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Antiinflamasi Ekstrak Daun Trembesi (Samanea saman (Jacq.)Merr.) Terhadap Ekspresi Enzim Siklooksigenase-2 (COX-2) Sa'adah, Nikmatus; Lukis, Prima Agusti; Asri, Arilis Larasati Ode; Istiati, Istiati; Asmarani, Yolanda Kartika; Moelok, Iqbal Moch; Adriansyah, Agus Aan; Setianto, Budhi
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.20950

Abstract

Background: The cyclooxygenase-2 (COX-2) enzyme is the main source of prostanoids in inflammation and has various effects on nerve endings, blood vessels, and cells involved in inflammation. Trembesi leaves (Samanea summons (Jacq.) Merr.) are one of the herbal plants that have anti-inflammatory properties because it contains steroid compounds with high antioxidant capacity, active compounds of flavonoids, and tannins. With antioxidant activity and high flavonoid, trembesi leaf extract can act as an anti-inflammatory and influence the COX-2 enzymes and can cause pro-inflammatory effects. Objective : To discover the effect of trembesi leaf extract as an anti-inflammatory on COX-2 enzyme levels. Laboratory experimental method live with 30 (Rattus norvegicus) with 3 sample groups: the negative control group was CMC NA, and the treatment group was given trembesi leaf extract 100 mg/KgBW and a dose of 200 mg/KgBW. COX-2 expression was examined using the immunohistochemical staining method. Then do data analysis with normality test, homogeneity test, test Kruskal-Wallis, and test Mann Whitney. Results : Trembesi leaf extract at a dose of 100 mg/KgBW with a concentration of 12% had the effect of inhibiting COX-2 enzyme expression compared to the negative control group and the extract group at a dose of 200 mg/KgBW at a concentration of 12%. Conclusion : Trembesi leaf extract has an effect on reducing inflammation of the cyclooxygenase-2 (COX-2) enzyme.
Peningkatan Angiogenesis Pada Ulkus Traumatikus Setelah Pemberian Gel Ekstrak Daun Kemangi (Ocimum sanctum L.) Prehananto, Herlambang; Tuti Hendrarti, Hening; Sa’adah, Nikmatus; Rizqullah, Widaad
Journal of Oral Health Care Vol. 9 No. 2 (2021): 2021
Publisher : Poltekkes Kemenkes Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/ohc.v9i2.1235

Abstract

Latar Belakang : Ulkus traumatikus merupakan suatu kelainan pada mukosa rongga mulut yang ditandai dengan hilangnya seluruh ketebalan epitel dan terbukanya jaringan mukosa dibawahnya yang disebabkan oleh suatu trauma baik secara mekanik, thermal, kimia, atau elektris. Pemberian anti inflamasi dapat mempercepat proses kesembuhan. Salah satu tanaman yang memiliki khasiat sebagai obat anti inflamasi yaitu daun kemangi. Metode : Penelitian eksperimental laboratorium dengan rancangan post test only control group design. Sampel yang digunakan hewan coba tikus putih Rattus norvegicus strain Wistar. Perlakuan menggunakan gel ekstrak daun kemangi yang diekstraksi dengan pelarut etanol 96% dengan metode maserasi dengan konsentrasi 0,5%; 1% ; 1,5% dan dan kontrol menggunakan gel CMC-Na. Data dianalisis dengan One Way Anova dan dilanjutkan dengan uji Least Significance Difference (LSD). Hasil : Uji One-Way Anova menunjukkan p-value < 0,05 artinya terdapat perbedaan jumlah pembuluh darah baru yang signifikan antar kelompok. Hasil uji LSD juga menunjukkan perbedaan yang signifikan pada perbandingan kelompok kontrol dan perlakuan pada semua hari pengamatan. Kesimpulan : Pemberian gel ekstrak daun kemangi konsentrasi 0,5; 1%; 1,5% mampu meningkatkan angiogenesis dalam penyembuhan ulkus traumatikus pada tikus Rattus norvegicus.
Improving Public Understanding about Chronic Hepatitis and Diabetes Mellitus in The Era of The Covid-19 Pandemic Effendy Effendy; Agus Aan Adriansyah; Akas Yekti Pulih Asih; Budhi Setianto; Nikmatus Sa’adah; Evy Afifah Syagran; Iqbal Firdaus
To Maega : Jurnal Pengabdian Masyarakat Vol 6, No 1 (2023): Februari 2023
Publisher : Universitas Andi Djemma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35914/tomaega.v6i1.1279

