, Muthiara Kusumawati, Dina Ari Lianty, Nozylianty Liberti Natalia Hia Lukman Hakim Lukman Hakim Maharani, Devi Mahmudah, Amirotul M.H Margolang, Khairul Fadhli Margono, Supardjan A. Marissa, Novaria Marlyn Dian Laksitorini Miftahul Huda Moh Salimi Muamaroh, Dzun Nur Nafi’ah Muassomah Muassomah Muhammad Faqih Muhammad Thamrin Nasrulloh Nasrulloh Neilcy Tjahja Mooniarsih Ningrum, Anita Dwi Juwita Norsandy, Dedi Novita Sari Nugroho, Agung Endro Nurhusna, Siti Deviana Rahma Nurul Qomariah Pakpahan, Aston Payung, Jendy Penny Respati Yurisa Poetra, Bilal Ambara Herlando Pradana, Muhammad Yudha Pramudia, Yogha Primasari, Firdhani Satia Pudjono, Pudjono Purba, Rakhmawati Purwatiningsih Purwatiningsih Putri, Hasna Tantowi Qotrunnada, Maulida Hasbiya Qowlits Tsabita, Qonita Qorrie Aini Rahmi, Atika Raihan, Muhammad Retno Murwanti Reynanda, Abbie Riptasari, Rhatna Dewi Rosmawiah Rosmawiah Roziki, Khafid Safitri, Saktya Dea Samrotul Fikriyah Sandiki, Frisilia Dewanti Sandy, Trio May Septianingsih, Aisyah Sesanti, Nyamik Rahayu Sibarani, Edi Budi Harjono Silvia Arianti Simanjuntak, Marthin Yohannes Simanjuntak, Martin Yohannes Siti Nurrohmah SRI RAHAYU Sudibyo Martono Sukmarini, Zhafira Sumiatie Syahrir Akil Tampubolon, Laswandi Tangkasiang, Yos Andy Tri Lestari Triwayuningtyas, Dyah Ugang, Yandi Wahyono, Djoko Wahyono, Djoko Wibowo, Friza Rahmawanto Wulandari, Diana Yaakob, Mohd. Faiz Mohd Yani, Asnita Yanti, Elyta Vivi Yerry Soepriyanto Yuliana, Palupi Dwi Yulianti Yulianti Yustha, Yulia Zahra, Husna wati Zullies Ikawati