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All Journal Jurnal Gizi dan Pangan INDONESIAN JOURNAL OF PHARMACY BIOEDUSCIENCE Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran Jurnal Multidisiplin Madani (MUDIMA) Pharmaceutical Sciences and Research (PSR) Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Khazanah Sosial
Yahdiana Harahap
Departemen Farmasi FMIPA, Universitas Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Effect of Various Anticoagulants on Ethinyl Estradiol and Levonorgestrel Analysis in Human Plasma in Vitro by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This research objective is to evaluate the different types of anticoagulant to ethinyl estradiol and levonorgestrel analysis in plasma using ultra performance liquid chromatography tandem mass spectrometry. Method: Chromatography condition was obtained with Acquity® UPLC BEH C18 column (1.7 µm; 50 x 2.1 mm); mobile phase consisting 0.1% formic acid in water – acetonitrile under gradient elution ; flow rate of 0.3 mL/minute; column temperature of 40ºC; injection volume of 10.0 µL; 5-minute analysis time and prednisone as internal standard. Sample preparation used protein precipitation followed by liquid-liquid extraction. Results: There was a linear result ranging from 5-500 pg/mL concentration of ethinyl estradiol and 100-10,000 pg/ml concentration of levonorgestrel. There was no significant difference for stability and recovery of ethinyl estradiol and levonorgestrel in citrate, heparin, and EDTA plasma (p > 0.05; ANOVA). However, significant difference for peak area ratio (p < 0.05; Kruskal Wallis), between citrate, EDTA, and heparin plasma was observed. Conclusion: Citrate and heparin plasma analysis had better result than EDTA plasma analysis.Keywords: Ethinyl estradiol, Levonorgestrel, Prednisone, EDTA, Heparin, Citrate.
Determination of Valproic Acid without Derivatization in Human Plasma using High Performance Liquid Chromatography-Photodiode Array Yahdiana Harahap
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: To develop and validate a simple and sensitive HPLC method without derivatization for determination of valproic acid in human plasma. Methods: Nonanoic acid as internal standard was added to 500 mL of plasma sample prior to liquid-liquid extraction using n-hexane and 0.5% triethylamine. Chromatographic separation was achieved on C-8 Symmetry® column (5µm; 150 x 3.9mm) in isocratic mode at 45°C. The mobile phase was 40 mM sodium dihydrogen phosphate pH 3.5 – acetonitrile (56:44 %v/v) with flow rate of 1.00 mL/min and was detected at 210 nm. Method validation referred to EMA Guideline 2011 for bioanalytical method validation in term of parameters lower limit of quantification (LLOQ), selectivity, calibration curve and linearity, carry over, recovery and stability. The valid method was applied in pharmacokinetic study of one healthy subject after administration of 500mg extended release caplet of valproic acid. The blood was collected as much as 7mL for twelve spots, which are predose, 1, 2, 3, 4, 5, 8, 10, 24, 36, 48, and 72 hours after drug administration. Results: The calibration curve valproic acid was linear over the concentration range of 2.0 – 200.0 µg/mL (r = 0.9992). Within-run and between-run precision and accuracy were studied at four concentrations and RSDs were less than 1.8 % and 5.4 %, while the bias (accuracy values) were less than 17.9 % and 13.1 %, respectively. Conclusion: The developed method provides sensitivity, linearity, precision, accuracy and is suitable for analysis of valproic acid in plasma samples for pharmacokinetic studies.Keywords: Valproic acid, Nonanoic acid, HPLC, Validation, Liquid-liquid extraction.
Development and Validation of Simultaneous Analysis of Amlodipine Besylate and Valsartan in Spiked Human Plasma Using Liquid Chromatography Tandem Mass Spectrometry Shania Rizki Ivany; Eme Stepani Sitepu; Reynatha Pangsibidang; Yahdiana Harahap
Journal of Global Pharma Technology Volume 14 Issue 05 (2022) May 2022
Publisher : Journal of Global Pharma Technology