Abstract

Hepatitis is an inflammation of the liver. In chronic hepatitis, inflammation of the heart lasts for at least 6 months. Several incidences of disease in hepatitis require good and simultaneous treatment. To increase public knowledge regarding hepatitis, a webinar was held "What and How is Chronic Hepatitis and Diabetes Mellitus in the Era of the Covid-19 Pandemic". The implementation of this community service was carried out at the Surabaya Ahmad Yani Islamic Hospital, in June-October 2022. This community service was carried out through webinar activities which were attended by 156 participants, followed by patients and non-patients which were packaged in an attractive manner in order to provide clearer information related to hepatitis and diabetes mellitus so that they are more aware and alert. The results of the webinar related to the explanation of chronic hepatitis and diabetes mellitus during the covid-19 pandemic have gone well. Evaluation of respondents' knowledge when participating in webinar activities has increased. Respondents have good knowledge regarding chronic hepatitis, transmission media for chronic hepatitis, how to prevent it, symptoms of diabetes mellitus, clean and healthy living behavior for diabetes mellitus prevention, and a good diet. Webinars held packed with interesting with webinar media you can increase the knowledge participant go on by 12%, expected through education carried out by the YouTube channel could realize a society that is more aware and care about the incidence of chronic hepatitis and diabetes mellitus. This community service activity is expected to be presented periodically with other disease topics to increase public knowledge and understanding regarding diseases, their causes, methods of prevention and treatment.
Support Workshop Enhancement Readiness and The Response of The Nahdlatul Ulama Hospital Against Covid-19 and Infectious Diseases New Other Umi Hanik; Agus Aan Adriansyah; Akas Yekti Pulih Asih; Budhi Setianto; Nikmatus Sa’adah; Iqbal Firdaus; Muhammad Zahid Abdillah
To Maega : Jurnal Pengabdian Masyarakat Vol 6, No 1 (2023): Februari 2023
Publisher : Universitas Andi Djemma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35914/tomaega.v6i1.1278

Abstract

Until October 2, 2021, the total number of cases of Covid-19 confirmation in the world is 234.110,530 cases with 4,788,697 deaths (Case Fatality Rate 2.0%) in 204 infected countries and 151 Transmission Countries communities. Government The Republic of Indonesia has reported 4,218,142 confirmed people positive for COVID-19 and there were 142,115 deaths (CFR: 3.4 %) related to COVID-19 reported and 4,042,215 patients have healed from the disease. Since Covid-19 was declared a pandemic, various efforts have been conducted by the government with Support cross-sectoral, as efforts increase knowledge power health in the environment Association House Islamic Hospital Nahdlatul Ulama, ARSINU together LETTERA Foundation organizes support workshop enhancement readiness and Nahdlatul Hospital response Ulama (NU) against Covid-19 and disease infectious new others, workshops held online and off this line followed by 183 participants held at the Surabaya Islamic Hospital Workshop involving 5 houses sick in ARSINU 's shade grabbed enthusiastically by participants, workshops held with this hybrid method increase participants ' knowledge go on by 20%, expected through this workshop whole power health capable give good contribution on implementation daily officer power health walk right his job in giving service to patient covid 19 and capable control self for infected Covid-19.
EFEK ANALGESIK EKTRAK DAUN TREMBESI (Samanea saman (Jacq.) Merr.) TERHADAP MENCIT PUTIH (Mus Musculus) Nikmatus Sa’adah; Niswatun Chasanah; Sawitri Dwi Indah Pertami; Puspa Dila Rohmaniar; Agus Aan Adriansyah; Ahda Mas Ulah
Cakradonya Dental Journal Vol 14, No 1 (2022): Februari 2022
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v14i1.27305

