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All Journal Jurnal Gizi dan Pangan INDONESIAN JOURNAL OF PHARMACY BIOEDUSCIENCE Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran Jurnal Multidisiplin Madani (MUDIMA) Pharmaceutical Sciences and Research (PSR) Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Khazanah Sosial
Yahdiana Harahap
Departemen Farmasi FMIPA, Universitas Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Recent Updates on Dried Blood Spot and Volumetric Absorptive Microsampling as Microsampling Technique for Antiepileptic Drug Determination: A Systematic Review Pridilla, Asmiladita; Harahap, Yahdiana; Purwanto, Denni Joko; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose of this review article. A total of 342 articles were identified from databases. From 8 primary studies included, analytical methods for 21 drug compounds as antiepileptic agents and 4 of their metabolites in DBS and VAMS were found. A summary of sample preparation, analytical method, and validation were presented in the narrative form of this review. Concentrations measured using DBS and VAMS demonstrate a strong correlation with conventional matrices; however, conversion factors based on the blood-to-plasma ratio are necessary for accurate comparison. Additionally, the comparison results between DBS and VAMS technique for TDM is still unsatisfactory to prove their interchangeability. Therefore, this comparison needs further evaluation with more samples and more analytes. Analysis of antiepileptic drugs using VAMS is also still limited and further optimization can be carried out to produce more stable, sensitive, fast, and suitable for TDM practice.
The The Effect of Using Different Anticoagulant Types for Determination of Esomeprazole Levels in Human Plasma by High-Performance Liquid Chromatography Mardhiani, Rizka; Harahap, Yahdiana; Sitepu, Eme Stepani; Sunarsih
Jurnal Multidisiplin Madani Vol. 3 No. 10 (2023): October, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v3i10.4170

Abstract

Esomeprazole is a Proton Pump Inhibitor (PPI) drug formulated in delayed-release tablets, that are included in the mandatory bioequivalence test. In vitro method validation used human plasma from the Indonesian Red Cross that used citrate as an anticoagulant. In the implementation of in vivo study, usually using human plasma used EDTA or heparin as an anticoagulant. This study aims to evaluate the effect of using anticoagulant types that may affect the analysis of esomeprazole in human plasma. Optimum chromatographic conditions used column C18 SunfireTM (5 μm, 250 mm x 4.6 mm); column temperature 40°C; mobile phase acetonitrile - phosphate buffer (40:60% v/v) pH 7.6; 1.0 mL/min flow rate with lansoprazole as an internal standard and wavelength 300 nm (PDA). The extraction was carried out by liquid-liquid extraction method using 500 μl plasma and 5 ml dichloromethane as extraction solvent. The result showed that the concentration range of calibration curve linearity in 5 – 1500 ng/mL. Recovery and broad peak response data of esomeprazole in plasma have significant differences between heparin-EDTA and citrate-EDTA anticoagulants (p<0.05), but there is no significant difference for the stability test. In conclusion, heparin is better than EDTA as an anticoagulant for esomeprazole bioanalysis
Military Health Strategies Against Narcotics Threats within the CBRNE Framework Harefa, Faonaso; Yahdiana Harahap; Dian Andriani Ratna Dewi; Nurrobi, R.M. Tjahya; Sutanto
Khazanah Sosial Vol. 8 No. 1 (2026): Khazanah Sosial
Publisher : UIN Sunan Gunung Djati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ks.v8i1.51928

Abstract

This study positions narcotics as an emerging non-traditional threat within the CBRNE framework due to its chemical nature and its impact on public health and national resilience. Drug abuse in Indonesia has evolved into a multidimensional threat that not only disrupts social stability but also weakens public health resilience. This study aims to analyze the role of military health within its service and health support functions based on existing regulations, particularly its contribution to combating drug threats as a form of non-military threat endangering young generations and national defense. Using a descriptive qualitative method with data analysis conducted through NVivo 12. The findings reveal that regulation based military health support has a positive impact in reducing drug abuse and trafficking while strengthening both public health resilience and national defense. However, the involvement of military health in cross sectoral collaboration remains limited, despite its proven capability and resilience in managing health crises, as demonstrated during the Covid-19 pandemic.: This study emphasizes the need to strengthen the role of military health in drug control through formal cooperation mechanisms, such as a Memorandum of Understanding (MoU) with the leading sectors Badan Narkotika Nasional, the Kepolisian Negra Republik Indonesia, and Kementerian Kesehatan to ensure clear synergy, avoid overlapping authority, and establish an integrated and sustainable national health defense system. However, the study identifies a gap in formal institutional integration, which limits the optimization of military health roles
Challenges of Monitoring Blood Levels of Bedaquiline in Drug-Resistant Tuberculosis: A Narrative Review Nur Isra; Santi Purna Sari; Yahdiana Harahap; Raden Rara Diah Handayani
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50267