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Abstract

Amlodipinebesylate, a dihydropyridine calcium channel blocker, and valsartan, an angiotensin II receptor blocker, are antihypertensive agents. Fixed dose combination of amlodipine and valsartan can reduce blood pressure (BP) effectively than amlodipine or valsartan monotherapy. Amlodipine and valsartan have low concentration in blood, so a highly selective and sensitive method is required. This research is aimed to obtain an optimum and validated method for determiningamlodipinebesylate and valsartan in plasma using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Mass detection was performed by Waters Xevo TQD with Electrospray Ionization source at positive ion mode in the Multiple Reaction Monitoring. Amlodipine besylate, valsartan, and irbesartan were detected at m/z409.16 > 238.06; 436.22 > 291.15; and 429.22 > 207.1; respectively. The optimum analysis condition was obtained using Waters AcquityTM UPLC C18 1.7 µm (2.1 x 100 mm); the column temperature was45oC; eluted undera gradient of mobile phase of 0.1% formic acid in water and acetonitrile at a flow rate 0.2 mL/min within 6 minutes; and irbesartan as an internal standard. Sample preparation was carried out by liquid-liquid extraction with ammonium acetate and ethyl acetate; mixed with vortex for 2 minutes; centrifugated at 2043 G-force for 10 minutes; evaporated with nitrogen gas at 50oC for 10 minutes; and reconstituted with 100 µL of mobile phase. This method fulfilled the acceptance criteria of validation based on Bioanalytical Method Validation Guidance by Food and Drug Administration in 2018. This method was linear at 0.20 – 10.00 ng/mL with r ≥ 0.997357 for amlodipine and 5.00 – 6000.00 ng/mL r ≥ 0.998476 for valsartan.
Analysis of 4-Hydroxy-N-Desmethyltamoxifen and Tamoxifen in Dried Blood Spot of Breast Cancer Patients By Liquid Chromatography – Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

Tamoxifen is the first line hormonal therapy for breast cancer patients as their adjuvant therapy. The antiestrogen effect of tamoxifen is highly determined by its active metabolite, endoxifen. A simultaneous quantification method of tamoxifen and endoxifen in dried blood spot (DBS) using LC-MS/MS had been fully validated in this study. Extraction the analyte and metabolite from DBS card were conducted using methanol-acetonitrile (50:50). The separation was performed on UPLC Class BEH C18 column using 0.2% formic acid - acetonitrile as the mobile phase in gradient elution mode at 0.2ml/min. The detection of the mass was performed on Waters Xevo TQD using positive electrospray ionization for tamoxifen, endoxifen, and clomiphene as the internal standard with m/z value: 372.22>72.22; 374.29>58.2; 406.28>100.17, respectively. This method was linear in the range concentration of 5-200 ng/ml for tamoxifen and 1-40 ng/ml for endoxifen with r value 0.99. The method was applied to 40 breast cancer patients, where the results lied between 40.28 and 194.10 ng/ml for tamoxifen, meanwhile for endoxifen was 1.25 and 18.02 ng/ml. It showed that there were 4 patients received less effective tamoxifen therapy based on the endoxifen threshold in DBS sample, which was 3.3 ng/ml. This method has prospect future to optimize tamoxifen therapy by measuring tamoxifen and endoxifen concentration. Keywords: Breast cancer; Dried blood spot; Endoxifen; Tamoxifen; Clomiphene; Analysis;  LC-MS/MS; Validation.
Studi Pengaruh Iradiasi Gamma Terhadap Kadar Senyawa Bioaktif dan Aktivitas Antiinflamasi Jahe Merah (Zingiber officinale roscoe) Aulia Nova Kusumaningtyas; Yahdiana Harahap; Abdul Mun'im; Supandi Supandi
BIOEDUSCIENCE Vol 6 No 3 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/6310688