Abstract

Nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan akibat kerusakan jaringan. Daun Trembesi (Samanea saman (Jacq.) Merr.) dapat menjadi salah satu tanaman alternatif herbal sebagai analgesik. Senyawa metabolit sekunder flavonoid dan steroid pada ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) dapat berfungsi sebagai analgesik dengan cara menghambat mediator-mediator inflamasi dengan cara menghambat pelepasan asam arakidonat, sehingga kerja enzim siklooksigenase terblokir. Tujuan dari penelitian ini adalah mengetahui efek analgesik ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) terhadap mencit putih (Mus Musculus). Penelitian eksperimental laboratoris ini menggunakan teknik simple random sampling dengan sampel terdiri dari 30 ekor mencit yang dibagi menjadi 5 kelompok. Pemberian larutan secara per oral, kemudian diinduksi nyeri dengan asam asetat 1% secara intraperitonial. Jumlah geliat mencit diamati setiap 5 menit selama 30 menit, lalu dihitung presentase daya analgesik dan efektivitas analgesiknya. Dari hasil penelitian didapatkan ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) dosis 100mg/kgBB dapat memberikan efek analgesik yang lebih besar yaitu 9,2% dibandingkan dengan ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) dosis 25 mg/kgBB dan 50 mg/kgBB yang hanya memberikan efek analgesik sebesar 34,7% dan 23,1%. Disimpulkan bahwa terdapat efek analgesik ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) pada mencit putih (Mus Musculus).
Description Of Characteristics, Diagnosis And Financing Of BPJS Patients In ENT Poly Health Service Facility Level 2 Roesbiantoro, Andi; Budhi Setianto; Adriansyah, Agus Aan; Pulih Asih, Akas Yekti; Setiyowati, Eppy; Bistara, Difran Nobel; Sa'adah, Nikmatus
TEKNOLOGI MEDIS DAN JURNAL KESEHATAN UMUM Vol 6 No 2 (2022): Medical Technology and Public Health Journal September 2022
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mtphj.v6i2.3081

Abstract

The application of tariff applied in handling BPJS patients references the INA- CBGs and the payment model used by BPJS Kesehatan to replace the total bill by the hospital. Hospitals receive payments based on the INA- CBGs rate, which is the average cost spent by a group of diagnoses. It is expected to improve the quality and efficiency of hospitals. The benefit of implementing INA -CBGs in JKN is the tariffs in the form of packages cover all components of hospital costs. Cost efficiency efforts must be made. That is no deficit from the applicable INA-CBGS tariff. Quality and cost control efforts are very important in the implementation of ENT specialist poly services. This study aims to analyze the demographic characteristics of the patient, the patient's diagnosis, the difference in rates between INA CBGS payments and RSIS rates, the composition of financing and the Unit Cost of ENT Polyclinics. The research type is quantitative observational with cross-sectional design. The research location is at the Surabaya Islamic Hospital with BPJS TXT data, processing in January-December 2019. The results showed, the demographic characteristics of most patients were > 50 years old, and most of them were diagnosed with minor chronic diseases. The difference between Ina-CBGS payments and RSIS rates is Rp. 60,174 which means that each patient contributes a profit of Rp. 60,174. The composition of the financing for implementation of the ENT Polyclinic is the cost of consulting services. The unit cost of ENT Polyclinic patients is Rp. 132,774 per patient.
Implementation of Cultural Internalization Through Effective Communication Training as an Effort to Increase Work Motivation at Hospital Agus Aan Adriansyah; Budhi Setianto; Akas Yekti Pulih Asih; Yauwan Tobing Lukiyono; Nikmatus Sa’adah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT Vol. 4 No. 1 (2024): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Memaksimalkan Potensi
Publisher : Universitas Nahdlatul Ulama Surabaya