Abstract

Bedaquiline, a second-line drug for drug-resistant tuberculosis (MDR-TB), is one of the latest generation drugs in the treatment of tuberculosis (TB). However, the challenge in determining the optimal dose and individual pharmacokinetic variability requires the implementation of Therapeutic Drug Monitoring (TDM). This article aims to evaluate the challenges of TDM bedaquiline through a narrative review of the current literature. Relevant articles were identified through computerized searches on PubMed and Google Scholar using a combination of keywords related to bedaquiline, pharmacokinetics, and TDM. Limited clinical data indicate a lack of standard exposure targets and reliable efficacy thresholds. Pharmacokinetic variability is influenced by factors such as age, weight, gender, genetics, comorbidities, and serum albumin. Technical challenges include the need for precise analytical methods and the accessibility of technology in clinical practice. The use of TDM for bedaquiline offers the potential to improve the efficacy of MDR-TB treatment, but more research is needed to address pharmacokinetic variability and develop standardized guidelines.
Co-Authors . Harmita . Hayun . Hayun Abdul Mun'im Achmad Noerkhaerin Putra Ahmad Sulaeman Aldrat, Hendri Aldrat, Hendri Andranilla, Rr. Kirana Ani Susanti Ani Susanti Anja Tamabri Anjani, Qonita Kurnia Aulia Nova Kusumaningtyas Baitha Palanggatan Maggadani, Baitha Palanggatan Bambang Karsono Bantari Wisnu Kusuma Wardhani Binsar Simanjuntak Binsar Simanjuntak, Binsar Callista Andinie Mulyadi Chairunnisa, Dian Fitri Christine Estherina Christine Estherina, Christine Citra Nur Azizah Citra Nur Azizah, Citra Nur Cosphiadi Irawan Dadang Kusmana DENNI JOKO PURWANTO, DENNI JOKO Dewi, Dian Andriani Ratna Donnelly, Ryan F. Eliza Halim Eme Stepani Sitepu Erilia Kesumahati Erny Sagita, Erny Fadlina Chany Saputri Hardinsyah Harefa, Faonaso Harmita Harmita Harmita Harmita Harmita Harmita Harmita Harmita, Harmita Harryanto Reksodiputro, Harryanto Hartrianti, Pietradewi Hayun Hayun Hayun Hayun Heffen, Wan Lelly Heffen, Wan Lelly HENDRI ALDRAT Herman Suryadi I MADE ARTIKA Indah Widyaningsih Krismartina, Mirna Krismartina, Mirna Lestari Rahayu Letitia Tania Letitia Tania, Letitia Loedfiasfiati Alawiyah Maksum Radji Mardhiani, Rizka Maryati Kurniadi Meriska Sukandar Mun'im, Abdul Nadia Farhanah Syafhan Nasution, Azlaini Yus Noorwati Sutandyo Noorwati Sutandyo Noviyantih, Noviyantih Nu Alia Nu Alia, Nu Nur Isra Nurrobi, R.M. Tjahya Permata Sari, Kartika Citra Dewi Pridilla, Asmiladita Punu, Gabriella F. Punu, Gabriella Frederika Raden Rara Diah Handayani Rahmania, Tesia Aisyah Ramadhani, Dwi Asih RAMADON, DELLY Renesteen, Editha Reynatha Pangsibidang Rianto Setiabudy Rianto Setiabudy Rizka Andalusia Santi Purna Sari Shania Rizki Ivany Sherly Meilianti Sherly Meilianti, Sherly Sitepu, Eme Stepani Siti Hafilah Sri Wardatun Sunarsih Sunarsih Sunarsih Supandi Supandi Supandi Sutanto Syahrul Tuba Theresia Sinandang Theresia Sinandang, Theresia Timbul Partogi Haposan Simorangkir Trisina, Jessica Umar Mansur Umar Mansur Umar Mansur, Umar Vicha Vicha Wahono Sumaryono Wan Lelly H Wardhani, Bantari Wisynu Kusuma Widyati Widyati Winnugroho Wiratman