Abstract

Background: In Indonesia, the use of herbal plants in overcoming several health problems shows a fairly high rate. Red ginger is one of the herbs that is widely consumed and empirically has the property of relieving or reducing inflammation. However, as is well known, in general the microbiological contamination of herbs is quite high. To maintain the quality of herbal plants, special treatment is required, to ensure that microbial contamination is within safe limits. This study aims to determine the effect of gamma irradiation on the number of microbial contamination, and the bioactive content of 6,8,10-gingerol; 6-shogaol in 70% ethanol extract of red ginger, and its activity as an anti-inflammatory. Methodes: Samples of 70% ethanol extract of red ginger were irradiated with various doses of 0, 5, 7.5, 10 and 15 KGy. Microbiological contamination is determined in Total Plate Number and Yeast Mold Number. The content of compounds 6,8,10-gingerol and 6-shogaol was observed by high performance liquid method and their anti-inflammatory activity was observed by protein denaturation inhibition (BSA) method. Results: Gamma irradiation at doses of 0, 5, 7.5, 10 and 15 KGy reduced microbial contamination as the exposure dose increased, and did not affect the levels of bioactive 6,8,10-gingerol; 6-shogaol and its anti-inflammatory activity. The anti-inflammatory activity of 70% ethanol extract of red ginger is influenced by the content of bioactive compounds. Conclusion: Gamma irradiation is effective for decontaminating microbiological contaminants, and improving the quality of red ginger, and does not affect the bioactive levels contained and its anti-inflammatory activity (in vivo).
Studi Pengaruh Iradiasi Gamma Terhadap Kadar Senyawa Bioaktif dan Aktivitas Antiinflamasi Jahe Merah (Zingiber officinale roscoe) Aulia Nova Kusumaningtyas; Yahdiana Harahap; Abdul Mun'im; Supandi Supandi
BIOEDUSCIENCE Vol 6 No 3 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/6310688

Abstract

Background: In Indonesia, the use of herbal plants in overcoming several health problems shows a fairly high rate. Red ginger is one of the herbs that is widely consumed and empirically has the property of relieving or reducing inflammation. However, as is well known, in general the microbiological contamination of herbs is quite high. To maintain the quality of herbal plants, special treatment is required, to ensure that microbial contamination is within safe limits. This study aims to determine the effect of gamma irradiation on the number of microbial contamination, and the bioactive content of 6,8,10-gingerol; 6-shogaol in 70% ethanol extract of red ginger, and its activity as an anti-inflammatory. Methodes: Samples of 70% ethanol extract of red ginger were irradiated with various doses of 0, 5, 7.5, 10 and 15 KGy. Microbiological contamination is determined in Total Plate Number and Yeast Mold Number. The content of compounds 6,8,10-gingerol and 6-shogaol was observed by high performance liquid method and their anti-inflammatory activity was observed by protein denaturation inhibition (BSA) method. Results: Gamma irradiation at doses of 0, 5, 7.5, 10 and 15 KGy reduced microbial contamination as the exposure dose increased, and did not affect the levels of bioactive 6,8,10-gingerol; 6-shogaol and its anti-inflammatory activity. The anti-inflammatory activity of 70% ethanol extract of red ginger is influenced by the content of bioactive compounds. Conclusion: Gamma irradiation is effective for decontaminating microbiological contaminants, and improving the quality of red ginger, and does not affect the bioactive levels contained and its anti-inflammatory activity (in vivo).
Transdermal Delivery of Ketoprofen for Osteoarthritis Treatment and Management: A Literature Review on Current Progression Ramadhani, Dwi Asih; Harahap, Yahdiana; Sagita, Erny; Permata Sari, Kartika Citra Dewi; Andranilla, Rr. Kirana; Trisina, Jessica; Punu, Gabriella Frederika; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA pain, with ketoprofen recognized as one of the effective options. However, oral administration of ketoprofen may cause gastrointestinal irritation. Addressing this issue, Transdermal Drug Delivery Systems (TDDS) emerge as a promising alternative route of administration. TDDS facilitates delivery of various drugs through the skin without undergoing first-pass metabolism. Recent studies have centered on enhancing ketoprofen’s transdermal delivery, particularly focusing on different methods (such as patches, gels, electroporation technology, and stratum corneum bypass methods), with microneedles emerging as a promising approach for delivering anti-inflammatory drugs through transdermal routes. This review aims to explore recent advancements in transdermal drug delivery systems for managing OA. The utilization of transdermal ketoprofen presents innovative opportunities for future research and development in novel drug delivery systems.
Reaksi Merugikan Obat Kanker Berbasis Antrasiklin pada Pasien Kanker Payudara di RS Kanker Dharmais Chairunnisa, Dian Fitri; Harahap, Yahdiana; Syafhan, Nadia Farhanah; Purwanto, Denni Joko
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.164