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Abstract

The addition of new buildings and services at hospitals The millennial generation is now starting to dominate the world of work. This condition is a challenge for agencies in managing human resource (HR) management strategies because the generation gap presents differences in ways of working, perspectives and ways of communicating. With this gap, training is held regarding effective communication so that there are no differences in communication between gap generations. This training aims to intervene in the implementation of culture as an effort to increase work motivation. The training was attended by 64 structural officials using lectures, discussions and case studies. This training, which was packaged attractively and attended enthusiastically by the participants, has provided benefits to the participants. shows the final test on the data is higher than the initial test. However, the range of distribution of final test data also becomes smaller, this shows that there is an increase in knowledge regarding effective communication. The following are Paired sample correlations to test the influence related to the implementation of Cultural Internalization Implementation Training with Effective Communication Training at Hospital X as an Effort to Increase Work Motivation
Workshop On Preparing Complementary Foods For Breastfeeding (MP ASI) To Cadres In Stunting Prevention Umi Hanik; Budhi Setianto; Agus Aan Adriansyah; Merry Susantri; Hartatiek Nila Karmila; Yauwan Tobing Lukiyono; Nikmatus Sa'adah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT Vol. 4 No. 1 (2024): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Memaksimalkan Potensi
Publisher : Universitas Nahdlatul Ulama Surabaya

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Abstract

Various nutritional problems are found to occur in almost all economic strata of society, both in rural and urban areas. This shows that the underlying cause of these nutritional problems is not only poverty. But also the lack of public knowledge about healthy lifestyles and optimal nutritional fulfilment MPASI is food that can meet nutritional needs so that babies and children are healthy and can grow and develop optimally. Community Service related to the provision of MPASI education. Community service is carried out for cadre mothers in the work area of RW 07, Wonokromo Village, in the form of education related to MPASI for mothers of babies aged 0-1 years, it is hoped that it can increase the knowledge of mothers regarding MPASI so that in the future they can provide MPASI appropriately and well to babies which is useful for fulfilling nutrition as an effort to increase the ideal baby weight or according to the growth curve. Based on the results of the service, counselling on the provision of MPASI according to age and WHO standards as an effort to prevent stunting showed results by the objectives of the activity. Therefore, it is necessary to hold promotive activities in the form of continuous education by forming study groups with mothers of toddlers who are accompanied by cadres. Cadres also need to get supplies and assistance from the Puskesmas Nutrition Team this is expected to help improve the knowledge of mothers who have toddlers in preparing for MPASI so that mothers in Indonesia can play a role in reducing the incidence of stunting. Knowledge transfer can run continuously and in agreement. So that mothers who have babies and toddlers can understand MPASI and can apply it in everyday life. The significance value (2- tailed) of this case example is 0.000 (p <0.05). So that the results of the initial test and the final test experienced significant changes (meaningful). Based on the descriptive statistics of the initial test and the final test, it was proven that the final test was higher. It can be concluded that the Workshop in Preparing MP ASI affects increasing participant knowledge.
Campaign To Increase The Knowledge Of Health Cadres In Efforts To Prevent Hearing Loss Risks In Commemoration Of World Hearing Day Andi Roesbiantoro; Budhi Setianto; Agus Aan Adriansyah; Yauwan Tobing Lukiyono; Rizka Dany Afina; Hartatik Nila Karmila; Nikmatus Sa'adah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT Vol. 4 No. 1 (2024): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Memaksimalkan Potensi
Publisher : Universitas Nahdlatul Ulama Surabaya

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Abstract

Hearing loss is a threat to society and is age agnostic, including in the elderly. WHO commemorates World Hearing Day to raise awareness about the importance of ear care. This activity aims to educate health cadres and the community about hearing loss prevention. Socialisation activities were carried out in Wonokromo Village using lecture and question and answer methods. Before and after the socialisation, participants were asked questions to measure their knowledge about ear health. The counselling programme was attended by 74 participants. The pre-test and post-test results showed an increase in knowledge related to ear health and prevention of hearing loss. The mean value of the pre-test was 634, while the post- test increased to 861, showing a significant change (p < 0.05). This socialisation was effective in increasing participants' understanding and knowledge on how to maintain ear health. This is expected to increase public awareness and concern for the importance of hearing health and apply the results of counselling in everyday life. For the sustainability of this programme, it is recommended that education related to ear health be carried out regularly and involve various community groups. In addition, health cadres can be given further training to become agents of education in their neighbourhoods. Collaborative efforts between health, community and government are also needed to ensure equitable access to hearing health information and services.
Counseling On The Benefits Of Air Circulation In The House As An Effort To Prevent TB Disease Akas Yekti Pulih Asih; Budhi Setianto; Agus Aan Adriansyah; Effendi; Yauwan Tobing Lukiyono; Nathalya Dwi Kartika Sari; Nikmatus Sa’adah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT Vol. 4 No. 2 (2024): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Memaksimalkan Potensi
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/snpm.v4i2.1405