Abstract

Breast cancer is the type of cancer that most often affects women worldwide. Doxorubicin is an anthracycline class, a first-line anticancer therapy with clinical activity in breast cancer. Doxorubicin can cause cardiotoxic effects due to the formation of doxorubicinol as its primary metabolite. Adverse drug reactions also vary depending on the chemotherapy regimen. This study aimed to determine the adverse reactions to anthracycline-based drugs that breast cancer patients often experience. This observational descriptive study was conducted from April to July 2022 at the Dharmais Cancer Hospital, Jakarta. The sample in this study was breast cancer patients undergoing chemotherapy with anthracycline-based regimens. Data were collected through interviews and observation of medical records, which were analyzed by univariate analysis. The results showed that the most frequent drug reaction was alopecia, with a percentage of 97.1%. They were followed by nausea at 85.7%, vomiting at 71.4% and pain at 65.7%. The fastest time for nausea to appear is within 18-24 hours (peak days 2 to 3) after chemotherapy. Did not experience a decrease in left ventricular ejection fraction by 34.3%, and 65.7% experienced a reduction in left ventricular ejection fraction after doxorubicin chemotherapy. Patients who underwent a reduction in left ventricular ejection fraction after doxorubicin chemotherapy had a decrease in ejection fraction <10%, and no patients experienced a decline in left ventricular ejection fraction >10%. Breast cancer patients who receive anthracycline-based treatment can experience adverse drug reactions, including nausea, vomiting, alopecia, pain and decreased left ventricular ejection fraction.
Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review Mardhiani, Rizka; Harahap, Yahdiana; Wiratman, Winnugroho
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 5 No. 1 (2023): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V5i1.6010

Abstract

Abstract—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug. Phenytoin is one of the drugs whose risk of side effects may increase due to its narrow therapeutic window of 10-20 µg/mL if the metabolism is slow. The main literature was taken from publications through the library databases in 2017 – 2021. Studies and reviews describing the metabolism, CYP2C9 and CYP2C19 polymorphisms, and neurotoxicity of phenytoin were included, and unrelated research were excluded. There were 18 of 853 articles describing CYP2C9 and CYP2C19 polymorphisms, metabolism, and neurotoxicity events associated with phenytoin used. The authors conclude that based on the results from various literature, there is an association between CYP2C9 and CYP2C19 polymorphism, metabolism, and neurotoxicity after Phenytoin administration with CYP2C9*2 and CYP2C9*3 types of polymorphisms for CYP2C9 and CYP2C19*2 and CYP2C19*3 types for CYP2C19*3 enzymes which can slow down the phenytoin metabolism and increase its concentration in serum so that the risk of causing neurotoxicity. Keywords: CYP2C9, CYP2C19,metabolism, neurotoxicity, phenytoin Abstrak—Fenitoin merupakan obat antibangkitan yang dimetabolisme oleh enzim sitokrom P450 terutama oleh CYP2C9 (90%) dan CYP2C19 (10%), dimana kedua enzim tersebut bersifat polimorfik sehingga dapat mengalami polimorfisme dan dapat mempengaruhi laju metabolisme obat. fenitoin merupakan salah satu obat yang risiko efek sampingnya dapat meningkat jika metabolismenya lambat karena jendela terapeutiknya yang sempit, yaitu 10-20 µg/mL. Literatur utama diambil dari publikasi melalui database perpustakaan tahun 2017 – 2021. Penelitian dan ulasan yang menggambarkan metabolisme, polimorfisme CYP2C9 dan CYP2C19, dan neurotoksisitas fenitoin, dan penelitian yang tidak terkait dikeluarkan. Terdapat 18 dari 853 artikel yang menjelaskan polimorfisme CYP2C9 dan CYP2C19, metabolisme, dan kejadian neurotoksisitas terkait dengan fenitoin yang digunakan. Peneliti menyimpulkan bahwa berdasarkan hasil dari berbagai literatur, terdapat hubungan antara polimorfisme, metabolisme, dan neurotoksisitas CYP2C9 dan CYP2C19 setelah pemberian fenitin dengan jenis polimorfisme CYP2C9*2 dan CYP2C9*3 untuk CYP2C9 dan CYP2C19*2 dan CYP2C19*3 jenis enzim CYP2C19*3 yang dapat memperlambat metabolisme fenitoin dan meningkatkan konsentrasinya dalam serum sehingga berisiko menyebabkan neurotoksisitas. Kata kunci: CYP2C9, CYP2C19, fenitoin, metabolisme, neurotoksisitas
Solid Lipid Nanoparticles (SLN): Formulation and Fabrication Punu, Gabriella F.; Harahap, Yahdiana; Anjani, Qonita Kurnia; Hartrianti, Pietradewi; Donnelly, Ryan F.; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Abstract

Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids, and can be stabilized by a wide range of surfactants. SLN have garnered significant attention from researchers due to its innovative and versatile nature. Moreover, such delivery system has numerous advantages over traditional colloidal carriers, such as liposomes, polymeric nanoparticles, and emulsions. Several research groups have been developing SLN formulations and fabrication techniques based on their intended purpose, and this research number is still increasing globally. Given the vast potential for the development of SLN in the future, coupled with the wide variety of materials and techniques to be considered during the manufacturing process, this paper provides an extensive overview of the general introduction of SLN, their benefits and drawbacks, and the numerous excipients which can be associated with the SLN formulation. Various aspects related to the models of drug incorporation and fabrication methods are also systematically discussed in this review. In addition, an analysis of the factors that impact the stability of the SLN will also be documented to provide further insight for future advancements in SLN research.
Co-Authors . Harmita . Hayun . Hayun Abdul Mun'im Achmad Noerkhaerin Putra Ahmad Sulaeman Aldrat, Hendri Aldrat, Hendri Andranilla, Rr. Kirana Ani Susanti Ani Susanti Anja Tamabri Anjani, Qonita Kurnia Aulia Nova Kusumaningtyas Baitha Palanggatan Maggadani, Baitha Palanggatan Bambang Karsono Bantari Wisnu Kusuma Wardhani Binsar Simanjuntak Binsar Simanjuntak, Binsar Callista Andinie Mulyadi Chairunnisa, Dian Fitri Christine Estherina Christine Estherina, Christine Citra Nur Azizah Citra Nur Azizah, Citra Nur Cosphiadi Irawan Dadang Kusmana DENNI JOKO PURWANTO, DENNI JOKO Dewi, Dian Andriani Ratna Donnelly, Ryan F. Eliza Halim Eme Stepani Sitepu Erilia Kesumahati Erny Sagita, Erny Fadlina Chany Saputri Hardinsyah Harefa, Faonaso Harmita Harmita Harmita Harmita Harmita Harmita Harmita Harmita, Harmita Harryanto Reksodiputro, Harryanto Hartrianti, Pietradewi Hayun Hayun Hayun Hayun Heffen, Wan Lelly Heffen, Wan Lelly HENDRI ALDRAT Herman Suryadi I MADE ARTIKA Indah Widyaningsih Krismartina, Mirna Krismartina, Mirna Lestari Rahayu Letitia Tania Letitia Tania, Letitia Loedfiasfiati Alawiyah Maksum Radji Mardhiani, Rizka Maryati Kurniadi Meriska Sukandar Mun'im, Abdul Nadia Farhanah Syafhan Nasution, Azlaini Yus Noorwati Sutandyo Noorwati Sutandyo Noviyantih, Noviyantih Nu Alia Nu Alia, Nu Nur Isra Nurrobi, R.M. Tjahya Permata Sari, Kartika Citra Dewi Pridilla, Asmiladita Punu, Gabriella F. Punu, Gabriella Frederika Raden Rara Diah Handayani Rahmania, Tesia Aisyah Ramadhani, Dwi Asih RAMADON, DELLY Renesteen, Editha Reynatha Pangsibidang Rianto Setiabudy Rianto Setiabudy Rizka Andalusia Santi Purna Sari Shania Rizki Ivany Sherly Meilianti Sherly Meilianti, Sherly Sitepu, Eme Stepani Siti Hafilah Sri Wardatun Sunarsih Sunarsih Sunarsih Supandi Supandi Supandi Sutanto Syahrul Tuba Theresia Sinandang Theresia Sinandang, Theresia Timbul Partogi Haposan Simorangkir Trisina, Jessica Umar Mansur Umar Mansur Umar Mansur, Umar Vicha Vicha Wahono Sumaryono Wan Lelly H Wardhani, Bantari Wisynu Kusuma Widyati Widyati Winnugroho Wiratman