Abstract

One way to prevent TB is to maintain air circulation in the house. Good air circulation in the house is essential to create a healthy and comfortable environment. Good air circulation ensures fresh air. Community service aims to help provide insight to the community regarding the benefits of healthy air circulation at home as an effort to prevent TB disease in the work area of the Wonokromo sub-district health centre, Surabaya City. The service method used is counselling about tuberculosis with partners who are 62 residents of RW 05, Wonokromo Village, Surabaya City. The results of the community service can be concluded that the extension of the benefits of indoor air circulation as an effort to prevent TB disease can increase public knowledge about pulmonary tuberculosis in the work area of RW 07, Wonokromo Village. The results of implementing community service can significantly increase community knowledge about pulmonary tuberculosis by 86.6%. Suggestions: Regular education needs to be carried out as an effort to eliminate TB so that the morbidity rate for pulmonary tuberculosis in Wonokromo Village decreases.
Co-Authors Abd Ghafar, Siti Aisyah Afina, Rizka Dany Agus Aan Adriansyah Ahda Mas Ulah Ahda Mas Ulah Aizatun Nisa Akas Yekti Pulih Asih Andi Roesbiantoro Anggarwati, Fauziah Rizki Annisa Putri Arindis, Pinky Ayu Marsela Asmarani, Yolanda Kartika Asri, Arilis Larasati Ode Bagus Soebadi Binti MU’AROFAH Budhi Setianto Budhi Setianto Chasanah, Niswatun Dany Afina, Rizka Diffran Nobel Bistara Difran Nobel Bistara Dita Eri Triana Dwi Indah Pertami, Sawitri Effendi Effendi Effendi Effendi Effendi Effendy Effendy Eka Putri Pertiwi Eka Resti Efrata Elyana Asnar Endah Kusumastuti Eppy Setiyoati Eppy Setiyowati Evy Afifah Syagran Evy Afiyah Syagran Evy Afiyah Syagran Gadis Meinar Sari Gustina, Mara Hartatiek Nila Karmila Hartatiek Nila Karmila Hartatik Nila Karmila Hening Tuti Hendarti Herlambang Prehananto Herlambang Prehananto Herlambang Prehananto, Herlambang Ida Wahyuningsih Indah Lestari Indah Lestari Indah Lestari, Indah Iqbal Firdaus Iqbal Firdaus Istiati, Istiati Karmila, Hartatik Nila Kombih, Muhammad Fifin Kusumawati, Diah Retno Lailatul Arofah, Nur Lukis, Prima Agusti Mahayatma Soendoro Makki Makki Maya Purnia Sari Merry Susantri Mery Susantri Moelok, Iqbal Moch Muhammad Zahid Abdillah Multia Ranum Sari Nailah Tri Iswira Nashifah, Nur Sa'adah Nathalya Dwi Kartika Sari Niswatun Chasanah Niswatun Chasanah Niswatun Chasanah Nur Dianawati Nurul Jannatul Firdausi Pertami, Sawitri Dwi Indah Pinky Ayu Marsela Arindis Pinky Ayu Marsela Arindis Pulih Asih, Akas Yekti Puspa Dila Rohmaniar Puspa Dila Rohmaniar Ricky Ramadhan Rizka Dany Afina Rizki Astri A Rizqullah, Widaad Roesbiantoro, Andi Rohmaniar, Puspa Dila Rudi Irawan Rusdianingsih Rusdianingsih Sari, Ernita Sawitri Dwi Indah Pertami Sawitri Dwi Indah Pertami Sawitri Dwi Indah Pertami Sholihah, Mufidatus Silvia Veronica, Silvia Siti Mutmainah Suyitno Suyitno Syagran, Evy Thoifur Mashudi Tuti Hendrarti, Hening Ulah, Ahda Mas Umi Hanik Umi Hanik Umi Hanik Wahyu Eka Kurniawan Wisnu Abiarto N Yauwan Tobing Lukiyono Yuliani, Kartika